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ALNY

ALNYLAM PHARMACEUTICALS, INC.

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3132
SEC CIK
0001178670
Parsed reports
483

Last 12 months

Inside the activity.

0 purchase rows · 279 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 2025031
Dec 202500
Jan 20260111
Feb 2026011
Mar 20260106
Apr 2026014
May 202600
Jun 202605
Jul 202600
Aug 202600
Sep 202600
Oct 202601

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
October 18, 2018 Filed Nov 26, 2018 21:11 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
OtherCommon Stock 17 $0.00 $0.00
Disclosure

SEC source: 0001735276-18-000079 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Managed Account

Disclosed balance after: 3,038

F2 · kind: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F2 · price: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F2 · ownership.nature: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

Read SEC document
October 18, 2018 Filed Jun 7, 2019 20:04 UTC OtherCommon Stock 21 $0.00 $0.00
Disclosure

SEC source: 0001735276-19-000046 · edgardoc.xml · nonDerivative · entry 1

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Indirect · by Managed Account

Disclosed balance after: 2,905

F1 · kind: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F1 · price: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F1 · ownership.nature: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

Read SEC document
October 18, 2018 Filed Jun 7, 2019 20:03 UTC
Vaishnaw AkshayPresident, R&D
OtherCommon Stock 21 $0.00 $0.00
Disclosure

SEC source: 0001735276-19-000045 · edgardoc.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Indirect · by Managed Account

Disclosed balance after: 416

F1 · kind: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F1 · price: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F1 · ownership.nature: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

Read SEC document
October 18, 2018 Filed Jun 7, 2019 20:03 UTC
KEATING LAURIEEVP, Chief Legal Officer
OtherCommon Stock 14 $0.00 $0.00
Disclosure

SEC source: 0001735276-19-000044 · edgardoc.xml · nonDerivative · entry 1

KEATING LAURIE · CIK 0001620743 · EVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Managed Account

Disclosed balance after: 334

F1 · kind: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F1 · price: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F1 · ownership.nature: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:59 UTC
KEATING LAURIESVP, GC & Secretary
GrantPerformance Stock Option 2016 (right to buy) · Derivative 6,250 $0.00 Strike: $42.22 $0.00
Disclosure

SEC source: 0001735276-18-000076 · edgardoc.xml · derivative · entry 2

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 6,250 shares

Expires 2026-12-20

F2 · kind: On December 20, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development, regulatory or commercial events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:59 UTC
KEATING LAURIESVP, GC & Secretary
GrantPerformance Stock Option 2015 (right to buy) · Derivative 3,500 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000076 · edgardoc.xml · derivative · entry 1

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,500

Underlying: Common Stock · 3,500 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development and regulatory events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the third performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:58 UTC
Greenstreet YvonneEVP, Chief Operating Officer
GrantPerformance Stock Option 2016 (right to buy) · Derivative 6,250 $0.00 Strike: $42.22 $0.00
Disclosure

SEC source: 0001735276-18-000075 · edgardoc.xml · derivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 6,250 shares

Expires 2026-12-20

F1 · kind: On December 20, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development, regulatory or commercial events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:57 UTC
Vaishnaw AkshayPresident, R&D
GrantPerformance Stock Option 2016 (right to buy) · Derivative 6,250 $0.00 Strike: $42.22 $0.00
Disclosure

SEC source: 0001735276-18-000074 · edgardoc.xml · derivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 6,250 shares

Expires 2026-12-20

F2 · kind: On December 20, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development, regulatory or commercial events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:57 UTC
Vaishnaw AkshayPresident, R&D
GrantPerformance Stock Option 2015 (right to buy) · Derivative 7,500 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000074 · edgardoc.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 7,500 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development and regulatory events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the third performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:55 UTC
Mason MichaelVP, Finance and Treasurer
GrantPerformance Stock Option 2016 (right to buy) · Derivative 1,387 $0.00 Strike: $42.22 $0.00
Disclosure

