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Nasdaq · USD

AMLX

Amylyx Pharmaceuticals, Inc.

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Tapewire entity
259
SEC CIK
0001658551
Parsed reports
204

Last 12 months

Inside the activity.

2 purchase rows · 31 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202511
Jan 202607
Feb 202605
Mar 202605
Apr 202600
May 202610
Jun 202600
Jul 202602
Aug 202600
Sep 2026010
Oct 202601

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
March 27, 2023 Filed Mar 29, 2023 20:05 UTC SaleCommon Stock 28,000 $30.80 $862,400.00
Disclosure

SEC source: 0000899243-23-009972 · doc4.xml · nonDerivative · entry 2

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,126,350

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.74 to $30.88, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F4 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 27, 2023 Filed Mar 29, 2023 20:05 UTC SaleCommon Stock 32,964 $30.25 $997,161.00
Disclosure

SEC source: 0000899243-23-009972 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,154,350

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.67 to $30.65, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F4 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 21, 2023 Filed Mar 23, 2023 20:05 UTC SaleCommon Stock 28,807 $32.17 $926,721.19
Disclosure

SEC source: 0000899243-23-009506 · doc4.xml · nonDerivative · entry 2

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,187,314

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.005 to $32.38, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F3 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 21, 2023 Filed Mar 23, 2023 20:05 UTC SaleCommon Stock 34,641 $31.69 $1,097,773.29
Disclosure

SEC source: 0000899243-23-009506 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,216,121

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.00 to $32.00, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F3 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 16, 2023 Filed Mar 17, 2023 20:05 UTC SaleCommon Stock 9,122 $32.55 $296,921.10
Disclosure

SEC source: 0000899243-23-008858 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,250,762

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.50 to $32.93, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F2 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC SaleCommon Stock 1,916 $32.45 $62,171.71
Disclosure

SEC source: 0000899243-23-009179 · doc4.xml · nonDerivative · entry 2

MILNE GEORGE M JR · CIK 0001179552 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 862,021

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 16, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.30 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC SaleCommon Stock 33,084 $31.86 $1,053,900.75
Disclosure

SEC source: 0000899243-23-009179 · doc4.xml · nonDerivative · entry 1

MILNE GEORGE M JR · CIK 0001179552 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 863,937

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 16, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.30 to $32.29. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:21 UTC
Cohen Joshua BDirector · Co-Chief Executive Officer
GrantStock Option (right to buy) · Derivative 225,000 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009171 · doc4.xml · derivative · entry 4

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2033-03-16

F5 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:21 UTC
Cohen Joshua BDirector · Co-Chief Executive Officer
GrantCommon Stock 50,000 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009171 · doc4.xml · nonDerivative · entry 3

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,842,617

F4 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:21 UTC
Cohen Joshua BDirector · Co-Chief Executive Officer
SaleCommon Stock 3,924 $32.45 $127,314.57
Disclosure

SEC source: 0000899243-23-009171 · doc4.xml · nonDerivative · entry 2

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,792,617

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.26 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:21 UTC
Cohen Joshua BDirector · Co-Chief Executive Officer
SaleCommon Stock 96,076 $31.84 $3,059,021.41
Disclosure

SEC source: 0000899243-23-009171 · doc4.xml · nonDerivative · entry 1

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,796,541

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.26 to $32.25. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 20, 2023 20:27 UTC
Olinger MargaretChief Commercial Officer
GrantStock Option (right to buy) · Derivative 82,500 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009180 · doc4.xml · derivative · entry 2

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,500

Underlying: Common Stock · 82,500 shares

Expires 2033-03-16

F2 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 20, 2023 20:27 UTC
Olinger MargaretChief Commercial Officer
GrantCommon Stock 18,333 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009180 · doc4.xml · nonDerivative · entry 1

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 232,688

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:31 UTC
Klee Justin B.Director · Co-Chief Executive Officer
GrantStock Option (right to buy) · Derivative 225,000 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009182 · doc4.xml · derivative · entry 4

Klee Justin B. · CIK 0001898314 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2033-03-16

F5 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:31 UTC
Klee Justin B.Director · Co-Chief Executive Officer
GrantCommon Stock 50,000 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009182 · doc4.xml · nonDerivative · entry 3

