AMLX

SEC source: 0000950170-24-022434 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2034-02-25

F3 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

SEC source: 0000950170-24-022434 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,035

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

SEC source: 0000950170-24-022400 · ownership.xml · derivative · entry 2

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires 2034-02-25

F2 · derivative.exercise_date: 1/4 of the shares subject to the option shall vest and become exercisable on the first day of the month of the one year anniversary of the date of grant, and the remaining shares shall vest monthly over the remaining 36 months, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

SEC source: 0000950170-24-022400 · ownership.xml · nonDerivative · entry 1

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,912

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSU shall vest in 4 equal annual installments, with the first installment vesting on the first day of the month of the one year anniversary of the date of grant, subject to the Reporting Person's continued service to the Issuer through such vesting date.

SEC source: 0000950170-24-021472 · ownership.xml · nonDerivative · entry 1

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,245

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.61 to $19.02. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-24-008347 · ownership.xml · nonDerivative · entry 1

MILNE GEORGE M JR · CIK 0001179552 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 758,571

SEC source: 0000950170-24-005437 · ownership.xml · nonDerivative · entry 1

MILNE GEORGE M JR · CIK 0001179552 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 767,671

SEC source: 0000950170-24-003981 · ownership.xml · nonDerivative · entry 1

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,900,470

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.18 to $16.70. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-24-003985 · ownership.xml · nonDerivative · entry 1

Klee Justin B. · CIK 0001898314 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,836,776

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.18 to $16.70. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-24-003984 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,035

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.18 to $16.70. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-24-003974 · ownership.xml · nonDerivative · entry 1

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,605

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F1 · shares: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.18 to $16.70. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-23-073837 · ownership.xml · derivative · entry 2

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,577

Underlying: Common Stock · 25,000 shares

Expires 2029-05-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0000950170-23-073837 · ownership.xml · nonDerivative · entry 1

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 276,108

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-071533 · ownership.xml · nonDerivative · entry 1

Firestone Karen · CIK 0001969821 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

SEC source: 0000950170-23-066796 · ownership.xml · derivative · entry 2

Bedrosian Camille L · CIK 0001326969 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,500

Underlying: Common Stock · 162,500 shares

Expires 2033-11-26

F2 · derivative.exercise_date: 25% of the shares subject to the option shall vest and become exercisable on December 1, 2024, with the remainder vesting in a series of 36 successive monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer through each such vesting date.

SEC source: 0000950170-23-066796 · ownership.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,333

F1 · shares: The reported transaction involves the Reporting Person's receipt of a restricted stock unit ("RSU") award. The RSU shall vest in 4 annual installments, with the first installment vesting on December 1, 2024, subject to the Reporting Person's continuous service with the Issuer through each such vesting date.

SEC source: 0000950170-23-065259 · ownership.xml · derivative · entry 2

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,306

Underlying: Common Stock · 63,694 shares

Expires 2025-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 25,012 shares subject to such option vested and became exercisable on February 26, 2021, with the remaining shares vesting in monthly installments of 2,083 shares thereafter.

SEC source: 0000950170-23-065259 · ownership.xml · nonDerivative · entry 1

Cohen Joshua B · CIK 0001898644 · Director · Co-Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,906,311

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-058113 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 11,072

F1 · shares: On October 31, 2023, the James M. Frates Grantor Retained Annuity Trust 2021, for which the Reporting Person served as trustee and sole annuitant, liquidated and returned 8,410 shares to the Reporting Person as an annuity payment, transferring the remaining 11,072 shares to the FRATES FAMILY 2013 IRREV TRUST for no consideration.

F2 · ownership.nature: Shares held by the FRATES FAMILY 2013 IRREV TRUST, for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.

SEC source: 0000950170-23-044381 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,835

Underlying: Common Stock · 18,165 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

SEC source: 0000950170-23-044381 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,341

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-104191 · ownership.xml · derivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,835

Underlying: Common Stock · 18,165 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

SEC source: 0000950170-24-104191 · ownership.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,841

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: On August 24, 2023, a Form 4 was filed on behalf of the Reporting Person which inadvertently overstated the number of securities reported in Column 5 of Table I by 32,500 shares due to an administrative error. This Form 4 amendment is being filed to correct the aggregate number of shares beneficially owned by the Reporting Person as of the original transaction date, as well as the corresponding amounts that were carried forward on Form 4 reports subsequently filed on behalf of the Reporting Person.

SEC source: 0000899243-23-018211 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,997,302

F1 · shares: Reflects the gift / charitable donation of common stock to a 501(c)(3) non-profit organization. This is not a market transaction, thus no price has been reported. No value was received by the seller for the gifted shares.

F2 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL and disclaim any personal beneficial ownership of any shares held by MVIL.

SEC source: 0000950170-23-043242 · ownership.xml · nonDerivative · entry 1

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,083

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 16, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $20.41 to $21.32. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-23-033003 · ownership.xml · derivative · entry 2

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,577

Underlying: Common Stock · 20,000 shares

Expires 2029-05-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: As of the date of this filing, 67,156 shares subject to the option are vested and exercisable. 2,421 shares subject to such option vest and become exercisable in substantially equal monthly installments until August 13, 2023.

