TapewireFind a company

person · Reporting owner

FRATES JAMES M

Disclosed activity across 3 companies

Tapewire entity
21224
SEC CIK
0001235598

Export transaction history ↓

Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Alkermes plc.ALKS · Entity 2392SVP, Alks Inc; CFO ALKSMay 14, 2020May 14, 2020
Amylyx Pharmaceuticals, Inc.AMLX · Entity 259Chief Financial OfficerSeptember 10, 2026September 14, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Alkermes plc.

Report date May 14, 2020 · Filed May 14, 2020

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Ordinary SharesSEC Table I · non-derivativeDirect91,828 Reported balance After 2020-05-14 transaction · row 1
1 source row

Row 1 · 2020-05-14 · Exercise / conversion · Acquired 21,983 · Balance 91,828

Employee Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $11.74 · Expires 2020-05-17Direct0 Reported balance After 2020-05-14 transaction · row 5 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 5 · 2020-05-14 · Exercise / conversion · Disposed 21,983 · Balance 0

F3: These options are fully vested in accordance with their terms.

Ordinary SharesSEC Table I · non-derivativeIndirectBy 2018 GRAT No. 21,669 Reported balance Holding disclosure · report date 2020-05-14 · row 2 Holding and transaction disclosures are not merged.
1 source row

Row 2 · Balance 1,669

F1: Shares held by James M. Frates 2018 Grantor Retained Annuity Trust No. 2 dated May 25, 2018 (the "2018 GRAT No. 2"). The Reporting Person is a trustee and beneficiary of the 2018 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2018 GRAT No. 2.

Ordinary SharesSEC Table I · non-derivativeIndirectBy 2019 GRAT No. 1150,000 Reported balance Holding disclosure · report date 2020-05-14 · row 3 Holding and transaction disclosures are not merged.
1 source row

Row 3 · Balance 150,000

F2: Shares held by the 2019 GRAT No. 1. The Reporting Person is a trustee and beneficiary of the 2019 GRAT No. 1 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2019 GRAT No. 1.

Ordinary SharesSEC Table I · non-derivativeIndirectBy Sons4,000 Reported balance Holding disclosure · report date 2020-05-14 · row 4 Holding and transaction disclosures are not merged.
1 source row

Row 4 · Balance 4,000

Filing footnotes · ownership attribution and instrument terms

F1: Shares held by James M. Frates 2018 Grantor Retained Annuity Trust No. 2 dated May 25, 2018 (the "2018 GRAT No. 2"). The Reporting Person is a trustee and beneficiary of the 2018 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2018 GRAT No. 2.

F2: Shares held by the 2019 GRAT No. 1. The Reporting Person is a trustee and beneficiary of the 2019 GRAT No. 1 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2019 GRAT No. 1.

F3: These options are fully vested in accordance with their terms.

Amylyx Pharmaceuticals, Inc.

Report date September 10, 2026 · Filed September 14, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect233,625 Ending reported balance After 2026-09-10 transaction · row 2
2 source rows · reconciled sequence

Row 1 · 2026-09-10 · Sale · Disposed 9,768 · Balance 234,667

F1: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.805 to $32.71. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Row 2 · 2026-09-10 · Sale · Disposed 1,042 · Balance 233,625

F1: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F3: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.84 to $33.45. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Common StockSEC Table I · non-derivativeIndirectBy Trust100,000 Reported balance Holding disclosure · report date 2026-09-10 · row 3 Holding and transaction disclosures are not merged.
1 source row

Row 3 · Balance 100,000

F4: Shares held by the JAMES M. FRATES 2025 GRAT NO 1 U/A DTD 12/12/2025, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

Common StockSEC Table I · non-derivativeIndirectBy Trust15,459 Reported balance Holding disclosure · report date 2026-09-10 · row 4 Holding and transaction disclosures are not merged.
1 source row

Row 4 · Balance 15,459

F5: Shares held by the James M. Frates 2024 Grantor Retained Annuity Trust No. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

Common StockSEC Table I · non-derivativeIndirectBy Trust11,072 Reported balance Holding disclosure · report date 2026-09-10 · row 5 Holding and transaction disclosures are not merged.
1 source row

Row 5 · Balance 11,072

F6: Shares held by the FRATES FAMILY 2013 IRREV TRUST, for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

Common StockSEC Table I · non-derivativeIndirectBy Trust40,000 Reported balance Holding disclosure · report date 2026-09-10 · row 6 Holding and transaction disclosures are not merged.
1 source row

