KABAKOFF DAVID S

SEC source: 0000905148-26-003044 · form4.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,510

Underlying: Common Stock · 3,510 shares

Expires 2036-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2027 and the date of the 2027 Annual Meeting of Stockholders.

SEC source: 0000905148-25-002244 · form4.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,050

Underlying: Common Stock · 28,050 shares

Expires 2035-06-19

F1 · derivative.exercise_date: The option vests in full on the earlier of June 20, 2026 and the date of the 2026 Annual Meeting of Stockholders.

SEC source: 0000905148-24-001768 · form4.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,050

Underlying: Common Stock · 28,050 shares

Expires 2034-06-19

F1 · derivative.exercise_date: The option vests in full on the earlier of June 20, 2025 and the date of the 2025 Annual Meeting of Stockholders.

SEC source: 0001140361-23-031194 · form4.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,250

Underlying: Common Stock · 14,250 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The option vests in full on the earlier of June 22, 2024 and the date of the 2024 Annual Meeting of Stockholders.

SEC source: 0001567619-22-013366 · doc1.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,250

Underlying: Common Stock · 14,250 shares

Expires 2032-06-22

F1 · derivative.exercise_date: The option vests in full on the earlier of June 23, 2023 and the date of the 2023 Annual Meeting of Stockholders.

SEC source: 0001567619-21-012669 · doc1.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,250

Underlying: Common Stock · 14,250 shares

Expires 2031-06-23

F1 · derivative.exercise_date: The option vests in full on the earlier of June 24, 2022 and the date of the 2022 Annual Meeting of Stockholders.

SEC source: 0001447362-21-000152 · wf-form4_162431202430123.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 503,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $75.0453 to $75.0922, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000144 · wf-form4_162370283967707.xml · derivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 830

Underlying: Common Stock · 830 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock.

F2 · derivative.exercise_date: The RSUs vest in full on the one-year anniversary of the date of grant on June 10, 2022.

F2 · derivative.expiration_date: The RSUs vest in full on the one-year anniversary of the date of grant on June 10, 2022.

SEC source: 0001447362-21-000144 · wf-form4_162370283967707.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,379

Underlying: Common Stock · 3,379 shares

Expires 2031-06-09

SEC source: 0001447362-21-000070 · wf-form4_161783372923988.xml · nonDerivative · entry 3

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 533,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $73.4821 to $74.1945, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000070 · wf-form4_161783372923988.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 573,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $73.1857 to $73.2564, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000070 · wf-form4_161783372923988.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 593,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $71.1820 to $72.1647, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000067 · wf-form4_161740106185755.xml · nonDerivative · entry 4

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 643,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $70.5502 to $71.0532, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000067 · wf-form4_161740106185755.xml · nonDerivative · entry 3

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 663,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $69.3558 to $70.3535, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000067 · wf-form4_161740106185755.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 703,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000067 · wf-form4_161740106185755.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 713,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $67.0821 to $68.0430, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000059 · wf-form4_161653494158788.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 733,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000059 · wf-form4_161653494158788.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 743,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000055 · wf-form4_161609844748968.xml · nonDerivative · entry 5

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 753,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000055 · wf-form4_161609844748968.xml · nonDerivative · entry 4

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 763,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $65.7011 to $65.7554, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000055 · wf-form4_161609844748968.xml · nonDerivative · entry 3

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 783,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $64.4900 to $64.7471, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000055 · wf-form4_161609844748968.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 823,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $63.4256 to $63.9355, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-21-000055 · wf-form4_161609844748968.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 853,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $61.1168 to $61.3623, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000235 · wf-form4_160259596962150.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 883,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000235 · wf-form4_160259596962150.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 908,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000233 · wf-form4_160218819191283.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 933,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $53.0300 to $53.1561, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000231 · wf-form4_160201498604990.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 983,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000231 · wf-form4_160201498604990.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,008,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000205 · wf-form4_159959556260286.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,033,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000187 · wf-form4_159804034038113.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,058,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $44.16 to $45.13, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000172 · wf-form4_159726950602439.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,133,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000150 · wf-form4_159536353776598.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,158,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000144 · wf-form4_159467054492303.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,183,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $43.1220 to $44.0854, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000137 · wf-form4_159295798278906.xml · nonDerivative · entry 3

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,233,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000137 · wf-form4_159295798278906.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,258,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000137 · wf-form4_159295798278906.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,283,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on May 22, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $40.2111 to $41.0764, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001123292-20-000879 · edgar.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,250

Underlying: Common Stock · 14,250 shares

Expires 2030-06-10

F1 · derivative.exercise_date: The option vests in full on the earlier of June 11, 2021 and the date of the 2021 Annual Meeting of Stockholders.

