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Nasdaq · USD

AGIO

AGIOS PHARMACEUTICALS, INC.

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Tapewire entity
4499
SEC CIK
0001439222
Parsed reports
520

Last 12 months

Inside the activity.

0 purchase rows · 39 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202502
Dec 202506
Jan 202601
Feb 202600
Mar 2026021
Apr 202607
May 202600
Jun 202600
Jul 202601
Aug 202601
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
August 11, 2025 Filed Aug 13, 2025 20:55 UTC Exercise / conversionRestricted stock units · Derivative 2,302 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000097 · wk-form4_1755118521.xml · derivative · entry 2

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,302 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F2 · derivative.expiration_date: The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

Read SEC document
August 11, 2025 Filed Aug 13, 2025 20:55 UTC Exercise / conversionCommon stock 2,302 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000097 · wk-form4_1755118521.xml · nonDerivative · entry 1

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,414

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 08, 2025 Filed Aug 12, 2025 20:24 UTC
Goff BrianDirector · Chief Executive Officer
Exercise / conversionRestricted stock units · Derivative 22,691 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000093 · wk-form4_1755030260.xml · derivative · entry 3

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 22,691 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on August 8, 2022. Beginning on August 8, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on August 8, 2022. Beginning on August 8, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

Read SEC document
August 08, 2025 Filed Aug 12, 2025 20:24 UTC
Goff BrianDirector · Chief Executive Officer
SaleCommon stock 11,085 $36.67 $406,486.95
Disclosure

SEC source: 0001439222-25-000093 · wk-form4_1755030260.xml · nonDerivative · entry 2

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 123,528

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated August 8, 2022.

Read SEC document
August 08, 2025 Filed Aug 12, 2025 20:24 UTC
Goff BrianDirector · Chief Executive Officer
Exercise / conversionCommon stock 22,691 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000093 · wk-form4_1755030260.xml · nonDerivative · entry 1

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 134,613

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 10, 2025 Filed Jul 15, 2025 20:05 UTC Exercise / conversionStock options (right to buy) · Derivative 1,400 $0.00 Strike: $18.09 $0.00
Disclosure

SEC source: 0001439222-25-000084 · wk-form4_1752609950.xml · derivative · entry 3

Scadden David · CIK 0001707715 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,707

Underlying: Common stock · 1,400 shares

Expires 2032-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · derivative.exercise_date: This option was granted on June 21, 2022. The shares underlying this option vest 100% one year from grant date.

Read SEC document
July 10, 2025 Filed Jul 15, 2025 20:05 UTC SaleCommon stock 1,400 $40.00 $56,000.00
Disclosure

SEC source: 0001439222-25-000084 · wk-form4_1752609950.xml · nonDerivative · entry 2

Scadden David · CIK 0001707715 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,603

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
July 10, 2025 Filed Jul 15, 2025 20:05 UTC Exercise / conversionCommon stock 1,400 $18.09 $25,326.00
Disclosure

SEC source: 0001439222-25-000084 · wk-form4_1752609950.xml · nonDerivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,003

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:59 UTC
Gheuens SarahChief Medical Officer
Exercise / conversionStock options (right to buy) · Derivative 11,914 $0.00 Strike: $25.01 $0.00
Disclosure

SEC source: 0001439222-25-000082 · wk-form4_1752267546.xml · derivative · entry 4

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,086

Underlying: Common stock · 11,914 shares

Expires 2033-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option was originally granted on March 1, 2023 for the purchase of 44,000 shares of common stock. The shares underlying this option vest as to 25% of the underlying shares on March 1, 2024, with the remaining 75% vesting in 36 equal monthly installments thereafter.

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July 09, 2025 Filed Jul 11, 2025 20:59 UTC
Gheuens SarahChief Medical Officer
SaleCommon stock 847 $38.76 $32,829.72
Disclosure

SEC source: 0001439222-25-000082 · wk-form4_1752267546.xml · nonDerivative · entry 3

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,271

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $38.55 to $38.87. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:59 UTC
Gheuens SarahChief Medical Officer
SaleCommon stock 11,067 $37.93 $419,771.31
Disclosure

SEC source: 0001439222-25-000082 · wk-form4_1752267546.xml · nonDerivative · entry 2

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 62,118

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $37.52 to $38.49. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:59 UTC
Gheuens SarahChief Medical Officer
Exercise / conversionCommon stock 11,914 $25.01 $297,969.14
Disclosure

SEC source: 0001439222-25-000082 · wk-form4_1752267546.xml · nonDerivative · entry 1

