First Eagle Investment Management, LLC

SEC source: 0001140361-24-011418 · form4.xml · nonDerivative · entry 1

FEPCF Founders Fund, L.P. · CIK 0001979612 · 10% owner

FEPCF Founders Fund GP LLC · CIK 0001985381 · 10% owner

First Eagle Alternative Credit, LLC · CIK 0001491455 · 10% owner

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 8,323,734.508

F1 · ownership.nature: These securities are held directly by FEPCF Founders Fund, L.P. ("Founders Fund"). FEPCF Founders Fund GP LLC ("Founders Fund GP") is the sole general partner of Founders Fund. First Eagle Alternative Credit, LLC ("FEAC") is the investment advisor to Founders Fund and sole member of Founders Fund GP. First Eagle Investment Management, LLC ("FEIM") is the sole and managing member of FEAC. First Eagle Holdings, Inc. ("FEH") is the managing member of FEIM.

F2 · ownership.nature: Each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership) disclaims beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0001140361-23-047838 · form4.xml · nonDerivative · entry 2

FEPCF Founders Fund, L.P. · CIK 0001979612 · 10% owner

FEPCF Founders Fund GP LLC · CIK 0001985381 · 10% owner

First Eagle Alternative Credit, LLC · CIK 0001491455 · 10% owner

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 6,265,274.236

F1 · ownership.nature: These securities are held directly by FEPCF Founders Fund, L.P. ("Founders Fund"). FEPCF Founders Fund GP LLC ("Founders Fund GP") is the sole general partner of Founders Fund. First Eagle Alternative Credit, LLC ("FEAC") is the investment advisor to Founders Fund and sole member of Founders Fund GP. First Eagle Investment Management, LLC ("FEIM") is the sole and managing member of FEAC. First Eagle Holdings, Inc. ("FEH") is the managing member of FEIM.

F2 · ownership.nature: Each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership), disclaims beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0001140361-23-047838 · form4.xml · nonDerivative · entry 1

FEPCF Founders Fund, L.P. · CIK 0001979612 · 10% owner

FEPCF Founders Fund GP LLC · CIK 0001985381 · 10% owner

First Eagle Alternative Credit, LLC · CIK 0001491455 · 10% owner

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,212,729.08

F1 · ownership.nature: These securities are held directly by FEPCF Founders Fund, L.P. ("Founders Fund"). FEPCF Founders Fund GP LLC ("Founders Fund GP") is the sole general partner of Founders Fund. First Eagle Alternative Credit, LLC ("FEAC") is the investment advisor to Founders Fund and sole member of Founders Fund GP. First Eagle Investment Management, LLC ("FEIM") is the sole and managing member of FEAC. First Eagle Holdings, Inc. ("FEH") is the managing member of FEIM.

F2 · ownership.nature: Each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership), disclaims beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0001140361-23-034294 · form4.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,052,000

F1 · ownership.nature: These securities are held directly by FEPCF Founders Fund, L.P. ("Founders Fund"). FEPCF Founders Fund GP LLC ("Founders Fund GP") is the sole general partner of Founders Fund. First Eagle Alternative Credit, LLC ("FEAC") is the investment advisor to Founders Fund and sole member of Founders Fund GP. First Eagle Investment Management, LLC ("FEIM") is the sole and managing member of FEAC. First Eagle Holdings, Inc. ("FEH") is the managing member of FEIM.

F2 · ownership.nature: Each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership), disclaims beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, each of the Reporting Persons (other than the direct holder of securities to the extent of its direct ownership) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-23-018207 · doc4.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F1 · price: On March 9, 2023, pursuant to an Agreement and Plan of Merger dated as of October 3, 2022 (the "Merger Agreement"), First Eagle Alternative Capital BDC, Inc., Crescent Capital BDC, Inc. ("CCAP"), Echelon Acquisition Sub, Inc., Echelon Acquisition Sub LLC and Crescent Cap Advisors, LLC ("CCAP Advisor") effected a merger pursuant to which CCAP acquired all of the outstanding shares of FCRDs common stock in a multi-step stock and cash transaction (the "Mergers"). Pursuant to the Merger Agreement, upon completion of the Mergers, each issued and outstanding share of FCRD common stock was converted into the right to receive a pro rata portion, subject to FCRD stockholder elections and the adjustment mechanisms set forth in the Merger Agreement with respect to the CCAP Consideration (as defined below), of (1) approximately $8.6 million in cash payable by CCAP, (2) 6,174,383 validly issued, fully paid and

F2 · price: continued from footnote 1: non-assessable shares of CCAPs common stock, par value $0.001 per share (together, the "CCAP Consideration") and (3) $35 million in cash payable by CCAP Advisor.

