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SIMPSON CAMILLA V

Disclosed activity across 2 companies

Tapewire entity
44226
SEC CIK
0001822557

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
GRI Bio, Inc.GRI · Entity 8336DirectorSeptember 18, 2025September 22, 2025
SPRUCE BIOSCIENCES, INC.SPRB · Entity 6471DirectorMay 21, 2026May 26, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

GRI Bio, Inc.

Report date September 18, 2025 · Filed September 22, 2025

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $1.93 · Expires 2035-09-18Direct23,605 Reported balance After 2025-09-18 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2025-09-18 · Grant · Acquired 23,605 · Balance 23,605

F1: Options to purchase 17,621 shares vested in full upon the date of grant and options to purchase 5,984 shares will vest in four substantially equal quarterly installments such that the stock option is fully vested on the first anniversary of the date of grant.

Filing footnotes · ownership attribution and instrument terms

F1: Options to purchase 17,621 shares vested in full upon the date of grant and options to purchase 5,984 shares will vest in four substantially equal quarterly installments such that the stock option is fully vested on the first anniversary of the date of grant.

SPRUCE BIOSCIENCES, INC.

Report date May 21, 2026 · Filed May 26, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $52.70 · Expires 2036-05-20Direct1,700 Reported balance After 2026-05-21 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-05-21 · Grant · Acquired 1,700 · Balance 1,700

F1: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2027 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

Filing footnotes · ownership attribution and instrument terms

F1: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2027 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
May 21, 2026 Filed May 26, 2026 20:30 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 1,700 $0.00 Strike: $52.70 $0.00
Disclosure

SEC source: 0001822557-26-000002 · form4-05262026_040508.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,700

Underlying: Common Stock · 1,700 shares

Expires 2036-05-20

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2027 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Disposition to issuerStock Option (Right to Buy) · Derivative 400 Not disclosed Strike: $169.50 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 10

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 400 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 400 Not disclosed Strike: $104.13 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 9

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400

Underlying: Common Stock · 400 shares

Expires 2033-05-24

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Disposition to issuerStock Option (right to buy) · Derivative 133 Not disclosed Strike: $1,143.00 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 8

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 133 shares

Expires 2031-05-19

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (right to buy) · Derivative 133 Not disclosed Strike: $104.13 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 7

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133

Underlying: Common Stock · 133 shares

Expires 2031-05-19

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Disposition to issuerStock Option (Right to Buy) · Derivative 362 Not disclosed Strike: $230.25 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 6

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 362 shares

Expires 2030-08-06

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 362 Not disclosed Strike: $104.13 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 5

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 362

Underlying: Common Stock · 362 shares

Expires 2030-08-06

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Disposition to issuerStock Option (Right to Buy) · Derivative 309 Not disclosed Strike: $123.00 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 4

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 309 shares

Expires 2030-06-07

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 309 Not disclosed Strike: $104.13 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 3

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 309

Underlying: Common Stock · 309 shares

Expires 2030-06-07

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Disposition to issuerStock Option (Right to Buy) · Derivative 173 Not disclosed Strike: $108.00 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 2

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 173 shares

Expires 2029-07-22

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 23:50 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 173 Not disclosed Strike: $104.13 Not disclosed
Disclosure

SEC source: 0001822557-25-000007 · form4-12152025_111206.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 173

Underlying: Common Stock · 173 shares

Expires 2029-07-22

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

Read SEC document
September 18, 2025 Filed Sep 22, 2025 20:05 UTC GRI Bio, Inc. GRI · Entity 8336 GrantStock Option (Right to Buy) · Derivative 23,605 $0.00 Strike: $1.93 $0.00
Disclosure

SEC source: 0001822557-25-000005 · wk-form4_1758571550.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,605

Underlying: Common Stock · 23,605 shares

Expires 2035-09-18

F1 · derivative.exercise_date: Options to purchase 17,621 shares vested in full upon the date of grant and options to purchase 5,984 shares will vest in four substantially equal quarterly installments such that the stock option is fully vested on the first anniversary of the date of grant.

Read SEC document
August 26, 2025 Filed Aug 27, 2025 12:24 UTC GRI Bio, Inc. GRI · Entity 8336 GrantStock Option (Right to Buy) · Derivative 5,994 $0.00 Strike: $1.41 $0.00
Disclosure

SEC source: 0001824293-25-000139 · wk-form4_1756297487.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,994

Underlying: Common Stock · 5,994 shares

Expires 2035-08-26

F1 · derivative.exercise_date: Options to purchase 4,044 shares vested in full upon the date of grant and options to purchase 1,950 shares will vest in four substantially equal quarterly installments such that the stock option is fully vested on the first anniversary of the date of grant.