Row 6 · Balance 40,000

F7: Shares held by the JAMES M. FRATES 2026 GRANTOR RETAINED ANNUITY TRUST NO. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

Filing footnotes · ownership attribution and instrument terms

F1: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.805 to $32.71. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.84 to $33.45. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4: Shares held by the JAMES M. FRATES 2025 GRAT NO 1 U/A DTD 12/12/2025, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

F5: Shares held by the James M. Frates 2024 Grantor Retained Annuity Trust No. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

F6: Shares held by the FRATES FAMILY 2013 IRREV TRUST, for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

F7: Shares held by the JAMES M. FRATES 2026 GRANTOR RETAINED ANNUITY TRUST NO. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

Past disclosures · reporting ended (1)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

Sage Therapeutics, Inc.

Report date July 31, 2025 · Filed July 31, 2025

Section 16 reporting ended · disclosed 2025-07-31. Current position is not established by this disclosure.

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect0 Reported balance After 2025-07-31 transaction · row 1
1 source row

Row 1 · 2025-07-31 · Other · Disposed 2,845 · Balance 0

F1: This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger (the "Merger Agreement"), dated as of June 13, 2025, among Sage Therapeutics, Inc. (the "Issuer"), Supernus Pharmaceuticals, Inc. ("Parent"), and Saphire, Inc., a wholly owned subsidiary of Parent ("Purchaser"), pursuant to which Purchaser completed a cash tender offer for shares of common stock of the Issuer (each, a "Share") and thereafter merged with and into the Issuer, effective as of July 31, 2025 (the effective time of the merger, the "Effective Time"). At the Effective Time, each issued and outstanding Share was cancelled and converted into the right to receive (i) $8.50 per Share in cash (the "Closing Amount"), plus (ii) one contingent value right ("CVR") per Share, each without interest and subject to the withholding of applicable taxes.

F2: (Continued from footnote 1) Each CVR represents the right to receive up to $3.50 per Share in cash upon the satisfaction of specified milestones, as described in the Form 8-K filed by the Issuer with the Securities and Exchange Commission on June 16, 2025.

Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $6.14 · Expires 2035-01-03Direct0 Reported balance After 2025-07-31 transaction · row 2 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 2 · 2025-07-31 · Disposition to issuer · Disposed 19,154 · Balance 0

F3: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $6.77 · Expires 2035-06-10Direct0 Reported balance After 2025-07-31 transaction · row 3 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 3 · 2025-07-31 · Disposition to issuer · Disposed 21,500 · Balance 0

F3: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

Filing footnotes · ownership attribution and instrument terms

F1: This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger (the "Merger Agreement"), dated as of June 13, 2025, among Sage Therapeutics, Inc. (the "Issuer"), Supernus Pharmaceuticals, Inc. ("Parent"), and Saphire, Inc., a wholly owned subsidiary of Parent ("Purchaser"), pursuant to which Purchaser completed a cash tender offer for shares of common stock of the Issuer (each, a "Share") and thereafter merged with and into the Issuer, effective as of July 31, 2025 (the effective time of the merger, the "Effective Time"). At the Effective Time, each issued and outstanding Share was cancelled and converted into the right to receive (i) $8.50 per Share in cash (the "Closing Amount"), plus (ii) one contingent value right ("CVR") per Share, each without interest and subject to the withholding of applicable taxes.

F2: (Continued from footnote 1) Each CVR represents the right to receive up to $3.50 per Share in cash upon the satisfaction of specified milestones, as described in the Form 8-K filed by the Issuer with the Securities and Exchange Commission on June 16, 2025.

F3: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

Transaction history

JSON API
Reset

Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
September 10, 2026 Filed Sep 14, 2026 20:00 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 1,042 $33.23 $34,625.87
Disclosure

SEC source: 0001193125-26-390509 · ownership.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 233,625

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.84 to $33.45. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
September 10, 2026 Filed Sep 14, 2026 20:00 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 9,768 $32.27 $315,194.80
Disclosure

SEC source: 0001193125-26-390509 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 234,667

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.805 to $32.71. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
August 18, 2026 Filed Aug 21, 2026 01:00 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 22,807 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-359679 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 244,435

F1 · shares: The reported shares are represented by performance share units, or PSUs, and were awarded upon the achievement of certain performance metrics. Shares subject to the PSU vested on August 18, 2026.

