Muller Lorenz

SEC source: 0001771207-26-000004 · form4-02042026_100201.xml · derivative · entry 2

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 136,000

Underlying: Common Shares · 136,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one common share.

F3 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the restricted stock unit award vest on each of February 2, 2027, February 2, 2028, February 2, 2029 and February 2, 2030, subject to the Reporting Person continuing to provide service through each such date.

F3 · derivative.expiration_date: One-fourth (1/4th) of the shares subject to the restricted stock unit award vest on each of February 2, 2027, February 2, 2028, February 2, 2029 and February 2, 2030, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001771207-26-000004 · form4-02042026_100201.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 204,000

Underlying: Common Shares · 204,000 shares

Expires 2036-02-02

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on February 2, 2027, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001771207-26-000005 · form4a-02052026_040210.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 204,000

Underlying: Common Shares · 204,000 shares

Expires 2036-02-02

F1 · derivative.exercise_price: The exercise price on the initial filings was incorrectly stated.

F2 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on February 2, 2027, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001771207-26-000002 · form4-01282026_060105.xml · derivative · entry 6

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,300

Underlying: Common Shares · 20,100 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents a contingent right to receive one common share.

F7 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the RSU award vested or will vest on each of January 26, 2026, January 26, 2027, January 26, 2028 and January 26, 2029, subject to the Reporting Person continuing to provide service through each such date.

F7 · derivative.expiration_date: One-fourth (1/4th) of the shares subject to the RSU award vested or will vest on each of January 26, 2026, January 26, 2027, January 26, 2028 and January 26, 2029, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001771207-26-000002 · form4-01282026_060105.xml · nonDerivative · entry 4

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,406

F3 · kind: Represents shares sold pursuant to a sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of PSUs or restricted stock unit ("RSU") awards only, respectively.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001771207-26-000002 · form4-01282026_060105.xml · nonDerivative · entry 3

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 216,586

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU represents a contingent right to receive one common share.

SEC source: 0001771207-26-000002 · form4-01282026_060105.xml · nonDerivative · entry 2

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 196,486

F3 · kind: Represents shares sold pursuant to a sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of PSUs or restricted stock unit ("RSU") awards only, respectively.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001771207-26-000002 · form4-01282026_060105.xml · derivative · entry 5

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Shares · 100,000 shares

Expires 2034-05-06

F6 · derivative.exercise_date: 50% of the option will vest on June 12, 2026 and 50% will vest on December 12, 2026, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001771207-26-000002 · form4-01282026_060105.xml · nonDerivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,052

F1 · shares: Represents a performance stock unit ("PSU") award that vested upon the certification by the Compensation Committee of the Board of Directors of the Issuer that the U.S. Food and Drug Administration has provided a New Drug Application Approval Letter granting approval of Cardamyst (etripamil).

F2 · price: Each PSU represents a contingent right to receive one common share.

SEC source: 0001771207-25-000002 · form4-12112025_041204.xml · nonDerivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,052

F1 · kind: Represents a bona fide gift for no consideration to members of the Reporting Person's family outside the Reporting Person's household.

SEC source: 0001415889-25-019771 · form4-07152025_040705.xml · derivative · entry 3

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,666

Underlying: Common Shares · 66,666 shares

Expires 2030-07-11

F1 · price: The reported securities are included within 66,666 Issuer Units purchased by the Reporting Person for $1.50 per Unit. Each Unit consists of one common share, one Series A common warrant and one Series B common warrant, each warrant represents the right to purchase 66,666 shares of common stock.

F2 · derivative.exercise_date: Fully vested and exercisable.

SEC source: 0001415889-25-019771 · form4-07152025_040705.xml · derivative · entry 2

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,666

Underlying: Common Shares · 66,666 shares

Expires 2026-07-11

F1 · price: The reported securities are included within 66,666 Issuer Units purchased by the Reporting Person for $1.50 per Unit. Each Unit consists of one common share, one Series A common warrant and one Series B common warrant, each warrant represents the right to purchase 66,666 shares of common stock.

