ALNY

SEC source: 0001325812-16-000107 · edgardoc.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · EVP, R&D, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2026-12-20

F1 · shares: Represents the time-vested portion of the reporting person's 2016 Annual Stock Option award. The reporting person also received an option to purchase 25,000 shares of ALNY common stock that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the option vests.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001325812-16-000111 · edgardoc.xml · derivative · entry 1

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,550

Underlying: Common Stock · 5,550 shares

Expires 2026-12-20

F1 · shares: Represents the time-vested portion of the reporting person's 2016 Annual Stock Option award. The reporting person also received an option to purchase 5,550 shares of ALNY common stock that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the option vests.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001325812-16-000109 · edgardoc.xml · derivative · entry 1

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2026-12-20

F1 · shares: Represents the time-vested portion of the reporting person's 2016 Annual Stock Option award. The reporting person also received an option to purchase 25,000 shares of ALNY common stock that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the option vests.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001325812-16-000108 · edgardoc.xml · derivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2026-12-20

F1 · shares: Represents the time-vested portion of the reporting person's 2016 Annual Stock Option award. The reporting person also received an option to purchase 25,000 shares of ALNY common stock that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the option vests.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001325812-16-000106 · edgardoc.xml · derivative · entry 1

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2026-12-20

F1 · shares: Represents the time-vested portion of the reporting person's 2016 Annual Stock Option award. The reporting person also received an option to purchase 25,000 shares of ALNY common stock that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the option vests.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001325812-16-000097 · primary_doc.xml · derivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 30,151 shares

Expires 2016-12-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents a "net exercise" of outstanding stock options due to expire on December 14, 2016, as permitted under the governing ALNY stock incentive plan. These shares were withheld by ALNY for payment of the option exercise price and applicable tax withholding, based on the closing price of ALNY common stock on December 12, 2016.

F3 · derivative.exercise_date: The stock option vested as to 25% of the shares on the first anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001325812-16-000097 · primary_doc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,370

F1 · kind: Represents a "net exercise" of outstanding stock options due to expire on December 14, 2016, as permitted under the governing ALNY stock incentive plan. These shares were withheld by ALNY for payment of the option exercise price and applicable tax withholding, based on the closing price of ALNY common stock on December 12, 2016.

SEC source: 0001325812-16-000097 · primary_doc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 171,080

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents a "net exercise" of outstanding stock options due to expire on December 14, 2016, as permitted under the governing ALNY stock incentive plan. These shares were withheld by ALNY for payment of the option exercise price and applicable tax withholding, based on the closing price of ALNY common stock on December 12, 2016.

SEC source: 0001553878-16-000061 · primary_doc.xml · derivative · entry 6

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 55,605 shares

Expires 2016-12-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 6, 2016. The 31,825 options exercised and sold and the 23,780 options exercised and held by the reporting person were due to expire on December 14, 2016.

F6 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

F1 · derivative.expiration_date: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 6, 2016. The 31,825 options exercised and sold and the 23,780 options exercised and held by the reporting person were due to expire on December 14, 2016.

SEC source: 0001553878-16-000061 · primary_doc.xml · nonDerivative · entry 4

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,584

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 6, 2016. The 31,825 options exercised and sold and the 23,780 options exercised and held by the reporting person were due to expire on December 14, 2016.

F4 · price: Sale prices ranged from $44.00 to $44.13.

SEC source: 0001553878-16-000061 · primary_doc.xml · nonDerivative · entry 3

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,084

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 6, 2016. The 31,825 options exercised and sold and the 23,780 options exercised and held by the reporting person were due to expire on December 14, 2016.

F3 · price: Sale prices ranged from $43.00 to $43.92.

SEC source: 0001553878-16-000061 · primary_doc.xml · nonDerivative · entry 2

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,060

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 6, 2016. The 31,825 options exercised and sold and the 23,780 options exercised and held by the reporting person were due to expire on December 14, 2016.

F2 · price: Sale prices ranged from $42.00 to $42.99.

SEC source: 0001553878-16-000061 · primary_doc.xml · nonDerivative · entry 1

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,409

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 6, 2016. The 31,825 options exercised and sold and the 23,780 options exercised and held by the reporting person were due to expire on December 14, 2016.

SEC source: 0001553878-16-000060 · primary_doc.xml · derivative · entry 6

Vaishnaw Akshay · CIK 0001458494 · EVP, R&D, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 29,165 shares

Expires 2016-12-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 17, 2016. The 29,165 options exercised and sold by the reporting person were due to expire on December 14, 2016.

F6 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

F1 · derivative.expiration_date: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 17, 2016. The 29,165 options exercised and sold by the reporting person were due to expire on December 14, 2016.

SEC source: 0001553878-16-000060 · primary_doc.xml · nonDerivative · entry 4

Vaishnaw Akshay · CIK 0001458494 · EVP, R&D, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,750

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 17, 2016. The 29,165 options exercised and sold by the reporting person were due to expire on December 14, 2016.

F4 · price: Sale prices ranged from $45.98 to $46.80.

SEC source: 0001553878-16-000060 · primary_doc.xml · nonDerivative · entry 3

Vaishnaw Akshay · CIK 0001458494 · EVP, R&D, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,250

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 17, 2016. The 29,165 options exercised and sold by the reporting person were due to expire on December 14, 2016.

F3 · price: Sale prices ranged from $44.98 to $45.95.

SEC source: 0001553878-16-000060 · primary_doc.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · EVP, R&D, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,547

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 17, 2016. The 29,165 options exercised and sold by the reporting person were due to expire on December 14, 2016.

F2 · price: Sale prices ranged from $43.90 to $44.86.

SEC source: 0001553878-16-000060 · primary_doc.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · EVP, R&D, CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,915

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 17, 2016. The 29,165 options exercised and sold by the reporting person were due to expire on December 14, 2016.

SEC source: 0001553878-16-000059 · edgardoc.xml · nonDerivative · entry 1

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 27,900

F1 · ownership.nature: The shares of ALNY common stock were purchased by the David E I Pyott Trust, of which the reporting person is trustee.

SEC source: 0001553878-16-000057 · primary_doc.xml · derivative · entry 5

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,981

Underlying: Common Stock · 4,019 shares

Expires 2022-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the first anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001553878-16-000057 · primary_doc.xml · derivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,915

Underlying: Common Stock · 3,521 shares

Expires 2021-11-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the first anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001553878-16-000057 · primary_doc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,929

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001553878-16-000057 · primary_doc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,910

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001553878-16-000056 · edgardoc.xml · derivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2026-09-18

F1 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.