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,185

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 08, 2025 Filed Jul 10, 2025 20:14 UTC GrantRestricted stock units · Derivative 4,341 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000080 · wk-form4_1752178459.xml · derivative · entry 2

Backstrom Jay T. · CIK 0001796398 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,341

Underlying: Common stock · 4,341 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on July 8, 2025. Beginning on July 8, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on July 8, 2025. Beginning on July 8, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

Read SEC document
July 08, 2025 Filed Jul 10, 2025 20:14 UTC GrantStock options (right to buy) · Derivative 23,393 $0.00 Strike: $36.28 $0.00
Disclosure

SEC source: 0001439222-25-000080 · wk-form4_1752178459.xml · derivative · entry 1

Backstrom Jay T. · CIK 0001796398 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,393

Underlying: Common stock · 23,393 shares

Expires 2035-07-08

F1 · derivative.exercise_date: This option was granted on July 8, 2025. The shares underlying this option vest as to 25% of the underlying shares on July 8, 2026, with the remaining 75% vesting in 36 equal monthly installments thereafter.

Read SEC document
July 01, 2025 Filed Jul 3, 2025 20:01 UTC
Gheuens SarahChief Medical Officer
Exercise / conversionRestricted stock units · Derivative 8,374 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000073 · wk-form4_1751572884.xml · derivative · entry 3

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,375

Underlying: Common stock · 8,374 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on July 1, 2023. Beginning on July 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on July 1, 2023. Beginning on July 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

Read SEC document
July 01, 2025 Filed Jul 3, 2025 20:01 UTC
Gheuens SarahChief Medical Officer
SaleCommon stock 4,091 $34.17 $139,789.47
Disclosure

SEC source: 0001439222-25-000073 · wk-form4_1751572884.xml · nonDerivative · entry 2

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,271

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated July 1, 2023.

Read SEC document
July 01, 2025 Filed Jul 3, 2025 20:01 UTC
Gheuens SarahChief Medical Officer
Exercise / conversionCommon stock 8,374 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000073 · wk-form4_1751572884.xml · nonDerivative · entry 1

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,362

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:23 UTC
Milanova TsvetaChief Commercial Officer
Exercise / conversionPerformance share units · Derivative 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000065 · wk-form4_1750972990.xml · derivative · entry 3

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common stock · 6,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:23 UTC
Milanova TsvetaChief Commercial Officer
SaleCommon stock 2,770 $33.54 $92,905.80
Disclosure

SEC source: 0001439222-25-000065 · wk-form4_1750972990.xml · nonDerivative · entry 2

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,122

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2023.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:23 UTC
Milanova TsvetaChief Commercial Officer
Exercise / conversionCommon stock 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000065 · wk-form4_1750972990.xml · nonDerivative · entry 1

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,892

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:25 UTC
Gheuens SarahChief Medical Officer
Exercise / conversionPerformance share units · Derivative 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000069 · wk-form4_1750973125.xml · derivative · entry 3

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common stock · 6,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:25 UTC
Gheuens SarahChief Medical Officer
SaleCommon stock 2,909 $33.54 $97,567.86
Disclosure

SEC source: 0001439222-25-000069 · wk-form4_1750973125.xml · nonDerivative · entry 2

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,988

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2023.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:25 UTC
Gheuens SarahChief Medical Officer
Exercise / conversionCommon stock 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000069 · wk-form4_1750973125.xml · nonDerivative · entry 1

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 59,897

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:26 UTC
Burns James WilliamChief Legal Officer
Exercise / conversionPerformance share units · Derivative 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000071 · wk-form4_1750973184.xml · derivative · entry 3

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common stock · 6,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:26 UTC
Burns James WilliamChief Legal Officer
SaleCommon stock 2,799 $33.54 $93,878.46
Disclosure

SEC source: 0001439222-25-000071 · wk-form4_1750973184.xml · nonDerivative · entry 2

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,650

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2023.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:26 UTC
Burns James WilliamChief Legal Officer
Exercise / conversionCommon stock 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000071 · wk-form4_1750973184.xml · nonDerivative · entry 1

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,449

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:24 UTC
Jones CeciliaChief Financial Officer
Exercise / conversionPerformance share units · Derivative 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000067 · wk-form4_1750973073.xml · derivative · entry 3

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common stock · 6,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:24 UTC
Jones CeciliaChief Financial Officer
SaleCommon stock 1,780 $33.54 $59,701.20
Disclosure

SEC source: 0001439222-25-000067 · wk-form4_1750973073.xml · nonDerivative · entry 2