SEC source: 0001447362-20-000109 · wf-form4_159163343456364.xml · derivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2030-06-03

SEC source: 0001447362-20-000062 · wf-form4_158948675910469.xml · nonDerivative · entry 3

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,433,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F5 · price: This transaction was executed in multiple trades at prices ranging from $35.1750 to $35.6650, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000062 · wf-form4_158948675910469.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,533,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F4 · price: This transaction was executed in multiple trades at prices ranging from $34.0861 to $34.6399, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000062 · wf-form4_158948675910469.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,633,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · price: This transaction was executed in multiple trades at prices ranging from $33.0340 to $33.0400, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000015 · wf-form4_158232544082709.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,683,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000012 · wf-form4_158206493466077.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,708,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000010 · wf-form4_158137118397757.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,733,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000008 · wf-form4_158084850505165.xml · nonDerivative · entry 2

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,758,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000008 · wf-form4_158084850505165.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,783,577

F1 · kind: The transactions on this Form 4 were made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001447362-20-000006 · wf-form4_158042927390856.xml · nonDerivative · entry 1

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 1,808,577

F1 · kind: The transaction on this Form 4 was made pursuant to a Rule 10b5-1 plan adopted by Sofinnova HealthQuest Partners, L.P. on December 17, 2019.

F2 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the general partner of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001209191-19-043912 · doc4.xml · derivative · entry 11

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 0

Underlying: Common Stock · 11,572 shares

Expires 2019-07-29

F7 · shares: Immediately prior to the closing of the IPO, the warrant became exercisable for 11,572 shares of Common Stock.

F8 · derivative.exercise_date: Immediately exercisable.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the managing member of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001209191-19-043912 · doc4.xml · derivative · entry 10

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 0

Underlying: Common Stock · 83,453 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The principal amount of the Convertible Promissory Note held by HealthQuest Partners was $1,027,882. Upon closing of the IPO, all unpaid principal and accrued interest outstanding on the Convertible Promissory Note (the "Conversion Amount") automatically converted into the number of shares of Common Stock equal to the Conversion Amount as of the date immediately prior to the closing date divided by 80% of the IPO price per share of $16.00 per share.

F4 · reported_value: The principal amount of the Convertible Promissory Note held by HealthQuest Partners was $1,027,882. Upon closing of the IPO, all unpaid principal and accrued interest outstanding on the Convertible Promissory Note (the "Conversion Amount") automatically converted into the number of shares of Common Stock equal to the Conversion Amount as of the date immediately prior to the closing date divided by 80% of the IPO price per share of $16.00 per share.

F4 · price: The principal amount of the Convertible Promissory Note held by HealthQuest Partners was $1,027,882. Upon closing of the IPO, all unpaid principal and accrued interest outstanding on the Convertible Promissory Note (the "Conversion Amount") automatically converted into the number of shares of Common Stock equal to the Conversion Amount as of the date immediately prior to the closing date divided by 80% of the IPO price per share of $16.00 per share.

F4 · derivative.exercise_date: The principal amount of the Convertible Promissory Note held by HealthQuest Partners was $1,027,882. Upon closing of the IPO, all unpaid principal and accrued interest outstanding on the Convertible Promissory Note (the "Conversion Amount") automatically converted into the number of shares of Common Stock equal to the Conversion Amount as of the date immediately prior to the closing date divided by 80% of the IPO price per share of $16.00 per share.

F4 · derivative.expiration_date: The principal amount of the Convertible Promissory Note held by HealthQuest Partners was $1,027,882. Upon closing of the IPO, all unpaid principal and accrued interest outstanding on the Convertible Promissory Note (the "Conversion Amount") automatically converted into the number of shares of Common Stock equal to the Conversion Amount as of the date immediately prior to the closing date divided by 80% of the IPO price per share of $16.00 per share.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the managing member of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.

SEC source: 0001209191-19-043912 · doc4.xml · derivative · entry 9

KABAKOFF DAVID S · CIK 0001024008 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By L.P.

Disclosed balance after: 0

Underlying: Common Stock · 982,785 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Every 1.219 outstanding shares of Preferred Stock automatically converted into 1 share of Common Stock immediately prior to the closing of the Issuer's initial public offering (the "IPO"), for no additional consideration, with cash paid for any fractional shares. The Preferred Stock had no expiration date.

F2 · price: Every 1.219 outstanding shares of Preferred Stock automatically converted into 1 share of Common Stock immediately prior to the closing of the Issuer's initial public offering (the "IPO"), for no additional consideration, with cash paid for any fractional shares. The Preferred Stock had no expiration date.

F2 · derivative.exercise_date: Every 1.219 outstanding shares of Preferred Stock automatically converted into 1 share of Common Stock immediately prior to the closing of the Issuer's initial public offering (the "IPO"), for no additional consideration, with cash paid for any fractional shares. The Preferred Stock had no expiration date.

F2 · derivative.expiration_date: Every 1.219 outstanding shares of Preferred Stock automatically converted into 1 share of Common Stock immediately prior to the closing of the Issuer's initial public offering (the "IPO"), for no additional consideration, with cash paid for any fractional shares. The Preferred Stock had no expiration date.

F3 · ownership.nature: Held by Sofinnova HealthQuest Partners, L.P., or HealthQuest Partners. HealthQuest Venture Management, L.L.C., or HealthQuest Management, is the managing member of HealthQuest Partners. David Kabakoff, Ph.D., the Reporting Person, is a partner of HealthQuest Management. Garheng Kong is the managing member of HealthQuest Management and has sole voting and investment power over the shares held by HealthQuest Partners. Each of HealthQuest Management, Mr. Kong and Dr. Kabakoff disclaims beneficial ownership over all shares held by HealthQuest Partners except to the extent of any pecuniary interest therein.