Klee Justin B. · CIK 0001898314 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,842,617

F4 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:31 UTC
Klee Justin B.Director · Co-Chief Executive Officer
SaleCommon Stock 3,445 $32.48 $111,876.72
Disclosure

SEC source: 0000899243-23-009182 · doc4.xml · nonDerivative · entry 2

Klee Justin B. · CIK 0001898314 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,792,617

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.33 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:31 UTC
Klee Justin B.Director · Co-Chief Executive Officer
SaleCommon Stock 96,555 $31.84 $3,074,359.48
Disclosure

SEC source: 0000899243-23-009182 · doc4.xml · nonDerivative · entry 1

Klee Justin B. · CIK 0001898314 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,796,062

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.32 to $32.31. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC
Yeramian Patrick DChief Medical Officer
GrantStock Option (right to buy) · Derivative 41,250 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009178 · doc4.xml · derivative · entry 4

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,250

Underlying: Common Stock · 41,250 shares

Expires 2033-03-16

F5 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC
Yeramian Patrick DChief Medical Officer
GrantCommon Stock 9,167 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009178 · doc4.xml · nonDerivative · entry 3

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,839

F4 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC
Yeramian Patrick DChief Medical Officer
SaleCommon Stock 2,416 $32.43 $78,358.37
Disclosure

SEC source: 0000899243-23-009178 · doc4.xml · nonDerivative · entry 2

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,672

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.28 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC
Yeramian Patrick DChief Medical Officer
SaleCommon Stock 52,211 $31.85 $1,662,842.03
Disclosure

SEC source: 0000899243-23-009178 · doc4.xml · nonDerivative · entry 1

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,088

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.26 to $32.25. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC
Mazzariello GinaChief Legal Officer
GrantStock Option (right to buy) · Derivative 82,500 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009177 · doc4.xml · derivative · entry 2

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,500

Underlying: Common Stock · 82,500 shares

Expires 2033-03-16

F2 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:25 UTC
Mazzariello GinaChief Legal Officer
GrantCommon Stock 18,333 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009177 · doc4.xml · nonDerivative · entry 1

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,747

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:22 UTC GrantStock Option (Right to Buy) · Derivative 27,403 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009172 · doc4.xml · derivative · entry 2

Firestone Karen · CIK 0001969821 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,403

Underlying: Common Stock · 27,403 shares

Expires 2033-03-16

F2 · derivative.exercise_date: One-third of the shares subject to the option shall vest on the first anniversary of the date of grant, and the remaining two-thirds will vest in equal monthly installments over two years, provided, however, that all vesting shall cease if the director resigns from the Board or otherwise ceases to serve as a director of the Issuer.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:22 UTC PurchaseCommon Stock 1,000 $31.99 $31,990.00
Disclosure

SEC source: 0000899243-23-009172 · doc4.xml · nonDerivative · entry 1

Firestone Karen · CIK 0001969821 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,000

F1 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.96 to $32.00. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC
FRATES JAMES MChief Financial Officer
GrantStock Option (right to buy) · Derivative 97,500 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · derivative · entry 4

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Common Stock · 97,500 shares

Expires 2033-03-16

F5 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC
FRATES JAMES MChief Financial Officer
GrantCommon Stock 21,667 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · nonDerivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,176

F4 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC
FRATES JAMES MChief Financial Officer
SaleCommon Stock 1,704 $32.46 $55,320.19
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,509

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.33 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC
FRATES JAMES MChief Financial Officer
SaleCommon Stock 30,796 $31.86 $981,139.00
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,213

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.33 to $32.30. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment
FRATES JAMES MChief Financial Officer
Exercise / conversionStock Option (right to buy) · Derivative 32,500 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · derivative · entry 6

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 414,500

Underlying: Common Stock · 32,500 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F7 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment
FRATES JAMES MChief Financial Officer
GrantStock Option (right to buy) · Derivative 97,500 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · derivative · entry 5

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Common Stock · 97,500 shares

Expires 2033-03-16

F6 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment
FRATES JAMES MChief Financial Officer
GrantCommon Stock 21,667 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 4

