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ORLOFF JOHN J

Disclosed activity across 4 companies

Tapewire entity
37121
SEC CIK
0001643941

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Aegerion Pharmaceuticals, Inc.AEGR · Entity 180735EVP, Research and DevelopmentNovember 01, 2016November 04, 2016
NOVELION THERAPEUTICS INC.NVLN · Entity 152369DirectorAugust 09, 2018August 13, 2018
Zenas BioPharma, Inc.ZBIO · Entity 275DirectorJune 15, 2026June 17, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Aegerion Pharmaceuticals, Inc.

Report date November 01, 2016 · Filed November 04, 2016

This filing explicitly reported no securities owned.

NOVELION THERAPEUTICS INC.

Report date August 09, 2018 · Filed August 13, 2018

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $3.33 · Expires 2028-08-09Direct10,000 Reported balance After 2018-08-09 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2018-08-09 · Grant · Acquired 10,000 · Balance 10,000

F1: Each option has an exercise price equal to the closing price of a common share of the Issuer on the Nasdaq Global Select Market on the grant date.

F2: The option shall vest in twelve equal monthly installments, beginning one month after the grant date.

Filing footnotes · ownership attribution and instrument terms

F1: Each option has an exercise price equal to the closing price of a common share of the Issuer on the Nasdaq Global Select Market on the grant date.

F2: The option shall vest in twelve equal monthly installments, beginning one month after the grant date.

Zenas BioPharma, Inc.

Report date June 15, 2026 · Filed June 17, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $18.71 · Expires 2036-06-15Direct18,500 Reported balance After 2026-06-15 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-06-15 · Grant · Acquired 18,500 · Balance 18,500

F1: The option vests as to 100% of the underlying shares of common stock on June 15, 2027, the first anniversary of the vesting commencement date, subject to continued service.

Filing footnotes · ownership attribution and instrument terms

F1: The option vests as to 100% of the underlying shares of common stock on June 15, 2027, the first anniversary of the vesting commencement date, subject to continued service.

Past disclosures · reporting ended (1)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

ALEXION PHARMACEUTICALS, INC.

Report date July 21, 2021 · Filed July 23, 2021

Section 16 reporting ended · disclosed 2021-07-23. Current position is not established by this disclosure.

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common Stock, par value $.0001 per shareSEC Table I · non-derivativeDirect0 Reported balance After 2021-07-21 transaction · row 1
1 source row

Row 1 · 2021-07-21 · Disposition to issuer · Disposed 146,511 · Balance 0

F1: Represents shares of Alexion common stock disposed in connection with the Agreement and Plan of Merger (the "Merger Agreement") dated as of December 12, 2020, by and among Alexion and AstraZeneca PLC. In accordance with the Merger Agreement, upon the First Effective Time (as defined in the Merger Agreement), each share of Alexion common stock was converted into the right to receive (i) 2.1423 American Depositary Shares (ADSs) of AstraZeneca PLC and (ii) $60.00 in cash (the "Merger Consideration").

Filing footnotes · ownership attribution and instrument terms

F1: Represents shares of Alexion common stock disposed in connection with the Agreement and Plan of Merger (the "Merger Agreement") dated as of December 12, 2020, by and among Alexion and AstraZeneca PLC. In accordance with the Merger Agreement, upon the First Effective Time (as defined in the Merger Agreement), each share of Alexion common stock was converted into the right to receive (i) 2.1423 American Depositary Shares (ADSs) of AstraZeneca PLC and (ii) $60.00 in cash (the "Merger Consideration").

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
June 15, 2026 Filed Jun 17, 2026 22:02 UTC Zenas BioPharma, Inc. ZBIO · Entity 275 GrantStock Option (Right to Buy) · Derivative 18,500 $0.00 Strike: $18.71 $0.00
Disclosure

SEC source: 0001104659-26-075255 · tm2618042-7_4seq1.xml · derivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,500

Underlying: Common Stock · 18,500 shares

Expires 2036-06-15

F1 · derivative.exercise_date: The option vests as to 100% of the underlying shares of common stock on June 15, 2027, the first anniversary of the vesting commencement date, subject to continued service.

Read SEC document
June 10, 2025 Filed Jun 12, 2025 20:32 UTC Zenas BioPharma, Inc. ZBIO · Entity 275 GrantStock Option (Right to Buy) · Derivative 18,500 $0.00 Strike: $11.94 $0.00
Disclosure

SEC source: 0001104659-25-058922 · tm2517684-3_4seq1.xml · derivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,500

Underlying: Common Stock · 18,500 shares

Expires 2035-06-10

F1 · derivative.exercise_date: The option vests as to 100% of the underlying shares of common stock on June 10, 2026, the first anniversary of the vesting commencement date, subject to continued service.

Read SEC document
September 12, 2024 Filed Sep 17, 2024 01:05 UTC Zenas BioPharma, Inc. ZBIO · Entity 275 GrantStock Option (Right to Buy) · Derivative 18,500 $0.00 Strike: $17.00 $0.00
Disclosure

SEC source: 0001104659-24-100339 · tm2424157-2_4seq1.xml · derivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,500

Underlying: Common Stock · 18,500 shares

Expires 2034-09-11

F1 · derivative.exercise_date: The option vests as to 100% of the underlying shares of common stock on September 12, 2025, the first anniversary of the vesting commencement date, subject to continued service.

