Trigg Leslie

SEC source: 0001484612-26-000050 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 194,597

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 9,319 shares of Common Stock underlying RSUs granted to the reporting person on January 12, 2024 and June 10, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-26-000041 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 198,034

F1 · shares: Represents restricted stock units ("RSU") granted to the reporting person on June 26, 2026. Each RSU represents a contingent right to receive one share of common stock. These RSUs shall vest 33.33% on June 26, 2027, and the remaining 66.67% shall vest in equal installments over the course of the following two years on a quarterly basis on February 15th, May 15th, August 15th and November 15th, subject to the reporting person's continuous service through the applicable vesting date.

SEC source: 0001484612-26-000027 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,874

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 9,319 shares of Common Stock underlying RSUs granted to the reporting person on January 12, 2024 and June 10, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · balance_after: This balance reflects a correction to the number of shares of Common Stock sold by the reporting person to satisfy tax withholding obligations as previously reported on a Form 4 filed on February 19, 2026. Due to an administrative error, the prior Form 4 reported the sale of 3,361 shares instead of the correct number, 3,384 shares.

SEC source: 0001193125-26-118740 · ownership.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F2 · price: At the Effective Time, each share of Common Stock subject to vesting, repurchase or other lapse restriction and that was granted under an Issuer stock plan and outstanding as of immediately prior to the Effective Time was deemed to be fully vested and cancelled and converted into the right to receive the Merger Consideration, less any applicable tax withholding.

SEC source: 0001193125-26-118740 · ownership.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,925

F1 · price: On March 23, 2026, pursuant to the terms of that certain Agreement and Plan of Merger (the "Merger Agreement"), dated as of November 19, 2025, by and among Exact Sciences Corporation, a Delaware corporation (the "Issuer"), Abbott Laboratories, an Illinois corporation ("Parent"), and Badger Merger Sub I, Inc., a Delaware corporation and a direct, wholly owned subsidiary of Parent ("Merger Sub"), Merger Sub merged with and into the Issuer (the "Merger"), with the Issuer surviving the Merger as a direct, wholly owned subsidiary of Parent. At the effective time of the Merger (the "Effective Time"), on the terms and subject to the conditions set forth in the Merger Agreement, each share of the Issuer's common stock, par value $0.01 per share ("Common Stock"), issued and outstanding immediately prior to the Effective Time, with certain exceptions, was converted into the right to receive $105.00 in cash, without interest (the "Merger Consideration").

SEC source: 0001304125-26-000004 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,342

F1 · shares: Required number of shares sold by the reporting person to cover partial tax withholding obligations in connection with the vesting of an aggregate of 9,319 shares of Common Stock underlying RSUs granted to the reporting person on January 12, 2024 and June 10, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-26-000015 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,703

F1 · shares: Required number of shares sold by the reporting person to cover partial tax withholding obligations in connection with the vesting of an aggregate of 32,552 shares of Common Stock underlying RSUs granted to the reporting person on June 10, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-26-000015 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 107,823

F1 · shares: Required number of shares sold by the reporting person to cover partial tax withholding obligations in connection with the vesting of an aggregate of 32,552 shares of Common Stock underlying RSUs granted to the reporting person on June 10, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-26-000004 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,617

F1 · kind: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with 4,904 shares of Common Stock underlying PSUs (i) which were, as previously reported, originally earned based on the achievement of applicable performance criteria as of December 31, 2024 or January 6, 2025, as applicable, as certified by the Compensation Committee of the Issuer's Board of Directors on January 17, 2025 and (ii) vested and were released on January 6, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000080 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,412

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 1,770 shares of Common Stock underlying RSUs granted to the reporting person on January 6, 2023, and January 12, 2024. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000072 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,328

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 1,769 shares of Common Stock underlying RSUs granted to the reporting person on January 6, 2023, and January 12, 2024. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0000950170-25-086887 · ownership.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,169

F1 · shares: These shares of restricted stock were issued pursuant to the Company's non-employee director compensation policy.

SEC source: 0001484612-25-000060 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 123,232

F1 · shares: Represents restricted stock units ("RSU") granted to the reporting person on June 10, 2025. Each RSU represents a contingent right to receive one share of common stock. These RSUs shall vest 50% on January 17, 2026, and the remaining 50% shall vest in equal installments over the course of the following year on a quarterly basis on February 15th, May 15th, August 15th and November 15th, subject to the reporting person's continuous service through the applicable vesting date.

