Reinhart Harald

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,300

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F6 · price: Reflects a weighted average sale price of $141.92 per share, at prices ranging from $141.47 to $142.30 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · price: Reflects a weighted average sale price of $140.87 per share, at prices ranging from $140.47 to $141.26 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,800

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: Reflects a weighted average sale price of $139.27 per share, at prices ranging from $139.05 to $139.36 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,369

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: Reflects a weighted average sale price of $138.33 per share, at prices ranging from $137.89 to $138.67 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,269

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: Reflects a weighted average sale price of $137.39 per share, at prices ranging from $136.81 to $137.74 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-016870 · doc1.xml · derivative · entry 8

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,334

Underlying: Ordinary Shares · 10,000 shares

Expires 2027-05-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F7 · derivative.exercise_date: The options vest in equal annual installments over four years beginning on 5/12/2018, the first anniversary of the date of grant.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 7

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F6 · price: Reflects a weighted average sale price of $152.11 per share, at prices ranging from $151.85 to $152.50 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · price: Reflects a weighted average sale price of $151.28 per share, at prices ranging from $150.84 to $151.82 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,400

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: Reflects a weighted average sale price of $150.41 per share, at prices ranging from $149.80 to $150.78 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,400

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: Reflects a weighted average sale price of $148.69 per share, at prices ranging from $148.23 to $148.92 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,700

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: Reflects a weighted average sale price of $146.98 per share, at prices ranging from $146.66 to $147.30 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,900

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-016870 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-016336 · doc1.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-11-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 11/16/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-016336 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-016336 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-016336 · doc1.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-11-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 11/16/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-016336 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-016336 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-013527 · doc1.xml · derivative · entry 9

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2028-11-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 11/16/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-013527 · doc1.xml · derivative · entry 8

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2027-09-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 09/20/2018, the first anniversary of the date of grant.

SEC source: 0001567619-21-013527 · doc1.xml · nonDerivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-013527 · doc1.xml · nonDerivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-013527 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-013527 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-013527 · doc1.xml · derivative · entry 7

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2027-09-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 09/20/2018, the first anniversary of the date of grant.

SEC source: 0001567619-21-013527 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-013527 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-012383 · doc1.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2027-09-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 09/20/2018, the first anniversary of the date of grant.

SEC source: 0001567619-21-012383 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-012383 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-012383 · doc1.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-012383 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-012383 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-011217 · doc1.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-011217 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-011217 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-011217 · doc1.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-011217 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-011217 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-21-014995 · doc4.xml · derivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,050

Underlying: Ordinary Shares · 5,050 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one Ordinary Share of the issuer.

F3 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered to the reporting person following vesting.

F3 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered to the reporting person following vesting.

SEC source: 0000899243-21-014995 · doc4.xml · derivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,650

Underlying: Ordinary Shares · 26,650 shares

Expires 2031-04-01

F1 · derivative.exercise_date: The Stock Options vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant.