DOWNEY BRUCE

SEC source: 0001662579-24-000057 · wk-form4_1719000465.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,500

Underlying: Common Stock · 32,500 shares

Expires 2034-06-19

F1 · derivative.exercise_date: This option shall vest and become exercisable in full upon the earlier to occur of (i) June 20, 2025 and (ii) the next annual meeting of the Issuer's stockholders, subject to the recipient's continued service as a member of the Board on such date.

SEC source: 0001662579-23-000060 · wk-form4_1686947050.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,000

Underlying: Common Stock · 26,000 shares

Expires 2033-06-14

F1 · derivative.exercise_date: This option shall vest and become exercisable in full upon the earlier to occur of (i) June 15, 2024 and (ii) the next annual meeting of the Issuer's stockholders, subject to the recipient's continued service as a member of the Board on such date.

SEC source: 0000721371-23-000052 · wf-form5_169153838293516.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,729

SEC source: 0000721371-22-000162 · wf-form4_166811599108843.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,929

F1 · shares: Grant of restricted share units that will vest on November 9, 2023, except if the 2023 Annual Meeting of Shareholders is prior to November 9, 2023, then the restricted share units will vest on the date of the 2023 Annual Meeting of Shareholders.

SEC source: 0001209191-22-038861 · doc4.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2032-06-21

F1 · derivative.exercise_date: This option shall vest and become exercisable in full upon the earlier to occur of (i) June 22, 2023 and (ii) the next annual meeting of the Issuer's stockholders.

SEC source: 0000721371-21-000134 · wf-form4_163698188805846.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,621

F1 · shares: Grant of restricted share units that will vest on November 11, 2022, except if the 2022 Annual Meeting of Shareholders is prior to November 11, 2022, then the restricted share units will vest on the date of the 2022 Annual Meeting of Shareholders.

SEC source: 0001209191-21-041421 · doc4.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,500

Underlying: Common Stock · 23,500 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option shall vest and become exercisable in full upon the earlier to occur of (i) June 15, 2022 and (ii) the next annual meeting of the Issuer's stockholders.

SEC source: 0000721371-20-000156 · wf-form4_160504438095364.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,912

F1 · shares: Grant of restricted share units that will vest on November 9, 2021, except if the 2021 Annual Meeting of Shareholders is prior to November 9, 2021, then the restricted share units will vest on the date of the 2021 Annual Meeting of Shareholders.

SEC source: 0000899243-20-027695 · doc4.xml · derivative · entry 4

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 252,394 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

SEC source: 0000899243-20-027695 · doc4.xml · derivative · entry 3

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 237,148 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

SEC source: 0000899243-20-027695 · doc4.xml · nonDerivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 489,542

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

SEC source: 0000899243-20-027695 · doc4.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 237,148

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into the Issuer's Common Stock on a 8.4335-to-one basis upon the closing of the Issuer's initial public offering on October 6, 2020 and had no expiration date.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 11

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 25,000 shares

Expires 2030-06-23

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 10

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 25,000 shares

Expires 2029-06-19

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 9

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,855 shares

Expires 2028-06-20

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 8

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,207 shares

Expires 2027-06-20

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 7

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,000 shares

Expires 2026-06-23

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 6

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,750 shares

Expires 2025-06-10

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 5

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,750 shares

Expires 2024-06-12

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 4

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,750 shares

Expires 2023-06-11

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 3

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,750 shares

Expires 2022-06-13

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · derivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,750 shares

Expires 2021-06-14

F2 · price: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

F2 · derivative.exercise_date: Reflects disposition of options to acquire shares of Issuer common stock (each, an "Issuer Option") in accordance with the Merger Agreement, pursuant to which, effective immediately prior to the Effective Time, each Issuer Option held by the Reporting Person became vested in full and, as of the Effective Time, was cancelled and converted into the right to receive an amount in cash (without interest) equal to the product obtained by multiplying (x) the aggregate number of shares of Issuer common stock underlying such Issuer Option immediately prior to the Effective Time by (y) the amount, if any, by which the Offer Price exceeds the per share exercise price of such Issuer Option.

SEC source: 0001179110-20-010059 · edgar.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · price: Reflects disposition of Issuer common stock in connection with the consummation of the transactions contemplated by that certain Agreement and Plan of Merger, dated as of August 19, 2020 (the "Merger Agreement"), by and among Johnson & Johnson, Vigor Sub, Inc. ("Merger Sub") and the Issuer, including the completion of a tender offer to purchase all of the outstanding shares of Issuer common stock at a price of $52.50 per share in cash, without interest, less any required withholding taxes (the "Offer Price"), and the consummation of the merger (the "Merger") between the Issuer and Merger Sub on October 1, 2020. Pursuant to the Merger Agreement, as of the effective time of the Merger (the "Effective Time"), each outstanding share of Issuer common stock was cancelled in exchange for the right to receive an amount equal to the Offer Price.

SEC source: 0000899243-20-027445 · doc4.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2030-09-30

F1 · derivative.exercise_date: This option shall vest and become exercisable upon the earlier to occur of (i) October 1, 2021, and (ii) the next annual meeting of the Issuer's stockholders.

SEC source: 0001179110-20-007758 · edgar.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: Represents an option granted by the Company pursuant to the Company's 2013 Incentive Award Plan. The stock option will vest and become exercisable on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

SEC source: 0001179110-20-007144 · edgar.xml · derivative · entry 3

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2020-06-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The option vested as to 25% of the underlying shares at the end of each three-month period following the June 10, 2010 grant date, such that the option was fully vested on June 10, 2011.