SEC source: 0000950170-23-033003 · ownership.xml · nonDerivative · entry 1

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,108

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-23-015410 · doc4.xml · derivative · entry 1

MILNE GEORGE M JR · CIK 0001179552 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,985

Underlying: Common Stock · 16,985 shares

Expires 2033-06-08

F1 · derivative.exercise_date: The shares subject to this option shall vest in full upon the earlier of (i) June 8, 2024 or (ii) the date of the next annual meeting, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

SEC source: 0000899243-23-015406 · doc4.xml · derivative · entry 1

FONTEYNE PAUL R. · CIK 0001727550 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,985

Underlying: Common Stock · 16,985 shares

Expires 2033-06-08

F1 · derivative.exercise_date: The shares subject to this option shall vest in full upon the earlier of (i) June 8, 2024 or (ii) the date of the next annual meeting, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

SEC source: 0000899243-23-015412 · doc4.xml · derivative · entry 1

Firestone Karen · CIK 0001969821 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,908

Underlying: Common Stock · 3,908 shares

Expires 2033-06-08

F1 · derivative.exercise_date: The shares subject to this option shall vest in full upon the earlier of (i) June 8, 2024 or (ii) the date of the next annual meeting, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

SEC source: 0000899243-23-015408 · doc4.xml · derivative · entry 1

Quimi Daphne · CIK 0001543031 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,985

Underlying: Common Stock · 16,985 shares

Expires 2033-06-08

F1 · derivative.exercise_date: The shares subject to this option shall vest in full upon the earlier of (i) June 8, 2024 or (ii) the date of the next annual meeting, subject to the Reporting Person's continuous service to the Issuer through such vesting date.

SEC source: 0000950170-23-023942 · ownership.xml · nonDerivative · entry 1

Olinger Margaret · CIK 0001898725 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 231,108

SEC source: 0000950170-23-023240 · ownership.xml · nonDerivative · entry 1

Mazzariello Gina · CIK 0001913765 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,247

SEC source: 0000899243-23-013289 · doc4.xml · derivative · entry 5

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 382,000

Underlying: Common Stock · 32,500 shares

Expires 2031-01-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F5 · derivative.exercise_date: 113,024 shares underlying this option vested on January 25, 2022, with the remaining shares vesting in monthly installments of 9,416 shares thereafter.

SEC source: 0000899243-23-013289 · doc4.xml · nonDerivative · entry 3

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,676

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.59 to $27.61. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000899243-23-013289 · doc4.xml · nonDerivative · entry 2

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,176

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.36 to $27.35. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000899243-23-013289 · doc4.xml · nonDerivative · entry 1

FRATES JAMES M · CIK 0001235598 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 88,176

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 15, 2022.

SEC source: 0000950170-23-022775 · ownership.xml · derivative · entry 5

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,770

Underlying: Common Stock · 9,764 shares

Expires 2031-02-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F4 · derivative.exercise_date: As of the date of this filing, 13,746 shares subject to the option are vested and exercisable. 23,600 shares subject to such option vest and become exercisable in substantially equal monthly installments until December 19, 2023.

SEC source: 0000950170-23-022775 · ownership.xml · derivative · entry 4

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,404

Underlying: Common Stock · 2,201 shares

Expires 2029-03-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F3 · derivative.exercise_date: As of the date of this filing, 2,201 shares subject to the option are vested and exercisable. 15,404 shares subject to such option vest and become exercisable in substantially equal monthly installments until November 26, 2023.

SEC source: 0000950170-23-022775 · ownership.xml · nonDerivative · entry 3

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,417

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.00 to $29.19. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000950170-23-022775 · ownership.xml · nonDerivative · entry 2

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 220,382

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

SEC source: 0000950170-23-022775 · ownership.xml · nonDerivative · entry 1

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,618

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

SEC source: 0000899243-23-011461 · doc4.xml · derivative · entry 6

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,534

Underlying: Common Stock · 4,718 shares

Expires 2031-02-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F4 · derivative.exercise_date: As of the date of this filing, 18,464 shares subject to the option are vested and exercisable. 29,788 shares subject to such option vest and become exercisable in substantially equal monthly installments until December 19, 2023.

SEC source: 0000899243-23-011461 · doc4.xml · derivative · entry 5

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,605

Underlying: Common Stock · 44,861 shares

Expires 2029-03-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F3 · derivative.exercise_date: As of the date of this filing, 44,861 shares subject to the option are vested and exercisable. 17,605 shares subject to such option vest and become exercisable in substantially equal monthly installments until November 26, 2023.

SEC source: 0000899243-23-011461 · doc4.xml · nonDerivative · entry 4

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,417

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

SEC source: 0000899243-23-011461 · doc4.xml · nonDerivative · entry 3

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,717

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.93 to $30.91. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0000899243-23-011461 · doc4.xml · nonDerivative · entry 2

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 257,996

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

SEC source: 0000899243-23-011461 · doc4.xml · nonDerivative · entry 1

Yeramian Patrick D · CIK 0001358266 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 253,278

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 14, 2022.

SEC source: 0000899243-23-010078 · doc4.xml · nonDerivative · entry 1

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,997,302

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.09 to $31.06, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F2 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.

SEC source: 0000899243-23-009972 · doc4.xml · nonDerivative · entry 3

Morningside Venture Investments Ltd · CIK 0001543112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,026,350

F3 · price: (The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.06 to $30.86, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

F4 · ownership.direct: Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, the directors of Morningside Venture Investments Limited ("MVIL"), share voting and dispositive control over the shares held by MVIL.