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Combs Andrew

Disclosed activity across 1 company

Tapewire entity
67556
SEC CIK
0001825005

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Prelude Therapeutics IncPRLD · Entity 5561Chief Chemistry OfficerFebruary 04, 2026February 05, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Prelude Therapeutics Inc

Report date February 04, 2026 · Filed February 05, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Employee Stock Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $2.30 · Expires 2036-02-03Direct230,000 Reported balance After 2026-02-04 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-02-04 · Grant · Acquired 230,000 · Balance 230,000

F1: The stock option vests as to 25% of the total shares on Feb 4, 2027, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Filing footnotes · ownership attribution and instrument terms

F1: The stock option vests as to 25% of the total shares on Feb 4, 2027, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
February 04, 2026 Filed Feb 5, 2026 21:14 UTC Prelude Therapeutics Inc PRLD · Entity 5561 GrantEmployee Stock Option (right to buy) · Derivative 230,000 $0.00 Strike: $2.30 $0.00
Disclosure

SEC source: 0001825005-26-000002 · primarydocument.xml · derivative · entry 1

Combs Andrew · CIK 0001825005 · Chief Chemistry Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 230,000

Underlying: Common Stock · 230,000 shares

Expires 2036-02-03

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on Feb 4, 2027, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
March 25, 2025 Filed Mar 27, 2025 20:40 UTC Prelude Therapeutics Inc PRLD · Entity 5561 PurchaseCommon Stock 100,000 $0.69 $69,250.00
Disclosure

SEC source: 0001562180-25-002779 · primarydocument.xml · nonDerivative · entry 1

Combs Andrew · CIK 0001825005 · Chief Chemistry Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 480,123

F1 · balance_after: The reported total includes 2,500 shares of common stock the reporting person has acquired since the date of his last ownership report through the issuer's Employee Stock Purchase Plan in one or more transactions exempt pursuant to Rules 16b-3(c).

Read SEC document
February 04, 2025 Filed Feb 5, 2025 21:32 UTC Prelude Therapeutics Inc PRLD · Entity 5561 GrantEmployee Stock Option (right to buy) · Derivative 175,000 $0.00 Strike: $1.11 $0.00
Disclosure

SEC source: 0001562180-25-000957 · primarydocument.xml · derivative · entry 1

Combs Andrew · CIK 0001825005 · Chief Chemistry Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2035-02-04

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on Feb 4, 2026, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
December 23, 2024 Filed Dec 26, 2024 12:49 UTC Prelude Therapeutics Inc PRLD · Entity 5561 PurchaseCommon Stock 60,000 $1.37 $82,002.00
Disclosure

SEC source: 0001562180-24-008565 · primarydocument.xml · nonDerivative · entry 2

Combs Andrew · CIK 0001825005 · Chief Chemistry Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 377,623

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.20 to $1.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.

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December 20, 2024 Filed Dec 26, 2024 12:49 UTC Prelude Therapeutics Inc PRLD · Entity 5561 PurchaseCommon Stock 3,075 $1.15 $3,536.25
Disclosure

SEC source: 0001562180-24-008565 · primarydocument.xml · nonDerivative · entry 1

Combs Andrew · CIK 0001825005 · Chief Chemistry Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 317,623

F1 · balance_after: The reported total includes 10,106 shares of common stock the reporting person has acquired since the date of his last ownership report through the issuer's Employee Stock Purchase Plan in one or more transactions exempt pursuant to Rules 16b-3(c).

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March 01, 2024 Filed Mar 4, 2024 23:05 UTC Prelude Therapeutics Inc PRLD · Entity 5561 GrantEmployee Stock Option (right to buy) · Derivative 150,000 $0.00 Strike: $4.59 $0.00
Disclosure

SEC source: 0001562180-24-002136 · primarydocument.xml · derivative · entry 1

Combs Andrew · CIK 0001825005 · Chief Chemistry Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2034-02-28

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on March 1, 2025, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
February 07, 2023 Filed Feb 9, 2023 21:08 UTC Prelude Therapeutics Inc PRLD · Entity 5561 GrantEmployee Stock Option (right to buy) · Derivative 135,000 $0.00 Strike: $7.20 $0.00
Disclosure

SEC source: 0001562180-23-001169 · primarydocument.xml · derivative · entry 1

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common Stock · 135,000 shares

Expires 2033-02-06

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on February 7, 2024, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
April 01, 2022 Filed Apr 4, 2022 21:08 UTC Prelude Therapeutics Inc PRLD · Entity 5561 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 36,062 $0.00 Strike: $1.89 $0.00
Disclosure

SEC source: 0001209191-22-022524 · doc4.xml · derivative · entry 2

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,397

Underlying: Common Stock · 36,062 shares

Expires 2030-03-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vested as to 25% of the total shares on March 6, 2021, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
March 31, 2022 Filed Apr 4, 2022 21:08 UTC Prelude Therapeutics Inc PRLD · Entity 5561 Exercise / conversionCommon Stock 36,062 $1.89 $68,157.18
Disclosure

SEC source: 0001209191-22-022524 · doc4.xml · nonDerivative · entry 1

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 304,442

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Certain of the shares are subject to forfeiture to the Issuer if underlying vesting conditions are not met.

Read SEC document
February 15, 2022 Filed Feb 18, 2022 00:07 UTC Prelude Therapeutics Inc PRLD · Entity 5561 GrantEmployee Stock Option (right to buy) · Derivative 100,000 $0.00 Strike: $10.58 $0.00
Disclosure

SEC source: 0001209191-22-011031 · doc4.xml · derivative · entry 1

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-02-14

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on February 15, 2023, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
December 14, 2021 Filed Dec 15, 2021 22:21 UTC Prelude Therapeutics Inc PRLD · Entity 5561 PurchaseCommon Stock 4,000 $11.60 $46,400.00
Disclosure

SEC source: 0001209191-21-069796 · doc4.xml · nonDerivative · entry 2

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,380

F1 · balance_after: Certain of the shares are subject to forfeiture to the Issuer if underlying vesting conditions are not met.

Read SEC document
December 13, 2021 Filed Dec 15, 2021 22:21 UTC Prelude Therapeutics Inc PRLD · Entity 5561 PurchaseCommon Stock 4,000 $12.12 $48,480.00
Disclosure

SEC source: 0001209191-21-069796 · doc4.xml · nonDerivative · entry 1

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264,380

F1 · balance_after: Certain of the shares are subject to forfeiture to the Issuer if underlying vesting conditions are not met.

Read SEC document
July 20, 2021 Filed Jul 22, 2021 22:07 UTC Prelude Therapeutics Inc PRLD · Entity 5561 GrantEmployee Stock Option (Right to Buy) · Derivative 95,000 $0.00 Strike: $31.23 $0.00
Disclosure

SEC source: 0001209191-21-047831 · doc4.xml · derivative · entry 1

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2031-07-19

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on July 20, 2022, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

Read SEC document
September 29, 2020 Filed Sep 30, 2020 00:11 UTC Prelude Therapeutics Inc PRLD · Entity 5561 PurchaseCommon Stock 1,000 $19.00 $19,000.00
Disclosure

SEC source: 0001209191-20-052405 · doc4.xml · nonDerivative · entry 1

Combs Andrew · CIK 0001825005 · EVP, Head of Chemistry

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 260,380

F1 · balance_after: Certain of the shares are subject to forfeiture to the Issuer if underlying vesting conditions are not met.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.