Shaikhly Samira

SEC source: 0001193125-26-291059 · ownership.xml · derivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,865

Underlying: Common Stock · 2,178 shares

Expires 2034-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-291059 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

SEC source: 0001193125-26-291059 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,971

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-273126 · ownership.xml · derivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,750

Underlying: Common Stock · 6,250 shares

Expires 2035-08-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-273126 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.19. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-273126 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,043

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-255997 · ownership.xml · derivative · entry 9

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,464

Underlying: Common Stock · 637 shares

Expires 2034-03-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-255997 · ownership.xml · derivative · entry 8

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,517

Underlying: Common Stock · 943 shares

Expires 2033-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such date.

SEC source: 0001193125-26-255997 · ownership.xml · derivative · entry 7

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,614

Underlying: Common Stock · 4,355 shares

Expires 2033-03-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such date.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 6

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.29 to $30.08. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 5

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,682

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.25 to $29.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 4

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,028

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.24 to $28.23. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,728

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,091

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,148

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-245713 · ownership.xml · derivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,043

Underlying: Common Stock · 11,798 shares

Expires 2034-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-245713 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.00 to $30.24. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-245713 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,591

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-092050 · ownership.xml · derivative · entry 8

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,101

Underlying: Common Stock · 5,101 shares

Expires 2034-03-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-092050 · ownership.xml · derivative · entry 7

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,460

Underlying: Common Stock · 11,638 shares

Expires 2033-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date.

SEC source: 0001193125-26-092050 · ownership.xml · derivative · entry 6

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,969

Underlying: Common Stock · 53,714 shares

Expires 2033-03-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 5

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $27.90 to $28.70. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 4

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,156

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $26.90 to $27.89. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,246

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,145

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,507

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 793 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in a transaction that was exempt under Rule 16b-3(c).

SEC source: 0001193125-26-045112 · ownership.xml · derivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106799 · ownership.xml · derivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.