SEC source: 0001735276-18-000072 · edgardoc.xml · derivative · entry 2

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,775

Underlying: Common Stock · 1,387 shares

Expires 2026-12-20

F2 · kind: On December 20, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development, regulatory or commercial events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:55 UTC
Mason MichaelVP, Finance and Treasurer
GrantPerformance Stock Option 2015 (right to buy) · Derivative 1,800 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000072 · edgardoc.xml · derivative · entry 1

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,400

Underlying: Common Stock · 1,800 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development and regulatory events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the third performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:54 UTC GrantPerformance Stock Option 2016 (right to buy) · Derivative 6,250 $0.00 Strike: $42.22 $0.00
Disclosure

SEC source: 0001735276-18-000071 · edgardoc.xml · derivative · entry 2

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 6,250 shares

Expires 2026-12-20

F2 · kind: On December 20, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development, regulatory or commercial events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:54 UTC GrantPerformance Stock Option 2015 (right to buy) · Derivative 10,000 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000071 · edgardoc.xml · derivative · entry 1

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 10,000 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development and regulatory events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the third performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:56 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
GrantPerformance Stock Option 2016 (right to buy) · Derivative 6,250 $0.00 Strike: $42.22 $0.00
Disclosure

SEC source: 0001735276-18-000073 · edgardoc.xml · derivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 6,250 shares

Expires 2026-12-20

F2 · kind: On December 20, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development, regulatory or commercial events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
September 27, 2018 Filed Sep 28, 2018 20:56 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
GrantPerformance Stock Option 2015 (right to buy) · Derivative 16,250 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000073 · edgardoc.xml · derivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,750

Underlying: Common Stock · 16,250 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development and regulatory events, as approved by our compensation committee. Effective September 27, 2018, the compensation committee of the Company determined the third performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 20:15 UTC
Greenstreet YvonneEVP, Chief Operating Officer
SaleCommon Stock 2,500 $120.00 $300,000.00
Disclosure

SEC source: 0001735276-18-000064 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,916

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 17, 2018.

Read SEC document
August 21, 2018 Filed Aug 23, 2018 20:15 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
GrantPerformance Stock Option 2015 (right to buy) · Derivative 16,250 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000062 · edgardoc.xml · derivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,500

Underlying: Common Stock · 16,250 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development or commercial events, as approved by our compensation committee. Effective August 21, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
August 21, 2018 Filed Aug 23, 2018 20:15 UTC GrantPerformance Stock Option 2015 (right to buy) · Derivative 10,000 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000061 · edgardoc.xml · derivative · entry 1

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development or commercial events, as approved by our compensation committee. Effective August 21, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
August 21, 2018 Filed Aug 23, 2018 20:15 UTC
Vaishnaw AkshayPresident, R&D
GrantPerformance Stock Option 2015 (right to buy) · Derivative 7,500 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000060 · edgardoc.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 7,500 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development or commercial events, as approved by our compensation committee. Effective August 21, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
August 21, 2018 Filed Aug 23, 2018 20:14 UTC
KEATING LAURIESVP, GC & Secretary
GrantPerformance Stock Option 2015 (right to buy) · Derivative 3,500 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000059 · edgardoc.xml · derivative · entry 1

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,000

Underlying: Common Stock · 3,500 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development or commercial events, as approved by our compensation committee. Effective August 21, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
August 21, 2018 Filed Aug 23, 2018 20:13 UTC
Mason MichaelVP, Finance and Treasurer
GrantPerformance Stock Option 2015 (right to buy) · Derivative 1,800 $0.00 Strike: $88.95 $0.00
Disclosure

SEC source: 0001735276-18-000058 · edgardoc.xml · derivative · entry 1

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,600

Underlying: Common Stock · 1,800 shares

Expires 2025-12-18

F1 · kind: On December 18, 2015, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. One quarter of the shares subject to the option will vest upon the achievement of each of four specific clinical development or commercial events, as approved by our compensation committee. Effective August 21, 2018, the compensation committee of the Company determined the second performance criterion had been met and the option vested as to one-quarter of the shares.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:55 UTC
Vaishnaw AkshayPresident, R&D
Tax withholdingCommon Stock 766 $90.95 $69,667.70
Disclosure

