AGIO

SEC source: 0001439222-25-000049 · wk-form4_1750709929.xml · nonDerivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,603

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-25-000051 · wk-form4_1750710009.xml · derivative · entry 3

Owen Adams Catherine · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000051 · wk-form4_1750710009.xml · derivative · entry 2

Owen Adams Catherine · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000061 · wk-form4_1750710427.xml · derivative · entry 3

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000061 · wk-form4_1750710427.xml · derivative · entry 2

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000059 · wk-form4_1750710331.xml · derivative · entry 3

CAPELLO JEFFREY D · CIK 0001224108 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying this option vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000059 · wk-form4_1750710331.xml · derivative · entry 2

CAPELLO JEFFREY D · CIK 0001224108 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,861

Underlying: Common stock · 2,861 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000057 · wk-form4_1750710263.xml · derivative · entry 4

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000057 · wk-form4_1750710263.xml · derivative · entry 3

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000055 · wk-form4_1750710197.xml · derivative · entry 3

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000055 · wk-form4_1750710197.xml · derivative · entry 2

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000053 · wk-form4_1750710074.xml · derivative · entry 3

Ho Maykin · CIK 0001646395 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000053 · wk-form4_1750710074.xml · derivative · entry 2

Ho Maykin · CIK 0001646395 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000047 · wk-form4_1750709855.xml · derivative · entry 3

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000047 · wk-form4_1750709855.xml · derivative · entry 2

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000049 · wk-form4_1750709929.xml · derivative · entry 3

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,768

Underlying: Common stock · 15,768 shares

Expires 2035-06-18

F3 · derivative.exercise_date: These options were granted on June 18, 2025. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2026.

SEC source: 0001439222-25-000049 · wk-form4_1750709929.xml · derivative · entry 2

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,816

Underlying: Common stock · 2,816 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000043 · wk-form4_1750191300.xml · derivative · entry 2

Owen Adams Catherine · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,976

Underlying: Common stock · 1,977 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 13, 2023. Beginning on June 13, 2024, the shares underlying the stock units will vest in three equal annual installments. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 13, 2023. Beginning on June 13, 2024, the shares underlying the stock units will vest in three equal annual installments. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000043 · wk-form4_1750191300.xml · nonDerivative · entry 1

Owen Adams Catherine · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,953

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-25-000045 · wk-form4_1750191390.xml · derivative · entry 2

CAPELLO JEFFREY D · CIK 0001224108 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,976

Underlying: Common stock · 1,977 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 13, 2023. Beginning on June 13, 2024, the shares underlying the stock units will vest in three equal annual installments. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 13, 2023. Beginning on June 13, 2024, the shares underlying the stock units will vest in three equal annual installments. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-25-000045 · wk-form4_1750191390.xml · nonDerivative · entry 1

CAPELLO JEFFREY D · CIK 0001224108 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,953

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-25-000029 · wk-form4_1744315371.xml · nonDerivative · entry 2

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 149,220

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated April 8, 2022.

SEC source: 0001439222-25-000029 · wk-form4_1744315371.xml · derivative · entry 3

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 15,933 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on April 8, 2022. Beginning on April 8, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on April 8, 2022. Beginning on April 8, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000029 · wk-form4_1744315371.xml · nonDerivative · entry 1

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 156,717

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-25-000027 · wk-form4_1741382325.xml · derivative · entry 2

Viswanadhan Krishnan · CIK 0001999913 · Chief Corp Dev & Strategy

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,374

Underlying: Common stock · 55,374 shares

Expires 2035-03-05

F3 · derivative.exercise_date: This option was granted on March 5, 2025. The shares underlying this option vest as to 25% of the underlying shares on March 5, 2026, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001439222-25-000027 · wk-form4_1741382325.xml · derivative · entry 1

Viswanadhan Krishnan · CIK 0001999913 · Chief Corp Dev & Strategy

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,300

Underlying: Common stock · 24,300 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on March 5, 2025. Beginning on March 5, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

F2 · derivative.expiration_date: The restricted stock units were granted on March 5, 2025. Beginning on March 5, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000017 · wk-form4_1741122771.xml · nonDerivative · entry 2

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,892

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · nonDerivative · entry 6

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,897

F4 · kind: hares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · nonDerivative · entry 4

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,911

F3 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2023.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · nonDerivative · entry 2

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,098

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2022.