F3 · ownership.nature: Shares held directly by First Eagle Alternative Credit, LLC ("FEAC"), which is the investment adviser to the Issuer. First Eagle Investment Management, LLC ("FEIM") is the sole and managing member of FEAC. First Eagle Holdings, Inc. ("FEH") is the managing member of FEIM. FEH may be deemed to have voting and investment power with respect to all of the shares held by FEIM and FEAC. FEIM may be deemed to have voting and investment power with respect to all shares held by FEAC. FEH disclaims beneficial ownership of the shares held by FEIM and FEAC, except to the extent of any pecuniary interests therein. FEIM disclaims beneficial ownership of the shares held by FEAC except to the extent of any pecuniary interests therein.

SEC source: 0001209191-23-018207 · doc4.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · price: On March 9, 2023, pursuant to an Agreement and Plan of Merger dated as of October 3, 2022 (the "Merger Agreement"), First Eagle Alternative Capital BDC, Inc., Crescent Capital BDC, Inc. ("CCAP"), Echelon Acquisition Sub, Inc., Echelon Acquisition Sub LLC and Crescent Cap Advisors, LLC ("CCAP Advisor") effected a merger pursuant to which CCAP acquired all of the outstanding shares of FCRDs common stock in a multi-step stock and cash transaction (the "Mergers"). Pursuant to the Merger Agreement, upon completion of the Mergers, each issued and outstanding share of FCRD common stock was converted into the right to receive a pro rata portion, subject to FCRD stockholder elections and the adjustment mechanisms set forth in the Merger Agreement with respect to the CCAP Consideration (as defined below), of (1) approximately $8.6 million in cash payable by CCAP, (2) 6,174,383 validly issued, fully paid and

F2 · price: continued from footnote 1: non-assessable shares of CCAPs common stock, par value $0.001 per share (together, the "CCAP Consideration") and (3) $35 million in cash payable by CCAP Advisor.

SEC source: 0001567619-19-017896 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · security: This Form 4 is filed by First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · kind: On September 1, 2019, the family office personnel of FEIM, including Messrs. Michael M. Kellen and Andrew Gundlach, separated their investment management business from that of FEIM, transferring their family's advisory client accounts, including the securities of the Company which were formerly controlled by FEIM, to the newly formed U.S. registered advisory firm named Bleichroeder LP. Accordingly, as of September 1, 2019, (i) none of the Entities nor any Entity account maintains any discretionary or proxy voting authority or pecuniary interest with respect to, any securities of the Company and (ii) no Entity could be deemed to beneficially own any securities of the Company.

F2 · shares: On September 1, 2019, the family office personnel of FEIM, including Messrs. Michael M. Kellen and Andrew Gundlach, separated their investment management business from that of FEIM, transferring their family's advisory client accounts, including the securities of the Company which were formerly controlled by FEIM, to the newly formed U.S. registered advisory firm named Bleichroeder LP. Accordingly, as of September 1, 2019, (i) none of the Entities nor any Entity account maintains any discretionary or proxy voting authority or pecuniary interest with respect to, any securities of the Company and (ii) no Entity could be deemed to beneficially own any securities of the Company.

F2 · balance_after: On September 1, 2019, the family office personnel of FEIM, including Messrs. Michael M. Kellen and Andrew Gundlach, separated their investment management business from that of FEIM, transferring their family's advisory client accounts, including the securities of the Company which were formerly controlled by FEIM, to the newly formed U.S. registered advisory firm named Bleichroeder LP. Accordingly, as of September 1, 2019, (i) none of the Entities nor any Entity account maintains any discretionary or proxy voting authority or pecuniary interest with respect to, any securities of the Company and (ii) no Entity could be deemed to beneficially own any securities of the Company.

F3 · ownership.nature: The shares of Common Stock reported herein were indirectly beneficially owned by FEHI, a Delaware corporation, and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM (i) was the general partner of 21 April Fund, LP ("April LP"), (ii) was the registered investment adviser to First Eagle Value in Biotechnology Master Fund, Ltd. as well as to April LP and 21 April Fund, Ltd. (collectively, the "Funds"), and (iii) is a subsidiary of FEHI. FEHI disclaimed beneficial ownership of the shares of Common Stock held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the beneficial owner of any such securities.

