SKYLER JAY S

SEC source: 0001193125-26-036147 · ownership.xml · derivative · entry 7

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 200,000 shares

Expires not disclosed

F4 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

SEC source: 0001193125-26-036147 · ownership.xml · derivative · entry 6

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,500 shares

Expires not disclosed

F4 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

SEC source: 0001193125-26-036147 · ownership.xml · derivative · entry 5

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,500 shares

Expires not disclosed

F4 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

SEC source: 0001193125-26-036147 · ownership.xml · derivative · entry 4

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,230 shares

Expires not disclosed

F4 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

SEC source: 0001193125-26-036147 · ownership.xml · derivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,460 shares

Expires not disclosed

F4 · price: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each option to purchase shares of common stock (each a "Stock Option") that has a per share exercise price that equals or exceeds the Closing Amount as of immediately prior to the Effective time (each such Stock Option, an "Out-of-the-Money Option"), to the extent not vested, was fully vested as of prior to the Effective Time. Any Out-of-the-Money Options that remained outstanding and unexercised as of the Effective Time were cancelled for no consideration at the Effective Time.

SEC source: 0001193125-26-036147 · ownership.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Pursuant to the terms of that certain Agreement and Plan of Merger (the "Merger Agreement") dated as of December, 11, 2025, among the Issuer, Cycle Group Holdings Limited and AT2B, INC. ("Purchaser"), Purchaser completed a tender offer for shares of Issuer and thereafter merged with and into the Issuer (the "Merger"), effective as of January 28, 2026, with the Issuer surviving the Merger. At the effective time of the Merger (the "Effective Time"), each outstanding share of Issuer common stock was cancelled and converted into the right to receive (i) $0.088 per share of common stock, net to the seller in cash, without interest (the "Closing Amount") plus (ii) one non-tradeable contingent value right, in accordance with the terms and subject to the conditions of a contingent value rights agreement (the "Merger Consideration").

F3 · kind: Pursuant to the Merger Agreement, each share of common stock tendered by the Reporting Person was tendered in exchange for the Merger Consideration.

F1 · price: Pursuant to the terms of that certain Agreement and Plan of Merger (the "Merger Agreement") dated as of December, 11, 2025, among the Issuer, Cycle Group Holdings Limited and AT2B, INC. ("Purchaser"), Purchaser completed a tender offer for shares of Issuer and thereafter merged with and into the Issuer (the "Merger"), effective as of January 28, 2026, with the Issuer surviving the Merger. At the effective time of the Merger (the "Effective Time"), each outstanding share of Issuer common stock was cancelled and converted into the right to receive (i) $0.088 per share of common stock, net to the seller in cash, without interest (the "Closing Amount") plus (ii) one non-tradeable contingent value right, in accordance with the terms and subject to the conditions of a contingent value rights agreement (the "Merger Consideration").

F3 · price: Pursuant to the Merger Agreement, each share of common stock tendered by the Reporting Person was tendered in exchange for the Merger Consideration.

SEC source: 0001193125-26-036147 · ownership.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,500

F1 · kind: Pursuant to the terms of that certain Agreement and Plan of Merger (the "Merger Agreement") dated as of December, 11, 2025, among the Issuer, Cycle Group Holdings Limited and AT2B, INC. ("Purchaser"), Purchaser completed a tender offer for shares of Issuer and thereafter merged with and into the Issuer (the "Merger"), effective as of January 28, 2026, with the Issuer surviving the Merger. At the effective time of the Merger (the "Effective Time"), each outstanding share of Issuer common stock was cancelled and converted into the right to receive (i) $0.088 per share of common stock, net to the seller in cash, without interest (the "Closing Amount") plus (ii) one non-tradeable contingent value right, in accordance with the terms and subject to the conditions of a contingent value rights agreement (the "Merger Consideration").

F2 · kind: Pursuant to the Merger Agreement, at the Effective Time, each outstanding RSU (whether vested or unvested) was deemed to have vested and was cancelled and automatically converted into the right to receive the Merger Consideration.