SEC source: 0001179110-20-007144 · edgar.xml · nonDerivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,844

SEC source: 0001179110-20-007144 · edgar.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,590

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000721371-19-000148 · wf-form4_157367987960097.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,573

F1 · shares: Grant of restricted share units that will vest on November 12, 2020, except if the 2020 Annual Meeting of Shareholders is prior to November 12, 2020, then the restricted share units will vest on the date of the 2020 Annual Meeting of Shareholders.

SEC source: 0001179110-19-008026 · edgar.xml · derivative · entry 3

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted Stock Units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: Subject to certain criteria, 100% of the restricted stock units shall vest on the first anniversary of the grant date.

F3 · derivative.expiration_date: Subject to certain criteria, 100% of the restricted stock units shall vest on the first anniversary of the grant date.

SEC source: 0001179110-19-008026 · edgar.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,590

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001179110-19-008026 · edgar.xml · derivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2029-06-19

F1 · derivative.exercise_date: Represents an option granted by the Company pursuant to the Company's 2013 Incentive Award Plan. The stock option will vest and become exercisable on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

SEC source: 0001461993-19-000032 · wf-form4_156036104257729.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Melinta Common Stock · 30,000 shares

Expires not disclosed

F1 · derivative.exercise_date: The restricted stock units will vest on the day before the 2020 Annual Meeting of Shareholders, or approximately June 7, 2020, subject to continued service with the Issuer through the applicable vesting date.

F1 · derivative.expiration_date: The restricted stock units will vest on the day before the 2020 Annual Meeting of Shareholders, or approximately June 7, 2020, subject to continued service with the Issuer through the applicable vesting date.

SEC source: 0001179110-19-004104 · edgar.xml · derivative · entry 3

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,000

Underlying: Common Stock · 20,000 shares

Expires 2019-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vested as to 8.33% of the underlying shares at the end of each three-month period following the June 11, 2009 grant date, such that the option was fully vested on June 11, 2012.

SEC source: 0001179110-19-004104 · edgar.xml · nonDerivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,234

F1 · price: This transaction was executed in multiple trades at prices ranging from $14.50 to $14.53. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001179110-19-004104 · edgar.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,234

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-18-029964 · doc4.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-10-31

F1 · derivative.exercise_date: One-third of the shares underlying the stock option will vest and become exercisable on October 31, 2019. The remainder will vest and become exercisable in substantially equal monthly installments during the two year period commencing on October 31, 2019.

SEC source: 0000721371-18-000117 · wf-form4_154214741790585.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,149

F1 · shares: Grant of restricted share units that will vest on November 9, 2019, except if the 2019 Annual Meeting of Shareholders is prior to November 9, 2019, then the restricted share units will vest on the date of the 2019 Annual Meeting of Shareholders.

SEC source: 0001179110-18-008970 · edgar.xml · derivative · entry 4

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,734 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Restricted Stock Units convert into common stock on a one-for-one basis.

F5 · derivative.exercise_date: Subject to certain criteria, 100% of the restricted stock units shall vest on the first anniversary of the grant date.

F5 · derivative.expiration_date: Subject to certain criteria, 100% of the restricted stock units shall vest on the first anniversary of the grant date.

SEC source: 0001179110-18-008970 · edgar.xml · derivative · entry 3

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,356

Underlying: Common Stock · 4,356 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of MNTA common stock.

F3 · derivative.exercise_date: Represents 4,356 restricted stock units, awarded pursuant to the Company's 2013 Incentive Award Plan, 100% of the restricted stock units shall vest on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

F3 · derivative.expiration_date: Represents 4,356 restricted stock units, awarded pursuant to the Company's 2013 Incentive Award Plan, 100% of the restricted stock units shall vest on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

SEC source: 0001179110-18-008970 · edgar.xml · derivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,855

Underlying: Common Stock · 8,855 shares

Expires 2028-06-20

F1 · derivative.exercise_date: Represents an option granted by the Company pursuant to the Company's 2013 Incentive Award Plan. The stock option will vest and become exercisable on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

SEC source: 0001179110-18-008970 · edgar.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,234

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000721371-17-000153 · wf-form4_151026650886565.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,985

F1 · shares: Grant of restricted share units that will vest on November 8, 2018, except if the 2018 Annual Meeting of Shareholders is prior to November 8, 2018, then restricted share units will vest on the date of the 2018 Annual Meeting of Shareholders.

SEC source: 0001179110-17-009454 · edgar.xml · derivative · entry 2

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,734

Underlying: Common Stock · 5,734 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of MNTA common stock.

F3 · derivative.exercise_date: Represents 5,734 restricted stock units, awarded pursuant to the Company's 2013 Incentive Award Plan, 100% of the restricted stock units shall vest on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

F3 · derivative.expiration_date: Represents 5,734 restricted stock units, awarded pursuant to the Company's 2013 Incentive Award Plan, 100% of the restricted stock units shall vest on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

SEC source: 0001179110-17-009454 · edgar.xml · derivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,207

Underlying: Common Stock · 11,207 shares

Expires 2027-06-20

F1 · derivative.exercise_date: Represents an option granted by the Company pursuant to the Company's 2013 Incentive Award Plan. The stock option will vest and become exercisable on the first anniversary of the grant date, subject to Mr. Downey's continued service to the Company.

SEC source: 0000721371-16-000347 · wf-form4_147852486150264.xml · nonDerivative · entry 1

DOWNEY BRUCE · CIK 0001237257 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,362

F1 · shares: Grant of restricted share units that will vest on November 3, 2017, except if the 2017 Annual Meeting of Shareholders is prior to November 3, 2017, then the restricted share units will vest on the date of the 2017 Annual Meeting of Shareholders.