SEC source: 0001567619-19-017899 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · security: This Form 4 is filed by First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F4 · kind: On September 1, 2019, the family office personnel of FEIM, including Messrs. Michael M. Kellen and Andrew Gundlach, separated their investment management business from that of FEIM, transferring their family's advisory client accounts, including the securities of Intevac, Inc. (the "Company") which were formerly controlled by FEIM, to the newly formed U.S. registered advisory firm named Bleichroeder LP. Accordingly, as of September 1, 2019, (i) none of the Entities nor any Entity account maintains any discretionary or proxy voting authority or pecuniary interest with respect to, any securities of the Company and (ii) no Entity could be deemed to beneficially own any securities of the Company.

F4 · shares: On September 1, 2019, the family office personnel of FEIM, including Messrs. Michael M. Kellen and Andrew Gundlach, separated their investment management business from that of FEIM, transferring their family's advisory client accounts, including the securities of Intevac, Inc. (the "Company") which were formerly controlled by FEIM, to the newly formed U.S. registered advisory firm named Bleichroeder LP. Accordingly, as of September 1, 2019, (i) none of the Entities nor any Entity account maintains any discretionary or proxy voting authority or pecuniary interest with respect to, any securities of the Company and (ii) no Entity could be deemed to beneficially own any securities of the Company.

F2 · balance_after: The shares of Common Stock reported herein were indirectly beneficially owned by FEHI, a Delaware corporation, and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM (i) was the registered investment adviser to 21 April Fund, Ltd. ("April Ltd."), (ii) is a subsidiary of FEHI and (iii) was investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F4 · balance_after: On September 1, 2019, the family office personnel of FEIM, including Messrs. Michael M. Kellen and Andrew Gundlach, separated their investment management business from that of FEIM, transferring their family's advisory client accounts, including the securities of Intevac, Inc. (the "Company") which were formerly controlled by FEIM, to the newly formed U.S. registered advisory firm named Bleichroeder LP. Accordingly, as of September 1, 2019, (i) none of the Entities nor any Entity account maintains any discretionary or proxy voting authority or pecuniary interest with respect to, any securities of the Company and (ii) no Entity could be deemed to beneficially own any securities of the Company.

F3 · ownership.nature: Represents 3,322,615 and 1,626,740 shares held directly by April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaimed Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, prior to September 1, 2019, and this report shall not be deemed an admission that FEHI was the Section 16 beneficial owner of any such securities prior to that time.

SEC source: 0001567619-19-017898 · doc1.xml · derivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Common Stock · 645,311 shares

Expires 2021-04-30

F10 · security: See Exhibit 99.1.

F11 · derivative.exercise_price: See Exhibit 99.1.

F2 · kind: See Exhibit 99.1.

F10 · kind: See Exhibit 99.1.

F12 · kind: See Exhibit 99.1.

F2 · shares: See Exhibit 99.1.

F10 · shares: See Exhibit 99.1.

F12 · shares: See Exhibit 99.1.

F13 · derivative.exercise_date: See Exhibit 99.1.

F11 · derivative.underlying_shares: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F8 · ownership.nature: See Exhibit 99.1.

F9 · ownership.nature: See Exhibit 99.1.

SEC source: 0001567619-19-017898 · doc1.xml · derivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Common Stock · 259,117 shares

Expires 2021-07-14

F4 · security: See Exhibit 99.1.

F5 · derivative.exercise_price: See Exhibit 99.1.

F2 · kind: See Exhibit 99.1.

F2 · shares: See Exhibit 99.1.

F6 · derivative.exercise_date: See Exhibit 99.1.

F7 · derivative.underlying_shares: See Exhibit 99.1.

F2 · balance_after: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F8 · ownership.nature: See Exhibit 99.1.

F9 · ownership.nature: See Exhibit 99.1.

SEC source: 0001567619-19-017898 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

F1 · security: See Exhibit 99.1.

F2 · kind: See Exhibit 99.1.

F2 · shares: See Exhibit 99.1.

F2 · balance_after: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F3 · ownership.nature: See Exhibit 99.1.

SEC source: 0001567619-19-017897 · doc1.xml · derivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 2,000,000 shares

Expires not disclosed

F4 · derivative.exercise_price: See Exhibit 99.1; Note 4.

F2 · kind: See Exhibit 99.1; Note 2.

F2 · shares: See Exhibit 99.1; Note 2.

F4 · derivative.exercise_date: See Exhibit 99.1; Note 4.

F4 · derivative.expiration_date: See Exhibit 99.1; Note 4.

F4 · derivative.underlying_shares: See Exhibit 99.1; Note 4.

F2 · balance_after: See Exhibit 99.1; Note 2.

F5 · ownership.nature: See Exhibit 99.1; Note 5.

