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Congleton Jon

Disclosed activity across 4 companies

Tapewire entity
30285
SEC CIK
0001644975

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
ALPINE IMMUNE SCIENCES, INC.NVLS · Entity 90802Director · President and CEOSeptember 12, 2016September 14, 2016
Avalyn Pharma Inc.AVLN · Entity 4662DirectorApril 29, 2026May 01, 2026
IMMUNIC, INC.IMUX · Entity 6306DirectorJuly 05, 2026July 07, 2026
Mineralys Therapeutics, Inc.MLYS · Entity 4432Director · Chief Executive OfficerSeptember 30, 2026October 02, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

ALPINE IMMUNE SCIENCES, INC.

Report date September 12, 2016 · Filed September 14, 2016

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $7.77 · Expires 2026-09-12Direct250,000 Reported balance After 2016-09-12 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2016-09-12 · Grant · Acquired 250,000 · Balance 250,000

F1: The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant.

F2: The options vest and become exercisable over a four-year period, with 25% vesting on the first anniversary of the grant date (September 12, 2017) and 1/48th of the options vesting monthly thereafter.

Filing footnotes · ownership attribution and instrument terms

F1: The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant.

F2: The options vest and become exercisable over a four-year period, with 25% vesting on the first anniversary of the grant date (September 12, 2017) and 1/48th of the options vesting monthly thereafter.

Avalyn Pharma Inc.

Report date April 29, 2026 · Filed May 01, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $18.00 · Expires 2036-04-28Direct26,978 Reported balance After 2026-04-29 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-04-29 · Grant · Acquired 26,978 · Balance 26,978

F1: 25% of the shares underlying this option vest and become exercisable on September 12, 2025, with the remaining 75% vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

Filing footnotes · ownership attribution and instrument terms

F1: 25% of the shares underlying this option vest and become exercisable on September 12, 2025, with the remaining 75% vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

IMMUNIC, INC.

Report date July 05, 2026 · Filed July 07, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock OptionSEC Table II · derivative / convertible security · Conversion / exercise price $14.80 · Expires 2036-07-05Direct25,370 Reported balance After 2026-07-05 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-07-05 · Grant · Acquired 25,370 · Balance 25,370

F1: The option vests in monthly increments over a period of one year from the grant date.

Filing footnotes · ownership attribution and instrument terms

F1: The option vests in monthly increments over a period of one year from the grant date.

Mineralys Therapeutics, Inc.

Report date September 30, 2026 · Filed October 02, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect528,621 Reported balance After 2026-09-30 transaction · row 1
1 source row

Row 1 · 2026-09-30 · Sale · Disposed 75,000 · Balance 528,621

F1: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 23, 2025.

F2: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $25.0000 to $25.8201. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Filing footnotes · ownership attribution and instrument terms

F1: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 23, 2025.

F2: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $25.0000 to $25.8201. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
September 30, 2026 Filed Oct 2, 2026 21:53 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 75,000 $25.46 $1,909,665.00
Disclosure

SEC source: 0001933414-26-000121 · wk-form4_1790978009.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 528,621

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 23, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $25.0000 to $25.8201. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
July 13, 2026 Filed Jul 16, 2026 00:58 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 10,700 $27.24 $291,441.25
Disclosure

SEC source: 0001933414-26-000100 · wk-form4_1784163491.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 603,621

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on January 28, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $26.80 to $27.58. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
July 05, 2026 Filed Jul 7, 2026 20:05 UTC IMMUNIC, INC. IMUX · Entity 6306 GrantStock Option · Derivative 25,370 $0.00 Strike: $14.80 $0.00
Disclosure

SEC source: 0001193805-26-000928 · e665631_4-congleton.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,370

Underlying: Common Stock · 25,370 shares

Expires 2036-07-05

F1 · derivative.exercise_date: The option vests in monthly increments over a period of one year from the grant date.

Read SEC document
June 30, 2026 Filed Jun 30, 2026 22:41 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 17,000 $26.82 $455,895.80
Disclosure

SEC source: 0001933414-26-000096 · wk-form4_1782859282.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 614,321

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $26.6450 to $26.8200. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

Read SEC document
June 30, 2026 Filed Jun 30, 2026 22:41 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 58,000 $25.94 $1,504,705.60
Disclosure

SEC source: 0001933414-26-000096 · wk-form4_1782859282.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 631,321

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $25.5600 to $26.5000. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
June 29, 2026 Filed Jun 29, 2026 20:34 UTC IMMUNIC, INC. IMUX · Entity 6306 GrantStock Option · Derivative 50,740 $0.00 Strike: $10.90 $0.00
Disclosure

SEC source: 0001193805-26-000892 · e665612_4-congleton.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,740

Underlying: Common Stock · 50,740 shares

Expires 2036-03-27

F1 · shares: Represents options to purchase shares of common stock conditionally approved by the Board of Directors on March 27, 2026, subject to approval of an amendment to the Company's 2019 Omnibus Equity Incentive Plan, as amended, by the Company's stockholders, which approval was obtained at the Company's 2026 Annual Meeting of Stockholders held on June 29, 2026.