Read SEC document
March 05, 2026 Filed Mar 9, 2026 20:00 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantStock Option (right to buy) · Derivative 143,985 $0.00 Strike: $14.10 $0.00
Disclosure

SEC source: 0001193125-26-098438 · ownership.xml · derivative · entry 5

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 143,985

Underlying: Common Stock · 143,985 shares

Expires 2036-03-05

F5 · derivative.exercise_date: 25% of the shares subject to the option shall vest and become exercisable on March 1, 2027, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

Read SEC document
March 05, 2026 Filed Mar 9, 2026 20:00 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 95,990 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-098438 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 261,628

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSUs shall vest in 4 equal annual installments, with the first installment vesting on March 1, 2027, subject to the Reporting Person's continued service to the Issuer through each such vesting date.

Read SEC document
March 02, 2026 Filed Mar 4, 2026 21:00 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 7,909 $14.52 $114,851.33
Disclosure

SEC source: 0001193125-26-091438 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 165,638

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.450 to $15.385. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
February 02, 2026 Filed Feb 4, 2026 21:05 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 3,557 $14.65 $52,096.89
Disclosure

SEC source: 0001193125-26-037553 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 173,547

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.460 to $14.790. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
January 06, 2026 Filed Jan 8, 2026 21:05 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 3,326 $11.11 $36,953.86
Disclosure

SEC source: 0001193125-26-007669 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 177,104

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.99 to $11.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
September 30, 2025 Filed Oct 2, 2025 20:15 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 10,558 $14.65 $154,650.42
Disclosure

SEC source: 0001193125-25-228341 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 280,430

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.35 to $15.075. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
July 31, 2025 Filed Jul 31, 2025 15:28 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 Disposition to issuerStock Option (Right to Buy) · Derivative 21,500 Not disclosed Strike: $6.77 Not disclosed
Disclosure

SEC source: 0000950170-25-100653 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 21,500 shares

Expires 2035-06-10

F3 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

F3 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

Read SEC document
July 31, 2025 Filed Jul 31, 2025 15:28 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 Disposition to issuerStock Option (Right to Buy) · Derivative 19,154 Not disclosed Strike: $6.14 Not disclosed
Disclosure

SEC source: 0000950170-25-100653 · ownership.xml · derivative · entry 2

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,154 shares

Expires 2035-01-03

F3 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

F3 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase Shares (a "Company Option") then outstanding and unexercised, whether or not vested, which had a per Share exercise price less than the Closing Amount was deemed fully vested and cancelled and converted into the right to receive (i) a cash payment (without interest and subject to the withholding of applicable taxes) equal to the product of (a) the excess of the Closing Amount over the per Share exercise price of such Company Option, multiplied by (b) the total number of Shares subject to such Company Option immediately prior to the Effective Time, plus (ii) one CVR for each Share subject to such Company Option immediately prior to the Effective Time. Each Company Option, whether or not vested, which had a per Share exercise price greater than or equal to the Closing Amount was cancelled with no consideration payable in respect thereof.

Read SEC document
July 31, 2025 Filed Jul 31, 2025 15:28 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 OtherCommon Stock 2,845 Not disclosed Not disclosed
Disclosure

SEC source: 0000950170-25-100653 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger (the "Merger Agreement"), dated as of June 13, 2025, among Sage Therapeutics, Inc. (the "Issuer"), Supernus Pharmaceuticals, Inc. ("Parent"), and Saphire, Inc., a wholly owned subsidiary of Parent ("Purchaser"), pursuant to which Purchaser completed a cash tender offer for shares of common stock of the Issuer (each, a "Share") and thereafter merged with and into the Issuer, effective as of July 31, 2025 (the effective time of the merger, the "Effective Time"). At the Effective Time, each issued and outstanding Share was cancelled and converted into the right to receive (i) $8.50 per Share in cash (the "Closing Amount"), plus (ii) one contingent value right ("CVR") per Share, each without interest and subject to the withholding of applicable taxes.

F2 · kind: (Continued from footnote 1) Each CVR represents the right to receive up to $3.50 per Share in cash upon the satisfaction of specified milestones, as described in the Form 8-K filed by the Issuer with the Securities and Exchange Commission on June 16, 2025.

