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BERTHELSEN SPENCER R

Disclosed activity across 1 company

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29926
SEC CIK
0001181548

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
IONIS PHARMACEUTICALS INCIONS · Entity 1182DirectorJuly 15, 2026July 17, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

IONIS PHARMACEUTICALS INC

Report date July 15, 2026 · Filed July 17, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect161,233 Reported balance After 2026-07-15 transaction · row 1
1 source row

Row 1 · 2026-07-15 · Exercise / conversion · Acquired 5,220 · Balance 161,233

F1: Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.

Restricted Stock UnitSEC Table II · derivative / convertible security · Conversion / exercise price $0.00Direct2,301 Reported balance After 2026-07-15 transaction · row 3 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 3 · 2026-07-15 · Exercise / conversion · Disposed 5,220 · Balance 2,301

F3: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4: Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Common StockSEC Table I · non-derivativeIndirectby Daughter70 Reported balance Holding disclosure · report date 2026-07-15 · row 2 Holding and transaction disclosures are not merged.
1 source row

Row 2 · Balance 70

F2: The reporting person disclaims beneficial ownership of all securities held by his daughter, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F1: Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.

F2: The reporting person disclaims beneficial ownership of all securities held by his daughter, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

F3: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4: Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
July 06, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · derivative · entry 9

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 666

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 06, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · nonDerivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,983

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 02, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · derivative · entry 8

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,777

Underlying: Common Stock · 889 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 02, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · nonDerivative · entry 3

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,316

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 12,000 $0.00 Strike: $60.20 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · derivative · entry 11

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2030-06-30

F6 · derivative.exercise_date: Grant of July 1, 2020 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2020.

F6 · derivative.expiration_date: Grant of July 1, 2020 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2020.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 5,333 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · derivative · entry 10

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,333

Underlying: Common Stock · 5,333 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Grant of July 1, 2020 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2020.

F5 · derivative.expiration_date: Grant of July 1, 2020 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2020.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 1,778 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · derivative · entry 7

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,332

Underlying: Common Stock · 1,778 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · derivative · entry 6

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 1,778 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · nonDerivative · entry 2

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,427

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000090 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,649

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 23:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionDirector Stock Option (right to buy) · Derivative 15,000 $0.00 Strike: $9.22 $0.00
Disclosure

SEC source: 0000874015-20-000074 · edgar.xml · derivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2020-06-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 23:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 15,000 $58.76 $881,400.00
Disclosure

SEC source: 0000874015-20-000074 · edgar.xml · nonDerivative · entry 2

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,983

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2020. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/28/2020.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 23:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 15,000 $9.22 $138,300.00
Disclosure

SEC source: 0000874015-20-000074 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,983

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2020. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/28/2020.

Read SEC document
July 03, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · derivative · entry 9

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,333

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 03, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · nonDerivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,983

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 02, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · derivative · entry 8

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,666

Underlying: Common Stock · 889 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 02, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · nonDerivative · entry 3

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,316

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 16,000 $0.00 Strike: $64.80 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · derivative · entry 11

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2029-06-30

F6 · derivative.exercise_date: Grant of July 1, 2019 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 1, 2020. The option shall be fully vested and exercisable on July 1, 2023. The option is exercisable to 0 shares on July 1, 2019.

F6 · derivative.expiration_date: Grant of July 1, 2019 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 1, 2020. The option shall be fully vested and exercisable on July 1, 2023. The option is exercisable to 0 shares on July 1, 2019.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 7,110 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · derivative · entry 10

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,110

Underlying: Common Stock · 7,110 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Grant of July 1, 2019 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 1, 2020. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 1, 2023. The RSU is vested as to 0 shares on July 1, 2019.

F5 · derivative.expiration_date: Grant of July 1, 2019 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 1, 2020. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 1, 2023. The RSU is vested as to 0 shares on July 1, 2019.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · derivative · entry 7

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 666

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · derivative · entry 6

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · nonDerivative · entry 2

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,427

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:37 UTC Amendment IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000095 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,760

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
June 24, 2019 Filed Jun 26, 2019 22:52 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionDirector Stock Option (right to buy) · Derivative 15,000 $0.00 Strike: $16.32 $0.00
Disclosure

SEC source: 0000874015-19-000079 · edgar.xml · derivative · entry 6

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2019-06-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2019 Filed Jun 26, 2019 22:52 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 9,690 $63.84 $618,638.67
Disclosure

SEC source: 0000874015-19-000079 · edgar.xml · nonDerivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,094

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.69 to $64.16, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.

Read SEC document
June 24, 2019 Filed Jun 26, 2019 22:52 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 9,690 $16.32 $158,140.80
Disclosure

SEC source: 0000874015-19-000079 · edgar.xml · nonDerivative · entry 3

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,784

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

Read SEC document
June 24, 2019 Filed Jun 26, 2019 22:52 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 5,310 $63.37 $336,473.99
Disclosure

SEC source: 0000874015-19-000079 · edgar.xml · nonDerivative · entry 2

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,094

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.68 to $63.68, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
June 24, 2019 Filed Jun 26, 2019 22:52 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 5,310 $16.32 $86,659.20
Disclosure

SEC source: 0000874015-19-000079 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,404

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2019. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/2019.