F2 · derivative.exercise_date: The options vest in thirty-six (36) equal installments on each monthly anniversary of March 27, 2026.

Read SEC document
April 29, 2026 Filed May 1, 2026 22:32 UTC Avalyn Pharma Inc. AVLN · Entity 4662 GrantStock Option (Right to Buy) · Derivative 26,978 $0.00 Strike: $18.00 $0.00
Disclosure

SEC source: 0001193125-26-201875 · ownership.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,978

Underlying: Common Stock · 26,978 shares

Expires 2036-04-28

F1 · derivative.exercise_date: 25% of the shares underlying this option vest and become exercisable on September 12, 2025, with the remaining 75% vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

Read SEC document
April 13, 2026 Filed Apr 16, 2026 01:45 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 15,730 $26.83 $421,979.27
Disclosure

SEC source: 0001933414-26-000075 · wk-form4_1776303917.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 689,321

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $26.81 to $26.96. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
March 31, 2026 Filed Apr 2, 2026 22:54 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 453 $27.05 $12,254.15
Disclosure

SEC source: 0001644975-26-000004 · wk-form4_1775170480.xml · nonDerivative · entry 3

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 705,051

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.

F4 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $27.0000 to $27.1000. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

Read SEC document
March 31, 2026 Filed Apr 2, 2026 22:54 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 55,183 $26.54 $1,464,474.05
Disclosure

SEC source: 0001644975-26-000004 · wk-form4_1775170480.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 705,504

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $26.0000 to $26.9999. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

Read SEC document
March 31, 2026 Filed Apr 2, 2026 22:54 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 19,364 $25.50 $493,793.62
Disclosure

SEC source: 0001644975-26-000004 · wk-form4_1775170480.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 760,687

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $25.0000 to $25.9994. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
February 19, 2026 Filed Feb 21, 2026 00:47 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 GrantStock Option · Derivative 187,900 $0.00 Strike: $28.06 $0.00
Disclosure

SEC source: 0001933414-26-000045 · wk-form4_1771634862.xml · derivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,900

Underlying: Common Stock · 187,900 shares

Expires 2036-02-19

F2 · derivative.exercise_date: The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month period following the date of grant

Read SEC document
February 19, 2026 Filed Feb 21, 2026 00:47 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 GrantCommon Stock 140,900 $0.00 $0.00
Disclosure

SEC source: 0001933414-26-000045 · wk-form4_1771634862.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 780,051

F1 · shares: Restricted Stock Units (RSUs) are granted to the reporting person for no additional cash consideration, each of which represents a contingent right to receive one share of common stock upon vesting. The RSUs vest in annual installments over a period of four years, with 1/4th of the total shares underlying the RSU vesting on each one-year anniversary of the date of grant.

Read SEC document
January 12, 2026 Filed Jan 14, 2026 01:43 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 7,117 $33.15 $235,932.11
Disclosure

SEC source: 0001644975-26-000002 · wk-form4_1768355020.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 639,151

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on January 28, 2025.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $32.8439 to $33.5000. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

Read SEC document
January 12, 2026 Filed Jan 14, 2026 01:43 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 9,119 $32.21 $293,707.49
Disclosure

SEC source: 0001644975-26-000002 · wk-form4_1768355020.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 646,268

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on January 28, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $31.8400 to $32.8028. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
November 21, 2025 Filed Nov 24, 2025 22:07 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 Exercise / conversionStock Option · Derivative 24,082 $0.00 Strike: $0.54 $0.00
Disclosure

SEC source: 0001644975-25-000006 · wk-form4_1764022035.xml · derivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 24,082 shares

Expires 2031-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was originally reported as $0.53 per share on the Reporting Person's Form 3 filed on February 9, 2023.

F2 · derivative.exercise_date: The stock option vested with respect to 25% of the underlying shares on March 12, 2022 and the remaining shares in 36 substantially equal monthly installments thereafter.

Read SEC document
November 21, 2025 Filed Nov 24, 2025 22:07 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 Exercise / conversionCommon Stock 24,082 $0.54 $13,004.28
Disclosure

SEC source: 0001644975-25-000006 · wk-form4_1764022035.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 655,387

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 11, 2025 Filed Nov 14, 2025 00:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 32,850 $46.89 $1,540,211.67
Disclosure

SEC source: 0001933414-25-000151 · wk-form4_1763078487.xml · nonDerivative · entry 6

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 631,305

F6 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $46.4400 to $47.4191. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.

