AGIO

SEC source: 0001209191-17-027983 · doc4.xml · nonDerivative · entry 1

Celgene European Investment Co LLC · CIK 0001577650 · 10% owner

Celgene Switzerland LLC · CIK 0001661486 · 10% owner

Celgene Alpine Investment Co., LLC · CIK 0001581774 · 10% owner

CELGENE CORP /DE/ · CIK 0000816284 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,856,353

F1 · ownership.nature: Of these shares, 624,575 shares are owned directly by Celgene Switzerland LLC ("Celgene Switzerland"), 708,333 shares are owned directly by Celgene Alpine Investment Co. LLC ("Celgene Alpine"), each a wholly-owned subsidiary of Celgene Corporation ("Celgene"), and Celgene has the power to vote, acquire, hold and dispose of all such shares. Celgene and Celgene European Investment Company LLC, a wholly owned subsidiary of Celgene ("CEICO"), disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein. The remaining 523,445 shares are owned directly by Celgene. CEICO, Celgene Switzerland and Celgene Alpine disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.

SEC source: 0001209191-17-027509 · doc4.xml · nonDerivative · entry 6

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 91,755

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $50.10 to $51.84. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-17-027509 · doc4.xml · nonDerivative · entry 5

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,715

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $50.10 to $51.84. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-027509 · doc4.xml · nonDerivative · entry 4

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 92,264

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $55.00 to $55.49. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-17-027509 · doc4.xml · nonDerivative · entry 3

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,224

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $55.00 to $55.49. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-027509 · doc4.xml · nonDerivative · entry 2

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 93,791

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $54.83 to $55.50. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-17-027509 · doc4.xml · nonDerivative · entry 1

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,751

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $54.83 to $55.50. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-025575 · doc4.xml · derivative · entry 4

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,011

Underlying: Common stock · 2,146 shares

Expires 2023-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option was originally granted on April 30, 2013 for the purchase of 68,181 shares of common stock. The option vests as to 50% of the underlying shares upon the achievement of a performance milestone, and as to the remaining 50% of upon the achievement of a second performance milestone. The Company's board of directors determined that the first performance milestone was achieved on December 3, 2015, resulting in the vesting of this option as to 34,091 shares. On January 26, 2017, the Company's board of directors determined that the second performance milestone was achieved, resulting in the vesting of this option as to the remaining 34,090 shares.

SEC source: 0001209191-17-025575 · doc4.xml · nonDerivative · entry 2

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,734

F3 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $57.18 to $58.89. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F2 · balance_after: Includes 264 shares purchased through the Company's employee stock purchase plan.

SEC source: 0001209191-17-025575 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,880

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · balance_after: Includes 264 shares purchased through the Company's employee stock purchase plan.

SEC source: 0001209191-17-025572 · doc4.xml · derivative · entry 5

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,656

Underlying: Common stock · 3,000 shares

Expires 2019-08-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option was granted on August 13, 2009. The shares underlying this option vest as to 25% of the shares on August 1, 2010, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-025572 · doc4.xml · nonDerivative · entry 2

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F2 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $58.01 to $58.97. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-025572 · doc4.xml · nonDerivative · entry 1

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-17-022761 · doc4.xml · nonDerivative · entry 4

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 94,300

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $53.50 to $54.30. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-17-022761 · doc4.xml · nonDerivative · entry 3

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,260

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $53.50 to $54.30. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-022761 · doc4.xml · nonDerivative · entry 2

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 94,809

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $51.50 to $52.79. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-17-022761 · doc4.xml · nonDerivative · entry 1

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,769

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $51.50 to $52.79. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-022346 · doc4.xml · derivative · entry 7

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,157

Underlying: Common stock · 5,933 shares

Expires 2023-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · derivative.exercise_date: This option was originally granted on April 30, 2013 for the purchase of 68,181 shares of common stock. The option vests as to 50% of the underlying shares upon the achievement of a performance milestone, and as to the remaining 50% of upon the achievement of a second performance milestone. The Company's board of directors determined that the first performance milestone was achieved on December 3, 2015, resulting in the vesting of this option as to 34,091 shares. On January 26, 2017, the Company's board of directors determined that the second performance milestone was achieved, resulting in the vesting of this option as to the remaining 34,090 shares.

SEC source: 0001209191-17-022346 · doc4.xml · derivative · entry 6

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,969

Underlying: Common stock · 505 shares

Expires 2020-12-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · derivative.exercise_date: This option was granted on December 7, 2010. The shares underlying this option vested as to 25% of the shares upon the achievement of a performance milestone, and as to the remaining 75% in 36 equal monthly installments thereafter. The performance criteria was met on June 23, 2015.

