ALNY

SEC source: 0001735276-21-000044 · edgardoc.xml · nonDerivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,096

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F4 · price: Sale prices ranged from $129.81 to $130.81.

SEC source: 0001735276-21-000044 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 241,217

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F3 · price: Sale prices ranged from $128.80 to $129.77.

SEC source: 0001735276-21-000044 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 245,729

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F2 · price: Sale prices ranged from $127.73 to $128.73.

SEC source: 0001735276-21-000044 · edgardoc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 248,744

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 11

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,119

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 10

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,226

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F10 · price: Sale prices ranged from $137.42 to $138.10.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 9

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,756

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F9 · price: Sale prices ranged from $136.41 to $137.33.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 8

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,648

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F8 · price: Sale prices ranged from $135.24 to $135.96.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 7

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,851

F7 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 6

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,936

F7 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000040 · edgardoc.xml · nonDerivative · entry 3

Poulton Jeffrey V. · CIK 0001782962 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,135

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000040 · edgardoc.xml · nonDerivative · entry 2

Poulton Jeffrey V. · CIK 0001782962 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,185

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000039 · edgardoc.xml · nonDerivative · entry 3

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,023

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000039 · edgardoc.xml · nonDerivative · entry 2

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,108

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000038 · edgardoc.xml · nonDerivative · entry 3

KEATING LAURIE · CIK 0001620743 · EVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,866

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000038 · edgardoc.xml · nonDerivative · entry 2

KEATING LAURIE · CIK 0001620743 · EVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,941

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000037 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,765

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000037 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,035

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 5

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,202

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F6 · price: Sale prices ranged from $139.72 to $140.18.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 4

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,619

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F5 · price: Sale prices ranged from $138.34 to $139.27.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 3

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,241

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F4 · price: Sale prices ranged from $137.28 to $138.13.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,230

F2 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on April 20, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F3 · price: Sale prices ranged from $136.21 to $137.17.

SEC source: 0001735276-21-000041 · edgardoc.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,908

F1 · kind: On February 26, 2020, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2019 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the first performance criterion was met and one-third of the PSU award vested as of April 19, 2021.

SEC source: 0001735276-21-000040 · edgardoc.xml · nonDerivative · entry 1

Poulton Jeffrey V. · CIK 0001782962 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,518

F1 · kind: On February 26, 2020, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2019 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the first performance criterion was met and one-third of the PSU award vested as of April 19, 2021.

SEC source: 0001735276-21-000039 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,374

F1 · kind: On February 26, 2020, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2019 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the first performance criterion was met and one-third of the PSU award vested as of April 19, 2021.

SEC source: 0001735276-21-000038 · edgardoc.xml · nonDerivative · entry 1

KEATING LAURIE · CIK 0001620743 · EVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,955

F1 · kind: On February 26, 2020, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2019 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the first performance criterion was met and one-third of the PSU award vested as of April 19, 2021.

SEC source: 0001735276-21-000037 · edgardoc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 222,272

F1 · kind: On February 26, 2020, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2019 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the first performance criterion was met and one-third of the PSU award vested as of April 19, 2021.

SEC source: 0001735276-21-000020 · edgardoc.xml · derivative · entry 15

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,936

Underlying: Common Stock · 33,979 shares

Expires 2021-11-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F16 · derivative.exercise_date: The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 12

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 206,036

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F12 · price: Sale prices ranged from $154.37 to $154.68.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 11

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 206,635

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F11 · price: Sale prices ranged from $153.05 to $153.90.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 10

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207,066

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F10 · price: Sale prices ranged from $151.92 to $152.76.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 9

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 208,204

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F9 · price: Sale prices ranged from $150.88 to $151.68.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 8

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,619

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F8 · price: Sale prices ranged from $149.73 to $150.62.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 7

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 211,673

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F7 · price: Sale prices ranged from $148.66 to $149.65.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 6

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,037

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F6 · price: Sale prices ranged from $147.60 to $148.59.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 5

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217,412

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F5 · price: Sale prices ranged from $146.59 to $147.59.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 223,509

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F4 · price: Sale prices ranged from $145.55 to $146.55.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,885

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F3 · price: Sale prices ranged from $144.54 to $145.54.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 239,014

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F2 · price: Sale prices ranged from $143.50 to $144.43.

SEC source: 0001735276-21-000020 · edgardoc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 240,015

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.

SEC source: 0001735276-21-000024 · edgardoc.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,800

Underlying: Common Stock · 28,800 shares

Expires 2031-02-23

F1 · shares: Represents the time-vested stock option portion of the reporting person's Annual Equity Award for 2020. The reporting person also received 15,437 performance stock units that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the performance stock units vest.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000023 · edgardoc.xml · derivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,800

Underlying: Common Stock · 28,800 shares

Expires 2031-02-23

F1 · shares: Represents the time-vested stock option portion of the reporting person's Annual Equity Award for 2020. The reporting person also received 15,437 performance stock units that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the performance stock units vest.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000022 · edgardoc.xml · derivative · entry 1

KEATING LAURIE · CIK 0001620743 · EVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,846

Underlying: Common Stock · 17,846 shares

Expires 2031-02-23

F1 · shares: Represents the time-vested stock option portion of the reporting person's Annual Equity Award for 2020. The reporting person also received 9,566 performance stock units that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the performance stock units vest.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000020 · edgardoc.xml · derivative · entry 14

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,998

Underlying: Common Stock · 79,998 shares

Expires 2031-02-23

F14 · shares: Represents the time-vested stock option portion of the reporting person's Annual Equity Award for 2020. The reporting person also received 42,879 performance stock units that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the performance stock units vest.

F15 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000021 · edgardoc.xml · derivative · entry 1

Poulton Jeffrey V. · CIK 0001782962 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,200

Underlying: Common Stock · 23,200 shares

Expires 2031-02-23

F1 · shares: Represents the time-vested stock option portion of the reporting person's Annual Equity Award for 2020. The reporting person also received 12,435 performance stock units that will vest upon the achievement of four specific performance conditions, which will be reported on a Form 4 if and when each performance condition is met and the performance stock units vest.

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000014 · edgardoc.xml · nonDerivative · entry 3

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,825

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000014 · edgardoc.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,917

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000013 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 206,036

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000013 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 206,343

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000012 · edgardoc.xml · nonDerivative · entry 3

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,291

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.