F1 · price: Pursuant to the terms of that certain Agreement and Plan of Merger (the "Merger Agreement") dated as of December, 11, 2025, among the Issuer, Cycle Group Holdings Limited and AT2B, INC. ("Purchaser"), Purchaser completed a tender offer for shares of Issuer and thereafter merged with and into the Issuer (the "Merger"), effective as of January 28, 2026, with the Issuer surviving the Merger. At the effective time of the Merger (the "Effective Time"), each outstanding share of Issuer common stock was cancelled and converted into the right to receive (i) $0.088 per share of common stock, net to the seller in cash, without interest (the "Closing Amount") plus (ii) one non-tradeable contingent value right, in accordance with the terms and subject to the conditions of a contingent value rights agreement (the "Merger Consideration").

F2 · price: Pursuant to the Merger Agreement, at the Effective Time, each outstanding RSU (whether vested or unvested) was deemed to have vested and was cancelled and automatically converted into the right to receive the Merger Consideration.

SEC source: 0001193125-25-325007 · ownership.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2035-12-16

F1 · security: Represents the 2025 annual grant to the Reporting Person as a member of the Board of Directors of the Issuer. Shares underlying the option vest in two equal annual installments on December 16, 2026 and December 16, 2027.

F2 · security: This award was made pursuant to the Issuer's 2021 Omnibus Equity Incentive Plan, as amended.

F1 · derivative.exercise_date: Represents the 2025 annual grant to the Reporting Person as a member of the Board of Directors of the Issuer. Shares underlying the option vest in two equal annual installments on December 16, 2026 and December 16, 2027.

SEC source: 0000950170-25-084618 · ownership.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest in 36 equal monthly installments from the grant date, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000950170-24-084299 · ownership.xml · derivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2034-07-15

F2 · security: Represents the inaugural grant to the Reporting Person as a member of the Board. Shares underlying the option vest in three equal annual installments on May 3, 2025, 2026, and 2027.

F3 · security: This award was made pursuant to the Issuer's 2021 Omnibus Equity Incentive Plan, as amended.

F2 · derivative.exercise_date: Represents the inaugural grant to the Reporting Person as a member of the Board. Shares underlying the option vest in three equal annual installments on May 3, 2025, 2026, and 2027.

SEC source: 0000950170-24-084299 · ownership.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2034-07-15

F1 · security: Represents the 2024 annual grant to the Reporting Person as a member of the Board of Directors of the Issuer (the "Board"). Shares underlying the option vest in two equal annual installments on July 15, 2025, and 2026.

F3 · security: This award was made pursuant to the Issuer's 2021 Omnibus Equity Incentive Plan, as amended.

F1 · derivative.exercise_date: Represents the 2024 annual grant to the Reporting Person as a member of the Board of Directors of the Issuer (the "Board"). Shares underlying the option vest in two equal annual installments on July 15, 2025, and 2026.

SEC source: 0000950170-24-070638 · ownership.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

F1 · shares: Consists of compensatory Restricted Stock Units granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. Each compensatory Restricted Stock Unit represents a contingent right to receive one share of the issuer's common stock. One-fourth (1/4th) of the Restricted Stock Units shall vest on a quarterly basis from June 6, 2024 until the earlier of (i) the first anniversary of the date of grant and (ii) the date of the issuer's next annual stockholder meeting, in each case, subject to the reporting person's continuous service as of each such date.

SEC source: 0001209191-23-035600 · doc4.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

F1 · shares: Consists of compensatory Restricted Stock Units granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. Each compensatory Restricted Stock Unit represents a contingent right to receive one share of the issuer's common stock. One-fourth (1/4th) of the Restricted Stock Units shall vest on each of September 6, 2023, December 6, 2023, March 6, 2024 and the date which is the earlier of June 6, 2024 and the 2024 annual stockholder meeting, subject to the Reporting Person continuing to provide services through each such date.