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,676

F5 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment
FRATES JAMES MChief Financial Officer
SaleCommon Stock 1,704 $32.46 $55,320.19
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,009

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.33 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

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March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment
FRATES JAMES MChief Financial Officer
SaleCommon Stock 30,796 $31.86 $981,139.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,713

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.33 to $32.30. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment
FRATES JAMES MChief Financial Officer
Exercise / conversionCommon Stock 32,500 $6.88 $223,600.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,509

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
Exercise / conversionStock Option (right to buy) · Derivative 16,748 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · derivative · entry 10

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,252

Underlying: Common Stock · 16,748 shares

Expires 2031-02-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F9 · derivative.exercise_date: 16,256 shares underlying this option vested on February 19, 2022, with the remaining shares vesting in monthly installments of 1,354 shares thereafter.

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March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
Exercise / conversionStock Option (right to buy) · Derivative 30,041 $0.00 Strike: $0.37 $0.00
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · derivative · entry 9

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,466

Underlying: Common Stock · 30,041 shares

Expires 2029-03-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F8 · derivative.exercise_date: As of the date of this filing, 39,688 shares subject to the option are vested and exercisable. 52,819 shares subject to such option vest and become exercisable in substantially equal monthly installments until November 26, 2023.

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March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
Exercise / conversionStock Option (right to buy) · Derivative 2,789 $0.00 Strike: $0.33 $0.00
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · derivative · entry 8

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,789 shares

Expires 2028-02-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F7 · derivative.exercise_date: The shares subject to such option are vested and currently exercisable.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
GrantStock Option (right to buy) · Derivative 41,250 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · derivative · entry 7

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,250

Underlying: Common Stock · 41,250 shares

Expires 2033-03-16

F6 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

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March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
GrantCommon Stock 9,167 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · nonDerivative · entry 6

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,417

F5 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
SaleCommon Stock 2,416 $32.43 $78,358.37
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · nonDerivative · entry 5

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 199,250

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.28 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
SaleCommon Stock 52,211 $31.85 $1,662,842.03
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · nonDerivative · entry 4

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 201,666

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.26 to $32.25. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
Exercise / conversionCommon Stock 16,748 $6.88 $115,226.24
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · nonDerivative · entry 3

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 253,877

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
Exercise / conversionCommon Stock 30,041 $0.37 $11,115.17
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · nonDerivative · entry 2

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 237,129

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:45 UTC Amendment
Yeramian Patrick DChief Medical Officer
Exercise / conversionCommon Stock 2,789 $0.33 $920.37
Disclosure

SEC source: 0000899243-23-009600 · doc4a.xml · nonDerivative · entry 1

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 207,088

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of an aggregate of 49,578 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 15, 2023 Filed Mar 16, 2023 20:11 UTC SaleCommon Stock 41,066 $33.68 $1,383,102.88
Disclosure

SEC source: 0000899243-23-008733 · doc4.xml · nonDerivative · entry 3

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,259,884

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.505 to $34.460, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F4 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 15, 2023 Filed Mar 16, 2023 20:11 UTC SaleCommon Stock 108,934 $33.12 $3,607,894.08
Disclosure

SEC source: 0000899243-23-008733 · doc4.xml · nonDerivative · entry 2

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,300,950

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.5 to $33.5, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F4 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 14, 2023 Filed Mar 16, 2023 20:11 UTC SaleCommon Stock 70,714 $34.54 $2,442,461.56
Disclosure

SEC source: 0000899243-23-008733 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,409,884

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.50 to $34.88, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F4 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
March 02, 2023 Filed Mar 6, 2023 14:10 UTC SaleCommon Stock 50,000 $33.75 $1,687,500.00
Disclosure

SEC source: 0000899243-23-007120 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,480,598

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.38 to $34.04, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F2 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

Read SEC document
February 24, 2023 Filed Feb 28, 2023 21:42 UTC
Mazzariello GinaChief Legal Officer
SaleCommon Stock 3,586 $34.49 $123,671.82
Disclosure

SEC source: 0000899243-23-006418 · doc4.xml · nonDerivative · entry 1

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,414

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and intended to qualify under Rule 10b5-1.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.25 to $34.84. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.