SEC source: 0001209191-17-022346 · doc4.xml · nonDerivative · entry 4

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,470

F2 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-17-022346 · doc4.xml · nonDerivative · entry 3

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,975

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-17-022346 · doc4.xml · nonDerivative · entry 2

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,470

F2 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-17-022346 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,403

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001012975-17-000195 · edgar.xml · nonDerivative · entry 4

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 0

F4 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000195 · edgar.xml · nonDerivative · entry 3

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 40

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $52.10 to $52.27.

F4 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000195 · edgar.xml · nonDerivative · entry 2

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 440

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.03 to $51.98.

F4 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000195 · edgar.xml · nonDerivative · entry 1

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 9,174

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.02 to $51.02. The reporting person undertakes to provide to AGIO, any security holder of AGIO, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2) and (3) to this Form 4.

F4 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001209191-17-017611 · doc4.xml · derivative · entry 5

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,656

Underlying: Common stock · 3,000 shares

Expires 2019-08-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option was granted on August 13, 2009. The shares underlying this option vest as to 25% of the shares on August 1, 2010, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-017611 · doc4.xml · nonDerivative · entry 2

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F2 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $50.06 to $50.70. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-017611 · doc4.xml · nonDerivative · entry 1

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001012975-17-000182 · edgar.xml · nonDerivative · entry 5

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 40,599

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.0025 to $50.49.

F6 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000182 · edgar.xml · nonDerivative · entry 4

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 60,836

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.00 to $50.00.

F6 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000182 · edgar.xml · nonDerivative · entry 3

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 88,458

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.88 to $50.54.

F6 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000182 · edgar.xml · nonDerivative · entry 2

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 145,946

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.87 to $49.87.

F6 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000182 · edgar.xml · nonDerivative · entry 1

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 229,696

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $47.86 to $48.85. The reporting person undertakes to provide to AGIO, any security holder of AGIO, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2), (3), (4), and (5) to this Form 4.

F6 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 6

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 283,681

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.51 to $49.06.

F7 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 5

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 292,081

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $47.50 to $48.24.

F7 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 4

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 334,677

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.255 to $50.68.

F7 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 3

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 335,677

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.25 to $50.25.

F7 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001209191-17-013738 · doc4.xml · derivative · entry 1

Alenson Carman · CIK 0001688865 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,300

Underlying: Common stock · 3,300 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · kind: All of the restricted stock units will vest on February 21, 2019. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.exercise_date: All of the restricted stock units will vest on February 21, 2019. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: All of the restricted stock units will vest on February 21, 2019. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001209191-17-013751 · doc4.xml · derivative · entry 1

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,900

Underlying: Common stock · 142,900 shares

Expires 2027-02-20

F1 · derivative.exercise_date: This option was granted on February 21, 2017. The shares underlying this option vest as to 25% of the underlying shares on February 21, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 2

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 382,615

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.50 to $50.74.

F7 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 1

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VII, L.P.

Disclosed balance after: 417,265

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $54.00 to $54.36. The reporting person undertakes to provide to AGIO, any security holder of AGIO, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2), (3), (4), (5) and (6) to this Form 4.

F7 · ownership.nature: These shares are owned directly by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"). The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"). The Managing Directors of ARCH VII LLC, Robert T. Nelsen, Keith Crandell and Clinton Bybee, are deemed to have voting and dispositive power over the shares and may be deemed to beneficially own certain shares held by ARCH Fund VII. Each Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of such securities for Section 16 or any other purpose.

SEC source: 0001209191-17-013749 · doc4.xml · derivative · entry 1

Hoerter Steven L. · CIK 0001533451 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,600

Underlying: Common stock · 47,600 shares

Expires 2027-02-20

F1 · derivative.exercise_date: This option was granted on February 21, 2017. The shares underlying this option vest as to 25% of the underlying shares on February 21, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-013746 · doc4.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,600

Underlying: Common stock · 47,600 shares

Expires 2027-02-20

F1 · derivative.exercise_date: This option was granted on February 21, 2017. The shares underlying this option vest as to 25% of the underlying shares on February 21, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-013743 · doc4.xml · derivative · entry 1

Bowden Christopher · CIK 0001608601 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,600

Underlying: Common stock · 47,600 shares

Expires 2027-02-20

F1 · derivative.exercise_date: This option was granted on February 21, 2017. The shares underlying this option vest as to 25% of the underlying shares on February 21, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-013742 · doc4.xml · derivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,600

Underlying: Common stock · 47,600 shares

Expires 2027-02-20

F1 · derivative.exercise_date: This option was granted on February 21, 2017. The shares underlying this option vest as to 25% of the underlying shares on February 21, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-012144 · doc4.xml · derivative · entry 5

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 201,656

Underlying: Common stock · 6,000 shares

Expires 2019-08-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option was granted on August 13, 2009. The shares underlying this option vest as to 25% of the shares on August 1, 2010, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-17-012144 · doc4.xml · nonDerivative · entry 2

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F2 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $50.00 to $50.05. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-17-012144 · doc4.xml · nonDerivative · entry 1

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.