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,049

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2023.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:24 UTC
Jones CeciliaChief Financial Officer
Exercise / conversionCommon stock 6,000 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000067 · wk-form4_1750973073.xml · nonDerivative · entry 1

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,829

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:22 UTC
Goff BrianDirector · Chief Executive Officer
Exercise / conversionPerformance share units · Derivative 12,750 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000063 · wk-form4_1750972918.xml · derivative · entry 6

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,750

Underlying: Common stock · 12,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F5 · derivative.exercise_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F5 · derivative.expiration_date: The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

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June 24, 2025 Filed Jun 26, 2025 21:22 UTC
Goff BrianDirector · Chief Executive Officer
Exercise / conversionPerformance share units · Derivative 25,527 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000063 · wk-form4_1750972918.xml · derivative · entry 5

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,056

Underlying: Common stock · 25,527 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The PSUs were granted on August 8, 2022. The PSUs vest as to 15% of the underlying shares upon the achievement of a specified research milestone and as to the remaining underlying shares upon the achievement of other clinical and regulatory milestones. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 15% of the underlying shares of common stock. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The PSUs were granted on August 8, 2022. The PSUs vest as to 15% of the underlying shares upon the achievement of a specified research milestone and as to the remaining underlying shares upon the achievement of other clinical and regulatory milestones. The performance criteria for the specified research milestone was determined to have been met on June 24, 2025, resulting in the vesting of the PSUs as to 15% of the underlying shares of common stock. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:22 UTC
Goff BrianDirector · Chief Executive Officer
SaleCommon stock 6,229 $33.54 $208,920.66
Disclosure

SEC source: 0001439222-25-000063 · wk-form4_1750972918.xml · nonDerivative · entry 4

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,922

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2023.

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June 24, 2025 Filed Jun 26, 2025 21:22 UTC
Goff BrianDirector · Chief Executive Officer
Exercise / conversionCommon stock 12,750 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000063 · wk-form4_1750972918.xml · nonDerivative · entry 3

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 118,151

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:22 UTC
Goff BrianDirector · Chief Executive Officer
SaleCommon stock 12,471 $33.54 $418,277.34
Disclosure

SEC source: 0001439222-25-000063 · wk-form4_1750972918.xml · nonDerivative · entry 2

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,401

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated August 8, 2022.

Read SEC document
June 24, 2025 Filed Jun 26, 2025 21:22 UTC
Goff BrianDirector · Chief Executive Officer
Exercise / conversionCommon stock 25,527 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000063 · wk-form4_1750972918.xml · nonDerivative · entry 1

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,872

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:20 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000051 · wk-form4_1750710009.xml · derivative · entry 4

Owen Adams Catherine · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:20 UTC Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000051 · wk-form4_1750710009.xml · nonDerivative · entry 1

Owen Adams Catherine · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,073

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:27 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000061 · wk-form4_1750710427.xml · derivative · entry 4

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:27 UTC Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000061 · wk-form4_1750710427.xml · nonDerivative · entry 1

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,112

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:25 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000059 · wk-form4_1750710331.xml · derivative · entry 4

CAPELLO JEFFREY D · CIK 0001224108 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:25 UTC Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000059 · wk-form4_1750710331.xml · nonDerivative · entry 1

CAPELLO JEFFREY D · CIK 0001224108 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,073

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:24 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000057 · wk-form4_1750710263.xml · derivative · entry 5

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:24 UTC Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000057 · wk-form4_1750710263.xml · nonDerivative · entry 1

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,468

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:23 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000055 · wk-form4_1750710197.xml · derivative · entry 4

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:23 UTC Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000055 · wk-form4_1750710197.xml · nonDerivative · entry 1

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,340

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:21 UTC
Ho MaykinDirector
Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000053 · wk-form4_1750710074.xml · derivative · entry 4

Ho Maykin · CIK 0001646395 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:21 UTC
Ho MaykinDirector
Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000053 · wk-form4_1750710074.xml · nonDerivative · entry 1

Ho Maykin · CIK 0001646395 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,032

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:17 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000047 · wk-form4_1750709855.xml · derivative · entry 4

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:17 UTC Exercise / conversionCommon stock 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000047 · wk-form4_1750709855.xml · nonDerivative · entry 1

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,112

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 20, 2025 Filed Jun 23, 2025 20:18 UTC Exercise / conversionRestricted stock units · Derivative 2,120 $0.00 $0.00
Disclosure

SEC source: 0001439222-25-000049 · wk-form4_1750709929.xml · derivative · entry 4

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 2,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 20, 2024. The shares underlying the stock units vest in full on June 20, 2025. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.