Read SEC document
August 13, 2025 Filed Aug 14, 2025 20:58 UTC GRI Bio, Inc. GRI · Entity 8336 GrantStock Option (Right to Buy) · Derivative 4,527 $0.00 Strike: $1.30 $0.00
Disclosure

SEC source: 0001824293-25-000119 · wk-form4_1755205119.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,527

Underlying: Common Stock · 4,527 shares

Expires 2035-08-13

F1 · derivative.exercise_date: The stock option vests in 4 equal quarterly installments such that the stock option is fully vested on the first anniversary of the date of grant.

Read SEC document
July 22, 2025 Filed Jul 24, 2025 23:38 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 30,000 $0.00 Strike: $0.12 $0.00
Disclosure

SEC source: 0001415889-25-020269 · form4-07242025_110757.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-07-21

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2026 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

Read SEC document
January 23, 2025 Filed Jan 24, 2025 22:57 UTC GRI Bio, Inc. GRI · Entity 8336 GrantStock Option (Right to Buy) · Derivative 30,297 $0.69 Strike: $0.69 $20,774.65
Disclosure

SEC source: 0001824293-25-000032 · wk-form4_1737759469.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,297

Underlying: Common Stock · 30,297 shares

Expires 2035-01-23

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May 22, 2024 Filed May 24, 2024 20:27 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 30,000 $0.00 Strike: $0.75 $0.00
Disclosure

SEC source: 0001415889-24-014492 · form4-05242024_080514.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-21

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2025 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

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August 10, 2023 Filed Aug 14, 2023 20:07 UTC GRI Bio, Inc. GRI · Entity 8336 GrantStock Option (Right to Buy) · Derivative 34,483 $2.90 Strike: $2.90 $100,000.70
Disclosure

SEC source: 0001824293-23-000154 · wk-form4_1692043648.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,483

Underlying: Common Stock · 34,483 shares

Expires 2033-08-10

F1 · derivative.exercise_date: Vests as to 1/12th of the underlying shares of common stock on the date of grant, then in 11 equal quarterly installments such that the stock option is fully vested on the third annual anniversary of the date of grant.

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May 25, 2023 Filed May 26, 2023 21:39 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 30,000 $0.00 Strike: $2.26 $0.00
Disclosure

SEC source: 0001209191-23-032661 · doc4.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-05-24

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2024 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

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May 25, 2022 Filed May 27, 2022 20:06 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 22,500 $0.00 Strike: $1.32 $0.00
Disclosure

SEC source: 0001209191-22-032493 · doc4.xml · derivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2023 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

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May 20, 2021 Filed May 22, 2021 01:10 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $15.24 $0.00
Disclosure

SEC source: 0001209191-21-035151 · doc4.xml · derivative · entry 4

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-05-19

F3 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2022 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

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May 20, 2021 Filed May 22, 2021 01:10 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Exercise / conversionStock Option (Right to Buy) · Derivative 334 $0.00 Strike: $0.85 $0.00
Disclosure

SEC source: 0001209191-21-035151 · doc4.xml · derivative · entry 3

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,673

Underlying: Common Stock · 2,007 shares

Expires 2027-10-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the stock option vest over a four-year period commencing October 19, 2017, with 1/4th of the shares vesting on October 19, 2018 and 1/36th of the remaining shares vesting on a monthly basis.

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May 20, 2021 Filed May 22, 2021 01:10 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 SaleCommon Stock 334 $15.29 $5,106.86
Disclosure

SEC source: 0001209191-21-035151 · doc4.xml · nonDerivative · entry 2

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

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May 20, 2021 Filed May 22, 2021 01:10 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Exercise / conversionCommon Stock 334 $0.85 $283.90
Disclosure

SEC source: 0001209191-21-035151 · doc4.xml · nonDerivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 334

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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April 30, 2021 Filed May 5, 2021 01:09 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Exercise / conversionStock Option (Right to Buy) · Derivative 14,045 $0.00 Strike: $0.85 $0.00
Disclosure

SEC source: 0001209191-21-030171 · doc4.xml · derivative · entry 3

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,007

Underlying: Common Stock · 16,052 shares

Expires 2027-10-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the stock option vest over a four-year period commencing October 19, 2017, with 1/4th of the shares vesting on October 19, 2018 and 1/36th of the remaining shares vesting on a monthly basis.

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April 30, 2021 Filed May 5, 2021 01:09 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 SaleCommon Stock 14,045 $16.14 $226,663.83
Disclosure

SEC source: 0001209191-21-030171 · doc4.xml · nonDerivative · entry 2

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · price: Represents a weighted-average sales price per share. These shares were sold in multiple transactions at prices ranging from $15.64 to $17.09. The Reporting Person has provided to the issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

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April 30, 2021 Filed May 5, 2021 01:09 UTC SPRUCE BIOSCIENCES, INC. SPRB · Entity 6471 Exercise / conversionCommon Stock 14,045 $0.85 $11,938.25
Disclosure

SEC source: 0001209191-21-030171 · doc4.xml · nonDerivative · entry 1

SIMPSON CAMILLA V · CIK 0001822557 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,045

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.