SEC source: 0001325812-18-000030 · primary_doc.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,173

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:55 UTC
Vaishnaw AkshayPresident, R&D
GrantCommon Stock 1,724 $0.00 $0.00
Disclosure

SEC source: 0001325812-18-000030 · primary_doc.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,939

F1 · kind: On January 4, 2016, the reporting person was granted a restricted stock unit (RSU) to purchase shares of ALNY common stock. The shares subject to release vest upon the commercial launch of Alnylams first internally developed product, as approved by our compensation committee. Effective August 13, 2018, the compensation committee of the Company determined the performance criterion has been met and the RSU shares have vested.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:21 UTC
Greenstreet YvonneEVP, Chief Operating Officer
GrantPerformance Stock Option 2016 (right to buy) · Derivative 25,000 $0.00 Strike: $77.10 $0.00
Disclosure

SEC source: 0001735276-18-000051 · edgardoc.xml · derivative · entry 5

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2026-09-19

F3 · kind: On September 19, 2016, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. The shares subject to the option will vest upon the commercial launch of Alnylams first internally developed product, as approved by our compensation committee. Effective August 13, 2018, the compensation committee of the Company determined the performance criterion has been met and the option shares have vested.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:21 UTC
Greenstreet YvonneEVP, Chief Operating Officer
Tax withholdingCommon Stock 3,084 $90.95 $280,489.80
Disclosure

SEC source: 0001735276-18-000051 · edgardoc.xml · nonDerivative · entry 2

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,416

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:21 UTC
Greenstreet YvonneEVP, Chief Operating Officer
GrantCommon Stock 7,500 $0.00 $0.00
Disclosure

SEC source: 0001735276-18-000051 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

F1 · kind: On June 29, 2017, the reporting person was granted a restricted stock unit (RSU) to purchase shares of ALNY common stock. One half of the shares subject to release will vest upon the achievement of each of two specific commercial events as approved by our compensation committee. Effective August 13, 2018, the compensation committee of the Company determined the first performance criterion has been met and one half of the shares have vested.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:05 UTC
KEATING LAURIESVP, GC & Secretary
Tax withholdingCommon Stock 605 $90.95 $55,024.75
Disclosure

SEC source: 0001735276-18-000050 · edgardoc.xml · nonDerivative · entry 2

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,258

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:05 UTC
KEATING LAURIESVP, GC & Secretary
GrantCommon Stock 1,363 $0.00 $0.00
Disclosure

SEC source: 0001735276-18-000050 · edgardoc.xml · nonDerivative · entry 1

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,863

F1 · kind: On January 4, 2016, the reporting person was granted a restricted stock unit (RSU) to purchase shares of ALNY common stock. The shares subject to release vest upon the commercial launch of Alnylams first internally developed product, as approved by our compensation committee. Effective August 13, 2018, the compensation committee of the Company determined the performance criterion has been met and the RSU shares have vested.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:00 UTC
Mason MichaelVP, Finance and Treasurer
Tax withholdingCommon Stock 449 $90.95 $40,836.55
Disclosure

SEC source: 0001735276-18-000049 · edgardoc.xml · nonDerivative · entry 2

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 563

Read SEC document
August 13, 2018 Filed Aug 14, 2018 22:00 UTC
Mason MichaelVP, Finance and Treasurer
GrantCommon Stock 1,012 $0.00 $0.00
Disclosure

SEC source: 0001735276-18-000049 · edgardoc.xml · nonDerivative · entry 1

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,012

F1 · kind: On January 4, 2016, the reporting person was granted a restricted stock unit (RSU) to purchase shares of ALNY common stock. The shares subject to release vest upon the commercial launch of Alnylams first internally developed product, as approved by our compensation committee. Effective August 13, 2018, the compensation committee of the Company determined the performance criterion has been met and the RSU shares have vested.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 21:54 UTC
Soni Manmeet SinghChief Financial Officer
GrantPerformance Stock Option 2017 (right to buy) · Derivative 25,000 $0.00 Strike: $52.61 $0.00
Disclosure

