Heron Patrick J

SEC source: 0001209191-18-053535 · doc4.xml · nonDerivative · entry 2

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 589,194

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series B Preferred Stock, Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F2 · ownership.direct: The reportable securities are held directly by Frazier Life Sciences VIII, L.P. ("FLS LP"). FHM Life Sciences VIII, L.P. ("FHM LP") is the general partner of FLS LP. FHM Life Sciences VIII, L.L.C. ("FHM LLC") is the general partner of FHM LP. James Topper and Patrick Heron are the sole managing members of FHM LLC. Mr. Heron, FHM LP and FHM LLC disclaims beneficial ownership of the securities held by FLS LP except, to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-053535 · doc4.xml · nonDerivative · entry 1

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 337,707

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series B Preferred Stock, Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F2 · ownership.direct: The reportable securities are held directly by Frazier Life Sciences VIII, L.P. ("FLS LP"). FHM Life Sciences VIII, L.P. ("FHM LP") is the general partner of FLS LP. FHM Life Sciences VIII, L.L.C. ("FHM LLC") is the general partner of FHM LP. James Topper and Patrick Heron are the sole managing members of FHM LLC. Mr. Heron, FHM LP and FHM LLC disclaims beneficial ownership of the securities held by FLS LP except, to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001104659-18-042315 · a4.xml · derivative · entry 7

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 795,553 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001104659-18-042315 · a4.xml · derivative · entry 6

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,197,076 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001104659-18-042315 · a4.xml · derivative · entry 5

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,047,450 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001104659-18-042315 · a4.xml · nonDerivative · entry 4

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,190,079

F3 · shares: On June 25, 2018, FLS-VIII purchased 150,000 shares of common stock of the Issuer at a price of $16.00 per share pursuant to an underwritten public offering.

F2 · ownership.direct: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001104659-18-042315 · a4.xml · nonDerivative · entry 3

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,040,079

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F2 · ownership.direct: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001104659-18-042315 · a4.xml · nonDerivative · entry 2

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,244,526

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F2 · ownership.direct: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001104659-18-042315 · a4.xml · nonDerivative · entry 1

Frazier Life Sciences VIII, L.P. · CIK 0001655827 · 10% owner

FHM LIFE SCIENCES VIII, L.P. · CIK 0001698755 · 10% owner

FHM LIFE SCIENCES VIII, L.L.C. · CIK 0001698823 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,047,450

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F1 · price: Each share of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 27.58621-for-one basis immediately prior to the closing of the Issuer's initial public offering without payment or consideration. The shares of Series A-1 Convertible Preferred Stock, Series A-2 Convertible Preferred Stock and Series B Convertible Preferred Stock had no expiration date.

F2 · ownership.direct: The shares are held directly by Frazier Life Sciences VIII, L.P. ("FLS-VIII") and this report is filed jointly by Frazier Life Sciences VIII, L.P. ("FLS-VIII L.P."), FHM Life Sciences VIII, L.P. (FHM-VIII L.P."), FHM Life Sciences VIII, L.L.C. ("FHM-VIII LLC") and Patrick J. Heron. Shares are held directly by FLS-VIII. FHM-VIII L.P. serves as the sole general partner of FLS-VIII and owns no shares directly. FHM-VIII LLC serves as the sole general partner of FHM-VIII L.P. and owns no shares directly. Mr. Heron and James Topper are members of FHM-VIII LLC and share voting and dispositive power over the shares held by FLS-VIII; however, they disclaim beneficial ownership of the shares held by FLS-VIII except to the extent of their pecuniary interests therein.

SEC source: 0001209191-18-034197 · doc4.xml · derivative · entry 14

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 0

Underlying: Ordinary Shares · 44,940 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F4 · derivative.exercise_date: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F6 · derivative.expiration_date: Not applicable.

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · derivative · entry 13

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 0

Underlying: Ordinary Shares · 53,899 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F3 · derivative.exercise_date: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F6 · derivative.expiration_date: Not applicable.

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · derivative · entry 12

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 0

Underlying: Ordinary Shares · 141,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F1 · derivative.exercise_date: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F6 · derivative.expiration_date: Not applicable.

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · derivative · entry 11

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 0

Underlying: Ordinary Shares · 157,701 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F4 · derivative.exercise_date: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F6 · derivative.expiration_date: Not applicable.

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · derivative · entry 10

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 0

Underlying: Ordinary Shares · 189,141 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F3 · derivative.exercise_date: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F6 · derivative.expiration_date: Not applicable.

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · derivative · entry 9

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 0

Underlying: Ordinary Shares · 495,370 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F1 · derivative.exercise_date: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F6 · derivative.expiration_date: Not applicable.

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 8

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 341,155

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 7

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 240,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 6

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 195,065

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 5

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII-A, L.P.

Disclosed balance after: 141,166

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F5 · ownership.nature: These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 4

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 1,197,161

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 3

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 842,212

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 2

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 684,511

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-034197 · doc4.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director · 10% owner

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Frazier Healthcare VII, L.P.

Disclosed balance after: 495,370

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F2 · ownership.nature: These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0001209191-18-033879 · doc4.xml · derivative · entry 1

Heron Patrick J · CIK 0001365617 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,154

Underlying: Ordinary Shares · 6,154 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Ordinary Shares.

F2 · derivative.exercise_date: Subject to the Reporting Person providing continuous service, the RSU shall vest on May 24, 2019.

F2 · derivative.expiration_date: Subject to the Reporting Person providing continuous service, the RSU shall vest on May 24, 2019.

SEC source: 0001012975-18-000437 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 973,612

F1 · kind: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · ownership.nature: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-18-000436 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973,612

F1 · kind: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · ownership.direct: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000092 · edgar.xml · derivative · entry 2

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 117,235 shares

Expires 2018-11-04

F1 · derivative.exercise_date: This warrant is exercisable at any time.

F2 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000092 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,345,612

F2 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000091 · edgar.xml · derivative · entry 2

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 117,235 shares

Expires 2018-11-04

F1 · derivative.exercise_date: This warrant is exercisable at any time.

F2 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000091 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,345,612

F2 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 12

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 209,095 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 11

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 733,740 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.direct: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 10

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 195,751 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.exercise_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.expiration_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 9

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 604,055 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.exercise_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.expiration_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 8

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,428,571 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.exercise_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.expiration_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 7

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 88,709

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 6

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 311,291

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.direct: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 5

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 209,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 4

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 733,740

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · ownership.direct: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 3

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 195,751

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F3 · price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 2

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 604,055

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F2 · price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,428,571

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 12

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 209,095 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 11

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 733,740 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.nature: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 10

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 195,751 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.exercise_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.expiration_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 9

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 604,055 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.exercise_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.expiration_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 8

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,428,571 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.exercise_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.expiration_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 7

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 88,709

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 6

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 311,291

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.nature: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 5

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 209,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.