Pizzuti Dana

SEC source: 0001628280-25-055054 · wk-form4_1764797309.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-25-055054 · wk-form4_1764797309.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,837

F2 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $45.02 per share. The range of sale prices on the transaction date was $44.59 to $45.51. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-25-055054 · wk-form4_1764797309.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,837

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 567 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · derivative · entry 4

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 74,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · nonDerivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $43.27 per share for 100 shares.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,370

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $42.65 per share. The range of sale prices on the transaction date was $42.14 to $43.09. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-25-049671 · wk-form4_1762380006.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001658247-25-000013 · wk-form4_1759524085.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 79,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vested on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001658247-25-000013 · wk-form4_1759524085.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F2 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $41.81 per share. The range of sales prices on the transaction date was $41.34 to $42.16 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001658247-25-000013 · wk-form4_1759524085.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: On September 4, 2025, the Reporting Person filed a Form 4 (the "Prior Form 4") which inadvertently reported that, following the transactions reported in the Prior Form 4, the Reporting Person directly owned 96,270 shares of the Issuer's common stock. In fact, the Reporting Person directly owned 66,270 shares of the Issuer's common stock following the transactions reported in the Prior Form 4.

SEC source: 0001948238-25-000009 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001948238-25-000009 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $32.10 per share. The range of sales prices on the transaction date was $32.00 to $32.24 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001948238-25-000009 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 101,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001948238-25-000007 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,042

Underlying: Common Stock · 30,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001948238-25-000007 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $30.43 per share. The range of sales prices on the transaction date was $30.00 to $30.98 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001948238-25-000007 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,270

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001948238-25-000005 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,270

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 21, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $29.18 per share. The range of sales prices on the transaction date was $28.94 to $29.47 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

F3 · balance_after: Includes 529 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-043407 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,233

F3 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.83 per share. The range of sales prices on the transaction date was $34.78 to $35.00 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-043407 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,360

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $34.17 per share. The range of sales prices on the transaction date was $33.78 to $34.77 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-025665 · ownership.xml · derivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 20, 2025.

SEC source: 0000950170-25-025665 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,748

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on March 15, 2026.

SEC source: 0000950170-25-014557 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 119,042

Underlying: Common Stock · 5,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-014557 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,748

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $39.07 per share. The range of sales prices on the transaction date was $38.89 to $39.49 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-25-014557 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,748

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-002869 · ownership.xml · derivative · entry 5

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,500

Underlying: Common Stock · 2,500 shares

Expires 2033-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 1/48th of the shares subject to the option vested on April 1, 2023, and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-002869 · ownership.xml · nonDerivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,748

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-002869 · ownership.xml · derivative · entry 4

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 124,042

Underlying: Common Stock · 15,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-25-002869 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,248

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $52.09 per share. The range of sales prices on the transaction date was $51.60 to $52.60 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

F3 · balance_after: Includes 741 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-002869 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,248

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-113082 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,042

Underlying: Common Stock · 14,375 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-24-113082 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,507

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $54.63 per share. The range of sales prices on the transaction date was $53.53 to $55.29 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-24-113082 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,882

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-081878 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 153,417

Underlying: Common Stock · 14,375 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-24-081878 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,507

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $44.87 per share. The range of sales prices on the transaction date was $44.24 to $45.55 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

F3 · balance_after: Includes 721 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-24-081878 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,882

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-077402 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 167,792

Underlying: Common Stock · 9,500 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-24-077402 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,786

F1 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $45.73 per share. The range of sales prices on the transaction date was $45.53 to $45.88 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-24-077402 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,286

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-045142 · ownership.xml · derivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,292

Underlying: Common Stock · 14,375 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0000950170-24-045142 · ownership.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,786

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $44.47 per share. The range of sales prices on the transaction date was $43.98 to $44.75 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0000950170-24-045142 · ownership.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,161

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-24-005061 · doc4.xml · derivative · entry 7

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,667

Underlying: Common Stock · 10,000 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001209191-24-005061 · doc4.xml · derivative · entry 6

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 201,667

Underlying: Common Stock · 4,375 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option is exercisable as follows: 25% of the shares subject to the option vest on September 30, 2023, and the remaining number of shares subject to the option vest monthly thereafter in thirty-six equal monthly installments, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001209191-24-005061 · doc4.xml · nonDerivative · entry 5

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,786

SEC source: 0001209191-24-005061 · doc4.xml · nonDerivative · entry 4

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,500

F1 · price: The common stock was sold by the reporting person in open market transactions on the transaction date, with a volume weighted average sales price of $43.28 per share. The range of sales prices on the transaction date was $42.70 to $43.77 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

SEC source: 0001209191-24-005061 · doc4.xml · nonDerivative · entry 3

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-24-005061 · doc4.xml · nonDerivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,500

SEC source: 0001209191-24-005061 · doc4.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,875

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-24-005013 · doc4.xml · nonDerivative · entry 1

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,500

F1 · kind: Represents the number of shares of common stock withheld by the Issuer to cover the reporting person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 1, 2023. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001209191-24-004607 · doc4.xml · derivative · entry 2

Pizzuti Dana · CIK 0001948238 · Chief Med and Dev Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,000

Underlying: Common Stock · 87,000 shares

Expires 2034-03-03

F2 · derivative.exercise_date: The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of March 4, 2024.