SEC source: 0001567619-19-017897 · doc1.xml · derivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,000,000 shares

Expires not disclosed

F1 · security: See Exhibit 99.1; Note 1.

F4 · derivative.exercise_price: See Exhibit 99.1; Note 4.

F2 · kind: See Exhibit 99.1; Note 2.

F2 · shares: See Exhibit 99.1; Note 2.

F4 · derivative.exercise_date: See Exhibit 99.1; Note 4.

F4 · derivative.expiration_date: See Exhibit 99.1; Note 4.

F4 · derivative.underlying_shares: See Exhibit 99.1; Note 4.

F2 · balance_after: See Exhibit 99.1; Note 2.

SEC source: 0001567619-19-017897 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · security: See Exhibit 99.1; Note 1.

F2 · kind: See Exhibit 99.1; Note 2.

F2 · shares: See Exhibit 99.1; Note 2.

F2 · balance_after: See Exhibit 99.1; Note 2.

F3 · ownership.nature: See Exhibit 99.1; Note 3.

SEC source: 0001567619-19-013856 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 26,476,546

F1 · security: This Form 4 is filed by 21 April Fund, LP ("April LP"), 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April LP, April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · shares: Pursuant to a prospectus supplement, dated June 20, 2019, DURECT Corporation (the "Company") offered 29,000,000 shares of its common stock, par value $0.0001 per share (the "Common Stock") to certain investors of the Company. Pursuant to the terms that certain Securities Purchase Agreement, dated June 20, 2019, by and among the Company, April LP, April Ltd. and certain other persons, April LP and April Ltd purchased an aggregate of 4,000,000 shares of the Common Stock of the 29,000,000 made available in the offering at a price of $0.52 per share. The 4,000,000 shares of Common Stock represent 1,300,000 shares of Common Stock directly held by April LP and 2,700,000 shares of Common Stock directly held by April Ltd.

F3 · balance_after: Represents 4,726,893, 16,067,709, 5,586,944 and 95,000 shares of Common Stock held directly by 21 April LP, 21 April Ltd., FEVIBM and certain separately managed accounts, including accounts for which FEIM serves as registered investment adviser (the "Separately Managed Accounts"), respectively.

F4 · ownership.nature: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) the investment adviser to certain of the Separately Managed Accounts. FEHI disclaims beneficial ownership of the shares of Common Stock held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the beneficial owner of any such securities.

SEC source: 0001567619-19-009760 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,362,072

Underlying: Common Stock · 16,505 shares

Expires 2021-04-30

F1 · security: See Exhibit 99.1.

F4 · security: See Exhibit 99.1.

F5 · derivative.exercise_price: See Exhibit 99.1.

F7 · kind: See Exhibit 99.1.

F5 · shares: See Exhibit 99.1.

F7 · shares: See Exhibit 99.1.

F6 · derivative.exercise_date: See Exhibit 99.1.

F5 · derivative.underlying_shares: See Exhibit 99.1.

F5 · balance_after: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F3 · ownership.nature: See Exhibit 99.1.

SEC source: 0001567619-18-005067 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,276,076

Underlying: Common Stock · 27,076 shares

Expires 2021-04-30

F1 · security: See Exhibit 99.1.

F4 · security: See Exhibit 99.1.

F5 · derivative.exercise_price: See Exhibit 99.1.

F7 · kind: See Exhibit 99.1.

F5 · shares: See Exhibit 99.1.

F7 · shares: See Exhibit 99.1.

F7 · price: See Exhibit 99.1.

F6 · derivative.exercise_date: See Exhibit 99.1.

F5 · derivative.underlying_shares: See Exhibit 99.1.

F5 · balance_after: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F3 · ownership.nature: See Exhibit 99.1.

SEC source: 0001140361-18-026734 · doc1.xml · derivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,019,232

Underlying: Common Stock · 407,693 shares

Expires not disclosed

F2 · derivative.exercise_price: See Exhibit 99.1; Note 2.

F2 · derivative.exercise_date: See Exhibit 99.1; Note 2.

F2 · derivative.expiration_date: See Exhibit 99.1; Note 2.

F2 · derivative.underlying_shares: See Exhibit 99.1; Note 2.

F4 · ownership.nature: See Exhibit 99.1; Note 4.

SEC source: 0001140361-18-026734 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,980,768

Underlying: Common Stock · 1,592,307 shares

Expires not disclosed

F1 · security: See Exhibit 99.1; Note 1.

F2 · derivative.exercise_price: See Exhibit 99.1; Note 2.

F3 · shares: See Exhibit 99.1; Note 3.