SEC source: 0001439222-25-000021 · wk-form4_1741123013.xml · nonDerivative · entry 6

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,449

F4 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.

SEC source: 0001439222-25-000021 · wk-form4_1741123013.xml · nonDerivative · entry 4

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,463

F3 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2023.

SEC source: 0001439222-25-000021 · wk-form4_1741123013.xml · nonDerivative · entry 2

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,650

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2022.

SEC source: 0001439222-25-000019 · wk-form4_1741122903.xml · nonDerivative · entry 4

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,829

F3 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.

SEC source: 0001439222-25-000019 · wk-form4_1741122903.xml · nonDerivative · entry 2

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,843

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2023.

SEC source: 0001439222-25-000015 · wk-form4_1741122616.xml · nonDerivative · entry 4

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 92,345

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.

SEC source: 0001439222-25-000015 · wk-form4_1741122616.xml · nonDerivative · entry 2

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 83,139

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2023.

SEC source: 0001439222-25-000011 · wk-form4_1741122407.xml · derivative · entry 11

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,900

Underlying: Common stock · 2,450 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F10 · derivative.exercise_date: The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.

F10 · derivative.expiration_date: The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000011 · wk-form4_1741122407.xml · nonDerivative · entry 6

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,414

F4 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.

SEC source: 0001439222-25-000011 · wk-form4_1741122407.xml · nonDerivative · entry 4

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,691

F3 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2023.

SEC source: 0001439222-25-000011 · wk-form4_1741122407.xml · nonDerivative · entry 2

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,038

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2022.

SEC source: 0001439222-25-000017 · wk-form4_1741122771.xml · derivative · entry 5

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,333

Underlying: Common stock · 5,667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F5 · derivative.exercise_date: The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.

F5 · derivative.expiration_date: The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000017 · wk-form4_1741122771.xml · derivative · entry 4

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,500

Underlying: Common stock · 43,500 shares

Expires 2035-03-01

F4 · derivative.exercise_date: This option was granted on March 1, 2025. The shares underlying this option vest as to 25% of the underlying shares on March 1, 2026, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001439222-25-000017 · wk-form4_1741122771.xml · derivative · entry 3

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common stock · 12,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on March 1, 2025. Beginning on March 1, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on March 1, 2025. Beginning on March 1, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000017 · wk-form4_1741122771.xml · nonDerivative · entry 1

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,573

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · derivative · entry 11

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,333

Underlying: Common stock · 5,667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F10 · derivative.exercise_date: The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.

F10 · derivative.expiration_date: The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · derivative · entry 10

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common stock · 4,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F9 · derivative.exercise_date: The restricted stock units were granted on March 1, 2023. Beginning on March 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

F9 · derivative.expiration_date: The restricted stock units were granted on March 1, 2023. Beginning on March 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · derivative · entry 9

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 3,833 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F8 · derivative.exercise_date: The restricted stock units were granted on March 1, 2022. Beginning on March 1, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F8 · derivative.expiration_date: The restricted stock units were granted on March 1, 2022. Beginning on March 1, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · derivative · entry 8

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,500

Underlying: Common stock · 43,500 shares

Expires 2035-03-01

F7 · derivative.exercise_date: This option was granted on March 1, 2025. The shares underlying this option vest as to 25% of the underlying shares on March 1, 2026, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001439222-25-000013 · wk-form4_1741122508.xml · derivative · entry 7

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common stock · 12,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F6 · derivative.exercise_date: The restricted stock units were granted on March 1, 2025. Beginning on March 1, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

F6 · derivative.expiration_date: The restricted stock units were granted on March 1, 2025. Beginning on March 1, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.