Read SEC document
July 21, 2021 Filed Jul 23, 2021 16:29 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Disposition to issuerCommon Stock, par value $.0001 per share 146,511 $0.00 $0.00
Disclosure

SEC source: 0000899866-21-000062 · wf-form4_162707216366619.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Represents shares of Alexion common stock disposed in connection with the Agreement and Plan of Merger (the "Merger Agreement") dated as of December 12, 2020, by and among Alexion and AstraZeneca PLC. In accordance with the Merger Agreement, upon the First Effective Time (as defined in the Merger Agreement), each share of Alexion common stock was converted into the right to receive (i) 2.1423 American Depositary Shares (ADSs) of AstraZeneca PLC and (ii) $60.00 in cash (the "Merger Consideration").

Read SEC document
July 14, 2021 Filed Jul 16, 2021 16:48 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 29,501 $0.00 $0.00
Disclosure

SEC source: 0000899866-21-000054 · wf-form4_162646847074936.xml · nonDerivative · entry 2

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 146,511

F2 · shares: On July 14, 2021 the Leadership and Compensation Committee certified that certain performance metrics under previously granted performance stock units were satisfied. These performance stock units were previously granted in February 2020 under the 2017 Stock Incentive Plan.

Read SEC document
July 14, 2021 Filed Jul 16, 2021 16:48 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 30,643 $0.00 $0.00
Disclosure

SEC source: 0000899866-21-000054 · wf-form4_162646847074936.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,010

F1 · shares: On July 14, 2021 the Leadership and Compensation Committee certified that certain performance metrics under previously granted performance stock units were satisfied. These performance stock units were previously granted in February 2019 under the 2017 Stock Incentive Plan.

Read SEC document
June 08, 2021 Filed Jun 9, 2021 16:53 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 1,957 $177.00 $346,389.00
Disclosure

SEC source: 0000899866-21-000050 · wf-form4_162327201970263.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,367

F1 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

Read SEC document
February 28, 2021 Filed Mar 2, 2021 17:50 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 24,473 $0.00 $0.00
Disclosure

SEC source: 0000899866-21-000023 · wf-form4_161472540804716.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,324

F1 · shares: Award of Restricted Stock Units under the 2017 Incentive Plan. 25% vests on each anniversary of the grant date.

Read SEC document
December 16, 2020 Filed Dec 18, 2020 17:06 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 3,261 $157.96 $515,107.56
Disclosure

SEC source: 0000899866-20-000093 · wf-form4_160832918352160.xml · nonDerivative · entry 3

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,811

F3 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

Read SEC document
December 16, 2020 Filed Dec 18, 2020 17:06 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 18,134 $157.96 $2,864,446.64
Disclosure

SEC source: 0000899866-20-000093 · wf-form4_160832918352160.xml · nonDerivative · entry 2

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,072

F2 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Performance Stock Units.

Read SEC document
December 16, 2020 Filed Dec 18, 2020 17:06 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 40,677 $0.00 $0.00
Disclosure

SEC source: 0000899866-20-000093 · wf-form4_160832918352160.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,206

F1 · shares: Shares acquired on vesting of Performance Stock Units previously granted on February 28, 2018 under the 2017 Stock Incentive Plan.

Read SEC document
December 15, 2020 Filed Dec 18, 2020 17:06 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 40 $93.53 $3,741.20
Disclosure

SEC source: 0000899866-20-000093 · wf-form4_160832918352160.xml · nonDerivative · entry 4

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,851

F4 · shares: In accordance with the Alexion ESPP, these shares were purchased (for the ESPP purchase period from July 1, 2020 to December 15, 2020) based on 85% of the share price on July 1, 2020.

Read SEC document
June 08, 2020 Filed Jun 9, 2020 16:59 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 2,784 $114.61 $319,074.24
Disclosure

SEC source: 0000899866-20-000063 · wf-form4_159173638161609.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,529

F1 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

Read SEC document
March 02, 2020 Filed Mar 3, 2020 18:26 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 1,396 $90.54 $126,393.84
Disclosure

SEC source: 0000899866-20-000023 · wf-form4_158327798024153.xml · nonDerivative · entry 2

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,275

F2 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $90.48 - $92.45. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of shares sold at each price.

Read SEC document
February 28, 2020 Filed Mar 3, 2020 18:26 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 10,880 $0.00 $0.00
Disclosure

SEC source: 0000899866-20-000023 · wf-form4_158327798024153.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,671

F1 · shares: Award of Restricted Stock Units under the 2017 Incentive Plan. 25% vests on each anniversary of the grant date.

Read SEC document
December 15, 2019 Filed Mar 3, 2020 18:26 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 38 $93.86 $3,566.68
Disclosure

SEC source: 0000899866-20-000023 · wf-form4_158327798024153.xml · nonDerivative · entry 3

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,313

F4 · shares: In accordance with the Alexion ESPP, these shares were purchased (for the ESPP purchase period from June 30, 2019 to December 15, 2019) based on 85% of the closing price of the Issuer's common stock on December 15, 2019.