SEC source: 0001484612-25-000048 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,129

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 1,770 shares of Common Stock underlying RSUs granted to the reporting person on January 6, 2023, and January 12, 2024. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · balance_after: These numbers have been adjusted to reflect the 1-for-15 reverse stock split the Issuer effected on March 20, 2025 (the "Reverse Stock Split"). Includes 333 shares of Common Stock acquired pursuant to the Outset Medical, Inc. 2020 Employee Stock Purchase Plan ("ESPP"), for the purchase period of September 1, 2024 to February 28, 2025. This transaction is exempt from Rule 16b-3(c).

SEC source: 0000950170-25-061902 · ownership.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,499

F1 · security: These shares of restricted stock were issued pursuant to the Company's non-employee director compensation policy and vest in three equal annual installments beginning on the first anniversary of the grant date.

SEC source: 0001484612-25-000038 · edgardoc.xml · derivative · entry 5

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · Trigg 2002 Rev Trust

Disclosed balance after: 0

Underlying: Preferred Stock · 2,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

F2 · price: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

F2 · derivative.exercise_date: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

F2 · derivative.expiration_date: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

SEC source: 0001484612-25-000038 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · Trigg 2002 Rev Trust

Disclosed balance after: 625,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Issuer's stockholders approved the conversion of shares of the Issuer's Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") into shares of the Issuer's common stock ("Common Stock") at its Meeting of Stockholders, held on March 5, 2025, after which each share of Preferred Stock automatically converted into 250 shares of Common Stock on March 10, 2025.

SEC source: 0001484612-25-000038 · edgardoc.xml · derivative · entry 4

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · Trigg 2002 Rev Trust

Disclosed balance after: 2,500

Underlying: Preferred Stock · 2,500 shares

Expires not disclosed

F2 · derivative.exercise_price: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

F2 · price: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

F2 · derivative.exercise_date: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

F2 · derivative.expiration_date: These shares of Series A Non-Voting Convertible Preferred Stock ("Preferred Stock") were issued to the Reporting Person under securities purchase agreements entered into with the Issuer, pursuant to which the Issuer agreed to submit to its stockholders the approval of the conversion of the Preferred Stock into shares of Common Stock at its March 5, 2025 Meeting of Stockholders (the "Conversion Proposal"). The Issuer's stockholders approved the Conversion Proposal and each share of Preferred Stock will automatically convert into 250 shares of Common Stock, subject to certain limitations. The Preferred Stock has no expiration date.

SEC source: 0001484612-25-000033 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 880,969

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 28,379 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021, January 6, 2023, and January 12, 2024. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000025 · edgardoc.xml · nonDerivative · entry 4

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 895,580

F4 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of 50% of the PSUs, described in footnote (1) above, on January 17, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000025 · edgardoc.xml · nonDerivative · entry 3

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 914,029

F3 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with 100,000 shares of Common Stock underlying PRSUs which (i) represent 50% of the target shares underlying the original award (granted on January 12, 2024, as previously reported), which were earned based on performance as of December 31, 2024, upon certification by the Compensation Committee of the Issuer's Board of Directors, and (ii) vested and were released on January 17, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000025 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 956,413

F2 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with 11,706 shares of Common Stock underlying PSUs which (i) were, as previously reported, granted to the reporting person on February 2, 2022, (ii) were earned as of January 26, 2024 as certified by the Compensation Committee of the Issuer's Board of Directors of the satisfaction of specified performance criteria, and (iii) vested and were released on January 17, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000025 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 960,816

F1 · shares: On January 6, 2023, the reporting person was granted performance-based restricted stock units (PSUs) subject to the satisfaction of specified performance criteria as of December 31, 2024. The reported amount represents the number of PSUs earned by the reporting person on January 17, 2025, upon certification by the Compensation Committee of the Issuer's Board of Directors of the satisfaction of specified performance criteria. Each PSU represents a contingent right to receive a share of common stock. These PSUs vested 50% on January 17, 2025, and the remaining 50% shall vest on December 31, 2025, subject to the reporting person's continuous service through the vesting period.

SEC source: 0001484612-25-000016 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 861,397

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 70,826 shares of Common Stock underlying RSUs granted to the reporting person on January 12, 2024. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-25-000008 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 894,624

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with 22,469 shares of Common Stock underlying PSUs which (i) were, as previously reported, originally earned by the reporting person on January 12, 2024, upon certification by the Compensation Committee of the Issuer's Board of Directors of the satisfaction of specified performance criteria, and (ii) vested and were released on January 6, 2025. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-24-000074 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 904,851

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 14,740 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021, January 26, 2022, and January 6, 2023. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-24-000066 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 910,496

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 14,740 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021, January 26, 2022, and January 6, 2023. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001140361-24-035176 · form4.xml · derivative · entry 1

