ALEC

SEC source: 0000950170-23-028274 · ownership.xml · derivative · entry 4

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F4 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028274 · ownership.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,567

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028268 · ownership.xml · derivative · entry 2

Hammond Paula · CIK 0001805348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028268 · ownership.xml · nonDerivative · entry 1

Hammond Paula · CIK 0001805348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,709

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028275 · ownership.xml · derivative · entry 2

Gerngross Tillman U. · CIK 0001722061 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028275 · ownership.xml · nonDerivative · entry 1

Gerngross Tillman U. · CIK 0001722061 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,644,319

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028271 · ownership.xml · derivative · entry 3

LAVIGNE LOUIS J JR · CIK 0001214127 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F3 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028271 · ownership.xml · nonDerivative · entry 1

LAVIGNE LOUIS J JR · CIK 0001214127 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,709

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028270 · ownership.xml · derivative · entry 2

SCHELLER RICHARD H · CIK 0001214133 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028270 · ownership.xml · nonDerivative · entry 1

SCHELLER RICHARD H · CIK 0001214133 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,709

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028273 · ownership.xml · derivative · entry 2

Wehner David M. · CIK 0001534965 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028273 · ownership.xml · nonDerivative · entry 1

Wehner David M. · CIK 0001534965 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,330

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028272 · ownership.xml · derivative · entry 2

Yaffe Kristine · CIK 0001783895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028272 · ownership.xml · nonDerivative · entry 1

Yaffe Kristine · CIK 0001783895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,709

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028267 · ownership.xml · derivative · entry 2

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,360

Underlying: Common Stock · 12,360 shares

Expires 2033-06-14

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 14, 2023, provided that the shares subject to the option will vest in full on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-028267 · ownership.xml · nonDerivative · entry 1

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,709

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 14, 2024 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000950170-23-026481 · ownership.xml · nonDerivative · entry 1

Kenkare-Mitra Sara · CIK 0001895592 · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 184,149

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0000950170-23-026475 · ownership.xml · nonDerivative · entry 1

Romano Gary · CIK 0001799779 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,120

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0000950170-23-026473 · ownership.xml · nonDerivative · entry 1

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,651,095

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of RSUs.

SEC source: 0000950170-23-026477 · ownership.xml · nonDerivative · entry 1

GRASSO MARC · CIK 0001748894 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,361

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-020421 · doc4.xml · nonDerivative · entry 2

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,656,350

F2 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of RSUs.

SEC source: 0001209191-23-020421 · doc4.xml · nonDerivative · entry 1

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,671,536

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, all of which were fully vested on the grant date.

SEC source: 0001209191-23-016087 · doc4.xml · nonDerivative · entry 1

Kenkare-Mitra Sara · CIK 0001895592 · President and Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 188,241

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-016091 · doc4.xml · nonDerivative · entry 2

Romano Gary · CIK 0001799779 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,737

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-016080 · doc4.xml · nonDerivative · entry 1

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,628,546

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-016084 · doc4.xml · nonDerivative · entry 1

GRASSO MARC · CIK 0001748894 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,411

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-016091 · doc4.xml · nonDerivative · entry 1

Romano Gary · CIK 0001799779 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,975

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0000899243-22-036380 · doc4.xml · nonDerivative · entry 5

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 26,266

F11 · kind: Represents a change in the form of ownership of McGuire Family 2008 GST Non-Exempt Irrevocable Trust ("McGuire Family Trust") by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by PVM.

F12 · ownership.nature: Shares held by McGuire Family Trust. The Reporting Person, a member of the Issuer's board of directors, is the donor of McGuire Family Trust and may be deemed to have shared power to vote and dispose of the shares held by McGuire Family Trust.

SEC source: 0000899243-22-036380 · doc4.xml · nonDerivative · entry 4

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F10 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by PVM to its members.

F8 · shares: Shares held by PVM. 276 shares received from PVPFF VI, 78,869 shares received from PVP VI AIV and 19,388 shares received from PVP VI AIV-B. The Managing Members, including the Reporting Person who is a member of the Issuer's board of directors, are managing members of PVM and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F9 · shares: (Continued from footnote 8) Each of the Managing Members disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

F8 · ownership.nature: Shares held by PVM. 276 shares received from PVPFF VI, 78,869 shares received from PVP VI AIV and 19,388 shares received from PVP VI AIV-B. The Managing Members, including the Reporting Person who is a member of the Issuer's board of directors, are managing members of PVM and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F9 · ownership.nature: (Continued from footnote 8) Each of the Managing Members disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-22-036380 · doc4.xml · nonDerivative · entry 3

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 98,553

F7 · kind: Represents a change in the form of ownership of PVM by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by the Polaris Funds.