Read SEC document
November 11, 2025 Filed Nov 14, 2025 00:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 112,275 $45.83 $5,145,956.21
Disclosure

SEC source: 0001933414-25-000151 · wk-form4_1763078487.xml · nonDerivative · entry 5

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 664,155

F5 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $45.4300 to $46.4200. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

Read SEC document
November 11, 2025 Filed Nov 14, 2025 00:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 29,207 $45.20 $1,320,165.16
Disclosure

SEC source: 0001933414-25-000151 · wk-form4_1763078487.xml · nonDerivative · entry 4

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 776,430

F4 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $44.4800 to $45.4297. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

Read SEC document
November 11, 2025 Filed Nov 14, 2025 00:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 4,000 $43.50 $173,983.60
Disclosure

SEC source: 0001933414-25-000151 · wk-form4_1763078487.xml · nonDerivative · entry 3

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 805,637

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $43.1700 to $44.0500. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

Read SEC document
November 11, 2025 Filed Nov 14, 2025 00:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 8,862 $42.31 $374,946.79
Disclosure

SEC source: 0001933414-25-000151 · wk-form4_1763078487.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 809,637

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $42.0500 to $43.0400. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
November 11, 2025 Filed Nov 14, 2025 00:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 12,806 $41.64 $533,235.44
Disclosure

SEC source: 0001933414-25-000151 · wk-form4_1763078487.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 818,499

F1 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $41.0500 to $42.0000. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

Read SEC document
October 13, 2025 Filed Oct 15, 2025 23:04 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 1,552 $43.03 $66,782.40
Disclosure

SEC source: 0001933414-25-000129 · wk-form4_1760569470.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 831,305

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $42.9822 to $43.2030. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

Read SEC document
October 13, 2025 Filed Oct 15, 2025 23:04 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 13,548 $42.63 $577,544.47
Disclosure

SEC source: 0001933414-25-000129 · wk-form4_1760569470.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 832,857

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $41.9800 to $42.9800. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
July 11, 2025 Filed Jul 15, 2025 21:02 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 15,884 $14.51 $230,430.78
Disclosure

SEC source: 0001933414-25-000078 · wk-form4_1752613354.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 846,405

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $14.30 to $14.73. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Read SEC document
April 11, 2025 Filed Apr 16, 2025 00:33 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 15,319 $12.19 $186,802.95
Disclosure

SEC source: 0001933414-25-000044 · wk-form4_1744763608.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 862,289

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $12.0200 to $12.4087. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

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February 13, 2025 Filed Feb 24, 2025 23:58 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 GrantStock Option · Derivative 570,000 $0.00 Strike: $10.20 $0.00
Disclosure

SEC source: 0001933414-25-000014 · wk-form4_1740441525.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 570,000

Underlying: Common Stock · 570,000 shares

Expires 2035-02-13

F1 · derivative.exercise_date: The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month anniversary following the date of grant.

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January 13, 2025 Filed Jan 16, 2025 02:44 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 18,333 $9.06 $166,082.31
Disclosure

SEC source: 0001933414-25-000003 · wk-form4_1736995487.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 877,608

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $8.65 to $9.37. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

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October 11, 2024 Filed Oct 15, 2024 20:21 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 15,271 $13.52 $206,433.38
Disclosure

SEC source: 0001933414-24-000045 · wk-form4_1729023711.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 895,941

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $13.35 to $13.76. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

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July 11, 2024 Filed Jul 12, 2024 20:36 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 15,746 $13.34 $210,075.26
Disclosure

SEC source: 0001933414-24-000033 · wk-form4_1720816599.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 911,212

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $12.96 to $13.76. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

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June 20, 2024 Filed Jun 20, 2024 21:44 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 14,940 $11.73 $175,237.24
Disclosure

SEC source: 0001933414-24-000032 · wk-form4_1718919832.xml · nonDerivative · entry 3

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 926,958

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F4 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $11.525 to $12.05.

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June 18, 2024 Filed Jun 20, 2024 21:44 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 16,607 $11.99 $199,073.09
Disclosure

SEC source: 0001933414-24-000032 · wk-form4_1718919832.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 941,898

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $11.76 to $12.12.

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June 17, 2024 Filed Jun 20, 2024 21:44 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 17,766 $12.25 $217,711.67
Disclosure

SEC source: 0001933414-24-000032 · wk-form4_1718919832.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 958,505

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $12.0982 to $12.4627. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

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June 14, 2024 Filed Jun 14, 2024 22:15 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 16,229 $12.52 $203,162.74
Disclosure

SEC source: 0001933414-24-000029 · wk-form4_1718403341.xml · nonDerivative · entry 3

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 976,271

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F4 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $12.39 to $12.635.