SEC source: 0001735276-18-000048 · edgardoc.xml · derivative · entry 6

Soni Manmeet Singh · CIK 0001569769 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2027-05-08

F2 · kind: On May 8, 2017, the reporting person was granted a performance based stock option to purchase shares of ALNY common stock. The shares subject to the option will vest upon the commercial launch of Alnylams first internally developed product, as approved by our compensation committee. Effective August 13, 2018, the compensation committee of the Company determined the performance criterion has been met and the option shares have vested.

Read SEC document
August 10, 2018 Filed Aug 14, 2018 23:14 UTC GrantPerformance Based Stock Option 2014 (right to buy) · Derivative 15,875 $0.00 Strike: $96.45 $0.00
Disclosure

SEC source: 0001325812-18-000031 · primary_doc.xml · derivative · entry 7

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,625

Underlying: Common Stock · 15,875 shares

Expires 2024-12-17

F4 · kind: On December 17, 2014, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option vested as to the final third of the award

Read SEC document
August 10, 2018 Filed Aug 14, 2018 23:14 UTC GrantPerformance Based Stock Option 2013 (right to buy) · Derivative 15,000 $0.00 Strike: $63.00 $0.00
Disclosure

SEC source: 0001325812-18-000031 · primary_doc.xml · derivative · entry 6

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 15,000 shares

Expires 2023-12-18

F3 · kind: On December 18, 2013, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option will vest as to the final third of the award.

Read SEC document
August 10, 2018 Filed Aug 14, 2018 22:55 UTC
Vaishnaw AkshayPresident, R&D
GrantPerformance Based Stock Option 2014 (right to buy) · Derivative 11,707 $0.00 Strike: $96.45 $0.00
Disclosure

SEC source: 0001325812-18-000030 · primary_doc.xml · derivative · entry 6

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,125

Underlying: Common Stock · 11,707 shares

Expires 2024-12-17

F4 · kind: On December 17, 2014, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option vested as to the final third of the award.

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August 10, 2018 Filed Aug 14, 2018 22:55 UTC
Vaishnaw AkshayPresident, R&D
GrantPerformance Based Stock Option 2013 (right to buy) · Derivative 10,832 $0.00 Strike: $63.00 $0.00
Disclosure

SEC source: 0001325812-18-000030 · primary_doc.xml · derivative · entry 5

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,500

Underlying: Common Stock · 10,832 shares

Expires 2023-12-18

F3 · kind: On December 18, 2013, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option will vest as to the final third of the award.

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August 10, 2018 Filed Aug 14, 2018 22:33 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
GrantPerformance Based Stock Option 2014 (right to buy) · Derivative 25,000 $0.00 Strike: $96.45 $0.00
Disclosure

SEC source: 0001325812-18-000029 · primary_doc.xml · derivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 25,000 shares

Expires 2024-12-17

F2 · kind: On December 17, 2014, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option vested as to the final third of the award.

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August 10, 2018 Filed Aug 14, 2018 22:33 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
GrantPerformance Based Stock Option 2013 (right to buy) · Derivative 25,000 $0.00 Strike: $63.00 $0.00
Disclosure

SEC source: 0001325812-18-000029 · primary_doc.xml · derivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 15,000 shares

Expires 2023-12-18

F1 · kind: On December 18, 2013, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option will vest as to the final third of the award.

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August 10, 2018 Filed Aug 14, 2018 22:05 UTC
KEATING LAURIESVP, GC & Secretary
GrantPerformance Stock Option 2014 (right to buy) · Derivative 1,984 $0.00 Strike: $96.45 $0.00
Disclosure

SEC source: 0001735276-18-000050 · edgardoc.xml · derivative · entry 4

KEATING LAURIE · CIK 0001620743 · SVP, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,958

Underlying: Common Stock · 1,984 shares

Expires 2024-12-17

F3 · kind: On December 17, 2014, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option vested as to the final third of the award.