F8 · shares: Shares held by PVM. 276 shares received from PVPFF VI, 78,869 shares received from PVP VI AIV and 19,388 shares received from PVP VI AIV-B. The Managing Members, including the Reporting Person who is a member of the Issuer's board of directors, are managing members of PVM and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F9 · shares: (Continued from footnote 8) Each of the Managing Members disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

F8 · ownership.nature: Shares held by PVM. 276 shares received from PVPFF VI, 78,869 shares received from PVP VI AIV and 19,388 shares received from PVP VI AIV-B. The Managing Members, including the Reporting Person who is a member of the Issuer's board of directors, are managing members of PVM and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F9 · ownership.nature: (Continued from footnote 8) Each of the Managing Members disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-22-036380 · doc4.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,317

F5 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by PVPFF.

F6 · balance_after: 9,459 of such shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 16, 2023 or (ii) the date of the Issuer's next annual meeting of stockholders after June 16, 2022.

SEC source: 0000899243-22-036380 · doc4.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 11,853,817

F1 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI"), Polaris Venture Partners VI (AIV), L.P. ("PVP VI AIV") and Polaris Venture Partners VI (AIV-B), L.P. (p/k/a PVP VI (AIV) Feeder Corp. Holding Partnership, L.P., "PVP VI AIV-B" and, together with PVPFF VI, PVP VI AIV and Polaris Venture Partners VI, L.P. ("PVP VI"), the "Polaris Funds").

F2 · shares: 27,606 shares were distributed by PVPFF VI, 379,180 shares were distributed by PVP VI AIV and 93,214 shares were distributed by PVP VI AIV-B. The general partner of each of the Polaris Funds is Polaris Venture Management Co. VI, L.L.C. ("PVM"). Each of Amir Nashat, Brian Chee, David Barrett, Bryce Youngren, Jonathan Flint, and the Reporting Person, a member of the Issuer's board of directors, are managing members of PVM (collectively, the "Managing Members") and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F3 · shares: (Continued from footnote 2) Each of the Managing Members and PVM disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

F4 · ownership.nature: 654,463 shares are held by PVPFF VI, 8,589,364 shares are held by PVP VI AIV, 2,111,522 shares are held by PVP VI AIV-B and 498,468 shares are held by PVP VI. Each of the Managing Members and PVM disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-22-036406 · doc4.xml · nonDerivative · entry 3

Polaris Venture Management Co. VI, L.L.C. · CIK 0001665594 · 10% owner

Polaris Venture Partners VI (AIV), L.P. · CIK 0001767127 · 10% owner

Polaris Venture Partners Founders' Fund VI, L.P. · CIK 0001575691 · 10% owner

Polaris Venture Partners VI, L.P. · CIK 0001493463 · 10% owner

Polaris Venture Partners VI (AIV-B), L.P. · CIK 0001767130 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F8 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by PVM to its members.

F6 · shares: Shares held by PVM. 276 shares received from PVPFF VI, 78,869 shares received from PVP VI AIV and 19,388 shares received from PVP VI AIV-B. The Managing Members, including Terrance McGuire who is a member of the Issuer's board of directors, are managing members of PVM and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F7 · shares: (Continued from footnote 6) Each of the Managing Members disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-22-036406 · doc4.xml · nonDerivative · entry 2

Polaris Venture Management Co. VI, L.L.C. · CIK 0001665594 · 10% owner

Polaris Venture Partners VI (AIV), L.P. · CIK 0001767127 · 10% owner

Polaris Venture Partners Founders' Fund VI, L.P. · CIK 0001575691 · 10% owner

Polaris Venture Partners VI, L.P. · CIK 0001493463 · 10% owner

Polaris Venture Partners VI (AIV-B), L.P. · CIK 0001767130 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,533

F5 · kind: Represents a change in the form of ownership of PVM by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by the Polaris Funds.

F6 · shares: Shares held by PVM. 276 shares received from PVPFF VI, 78,869 shares received from PVP VI AIV and 19,388 shares received from PVP VI AIV-B. The Managing Members, including Terrance McGuire who is a member of the Issuer's board of directors, are managing members of PVM and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F7 · shares: (Continued from footnote 6) Each of the Managing Members disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-22-036406 · doc4.xml · nonDerivative · entry 1

Polaris Venture Management Co. VI, L.L.C. · CIK 0001665594 · 10% owner

Polaris Venture Partners VI (AIV), L.P. · CIK 0001767127 · 10% owner

Polaris Venture Partners Founders' Fund VI, L.P. · CIK 0001575691 · 10% owner

Polaris Venture Partners VI, L.P. · CIK 0001493463 · 10% owner

Polaris Venture Partners VI (AIV-B), L.P. · CIK 0001767130 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 11,853,817

F1 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI"), Polaris Venture Partners VI (AIV), L.P. ("PVP VI AIV") and Polaris Venture Partners VI (AIV-B), L.P. (p/k/a PVP VI (AIV) Feeder Corp. Holding Partnership, L.P., "PVP VI AIV-B" and, together with PVPFF VI, PVP VI AIV and Polaris Venture Partners VI, L.P. ("PVP VI"), the "Polaris Funds").

