Reinhart Harald

SEC source: 0000905148-24-001804 · form4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,619

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F4 · shares: These ADSs were sold automatically to cover taxes upon vesting of RSUs.

SEC source: 0000905148-24-001804 · form4.xml · derivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,500

Underlying: American Depositary Shares · 18,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU represents a contingent right to receive one ADS.

F5 · derivative.exercise_date: The RSUs vest in equal annual installments over four years beginning on 06/25/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F5 · derivative.expiration_date: The RSUs vest in equal annual installments over four years beginning on 06/25/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-001804 · form4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,050

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired upon vesting of Restricted Share Units ("RSUs").

F3 · price: Each RSU represents a contingent right to receive one ADS.

SEC source: 0000905148-24-001113 · form4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,800

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F3 · shares: These ADSs were sold automatically to cover taxes upon vesting of RSUs.

SEC source: 0000905148-24-001113 · form4.xml · derivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,811

Underlying: American Depositary Shares · 5,270 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one ADS.

F5 · derivative.exercise_date: The RSUs vest in equal annual installments over four years beginning on 04/03/2024, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F5 · derivative.expiration_date: The RSUs vest in equal annual installments over four years beginning on 04/03/2024, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-001113 · form4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,905

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired upon vesting of Restricted Share Units ("RSUs").

SEC source: 0000905148-24-001094 · form4.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,635

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F3 · shares: These ADSs were sold automatically to cover taxes upon vesting of Restricted Share Units.

SEC source: 0000905148-24-001094 · form4.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,048

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F3 · shares: These ADSs were sold automatically to cover taxes upon vesting of Restricted Share Units.

SEC source: 0000905148-24-001094 · form4.xml · derivative · entry 8

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,020

Underlying: American Depositary Shares · 1,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each Restricted Share Unit ("RSU") represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F9 · derivative.exercise_date: The RSUs vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F9 · derivative.expiration_date: The RSUs vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-001094 · form4.xml · derivative · entry 7

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,016

Underlying: American Depositary Shares · 3,338 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each Restricted Share Unit ("RSU") represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F8 · derivative.exercise_date: The RSUs vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F8 · derivative.expiration_date: The RSUs vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-001094 · form4.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,758

Underlying: American Depositary Shares · 69,758 shares

Expires not disclosed

F6 · derivative.exercise_price: Each Restricted Share Unit ("RSU") represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F7 · derivative.exercise_date: The RSUs vest in equal annual installments over four years beginning on 04/01/2025, the first anniversary of the date of grant, subject to continuous service. Vested shares will be delivered to the reporting person following vesting.

F7 · derivative.expiration_date: The RSUs vest in equal annual installments over four years beginning on 04/01/2025, the first anniversary of the date of grant, subject to continuous service. Vested shares will be delivered to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-001094 · form4.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 107,321

Underlying: American Depositary Shares · 107,321 shares

Expires 2034-04-01

F4 · security: Each Stock Option is exercisable for one ADS, which represents ten Ordinary Shares of the issuer.

F5 · derivative.exercise_date: The option vests in equal annual installments over four years beginning on 04/01/2025, the first anniversary of the date of grant, subject to continuous service.

F1 · derivative.underlying: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-001094 · form4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,408

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired on vesting of Restricted Share Units.

SEC source: 0000905148-24-001094 · form4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,398

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired on vesting of Restricted Share Units.

SEC source: 0000905148-24-000061 · form4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,060

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F4 · shares: These ADSs were sold automatically to cover taxes upon vesting of PSUs.

SEC source: 0000905148-24-000061 · form4.xml · derivative · entry 4

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: American Depositary Shares · 17,548 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each PSU represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F5 · derivative.exercise_date: The reporting person was granted PSUs on December 1, 2021 that vest based on the satisfaction of specified performance criteria between December 1, 2021 and December 31, 2025. On January 1, 2024, the performance-based vesting conditions were confirmed for PSUs representing 17,548 ADSs.