Read SEC document
July 03, 2018 Filed Jul 3, 2018 19:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000077 · edgar.xml · derivative · entry 5

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 03, 2018 Filed Jul 3, 2018 19:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000077 · edgar.xml · nonDerivative · entry 2

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,094

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 02, 2018 Filed Jul 3, 2018 19:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 16,000 $0.00 Strike: $42.88 $0.00
Disclosure

SEC source: 0000874015-18-000077 · edgar.xml · derivative · entry 7

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2028-07-01

F5 · derivative.exercise_date: Grant of July 2, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 2, 2019. The option shall be fully vested and exercisable on July 2, 2022. The option is exercisable to 0 shares on July 2, 2018.

F5 · derivative.expiration_date: Grant of July 2, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 2, 2019. The option shall be fully vested and exercisable on July 2, 2022. The option is exercisable to 0 shares on July 2, 2018.

Read SEC document
July 02, 2018 Filed Jul 3, 2018 19:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 3,555 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000077 · edgar.xml · derivative · entry 6

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,555

Underlying: Common Stock · 3,555 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Grant of July 2, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 2, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 2, 2022. The RSU is vested as to 0 shares on July 2, 2018.

F4 · derivative.expiration_date: Grant of July 2, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 2, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 2, 2022. The RSU is vested as to 0 shares on July 2, 2018.

Read SEC document
July 01, 2018 Filed Jul 3, 2018 19:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 2,000 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000077 · edgar.xml · derivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,999

Underlying: Common Stock · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2018 Filed Jul 3, 2018 19:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 2,000 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000077 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,427

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
June 25, 2018 Filed Jun 26, 2018 00:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionDirector Stock Option (right to buy) · Derivative 15,000 $0.00 Strike: $13.88 $0.00
Disclosure

SEC source: 0000874015-18-000073 · edgar.xml · derivative · entry 6

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2018-06-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 25, 2018 Filed Jun 26, 2018 00:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 9,300 $42.47 $394,971.00
Disclosure

SEC source: 0000874015-18-000073 · edgar.xml · nonDerivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,427

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.21 to $42.815, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.

Read SEC document
June 25, 2018 Filed Jun 26, 2018 00:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 9,300 $13.88 $129,084.00
Disclosure

SEC source: 0000874015-18-000073 · edgar.xml · nonDerivative · entry 3

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,727

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

Read SEC document
June 25, 2018 Filed Jun 26, 2018 00:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 5,700 $42.03 $239,571.00
Disclosure

SEC source: 0000874015-18-000073 · edgar.xml · nonDerivative · entry 2

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,427

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.76 to $42.20, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
June 25, 2018 Filed Jun 26, 2018 00:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 5,700 $13.88 $79,116.00
Disclosure

SEC source: 0000874015-18-000073 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,127

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2018. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 04/13/2018.

Read SEC document
July 03, 2017 Filed Jul 3, 2017 21:30 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 16,000 $0.00 Strike: $52.22 $0.00
Disclosure

SEC source: 0000874015-17-000036 · edgar.xml · derivative · entry 5

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2027-07-02

F5 · derivative.exercise_date: Grant of July 3, 2017 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended & Restated 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 3, 2018. The option shall be fully vested and exercisable on July 3, 2021. The stock option was exercisable as to 0 shares on July 3, 2017.

F5 · derivative.expiration_date: Grant of July 3, 2017 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended & Restated 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 3, 2018. The option shall be fully vested and exercisable on July 3, 2021. The stock option was exercisable as to 0 shares on July 3, 2017.

Read SEC document
July 03, 2017 Filed Jul 3, 2017 21:30 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 2,667 $0.00 $0.00
Disclosure

SEC source: 0000874015-17-000036 · edgar.xml · derivative · entry 4

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,667

Underlying: Common Stock · 2,667 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Grant of July 3, 2017 to reporting person of Restricted Stock Unit Award under the Ionis Pharmaceuticals, Inc. Amended and Restated 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 3, 2018. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 3, 2021. The RSU is vested as to 0 shares on July 3, 2017.

F4 · derivative.expiration_date: Grant of July 3, 2017 to reporting person of Restricted Stock Unit Award under the Ionis Pharmaceuticals, Inc. Amended and Restated 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 3, 2018. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 3, 2021. The RSU is vested as to 0 shares on July 3, 2017.

Read SEC document
July 01, 2017 Filed Jul 3, 2017 21:30 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 2,469 $0.00 $0.00
Disclosure

SEC source: 0000874015-17-000036 · edgar.xml · derivative · entry 3

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,999

Underlying: Common Stock · 2,469 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2017 Filed Jul 3, 2017 21:30 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 2,469 $0.00 $0.00
Disclosure

SEC source: 0000874015-17-000036 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,427

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
February 24, 2017 Filed Feb 28, 2017 00:15 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionDirector Stock Option (right to buy) · Derivative 12,500 $0.00 Strike: $9.77 $0.00
Disclosure

SEC source: 0000874015-17-000020 · edgar.xml · derivative · entry 3

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,500 shares

Expires 2017-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 24, 2017 Filed Feb 28, 2017 00:15 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 12,500 $9.77 $122,125.00
Disclosure

SEC source: 0000874015-17-000020 · edgar.xml · nonDerivative · entry 1

BERTHELSEN SPENCER R · CIK 0001181548 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,958

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2017.

F1 · shares: Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2017.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.