F2 · derivative.exercise_date: See Exhibit 99.1; Note 2.

F2 · derivative.expiration_date: See Exhibit 99.1; Note 2.

F2 · derivative.underlying_shares: See Exhibit 99.1; Note 2.

SEC source: 0001140361-18-022203 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,949,355

F1 · security: This Form 4 is filed by 21 April Fund, Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 3,322,615 and 1,626,740 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-021543 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,940,355

F6 · ownership.nature: Represents 3,315,233 and 1,625,122 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-021543 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,890,355

F5 · ownership.nature: Represents 3,274,222 and 1,616,133 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-021276 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,135,000

Underlying: Common Stock · 601,728 shares

Expires 2021-04-30

F1 · security: See Exhibit 99.1

F4 · security: See Exhibit 99.1

F5 · derivative.exercise_price: See Exhibit 99.1

F7 · kind: See Exhibit 99.1

F7 · shares: See Exhibit 99.1

F7 · price: See Exhibit 99.1

F6 · derivative.exercise_date: See Exhibit 99.1

F5 · derivative.underlying_shares: See Exhibit 99.1

F5 · balance_after: See Exhibit 99.1

F2 · ownership.nature: See Exhibit 99.1

F3 · ownership.nature: See Exhibit 99.1

SEC source: 0001140361-18-021543 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,834,655

F4 · ownership.nature: Represents 3,228,535 and 1,606,120 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-021543 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,819,755

F1 · security: This Form 4 is filed by 21 April Fund, Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 3,216,314 and 1,603,441 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-020485 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,784,055

F1 · security: This Form 4 is filed by 21 April Fund, Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 3,187,032 and 1,597,023 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-019529 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,684,055

F4 · ownership.nature: Represents 3,105,230 and 1,578,825 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-019529 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,562,058

F1 · security: This Form 4 is filed by 21 April Fund, Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 3,005,434 and 1,556,624 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-019696 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,684,055

F4 · price: The amendment is for purposes of reflecting the correct purchase price.

F5 · ownership.nature: Represents 3,105,230 and 1,578,825 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-019696 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,562,058

F1 · security: This Form 4 is filed by 21 April Fund, Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 3,005,434 and 1,556,624 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-015242 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,462,055

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,923,630 and 1,538,425 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-010092 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,433,606

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,897,030 and 1,536,576 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-009244 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,429,597

F4 · ownership.nature: Represents 2,893,494 and 1,536,103 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-009244 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,426,477

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,890,742 and 1,535,735 shares held directly by 21 April Ltd. and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by April Ltd. except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-008694 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,396,477

F5 · ownership.nature: Represents 2,864,282, 299,662 and 1,232,533 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-008694 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,381,686

F4 · ownership.nature: Represents 2,851,236, 299,662 and 1,230,788 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-008694 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,375,186

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,845,503, 299,662 and 1,230,021 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006973 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,373,086

F4 · ownership.nature: Represents 2,843,651, 299,662 and 1,229,773 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006973 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,360,414

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,832,474, 299,662 and 1,228,278 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006264 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,337,814

F4 · ownership.nature: Represents 2,812,541, 299,662 and 1,225,611 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006264 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,320,314

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,797,106, 299,662 and 1,223,546 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-005487 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,316,514

F5 · ownership.nature: Represents 2,793,754, 299,662 and 1,223,098 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-005487 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,270,680

F4 · ownership.nature: Represents 2,753,328, 299,662 and 1,217,690 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-005487 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,265,680

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,748,918, 299,662 and 1,217,100 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004930 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,230,182

F5 · ownership.nature: Represents 2,717,609, 299,662 and 1,212,911 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004930 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,219,882

F4 · ownership.nature: Represents 2,708,524, 299,662 and 1,211,696 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004372 · doc1.xml · nonDerivative · entry 5

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,184,274

F7 · price: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F7 · acquired: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F8 · ownership.nature: Represents 2,677,118, 299,662 and 1,207,494 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004826 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,210,186

F1 · security: This Form 4 is filed by 21 April Fund, LP ("April LP"), 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April LP, April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · price: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F2 · acquired: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F3 · ownership.nature: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) FEIM is investment adviser to certain of the Separately Managed Accounts. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004824 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,853,004

F1 · security: This Form 4 is filed by 21 April Fund, Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd. and FEIM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · price: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F2 · acquired: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F3 · ownership.nature: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to April Ltd., and (ii) a subsidiary of FEHI. FEHI disclaims Section 16 beneficial ownership of the shares except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004930 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,184,674

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,677,471, 299,662 and 1,207,541 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.