Trigg Leslie · CIK 0001304125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Class A ordinary shares · 30,000 shares

Expires not disclosed

F1 · derivative.exercise_price: In connection with the Business Combination Agreement, dated February 13, 2024, by and among the Issuer, Adagio Medical Holdings, Inc. (f/k/a Aja HoldCo, Inc.) ("HoldCo"), Aja Merger Sub 1 ("Merger Sub 1"), Aja Merger Sub 2, Inc. ("Merger Sub 2") and Adagio Medical, Inc. ("Adagio") (the transactions contemplated thereby, the "Business Combination"), Merger Sub merged with and into the Issuer and Merger Sub 2 merged with and into Adagio, with each of the Issuer and Adagio becoming a wholly owned subsidiary of HoldCo, and the Reporting Person's ordinary shares of the Issuer were automatically converted into shares of common stock of HoldCo, par value $0.0001 per share, on a one-for-one basis.

F1 · kind: In connection with the Business Combination Agreement, dated February 13, 2024, by and among the Issuer, Adagio Medical Holdings, Inc. (f/k/a Aja HoldCo, Inc.) ("HoldCo"), Aja Merger Sub 1 ("Merger Sub 1"), Aja Merger Sub 2, Inc. ("Merger Sub 2") and Adagio Medical, Inc. ("Adagio") (the transactions contemplated thereby, the "Business Combination"), Merger Sub merged with and into the Issuer and Merger Sub 2 merged with and into Adagio, with each of the Issuer and Adagio becoming a wholly owned subsidiary of HoldCo, and the Reporting Person's ordinary shares of the Issuer were automatically converted into shares of common stock of HoldCo, par value $0.0001 per share, on a one-for-one basis.

F1 · price: In connection with the Business Combination Agreement, dated February 13, 2024, by and among the Issuer, Adagio Medical Holdings, Inc. (f/k/a Aja HoldCo, Inc.) ("HoldCo"), Aja Merger Sub 1 ("Merger Sub 1"), Aja Merger Sub 2, Inc. ("Merger Sub 2") and Adagio Medical, Inc. ("Adagio") (the transactions contemplated thereby, the "Business Combination"), Merger Sub merged with and into the Issuer and Merger Sub 2 merged with and into Adagio, with each of the Issuer and Adagio becoming a wholly owned subsidiary of HoldCo, and the Reporting Person's ordinary shares of the Issuer were automatically converted into shares of common stock of HoldCo, par value $0.0001 per share, on a one-for-one basis.

F1 · derivative.exercise_date: In connection with the Business Combination Agreement, dated February 13, 2024, by and among the Issuer, Adagio Medical Holdings, Inc. (f/k/a Aja HoldCo, Inc.) ("HoldCo"), Aja Merger Sub 1 ("Merger Sub 1"), Aja Merger Sub 2, Inc. ("Merger Sub 2") and Adagio Medical, Inc. ("Adagio") (the transactions contemplated thereby, the "Business Combination"), Merger Sub merged with and into the Issuer and Merger Sub 2 merged with and into Adagio, with each of the Issuer and Adagio becoming a wholly owned subsidiary of HoldCo, and the Reporting Person's ordinary shares of the Issuer were automatically converted into shares of common stock of HoldCo, par value $0.0001 per share, on a one-for-one basis.

F1 · derivative.expiration_date: In connection with the Business Combination Agreement, dated February 13, 2024, by and among the Issuer, Adagio Medical Holdings, Inc. (f/k/a Aja HoldCo, Inc.) ("HoldCo"), Aja Merger Sub 1 ("Merger Sub 1"), Aja Merger Sub 2, Inc. ("Merger Sub 2") and Adagio Medical, Inc. ("Adagio") (the transactions contemplated thereby, the "Business Combination"), Merger Sub merged with and into the Issuer and Merger Sub 2 merged with and into Adagio, with each of the Issuer and Adagio becoming a wholly owned subsidiary of HoldCo, and the Reporting Person's ordinary shares of the Issuer were automatically converted into shares of common stock of HoldCo, par value $0.0001 per share, on a one-for-one basis.

SEC source: 0001484612-24-000046 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 915,804

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 14,739 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021, January 26, 2022, and January 6, 2023. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 1,801 shares of Common Stock acquired pursuant to the Outset Medical, Inc. 2020 Employee Stock Purchase Plan ("ESPP"), for the purchase period of September 1, 2023 to February 29, 2024. This transaction is exempt from Rule 16b-3(c).

