AGIO

SEC source: 0001439222-24-000006 · wk-form4_1704835508.xml · derivative · entry 3

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 3,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The PSUs were granted on February 10, 2021. The PSUs vest upon the achievement of a specified clinical milestone. The performance criteria for the specified clinical milestone was determined to have been met on January 5, 2024, resulting in the vesting of the PSUs. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The PSUs were granted on February 10, 2021. The PSUs vest upon the achievement of a specified clinical milestone. The performance criteria for the specified clinical milestone was determined to have been met on January 5, 2024, resulting in the vesting of the PSUs. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-24-000006 · wk-form4_1704835508.xml · nonDerivative · entry 1

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,499

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 359 shares purchased through the Company's employee stock purchase plan.

SEC source: 0001439222-24-000002 · wk-form4_1704489026.xml · derivative · entry 3

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,951

Underlying: Common stock · 8,475 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on January 3, 2023. Beginning on January 3, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on January 3, 2023. Beginning on January 3, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-24-000002 · wk-form4_1704489026.xml · nonDerivative · entry 1

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,306

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000133 · wk-form4_1695931360.xml · nonDerivative · entry 2

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,575

F2 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated 9/28/23.

SEC source: 0001439222-23-000133 · wk-form4_1695931360.xml · derivative · entry 3

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,945

Underlying: Common stock · 7,472 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on September 26, 2022. Beginning on September 26, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F4 · derivative.expiration_date: The restricted stock units were granted on September 26, 2022. Beginning on September 26, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-23-000133 · wk-form4_1695931360.xml · nonDerivative · entry 1

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,754

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 499 shares purchased through the Company's employee stock purchase plan.

SEC source: 0001439222-23-000131 · wk-form4_1692648215.xml · nonDerivative · entry 1

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,890

F1 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $26.21 to $26.36. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001439222-23-000129 · wk-form4_1692129995.xml · derivative · entry 2

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,604

Underlying: Common stock · 2,302 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F2 · derivative.expiration_date: The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-23-000129 · wk-form4_1692129995.xml · nonDerivative · entry 1

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,302

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000127 · wk-form4_1692129854.xml · derivative · entry 2

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,604

Underlying: Common stock · 2,302 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F2 · derivative.expiration_date: The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-23-000127 · wk-form4_1692129854.xml · nonDerivative · entry 1

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,302

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000125 · wk-form4_1691784273.xml · derivative · entry 4

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,307

Underlying: Common stock · 25,000 shares

Expires 2032-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option was granted on June 21, 2022. The shares underlying this option vest as to 100% of the underlying shares on June 21, 2023.

SEC source: 0001439222-23-000125 · wk-form4_1691784273.xml · nonDerivative · entry 2

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,524

F1 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $25.69 to $26.37. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001439222-23-000125 · wk-form4_1691784273.xml · nonDerivative · entry 1

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,524

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000123 · wk-form4_1691698025.xml · derivative · entry 3

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,382

Underlying: Common stock · 22,691 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on August 8, 2022. Beginning on August 8, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

F3 · derivative.expiration_date: The restricted stock units were granted on August 8, 2022. Beginning on August 8, 2023, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-23-000123 · wk-form4_1691698025.xml · nonDerivative · entry 2

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,592

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units.

SEC source: 0001439222-23-000123 · wk-form4_1691698025.xml · nonDerivative · entry 1

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,770

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000121 · wk-form4_1691611481.xml · nonDerivative · entry 1

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,741

F1 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $25.22 to $25.40. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001439222-23-000113 · wk-form4_1691006558.xml · derivative · entry 3

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 4,150 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on August 1, 2021. The shares underlying the stock units will vest in full on August 1, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested

F3 · derivative.expiration_date: The restricted stock units were granted on August 1, 2021. The shares underlying the stock units will vest in full on August 1, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested

SEC source: 0001439222-23-000113 · wk-form4_1691006558.xml · nonDerivative · entry 2

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,659

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units.

SEC source: 0001439222-23-000113 · wk-form4_1691006558.xml · nonDerivative · entry 1

Washburn Theodore James Jr. · CIK 0001874199 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,891

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000111 · wk-form4_1688673850.xml · derivative · entry 1

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,124

Underlying: Common stock · 25,124 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on July 1, 2023. Beginning on July 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

F2 · derivative.expiration_date: The restricted stock units were granted on July 1, 2023. Beginning on July 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.

SEC source: 0001439222-23-000099 · wk-form4_1688155347.xml · nonDerivative · entry 2

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,831

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units.