F1 · price: This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger (the "Merger Agreement"), dated as of June 13, 2025, among Sage Therapeutics, Inc. (the "Issuer"), Supernus Pharmaceuticals, Inc. ("Parent"), and Saphire, Inc., a wholly owned subsidiary of Parent ("Purchaser"), pursuant to which Purchaser completed a cash tender offer for shares of common stock of the Issuer (each, a "Share") and thereafter merged with and into the Issuer, effective as of July 31, 2025 (the effective time of the merger, the "Effective Time"). At the Effective Time, each issued and outstanding Share was cancelled and converted into the right to receive (i) $8.50 per Share in cash (the "Closing Amount"), plus (ii) one contingent value right ("CVR") per Share, each without interest and subject to the withholding of applicable taxes.

F2 · price: (Continued from footnote 1) Each CVR represents the right to receive up to $3.50 per Share in cash upon the satisfaction of specified milestones, as described in the Form 8-K filed by the Issuer with the Securities and Exchange Commission on June 16, 2025.

Read SEC document
June 11, 2025 Filed Jun 13, 2025 20:13 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 GrantStock Option (Right to Buy) · Derivative 21,500 $0.00 Strike: $6.77 $0.00
Disclosure

SEC source: 0001562180-25-004791 · primarydocument.xml · derivative · entry 1

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2035-06-11

F1 · derivative.exercise_date: The stock option award was issued pursuant to the Sage Therapeutics, Inc. 2024 Equity Incentive Plan in accordance with Sage's Non-Employee Director Compensation Program. The option will vest in full upon the earlier to occur of June 11, 2026 or the day immediately prior to the 2026 Annual Meeting of Sage's stockholders, subject to continued service as a director on such date.

Read SEC document
March 31, 2025 Filed Apr 2, 2025 21:22 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 10,896 $3.47 $37,805.85
Disclosure

SEC source: 0000950170-25-049581 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 290,988

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $3.44 to $3.58. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 06, 2025 Filed Mar 11, 2025 00:28 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantStock Option (right to buy) · Derivative 102,630 $0.00 Strike: $3.61 $0.00
Disclosure

SEC source: 0000950170-25-036707 · ownership.xml · derivative · entry 4

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,630

Underlying: Common Stock · 102,630 shares

Expires 2035-03-05

F4 · derivative.exercise_date: 25% of the shares subject to the option shall vest and become exercisable on March 1, 2026, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

Read SEC document
March 06, 2025 Filed Mar 11, 2025 00:28 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 68,420 $0.00 $0.00
Disclosure

SEC source: 0000950170-25-036707 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 301,884

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSUs shall vest in 4 equal annual installments, with the first installment vesting on March 1, 2026, subject to the Reporting Person's continued service to the Issuer through each such vesting date.

Read SEC document
January 03, 2025 Filed Jan 6, 2025 21:02 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 GrantStock Options (Right to buy) · Derivative 19,154 $0.00 Strike: $6.14 $0.00
Disclosure

SEC source: 0001562180-25-000163 · primarydocument.xml · derivative · entry 1

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,154

Underlying: Common Stock · 19,154 shares

Expires 2035-01-03

F1 · derivative.exercise_date: The reporting person elected to receive this stock option award in lieu of payment of all cash retainers that would otherwise be paid for the reporting person's service during 2025 on the issuer's board or its committees, as permitted under the issuer's non-employee director compensation program. The stock option is granted under and subject to the terms of the Sage Therapeutics, Inc. 2024 Equity Incentive Plan. The option will vest in full on December 31, 2025, subject to the reporting person's continued service through such date.

Read SEC document
September 12, 2024 Filed Sep 16, 2024 21:30 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 PurchaseCommon Stock 40,000 $2.53 $101,368.00
Disclosure

SEC source: 0000950170-24-106910 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 233,464

F1 · price: The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $2.4849 to $2.63. Full information regarding the number of shares purchased at each separate price can be furnished to the SEC staff upon request.

Read SEC document
June 10, 2024 Filed Jun 11, 2024 20:58 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 GrantStock Option (Right to Buy) · Derivative 12,500 $0.00 Strike: $10.90 $0.00
Disclosure

SEC source: 0001562180-24-004950 · primarydocument.xml · derivative · entry 1

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The stock option award was issued pursuant to the Sage Therapeutics, Inc. 2024 Equity Incentive Plan in accordance with Sage's Non-Employee Director Compensation Program. The option will vest in full upon the earlier to occur of June 10, 2025 or the day immediately prior to the 2025 Annual Meeting of Sage's stockholders, subject to continued service as a director on such date.