F2 · shares: 27,606 shares were distributed by PVPFF VI, 379,180 shares were distributed by PVP VI AIV and 93,214 shares were distributed by PVP VI AIV-B. The general partner of each of the Polaris Funds is Polaris Venture Management Co. VI, L.L.C. ("PVM"). Each of Amir Nashat, Brian Chee, David Barrett, Bryce Youngren, Jonathan Flint, and Terrance McGuire, a member of the Issuer's board of directors, are managing members of PVM (collectively, the "Managing Members") and may be deemed to have shared power to vote and dispose of the shares held by the Polaris Funds.

F3 · shares: (Continued from footnote 2) Each of the Managing Members and PVM disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

F4 · ownership.nature: 654,463 shares are held by PVPFF VI, 8,589,364 shares are held by PVP VI AIV, 2,111,522 shares are held by PVP VI AIV-B and 498,468 shares are held by PVP VI. Each of the Managing Members and PVM disclaims beneficial ownership of the securities held by the Polaris Funds, and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0001209191-22-052532 · doc4.xml · derivative · entry 2

Kenkare-Mitra Sara · CIK 0001895592 · President and Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,576

Underlying: Common Stock · 53,576 shares

Expires 2032-10-01

F2 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on November 1, 2022.

SEC source: 0001209191-22-052532 · doc4.xml · nonDerivative · entry 1

Kenkare-Mitra Sara · CIK 0001895592 · President and Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,365

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest in 12 equal quarterly installments beginning on March 1, 2023.

SEC source: 0001209191-22-052566 · doc4.xml · derivative · entry 2

Romano Gary · CIK 0001799779 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,365

Underlying: Common Stock · 13,365 shares

Expires 2032-10-01

F2 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on November 1, 2022.

SEC source: 0001209191-22-052566 · doc4.xml · nonDerivative · entry 1

Romano Gary · CIK 0001799779 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,120

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest in 12 equal quarterly installments beginning on March 1, 2023.

SEC source: 0001209191-22-052530 · doc4.xml · derivative · entry 6

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,446

Underlying: Common Stock · 119,446 shares

Expires 2032-10-01

F6 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on November 1, 2022.

SEC source: 0001209191-22-052530 · doc4.xml · nonDerivative · entry 1

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,634,395

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest in 12 equal quarterly installments beginning on March 1, 2023.

SEC source: 0001209191-22-052564 · doc4.xml · derivative · entry 2

King Robert · CIK 0001635264 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,384

Underlying: Common Stock · 14,384 shares

Expires 2032-10-01

F2 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on November 1, 2022.

SEC source: 0001209191-22-052564 · doc4.xml · nonDerivative · entry 1

King Robert · CIK 0001635264 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 550,871

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest in 12 equal quarterly installments beginning on March 1, 2023.

SEC source: 0001209191-22-052568 · doc4.xml · derivative · entry 2

GRASSO MARC · CIK 0001748894 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,801

Underlying: Common Stock · 23,801 shares

Expires 2032-10-01

F2 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on November 1, 2022.

SEC source: 0001209191-22-052568 · doc4.xml · nonDerivative · entry 1

GRASSO MARC · CIK 0001748894 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,702

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest in 12 equal quarterly installments beginning on March 1, 2023.

SEC source: 0001209191-22-049006 · doc4.xml · nonDerivative · entry 1

Romano Gary · CIK 0001799779 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,073

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-22-049000 · doc4.xml · nonDerivative · entry 1

King Robert · CIK 0001635264 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 529,295

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-22-038544 · doc4.xml · derivative · entry 4

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,918

Underlying: Common Stock · 18,918 shares

Expires 2032-06-16

F4 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 16, 2022, or if earlier, the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-22-038544 · doc4.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,888

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, which vest on the earlier of (i) June 16, 2023 or (ii) the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-22-038540 · doc4.xml · derivative · entry 2

Hammond Paula · CIK 0001805348 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,918

Underlying: Common Stock · 18,918 shares

Expires 2032-06-16

F2 · derivative.exercise_date: The shares subject to the option vest in 12 equal monthly installments beginning on July 16, 2022, or if earlier, the date of the Issuer's next annual meeting of stockholders.