SEC source: 0001093557-23-000143 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · by Partnership

Disclosed balance after: 63,348

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

F2 · balance_after: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-23-000143 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 8

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,460

Underlying: Common Stock · 20,460 shares

Expires 2029-05-12

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F3 · derivative.exercise_date: These Options are fully vested.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 7

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,460 shares

Expires 2029-05-12

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F3 · derivative.exercise_date: These Options are fully vested.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 6

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,230

Underlying: Common Stock · 10,230 shares

Expires 2030-06-03

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F3 · derivative.exercise_date: These Options are fully vested.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 5

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,230 shares

Expires 2030-06-03

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F3 · derivative.exercise_date: These Options are fully vested.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 4

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2031-06-02

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F3 · derivative.exercise_date: These Options are fully vested.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,500 shares

Expires 2031-06-02

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F3 · derivative.exercise_date: These Options are fully vested.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2032-06-02

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F2 · derivative.exercise_date: Reflects an initial grant of 16,500 Options granted on June 3, 2022 that vests as follows: One-twelfth (1/12th) of the shares subject to the Option shall vest on July 2, 2022 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date.

SEC source: 0001209191-22-044467 · doc4.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,500 shares

Expires 2032-06-02

F1 · kind: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F1 · price: The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options.

F2 · derivative.exercise_date: Reflects an initial grant of 16,500 Options granted on June 3, 2022 that vests as follows: One-twelfth (1/12th) of the shares subject to the Option shall vest on July 2, 2022 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date.

SEC source: 0001209191-22-034932 · doc4.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2032-06-02

F1 · derivative.exercise_date: Consists of Options granted to directors under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. One-twelfth (1/12th) of the shares subject to the Option shall vest on July 2, 2022 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date.

SEC source: 0001093557-22-000121 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 969

F2 · shares: The RSU Award was granted on May 20, 2022 and 100% of the RSU will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2023 Annual Meeting. Each share is represented by a restricted stock unit (RSU) that represents a contingent right to receive one share of DexCom, Inc. Common Stock upon settlement.

F3 · balance_after: Represents 969 restricted stock units which were granted on May 20, 2022 and will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2023 Annual Meeting.

SEC source: 0001093557-22-000121 · edgardoc.xml · nonDerivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 14,868

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

F4 · balance_after: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-22-000121 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

SEC source: 0001093557-21-000172 · edgardoc.xml · nonDerivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 13,968

F1 · shares: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 7, 2020, and amended effective February 17, 2021. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler.

F5 · price: This transaction was executed in multiple trades at prices ranging from $427.000 to $427.455. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

F3 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-21-000172 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 19,370

F1 · shares: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 7, 2020, and amended effective February 17, 2021. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler.

F4 · price: This transaction was executed in multiple trades at prices ranging from $426.00 to $426.99. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issurer full information regarding the number of shares and prices at which the transactions were effected.

F3 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-21-000172 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 27,704

F1 · shares: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 7, 2020, and amended effective February 17, 2021. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler.

F2 · price: This transaction was executed in multiple trades at prices ranging from $425.00 to $425.99. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

F3 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001209191-21-038429 · doc4.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2031-06-02

F1 · derivative.exercise_date: One-twelfth (1/12th) of the shares subject to the Option shall vest on July 3, 2021 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date.

SEC source: 0001093557-21-000147 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 900

F2 · shares: The RSU Award was granted on May 21, 2021 and 100% of the RSU will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2022 Annual Meeting. Each share is represented by a restricted stock unit (RSU) that represents a contingent right to receive one share of DexCom, Inc. Common Stock upon settlement.

F3 · balance_after: Represents 900 restricted stock units which were granted on May 21, 2021 and will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2022 Annual Meeting.

SEC source: 0001093557-21-000147 · edgardoc.xml · nonDerivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 33,968

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

F4 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-21-000147 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

SEC source: 0001209191-20-034795 · doc4.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,230

Underlying: Common Stock · 10,230 shares

Expires 2030-06-03

F1 · derivative.exercise_date: One-twelfth (1/12th) of the shares subject to the Option shall vest on July 4, 2020 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date.