Read SEC document
April 16, 2024 Filed Apr 19, 2024 00:23 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantStock Option (right to buy) · Derivative 120,000 $0.00 Strike: $2.01 $0.00
Disclosure

SEC source: 0000950170-24-045698 · ownership.xml · derivative · entry 4

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2034-04-15

F4 · derivative.exercise_date: 25% of the shares subject to the option shall vest and become exercisable on April 16, 2025, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

Read SEC document
April 16, 2024 Filed Apr 19, 2024 00:23 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 91,180 $0.00 $0.00
Disclosure

SEC source: 0000950170-24-045698 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,964

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSUs shall vest as follows: 33% on September 30, 2024, 33% on March 31, 2025 and 34% on September 30, 2025, subject to the Reporting Person's continued service to the Issuer through each such vesting date.

Read SEC document
March 05, 2024 Filed Mar 7, 2024 21:05 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 1,792 $18.73 $33,560.40
Disclosure

SEC source: 0000950170-24-027918 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 134,784

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.62 to $18.82. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
February 26, 2024 Filed Feb 28, 2024 23:44 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantStock Option (right to buy) · Derivative 60,000 $0.00 Strike: $17.56 $0.00
Disclosure

SEC source: 0000950170-24-022434 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2034-02-25

F3 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
February 26, 2024 Filed Feb 28, 2024 23:44 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 40,000 $0.00 $0.00
Disclosure

SEC source: 0000950170-24-022434 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,035

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
January 09, 2024 Filed Jan 11, 2024 22:11 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 2,716 $16.33 $44,347.12
Disclosure

SEC source: 0000950170-24-003984 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,035

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.18 to $16.70. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
January 03, 2024 Filed Jan 4, 2024 21:07 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 GrantStock Options (Right to buy) · Derivative 4,925 $0.00 Strike: $21.67 $0.00
Disclosure

SEC source: 0001562180-24-000226 · primarydocument.xml · derivative · entry 1

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,925

Underlying: Common Stock · 4,925 shares

Expires 2034-01-03

F1 · derivative.exercise_date: The reporting person elected to receive this stock option award in lieu of payment of all cash retainers that would otherwise be paid for the reporting person's service during 2024 on the issuer's board or its committees, as permitted under the issuer's amended and restated non-employee director compensation policy. The stock option is granted under and subject to the terms of the Sage Therapeutics, Inc. 2014 Stock Option and Incentive Plan. The option will vest in full on December 31, 2024, subject to the reporting person's continued service through such date.

Read SEC document
October 31, 2023 Filed Nov 2, 2023 19:33 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GiftCommon Stock 11,072 $0.00 $0.00
Disclosure

SEC source: 0000950170-23-058113 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 11,072

F1 · shares: On October 31, 2023, the James M. Frates Grantor Retained Annuity Trust 2021, for which the Reporting Person served as trustee and sole annuitant, liquidated and returned 8,410 shares to the Reporting Person as an annuity payment, transferring the remaining 11,072 shares to the FRATES FAMILY 2013 IRREV TRUST for no consideration.

F2 · ownership.nature: Shares held by the FRATES FAMILY 2013 IRREV TRUST, for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

Read SEC document
August 23, 2023 Filed Aug 24, 2023 20:15 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionStock Option (right to buy) · Derivative 18,165 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000950170-23-044381 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,835

Underlying: Common Stock · 18,165 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

Read SEC document
August 23, 2023 Filed Aug 24, 2023 20:15 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionCommon Stock 18,165 $6.88 $124,975.20
Disclosure

SEC source: 0000950170-23-044381 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,341

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 23, 2023 Filed Sep 5, 2024 23:55 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionStock Option (right to buy) · Derivative 18,165 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000950170-24-104191 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,835

Underlying: Common Stock · 18,165 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

Read SEC document
August 23, 2023 Filed Sep 5, 2024 23:55 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionCommon Stock 18,165 $6.88 $124,975.20
Disclosure

SEC source: 0000950170-24-104191 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,841

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: On August 24, 2023, a Form 4 was filed on behalf of the Reporting Person which inadvertently overstated the number of securities reported in Column 5 of Table I by 32,500 shares due to an administrative error. This Form 4 amendment is being filed to correct the aggregate number of shares beneficially owned by the Reporting Person as of the original transaction date, as well as the corresponding amounts that were carried forward on Form 4 reports subsequently filed on behalf of the Reporting Person.