F2 · derivative.exercise_date: Fully vested and exercisable.

SEC source: 0001415889-25-019771 · form4-07152025_040705.xml · nonDerivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 175,052

F1 · price: The reported securities are included within 66,666 Issuer Units purchased by the Reporting Person for $1.50 per Unit. Each Unit consists of one common share, one Series A common warrant and one Series B common warrant, each warrant represents the right to purchase 66,666 shares of common stock.

SEC source: 0001415889-25-002268 · form4-01292025_040111.xml · derivative · entry 2

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,400

Underlying: Common Shares · 80,400 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one common share.

F3 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the restricted stock unit award vest on each of Jaunary 27, 2026, Jaunary 27, 2027, Jaunary 27, 2028 and Jaunary 27, 2029, subject to the Reporting Person continuing to provide service through each such date.

F3 · derivative.expiration_date: One-fourth (1/4th) of the shares subject to the restricted stock unit award vest on each of Jaunary 27, 2026, Jaunary 27, 2027, Jaunary 27, 2028 and Jaunary 27, 2029, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001415889-25-002268 · form4-01292025_040111.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,600

Underlying: Common Shares · 120,600 shares

Expires 2035-01-27

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on Jaunary 27, 2026, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-23-010707 · doc4.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Shares · 105,000 shares

Expires 2033-02-16

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on February 16, 2024, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-22-020838 · doc4.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,000

Underlying: Common Shares · 160,000 shares

Expires 2032-03-21

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on March 23, 2023, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-21-023350 · doc4.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Shares · 200,000 shares

Expires 2031-03-24

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on March 24, 2022, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-048651 · doc4.xml · derivative · entry 2

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,754

Underlying: Common Stock · 5,700 shares

Expires 2027-10-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The original grant was for 140,100 option shares. Twenty-five percent (25%) of the shares subject to the option vested on October 11, 2018, and one thirty-sixth (1/36th) of the remaining shares subject to the option vested or shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-048651 · doc4.xml · nonDerivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,386

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-20-035110 · doc4.xml · derivative · entry 7

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Shares · 35,000 shares

Expires 2030-06-05

F3 · derivative.exercise_date: The shares subject to this option shall vest in twenty-four (24) equal monthly installments commencing on July 5, 2020, subject to the recipient continuing to provide service to the Issuer through each such date.

SEC source: 0001209191-20-035110 · doc4.xml · derivative · entry 6

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,903

Underlying: Common Shares · 18,043 shares

Expires 2028-10-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The original grant was for 50,946 option shares. Twenty-five percent (25%) of the shares subject to the option shall vest on October 15, 2019, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-035110 · doc4.xml · derivative · entry 5

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,454

Underlying: Common Shares · 32,528 shares

Expires 2027-10-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The original grant was for 140,100 option shares. Twenty-five percent (25%) of the shares subject to the option vested on October 11, 2018, and one thirty-sixth (1/36th) of the remaining shares subject to the option vested or shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-035110 · doc4.xml · nonDerivative · entry 3

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,686

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-20-035110 · doc4.xml · nonDerivative · entry 2

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,643

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-20-004895 · doc4.xml · derivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Shares · 60,000 shares

Expires 2030-01-23

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on January 23, 2021 and one forty-eighth (1/48th) of the shares subject to the option vest on each one month anniversary thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-035110 · doc4.xml · derivative · entry 4

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,982

Underlying: Common Shares · 2,500 shares

Expires 2027-10-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The original grant was for 140,100 option shares. Twenty-five percent (25%) of the shares subject to the option vested on October 11, 2018, and one thirty-sixth (1/36th) of the remaining shares subject to the option vested or shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-035110 · doc4.xml · nonDerivative · entry 1

Muller Lorenz · CIK 0001771207 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,115

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.