F5 · derivative.expiration_date: The reporting person was granted PSUs on December 1, 2021 that vest based on the satisfaction of specified performance criteria between December 1, 2021 and December 31, 2025. On January 1, 2024, the performance-based vesting conditions were confirmed for PSUs representing 17,548 ADSs.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-000061 · form4.xml · derivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,548

Underlying: American Depositary Shares · 17,548 shares

Expires not disclosed

F3 · derivative.exercise_price: Each PSU represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F5 · derivative.exercise_date: The reporting person was granted PSUs on December 1, 2021 that vest based on the satisfaction of specified performance criteria between December 1, 2021 and December 31, 2025. On January 1, 2024, the performance-based vesting conditions were confirmed for PSUs representing 17,548 ADSs.

F5 · derivative.expiration_date: The reporting person was granted PSUs on December 1, 2021 that vest based on the satisfaction of specified performance criteria between December 1, 2021 and December 31, 2025. On January 1, 2024, the performance-based vesting conditions were confirmed for PSUs representing 17,548 ADSs.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000905148-24-000061 · form4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,863

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired on vesting of performance-based share units (PSUs). Each ADS represents ten Ordinary Shares of the issuer.

F3 · price: Each PSU represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

SEC source: 0000950170-23-029861 · ownership.xml · derivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,750

Underlying: American Depositary Shares · 18,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · security: Each Restricted Share Unit represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F5 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over four years beginning on 06/25/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F5 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over four years beginning on 06/25/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000950170-23-029861 · ownership.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,315

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F3 · kind: This transaction represents the disposition of shares to cover taxes.

SEC source: 0000950170-23-029861 · ownership.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,497

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired on vesting of Restricted Share Units. Each ADS represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-23-010712 · doc4.xml · derivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,081

Underlying: American Depositary Shares · 21,081 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one American Depositary Share (ADS), which represents ten Ordinary Shares of the issuer.

F5 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over four years beginning on 04/03/2024, the first anniversary of the date of grant. Vested shares will be delivered to the reporting person following vesting.

F5 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over four years beginning on 04/03/2024, the first anniversary of the date of grant. Vested shares will be delivered to the reporting person following vesting.

F3 · derivative.underlying: Each ADS represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-23-010712 · doc4.xml · derivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,632

Underlying: American Depositary Shares · 109,632 shares

Expires 2033-04-03

F1 · shares: The Stock Options are exercisable for American Depositary Shares (ADSs). The number of securities underlying each option and the exercise price therefor are represented in ADSs. Each ADS represents ten Ordinary Shares of the issuer.

F2 · derivative.exercise_date: The Stock Options vest in equal annual installments over four years beginning on 04/03/2024, the first anniversary of the date of grant.

F3 · derivative.underlying: Each ADS represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-23-010212 · doc4.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,030

Underlying: American Depositary Shares · 1,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F6 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F6 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000899243-23-010212 · doc4.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,354

Underlying: American Depositary Shares · 3,338 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F5 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F5 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

SEC source: 0000899243-23-010212 · doc4.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,247

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F3 · kind: This transaction represents the disposition of shares to cover taxes.

SEC source: 0000899243-23-010212 · doc4.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,060

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired on vesting of Restricted Share Units. Each ADS represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-23-010212 · doc4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,722

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F3 · kind: This transaction represents the disposition of shares to cover taxes.

SEC source: 0000899243-23-010212 · doc4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,968

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · shares: ADSs acquired on vesting of Restricted Share Units. Each ADS represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-23-007331 · doc4.xml · derivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: American Depositary Shares · 11,480 shares

Expires 2027-05-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 08/23/2022, that expires on 06/30/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: The options vest in equal installments over four years beginning on 5/12/2018, the first anniversary of the date of grant.

SEC source: 0000899243-23-007331 · doc4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,958

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · kind: The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 08/23/2022, that expires on 06/30/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-23-007331 · doc4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,438

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

F2 · kind: The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 08/23/2022, that expires on 06/30/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-23-000205 · doc4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,958

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer.

F2 · kind: The shares were disposed of through a netting transaction to the issuer to cover taxes due.