Read SEC document
June 15, 2023 Filed Jun 16, 2023 20:06 UTC Sage Therapeutics, Inc. SAGE · Entity 77038 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $56.10 $0.00
Disclosure

SEC source: 0001562180-23-005265 · primarydocument.xml · derivative · entry 1

FRATES JAMES M · CIK 0001235598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2033-06-15

F1 · derivative.exercise_date: The stock option award was issued pursuant to the Sage Therapeutics, Inc. 2014 Stock Option and Incentive Plan in accordance with the terms of the Amended and Restated Non-Employee Director Compensation Policy. The option will vest in full upon the earlier to occur of June 15, 2024 or the day immediately prior to the 2024 Annual Meeting of Sage's stockholders, subject to continued service as a director on such date.

Read SEC document
May 16, 2023 Filed May 19, 2023 00:54 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionStock Option (right to buy) · Derivative 32,500 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000899243-23-013289 · doc4.xml · derivative · entry 5

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 382,000

Underlying: Common Stock · 32,500 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F5 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

Read SEC document
May 16, 2023 Filed May 19, 2023 00:54 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 500 $27.60 $13,800.00
Disclosure

SEC source: 0000899243-23-013289 · doc4.xml · nonDerivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,676

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.59 to $27.61. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
May 16, 2023 Filed May 19, 2023 00:54 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 32,000 $26.93 $861,651.20
Disclosure

SEC source: 0000899243-23-013289 · doc4.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,176

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.36 to $27.35. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
May 16, 2023 Filed May 19, 2023 00:54 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionCommon Stock 32,500 $6.88 $223,600.00
Disclosure

SEC source: 0000899243-23-013289 · doc4.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 88,176

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantStock Option (right to buy) · Derivative 97,500 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · derivative · entry 4

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Common Stock · 97,500 shares

Expires 2033-03-16

F5 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 21,667 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · nonDerivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,176

F4 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 1,704 $32.46 $55,320.19
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,509

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.33 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 21, 2023 00:18 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 30,796 $31.86 $981,139.00
Disclosure

SEC source: 0000899243-23-009168 · doc4.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,213

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.33 to $32.30. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionStock Option (right to buy) · Derivative 32,500 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · derivative · entry 6

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 414,500

Underlying: Common Stock · 32,500 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F7 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantStock Option (right to buy) · Derivative 97,500 $0.00 Strike: $32.08 $0.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · derivative · entry 5

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Common Stock · 97,500 shares

Expires 2033-03-16

F6 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 GrantCommon Stock 21,667 $0.00 $0.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 4

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,676

F5 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit award (a "RSU"). The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 1,704 $32.46 $55,320.19
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,009

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.33 to $32.93. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 30,796 $31.86 $981,139.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,713

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.33 to $32.30. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
March 16, 2023 Filed Mar 24, 2023 22:48 UTC Amendment Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionCommon Stock 32,500 $6.88 $223,600.00
Disclosure

SEC source: 0000899243-23-009602 · doc4a.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,509

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

F2 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F1 · balance_after: On March 16, 2023, the Reporting Person filed a Form 4 (the "Original Form 4") which inadvertently omitted the exercise of 32,500 options by the Reporting Person. The Original Form 4 reported the sale of shares of Common Stock of the Issuer ("Common Stock") underlying those options, pursuant to a Rule 10b5-1 trading plan. This Form 4 amendment is being filed for the purpose of amending and restating the Original Form 4 solely to report the exercise of the stock options and the resulting increase in beneficial ownership of Common Stock. The Reporting Person has not sold any additional shares of Common Stock beyond those sales reported in the Original Form 4.

Read SEC document
January 06, 2023 Filed Jan 11, 2023 00:20 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 822 $36.79 $30,240.39
Disclosure

SEC source: 0000899243-23-001523 · doc4.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,009

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and intended to qualify under Rule 10b5-1.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $36.59 to $37.01. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
January 06, 2023 Filed Jan 11, 2023 00:20 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 SaleCommon Stock 1,836 $36.08 $66,240.86
Disclosure

SEC source: 0000899243-23-001523 · doc4.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,831

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and intended to qualify under Rule 10b5-1.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.59 to $36.58. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Read SEC document
December 30, 2022 Filed Jan 5, 2023 02:33 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0000899243-23-000755 · doc4.xml · derivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 447,000

Underlying: Common Stock · 5,000 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

Read SEC document
December 30, 2022 Filed Jan 5, 2023 02:33 UTC Amylyx Pharmaceuticals, Inc. AMLX · Entity 259 Exercise / conversionCommon Stock 5,000 $6.88 $34,400.00
Disclosure

SEC source: 0000899243-23-000755 · doc4.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,667

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.