ALNY

SEC source: 0001735276-22-000008 · edgardoc.xml · nonDerivative · entry 2

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,508

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-22-000008 · edgardoc.xml · derivative · entry 3

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,025

Underlying: Common Stock · 5,026 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: On February 1, 2021 the reporting person received 10,051 restricted stock units, one-half of which vested on the first anniversary of the grant date, and one-half of which will vest on the second anniversary of the grant date.

F2 · derivative.expiration_date: On February 1, 2021 the reporting person received 10,051 restricted stock units, one-half of which vested on the first anniversary of the grant date, and one-half of which will vest on the second anniversary of the grant date.

SEC source: 0001735276-22-000008 · edgardoc.xml · nonDerivative · entry 1

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,026

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-22-000012 · edgardoc.xml · derivative · entry 2

Franchini Indrani Lall · CIK 0001708764 · EVP, CLO & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,182

Underlying: Common Stock · 29,182 shares

Expires 2032-01-31

F3 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-22-000012 · edgardoc.xml · derivative · entry 1

Franchini Indrani Lall · CIK 0001708764 · EVP, CLO & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,525

Underlying: Common Stock · 15,525 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ALNY common stock.

F2 · derivative.exercise_date: The restricted stock units vest ratably on each of the first, second and third anniversaries of the Grant Date.

F2 · derivative.expiration_date: The restricted stock units vest ratably on each of the first, second and third anniversaries of the Grant Date.

SEC source: 0001735276-22-000006 · edgardoc.xml · derivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,949

Underlying: Common Stock · 55,949 shares

Expires 2031-12-30

F1 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-22-000005 · edgardoc.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,380

Underlying: Common Stock · 22,380 shares

Expires 2031-12-30

F1 · derivative.exercise_date: The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 21

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,215

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F5 · price: Sale prices ranged from $194.82 to $195.43.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 20

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,518

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 19

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,663

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 18

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,789

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 17

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,862

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

F4 · price: Sale prices ranged from $191.14 to $191.80.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 16

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,862

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 15

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,987

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 14

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,129

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 13

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,202

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 12

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,207

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 11

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,351

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 10

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,495

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 9

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,503

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 8

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,576

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 7

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,703

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 6

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,833

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 5

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,970

F3 · kind: All sales reported on this Form 4, other than the sell-to-cover for taxes on December 22, 2021, were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 15, 2021.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 4

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,094

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 3

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,216

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,217

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000095 · edgardoc.xml · nonDerivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,663

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000095 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,982

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000095 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,984

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000094 · edgardoc.xml · nonDerivative · entry 4

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,902

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000094 · edgardoc.xml · nonDerivative · entry 3

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,024

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000094 · edgardoc.xml · nonDerivative · entry 2

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,025

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the PSU award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.

SEC source: 0001735276-21-000097 · edgardoc.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,632

F1 · kind: On February 28, 2019, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2018 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the final performance criterion was met and the final one-third of the PSU award vested as of December 21, 2021.

SEC source: 0001735276-21-000095 · edgardoc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 234,299

F1 · kind: On February 28, 2019, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2018 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the final performance criterion was met and the final one-third of the PSU award vested as of December 21, 2021.

SEC source: 0001735276-21-000094 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,440

F1 · kind: On February 28, 2019, the reporting person was granted performance-based restricted stock units (PSU) in connection with the 2018 year-end compensation review. One third of the PSU award vests upon the achievement of each of three specific clinical development, regulatory or commercial events. The People, Culture and Compensation Committee of the Board determined that the final performance criterion was met and the final one-third of the PSU award vested as of December 21, 2021.

SEC source: 0001735276-21-000091 · edgardoc.xml · derivative · entry 9

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,661

Underlying: Common Stock · 839 shares

Expires 2028-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to the remaining shares ratably at the end of each three-month period thereafter over the following thirty-three (33) months.

SEC source: 0001735276-21-000091 · edgardoc.xml · derivative · entry 8

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,964

Underlying: Common Stock · 1,036 shares

Expires 2024-12-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000091 · edgardoc.xml · derivative · entry 7

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,876

Underlying: Common Stock · 1,124 shares

Expires 2025-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000091 · edgardoc.xml · derivative · entry 6

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,632

Underlying: Common Stock · 2,368 shares

Expires 2026-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000091 · edgardoc.xml · nonDerivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,132

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-21-000091 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217,764

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-21-000091 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 216,925

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-21-000091 · edgardoc.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,801

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-21-000089 · edgardoc.xml · derivative · entry 8

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 33,978 shares

Expires 2021-11-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F8 · derivative.exercise_date: The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.

SEC source: 0001735276-21-000089 · edgardoc.xml · nonDerivative · entry 6

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,765

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F6 · price: Sale prices ranged from $174.05 to $174.63.

SEC source: 0001735276-21-000089 · edgardoc.xml · nonDerivative · entry 5

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,435

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F5 · price: Sale prices ranged from $172.90 to $173.34.

SEC source: 0001735276-21-000089 · edgardoc.xml · nonDerivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 216,118

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F4 · price: Sale prices ranged from $171.86 to $172.84.

SEC source: 0001735276-21-000089 · edgardoc.xml · nonDerivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,636

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F3 · price: Sale prices ranged from $170.85 to $171.82.

SEC source: 0001735276-21-000089 · edgardoc.xml · nonDerivative · entry 2

MARAGANORE JOHN · CIK 0001180432 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 238,378

F1 · kind: All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.

F2 · price: Sale prices ranged from $169.84 to $170.84.