FRAZIER ALAN D

SEC source: 0001012975-18-000437 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 973,612

F1 · kind: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · ownership.nature: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-18-000436 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973,612

F1 · kind: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · ownership.direct: Effective May 11, 2018, Frazier Healthcare V, L.P., distributed in-kind, without consideration, a total of 1,372,000 shares of Common Stock of the Issuer to its general and limited partners. The remaining securities are held by Frazier Healthcare V, L.P. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000092 · edgar.xml · derivative · entry 2

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 117,235 shares

Expires 2018-11-04

F1 · derivative.exercise_date: This warrant is exercisable at any time.

F2 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000092 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,345,612

F2 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000091 · edgar.xml · derivative · entry 2

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 117,235 shares

Expires 2018-11-04

F1 · derivative.exercise_date: This warrant is exercisable at any time.

F2 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000091 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,345,612

F2 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 12

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 209,095 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 11

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 733,740 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.direct: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 10

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 195,751 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.exercise_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.expiration_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 9

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 604,055 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.exercise_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.expiration_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · derivative · entry 8

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,428,571 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.exercise_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.expiration_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 7

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 88,709

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 6

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 311,291

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.direct: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 5

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 209,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 4

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 733,740

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · ownership.direct: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 3

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 195,751

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F3 · price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 2

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 604,055

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F2 · price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000071 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare VII, L.P. · CIK 0001553071 · 10% owner

Frazier Healthcare VII-A, L.P. · CIK 0001575192 · 10% owner

FHM VII, L.P. · CIK 0001654632 · 10% owner

FHM VII, L.L.C. · CIK 0001654631 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,428,571

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.nature: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 12

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 209,095 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 11

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 733,740 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.exercise_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F4 · derivative.expiration_date: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · derivative.underlying_shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.nature: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 10

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 195,751 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.exercise_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F3 · derivative.expiration_date: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 9

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 604,055 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.exercise_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F2 · derivative.expiration_date: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · derivative · entry 8

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,428,571 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.exercise_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F1 · derivative.expiration_date: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · derivative.underlying_shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 7

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 88,709

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 6

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 311,291

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F6 · ownership.nature: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 5

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 209,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · shares: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F7 · ownership.nature: Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 4

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 733,740

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · shares: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F4 · price: The Series D Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series D Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F6 · ownership.nature: Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 3

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,751

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F3 · price: The Series C-1 Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C-1 Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 2

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 604,055

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F2 · price: The Series C Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series C Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

SEC source: 0001012975-17-000069 · edgar.xml · nonDerivative · entry 1

Frazier Healthcare V, LP · CIK 0001341169 · 10% owner

FHM V, LP · CIK 0001346948 · 10% owner

FHM V, LLC · CIK 0001346944 · 10% owner

FRAZIER ALAN D · CIK 0001018534 · 10% owner

Naini Nader J · CIK 0001344203 · 10% owner

Every Nathan R · CIK 0001531105 · 10% owner

Heron Patrick J · CIK 0001365617 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,428,571

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

F1 · price: The Series B Preferred Stock converted into Common Stock on a 1-to-1 basis immediately prior to the consummation of the Issuer's initial public offering without payment of considerations. The Series B Preferred stock were convertible automatically immediately prior to the consummation of the Issuer's initial public offering, and the shares had no expiration date.

F5 · ownership.direct: Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.