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June 13, 2024 Filed Jun 14, 2024 22:15 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 39,961 $12.74 $509,027.21
Disclosure

SEC source: 0001933414-24-000029 · wk-form4_1718403341.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 992,500

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $12.49 to $13.04.

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June 12, 2024 Filed Jun 14, 2024 22:15 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 SaleCommon Stock 16,607 $12.77 $212,013.27
Disclosure

SEC source: 0001933414-24-000029 · wk-form4_1718403341.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,032,461

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 30, 2024.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $12.4587 to $13.35. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

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February 13, 2024 Filed Feb 15, 2024 21:26 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 GrantStock Option · Derivative 425,000 $0.00 Strike: $14.25 $0.00
Disclosure

SEC source: 0001628280-24-005064 · wk-form4_1708032345.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 425,000

Underlying: Common Stock · 425,000 shares

Expires 2034-02-13

F1 · derivative.exercise_date: The stock option vests as to 25% of the total number of shares of Common Stock subject to the option on the first anniversary of the grant date, and as to 1/48th of the total number of shares of Common Stock subject to the option on each monthly anniversary thereafter.

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November 22, 2023 Filed Nov 27, 2023 21:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 PurchaseCommon Stock 4,250 $5.97 $25,355.93
Disclosure

SEC source: 0001933414-23-000093 · wk-form4_1701118862.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,049,068

F1 · price: The price reported is the weighted-average purchase price, purchased in multiple transactions at prices ranging from $5.8850 to $5.9996. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4.

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September 06, 2023 Filed Sep 8, 2023 12:49 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 PurchaseCommon Stock 2,250 $12.08 $27,180.00
Disclosure

SEC source: 0001933414-23-000067 · wf-form4_169417735412478.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,044,818

F1 · price: The price reported is the weighted-average purchase price, purchased in multiple transactions at prices ranging from $11.9860 to $12.1202. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4.

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August 17, 2023 Filed Aug 21, 2023 20:03 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 PurchaseCommon Stock 2,250 $12.10 $27,225.00
Disclosure

SEC source: 0001933414-23-000065 · wf-form4_169264818560082.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,042,568

F1 · price: The price reported is the weighted-average purchase price, purchased in multiple transactions at prices ranging from $12.02 to $12.1473. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4.

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August 11, 2023 Filed Aug 11, 2023 23:11 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 PurchaseCommon Stock 2,000 $12.89 $25,780.00
Disclosure

SEC source: 0001933414-23-000061 · wf-form4_169179546088184.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,040,318

F1 · price: The price reported is the weighted-average purchase price, purchased in multiple transactions at prices ranging from $12.8522 to $12.9257. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4.

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March 17, 2023 Filed Mar 21, 2023 22:48 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 GrantStock Option · Derivative 99,800 $0.00 Strike: $15.44 $0.00
Disclosure

SEC source: 0001933414-23-000021 · wf-form4_167943887821849.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,800

Underlying: Common Stock · 99,800 shares

Expires 2033-03-17

F1 · derivative.exercise_date: The stock option vests as to 25% of the total number of shares of Common Stock subject to the option on the first anniversary of the grant date, and as to 1/48th of the total number of shares of Common Stock subject to the option on each monthly anniversary thereafter.

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February 09, 2023 Filed Feb 14, 2023 02:01 UTC Mineralys Therapeutics, Inc. MLYS · Entity 4432 GrantStock Option · Derivative 250,046 $0.00 Strike: $16.00 $0.00
Disclosure

SEC source: 0001628280-23-003425 · wf-form4_167634009091121.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 250,046

Underlying: Common Stock · 250,046 shares

Expires 2033-02-09

F1 · derivative.exercise_date: The stock option vests as to 25% of the total number of shares of Common Stock subject to the option on the first anniversary of the grant date, and as to 1/48th of the total number of shares of Common Stock subject to the option on each monthly anniversary thereafter.

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September 12, 2016 Filed Sep 14, 2016 16:15 UTC ALPINE IMMUNE SCIENCES, INC. NVLS · Entity 90802 GrantStock Option (Right to Buy) · Derivative 250,000 $0.00 Strike: $7.77 $0.00
Disclosure

SEC source: 0001104659-16-144630 · a4.xml · derivative · entry 1

Congleton Jon · CIK 0001644975 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2026-09-12

F1 · derivative.exercise_price: The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant.

F2 · derivative.exercise_date: The options vest and become exercisable over a four-year period, with 25% vesting on the first anniversary of the grant date (September 12, 2017) and 1/48th of the options vesting monthly thereafter.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.