SEC source: 0001093557-20-000162 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 822

F2 · shares: The RSU Award was granted on May 22, 2020 and 100% of the RSU will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2021 Annual Meeting. Each share is represented by a restricted stock unit (RSU) that represents a contingent right to receive one share of DexCom, Inc. Common Stock upon settlement.

F3 · balance_after: Represents 822 restricted stock units which were granted on May 22, 2020 and will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2020 Annual Meeting.

SEC source: 0001093557-20-000162 · edgardoc.xml · nonDerivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 33,146

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

F4 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-20-000162 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

SEC source: 0001093557-20-000006 · edgardoc.xml · nonDerivative · entry 4

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 30,417

F1 · shares: On August 6, 2019, Mr. Skyler adopted a 10b5-1 Plan. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler. The shares set forth above were sold pursuant to the 10b5-1 Plan.

F5 · price: This transaction was executed in multiple trades at prices ranging from $218.66 to $219.29. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001093557-20-000006 · edgardoc.xml · nonDerivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 33,503

F1 · shares: On August 6, 2019, Mr. Skyler adopted a 10b5-1 Plan. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler. The shares set forth above were sold pursuant to the 10b5-1 Plan.

F4 · price: This transaction was executed in multiple trades at prices ranging from $217.66 to $218.63. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001093557-20-000006 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 47,959

F1 · shares: On August 6, 2019, Mr. Skyler adopted a 10b5-1 Plan. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler. The shares set forth above were sold pursuant to the 10b5-1 Plan.

F3 · price: This transaction was executed in multiple trades at prices ranging from $216.66 to $217.63. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issurer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001093557-20-000006 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 53,523

F1 · shares: On August 6, 2019, Mr. Skyler adopted a 10b5-1 Plan. This 10b5-1 Plan allows the orderly disposition of shares owned by Mr. Skyler. The shares set forth above were sold pursuant to the 10b5-1 Plan.

F2 · price: This transaction was executed in multiple trades at prices ranging from $215.59 to $216.53. The price above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001093557-19-000153 · wf-form4_155969295305043.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,729

F2 · shares: The RSU Award was granted on May 31, 2019 and 100% of the RSU will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2020 Annual Meeting. Each share is represented by a restricted stock unit (RSU) that represents a contingent right to receive one share of DexCom, Inc. Common Stock upon settlement.

F3 · balance_after: Represents 2,729 restricted stock units which were granted on May 31, 2019 and will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2020 Annual Meeting.

SEC source: 0001093557-19-000153 · wf-form4_155969295305043.xml · nonDerivative · entry 3

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 56,223

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

F4 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-19-000153 · wf-form4_155969295305043.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.

SEC source: 0001209191-19-030085 · doc4.xml · derivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,460

Underlying: Common Stock · 20,460 shares

Expires 2029-05-12

F1 · derivative.exercise_date: One thirty-sixth (1/36th) of the shares subject to the Option shall vest each month commencing on June 13, 2019, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001093557-19-000004 · edgardoc.xml · derivative · entry 4

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 0

Underlying: Common Stock · 25,806 shares

Expires 2019-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-19-000004 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 52,616

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: Shares are held by Skyler Bach Family Limited Partnership, LLP, with respect to which the reporting person is a managing partner of the partnership and maintains voting rights of these shares.

SEC source: 0001093557-18-000138 · edgardoc.xml · nonDerivative · entry 1

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,607

F1 · shares: The RSU Award was granted on June 1, 2018 and 100% of the RSU will vest on the earlier of the one year anniversary of the grant date or the date of DexCom Inc's 2019 Annual Meeting. Each share is represented by a restricted stock unit (RSU) that represents a contingent right to receive one share of DexCom, Inc. commom stock upon settlement.

SEC source: 0001093557-19-000029 · edgardoc.xml · nonDerivative · entry 2

SKYLER JAY S · CIK 0001236386 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Partnership

Disclosed balance after: 26,810

F1 · shares: Shares were transferred from direct ownership to ownership under the Skyler Bach Family Limited Partnership, LLP, upon vesting of previously awarded restricted stock units.