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August 10, 2018 Filed Aug 14, 2018 22:00 UTC
Mason MichaelVP, Finance and Treasurer
GrantPerformance Stock Option 2014 (right to buy) · Derivative 2,750 $0.00 Strike: $96.45 $0.00
Disclosure

SEC source: 0001735276-18-000049 · edgardoc.xml · derivative · entry 7

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,750

Underlying: Common Stock · 2,750 shares

Expires 2024-12-17

F4 · kind: On December 17, 2014, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option vested as to the final third of the award.

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August 10, 2018 Filed Aug 14, 2018 22:00 UTC
Mason MichaelVP, Finance and Treasurer
GrantPerformance Stock Option 2013 (right to buy) · Derivative 1,666 $0.00 Strike: $63.00 $0.00
Disclosure

SEC source: 0001735276-18-000049 · edgardoc.xml · derivative · entry 6

Mason Michael · CIK 0001514291 · VP, Finance and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,666

Underlying: Common Stock · 1,666 shares

Expires 2023-12-18

F3 · kind: On December 18, 2013, the reporting person was granted a performance based stock option to purchase shares of ALNY Common Stock. One-third of the shares subject to the option will vest upon the achievement of each of three specific clinical development and regulatory events, as approved by our compensation committee. Effective August 10, 2018, the compensation committee of the Company determined the final performance criteria had been met and the option will vest as to the final third of the award.

Read SEC document
July 31, 2018 Filed Aug 14, 2018 23:14 UTC GiftCommon Stock 9,030 $0.00 $0.00
Disclosure

SEC source: 0001325812-18-000031 · primary_doc.xml · nonDerivative · entry 5

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 9,030

F2 · ownership.nature: The 9,030 shares were previously reported as directly beneficially owned. On 7/31/2018, the shares were contributed to the "Barry E. Greene Qualified Annuity Interest Trust" (GRAT). Barry E. Greene is the sole trustee.

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July 31, 2018 Filed Aug 14, 2018 23:14 UTC GiftCommon Stock 9,030 $0.00 $0.00
Disclosure

SEC source: 0001325812-18-000031 · primary_doc.xml · nonDerivative · entry 1

Greene Barry E · CIK 0001291963 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,938

Read SEC document
July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 50,000 $0.00 Strike: $21.35 $0.00
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · derivative · entry 9

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,636

Underlying: Common Stock · 50,000 shares

Expires 2018-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

F8 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

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July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
SaleCommon Stock 1,400 $106.25 $148,750.00
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 6

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 151,297

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

F6 · price: Sale prices ranged from $106.18 to $106.33.

Read SEC document
July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
SaleCommon Stock 34,995 $105.83 $3,703,520.85
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 5

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,697

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

F5 · price: Sale prices ranged from $105.17 to $106.13.

Read SEC document
July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
SaleCommon Stock 7,758 $104.83 $813,271.14
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 187,692

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

F4 · price: Sale prices ranged from $104.17 to $105.15.

Read SEC document
July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
SaleCommon Stock 3,847 $103.69 $398,895.43
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,450

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

F3 · price: Sale prices ranged from $103.10 to $104.04.

Read SEC document
July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
SaleCommon Stock 2,000 $102.51 $205,020.00
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 199,297

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

F2 · price: Sale prices ranged from $101.99 to $102.94.

Read SEC document
July 25, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
Exercise / conversionCommon Stock 50,000 $21.35 $1,067,500.00
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 201,297

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 16, 2018. The 50,000 options exercised and sold by the reporting person were due to expire on December 8, 2018.

Read SEC document
July 10, 2018 Filed Jul 27, 2018 20:07 UTC
MARAGANORE JOHNDirector · Chief Executive Officer
OtherCommon Stock 31 $0.00 $0.00
Disclosure

SEC source: 0001735276-18-000039 · edgardoc.xml · nonDerivative · entry 8

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Managed Account

Disclosed balance after: 3,021

F7 · kind: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F7 · price: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

F7 · ownership.nature: Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.