Read SEC document
June 07, 2019 Filed Jun 11, 2019 18:39 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 2,786 $118.61 $330,447.46
Disclosure

SEC source: 0000899866-19-000077 · wf-form4_156029278196014.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,791

F1 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

Read SEC document
February 28, 2019 Filed Mar 4, 2019 17:42 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 Tax withholdingCommon Stock, par value $.0001 per share 675 $132.92 $89,721.00
Disclosure

SEC source: 0000899866-19-000041 · wf-form4_155173932177992.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,115

F1 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $132.90- $135.01. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of shares sold at each price.

Read SEC document
February 28, 2019 Filed Mar 5, 2019 20:18 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 9,428 $0.00 $0.00
Disclosure

SEC source: 0000899866-19-000048 · wf-form4_155183507279607.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,577

F1 · shares: Award of Restricted Stock Units under the 2017 Incentive Plan. 25% vests on each anniversary of the grant date.

Read SEC document
December 15, 2018 Filed Mar 4, 2019 17:42 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 34 $93.01 $3,162.34
Disclosure

SEC source: 0000899866-19-000041 · wf-form4_155173932177992.xml · nonDerivative · entry 2

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,149

F3 · shares: In accordance with the Alexion ESPP, these shares were purchased (for the ESPP purchase period from June 30, 2018 to December 15, 2018) based on 85% of the closing price of the Issuer's common stock on December 15, 2018.

Read SEC document
August 09, 2018 Filed Aug 13, 2018 16:31 UTC NOVELION THERAPEUTICS INC. NVLN · Entity 152369 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $3.33 $0.00
Disclosure

SEC source: 0001104659-18-051506 · a4.xml · derivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Shares · 10,000 shares

Expires 2028-08-09

F1 · derivative.exercise_price: Each option has an exercise price equal to the closing price of a common share of the Issuer on the Nasdaq Global Select Market on the grant date.

F2 · derivative.exercise_date: The option shall vest in twelve equal monthly installments, beginning one month after the grant date.

Read SEC document
June 08, 2018 Filed Jun 12, 2018 16:51 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 SaleCommon Stock, par value $.0001 per share 2,115 $118.53 $250,690.95
Disclosure

SEC source: 0000899866-18-000101 · wf-form4_152883664251133.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,790

F1 · shares: This sale was made to cover withholding taxes immediately following the vesting of previously granted Restricted Stock Units.

Read SEC document
February 28, 2018 Filed Mar 2, 2018 17:00 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 8,940 $0.00 $0.00
Disclosure

SEC source: 0000899866-18-000059 · wf-form4_152002801458348.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,905

F1 · shares: Award of Restricted Stock Units under the 2017 Incentive Plan. 25% vests on each anniversary of the grant date.

Read SEC document
July 03, 2017 Filed Jul 5, 2017 16:01 UTC NOVELION THERAPEUTICS INC. NVLN · Entity 152369 GrantStock Option (Right to Buy) · Derivative 9,600 $0.00 Strike: $9.37 $0.00
Disclosure

SEC source: 0001104659-17-043555 · a4.xml · derivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,600

Underlying: Common Shares · 9,600 shares

Expires 2027-07-03

F1 · derivative.exercise_price: Each option has an exercise price equal to the closing price of a common share of the Issuer on the Nasdaq Global Select Market on the grant date.

F2 · derivative.exercise_date: The common shares underlying this stock option award will vest in equal monthly installments over 36 months, beginning one month after the grant date.

Read SEC document
June 07, 2017 Filed Jun 9, 2017 18:34 UTC ALEXION PHARMACEUTICALS, INC. ALXN · Entity 137086 GrantCommon Stock, par value $.0001 per share 24,965 $0.00 $0.00
Disclosure

SEC source: 0000899866-17-000133 · wf-form4_149704765549250.xml · nonDerivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · EVP, Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,965

F1 · shares: Award of Restricted Stock Units under the 2017 Incentive Plan. 25% vest on each anniversary of the grant date.

Read SEC document
December 22, 2016 Filed Dec 27, 2016 16:04 UTC NOVELION THERAPEUTICS INC. NVLN · Entity 152369 GrantStock Option (right to buy) · Derivative 166,020 $0.00 Strike: $8.65 $0.00
Disclosure

SEC source: 0001104659-16-163870 · a4.xml · derivative · entry 1

ORLOFF JOHN J · CIK 0001643941 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 166,020

Underlying: Common Shares · 166,020 shares

Expires 2016-12-22

F1 · derivative.exercise_price: Each option has an exercise price equal to the closing price of a common share of the Issuer on the Nasdaq Global Select Market on the grant date.

F2 · derivative.exercise_date: Subject, with limited exceptions, to the Reporting Person's continued employment with the Issuer or one of its affiliates, the common shares underlying this stock option award will vest in three equal installments on December 22, 2017, December 22, 2018 and December 22, 2019.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.