SEC source: 0000899243-22-036308 · doc4.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,480

Underlying: American Depositary Shares · 1,854 shares

Expires 2027-05-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: The shares were disposed of through a netting transaction to the issuer to cover taxes due. Due to an inadvertent administrative error, the disposition of such shares to cover taxes was not reported on the original Form 4.

F2 · derivative.exercise_date: The shares were disposed of through a netting transaction to the issuer to cover taxes due. Due to an inadvertent administrative error, the disposition of such shares to cover taxes was not reported on the original Form 4.

SEC source: 0000899243-22-036308 · doc4.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,861

F3 · kind: The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 8/23/2022, expires 6/30/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-22-036308 · doc4.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,961

F3 · kind: The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 8/23/2022, expires 6/30/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-22-036308 · doc4.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,715

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 8/23/2022, expires 6/30/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-22-024328 · doc4.xml · derivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,000

Underlying: American Depositary Shares · 73,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one American Depositary Share (ADS), which represents ten Ordinary Shares of the issuer.

F2 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over four years beginning on 06/25/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F2 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over four years beginning on 06/25/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

SEC source: 0000899243-22-013699 · doc4.xml · derivative · entry 4

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,040

Underlying: American Depositary Shares · 1,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F7 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F7 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2022, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-22-013699 · doc4.xml · derivative · entry 3

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,692

Underlying: American Depositary Shares · 16,692 shares

Expires not disclosed

F5 · derivative.exercise_price: Each Restricted Share Unit represents a contingent right to receive one ADS, which represents ten Ordinary Shares of the issuer.

F6 · derivative.exercise_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F6 · derivative.expiration_date: The Restricted Share Units vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant. Vested shares will be delivered in the form of ADSs to the reporting person following vesting.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-22-013699 · doc4.xml · derivative · entry 2

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,699

Underlying: American Depositary Shares · 87,699 shares

Expires 2032-04-01

F3 · shares: The Stock Options are exercisable for ADSs. The number of securities underlying each option and the exercise price therefor are represented in ADSs. Each ADS represents ten Ordinary Shares of the issuer.

F4 · derivative.exercise_date: The Stock Options vest in equal annual installments over five years beginning on 04/01/2023, the first anniversary of the date of grant.

F1 · derivative.underlying: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-22-013699 · doc4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,107

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer.

F2 · shares: ADSs acquired on vesting of Restricted Share Units. Each ADS represents ten Ordinary Shares of the issuer.

SEC source: 0000899243-22-036308 · doc4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,861

F1 · security: Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer.

F2 · security: The shares were disposed of through a netting transaction to the issuer to cover taxes due. Due to an inadvertent administrative error, the disposition of such shares to cover taxes was not reported on the original Form 4.

F2 · kind: The shares were disposed of through a netting transaction to the issuer to cover taxes due. Due to an inadvertent administrative error, the disposition of such shares to cover taxes was not reported on the original Form 4.

SEC source: 0001567619-21-022691 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,097

F1 · kind: The shares were disposed of through a netting transaction to the issuer to cover taxes due.

SEC source: 0000899243-21-049736 · doc4.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · See remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

SEC source: 0001567619-21-016964 · doc1.xml · derivative · entry 11

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,334

Underlying: Ordinary Shares · 10,000 shares

Expires 2027-05-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F11 · derivative.exercise_date: The options vest in equal annual installments over four years beginning on 5/12/2018, the first anniversary of the date of grant.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 10

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F10 · price: Reflects a weighted average sale price of $146.61 per share, at prices ranging from $146.50 to $146.76 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 9

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F9 · price: Reflects a weighted average sale price of $146.07 per share, at prices ranging from $145.49 to $146.46 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 8

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,900

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F8 · price: Reflects a weighted average sale price of $144.35 per share, at prices ranging from $144.09 to $144.99 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-016964 · doc1.xml · nonDerivative · entry 7

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,700

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated June 2, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F7 · price: Reflects a weighted average sale price of $143.34 per share, at prices ranging from $142.81 to $143.72 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.