SEC source: 0001439222-23-000105 · wk-form4_1688155583.xml · nonDerivative · entry 2

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,159

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units.

SEC source: 0001439222-23-000109 · wk-form4_1688155746.xml · nonDerivative · entry 2

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,285

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units.

SEC source: 0001439222-23-000107 · wk-form4_1688155663.xml · nonDerivative · entry 2

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,966

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units.

SEC source: 0001439222-23-000103 · wk-form4_1688155500.xml · nonDerivative · entry 2

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,079

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units.

SEC source: 0001439222-23-000101 · wk-form4_1688155416.xml · nonDerivative · entry 2

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,783

F1 · kind: Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units.

SEC source: 0001439222-23-000099 · wk-form4_1688155347.xml · derivative · entry 3

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,448

Underlying: Common stock · 5,449 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000099 · wk-form4_1688155347.xml · nonDerivative · entry 1

Milanova Tsveta · CIK 0001957180 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,449

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000105 · wk-form4_1688155583.xml · derivative · entry 3

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,750

Underlying: Common stock · 5,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000105 · wk-form4_1688155583.xml · nonDerivative · entry 1

Gheuens Sarah · CIK 0001881190 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,866

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000109 · wk-form4_1688155746.xml · derivative · entry 3

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,750

Underlying: Common stock · 5,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000109 · wk-form4_1688155746.xml · nonDerivative · entry 1

Burns James William · CIK 0001900772 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,992

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000107 · wk-form4_1688155663.xml · derivative · entry 3

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,900

Underlying: Common stock · 23,900 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000107 · wk-form4_1688155663.xml · nonDerivative · entry 1

FOUSE JACQUALYN A · CIK 0001405288 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,684

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000103 · wk-form4_1688155500.xml · derivative · entry 3

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 144,655

Underlying: Common stock · 25,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs vest as to 15% of the underlying shares upon the achievement of a specified clinical milestone and as to the remaining 85% of the underlying shares upon the achievement of other clinical, research and regulatory milestones. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 15% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs vest as to 15% of the underlying shares upon the achievement of a specified clinical milestone and as to the remaining 85% of the underlying shares upon the achievement of other clinical, research and regulatory milestones. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 15% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000103 · wk-form4_1688155500.xml · nonDerivative · entry 1

Goff Brian · CIK 0001546216 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,528

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000101 · wk-form4_1688155416.xml · derivative · entry 3

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,380

Underlying: Common stock · 5,380 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each performance share unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The PSUs vest as to 50% of the underlying shares upon the achievement of a specified clinical milestone and as to 50% of the underlying shares upon the achievement of a specified research milestone. The performance criteria for the specified clinical milestone was determined to have been met on June 28, 2023, resulting in the vesting of the PSUs as to 50% of the underlying shares of common stock on that date. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000101 · wk-form4_1688155416.xml · nonDerivative · entry 1

Jones Cecilia · CIK 0001840056 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,380

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000097 · wk-form4_1687552715.xml · derivative · entry 3

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 4,975 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F3 · derivative.expiration_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000097 · wk-form4_1687552715.xml · nonDerivative · entry 1

Foster-Cheek Kaye I · CIK 0001312622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,524

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000095 · wk-form4_1687552637.xml · derivative · entry 2

Ho Maykin · CIK 0001646395 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 4,975 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000095 · wk-form4_1687552637.xml · nonDerivative · entry 1

Ho Maykin · CIK 0001646395 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,524

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000093 · wk-form4_1687552551.xml · derivative · entry 2

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 4,975 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · derivative.exercise_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F2 · derivative.expiration_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000093 · wk-form4_1687552551.xml · nonDerivative · entry 1

Scadden David · CIK 0001707715 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000091 · wk-form4_1687552477.xml · derivative · entry 4

Schenkein David P · CIK 0001578200 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 4,975 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

F4 · derivative.expiration_date: The restricted stock units were granted on June 21, 2022. The shares underlying the stock units will vest in full on June 21, 2023. Vested shares will be delivered to the reporting person within three business days after such shares become vested.

SEC source: 0001439222-23-000091 · wk-form4_1687552477.xml · nonDerivative · entry 1

Schenkein David P · CIK 0001578200 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,854

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001439222-23-000089 · wk-form4_1686861126.xml · derivative · entry 2

Owen Catherine E. · CIK 0001816838 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,177

Underlying: Common stock · 33,177 shares

Expires 2033-06-13

F3 · derivative.exercise_date: This option was granted on June 13, 2023. The shares underlying this option vest as to 25% of the underlying shares on June 13, 2024, with the remaining 75% vesting in 36 equal monthly installments thereafter.