SEC source: 0001484612-24-000034 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 919,240

F2 · shares: Required number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of RSUs on February 23, 2024 described in footnote (1) above. This transaction does not represent a sale or discretionary trade by the reporting person.

SEC source: 0001484612-24-000034 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 964,778

F1 · shares: Represents restricted stock units (RSUs) granted to the reporting person on February 23, 2024 in lieu of 100% of the reporting person's 2023 annual cash bonus amount at the request of the reporting person. The RSUs were fully vested on the grant date.

SEC source: 0001484612-24-000031 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 833,091

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 14,748 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021, January 26, 2022 and January 6, 2023. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-24-000019 · edgardoc.xml · nonDerivative · entry 4

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 838,411

F4 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of PSUs on January 12, 2024 described in footnote (3) above. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-24-000019 · edgardoc.xml · nonDerivative · entry 3

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 846,537

F3 · shares: On February 2, 2022, the reporting person was granted performance-based restricted stock units ("PSUs") subject to the satisfaction of specified performance criteria as of December 31, 2023. The reported amount represents the number of PSUs earned by the reporting person on January 12, 2024, upon certification by the Compensation Committee of the Issuer's Board of Directors of the satisfaction of specified performance criteria. Each PSU represents a contingent right to receive one share of common stock. These PSUs vested 50% on January 12, 2024, and the remaining 50% shall vest on December 31, 2024, subject to the reporting person's continuous service through the vesting date.

SEC source: 0001484612-24-000019 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 801,599

F2 · shares: Represents performance-based restricted stock units ("PSUs") granted to the reporting person on January 12, 2024, that vest over a three year period based on the Issuer's common stock achieving specified prices per share, if not earlier vested upon satisfaction of specified performance criteria, subject to the reporting person's continuous service through the applicable vesting date. Each PSU represents a contingent right to receive one share of common stock.

SEC source: 0001484612-24-000019 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 601,599

F1 · shares: Represents restricted stock units ("RSU") granted to the reporting person on January 12, 2024. Each RSU represents a contingent right to receive one share of common stock. These RSUs shall vest 33.33% on January 12, 2025, and the remaining 66.67% shall vest in equal installments over the course of the following two years on a quarterly basis on each February 15th, May 15th, August 15th and November 15th, subject to the reporting person's continuous service through the applicable vesting date.

SEC source: 0001484612-24-000011 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 389,099

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of 35,393 shares of Common Stock underlying RSUs granted to the reporting person on January 6, 2023. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

SEC source: 0001484612-23-000090 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 403,287

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 5,892 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021 and January 26, 2022. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 1 share of Common Stock acquired pursuant to the Outset Medical, Inc. 2020 Employee Stock Purchase Plan ("ESPP"), for the purchase period of March 1, 2023 to August 31, 2023. This transaction is exempt from Rule 16b-3(c).

SEC source: 0001484612-23-000072 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 406,461

F1 · shares: Required number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of an aggregate of 5,891 shares of Common Stock underlying RSUs granted to the reporting person on March 15, 2021 and January 26, 2022. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The sale price of the reporting person's shares represents the weighted average price of all shares sold by a broker on August 16, 2023 on behalf of a group of employees of the Issuer to satisfy the payment of withholding tax liability of such employees.

SEC source: 0001484612-23-000058 · edgardoc.xml · derivative · entry 4

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,418

Underlying: Common Stock · 20,000 shares

Expires 2028-11-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F3 · derivative.exercise_date: In March 2021, following the expiration of the lock-up period in connection with our initial public offering, the applicable performance and market-based vesting conditions were met and the shares underlying this stock option award became fully vested.

SEC source: 0001484612-23-000058 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 409,489

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $20.00-$20.54. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001484612-23-000058 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 429,489

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

SEC source: 0001484612-23-000053 · edgardoc.xml · derivative · entry 4

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,418

Underlying: Common Stock · 20,000 shares

Expires 2028-11-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F3 · derivative.exercise_date: In March 2021, following the expiration of the lock-up period in connection with our initial public offering, the applicable performance and market-based vesting conditions were met and the shares underlying this stock option award became fully vested.

SEC source: 0001484612-23-000053 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 409,489

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from: $20.00 - $20.99 - 13,150 shares; and $21.00 - $21.99 - 6,850 shares. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold within the range set forth in this footnote.

SEC source: 0001484612-23-000053 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 429,489

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

SEC source: 0001484612-23-000050 · edgardoc.xml · derivative · entry 4

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,418

Underlying: Common Stock · 20,000 shares

Expires 2028-11-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F3 · derivative.exercise_date: In March 2021, following the expiration of the lock-up period in connection with our initial public offering, the applicable performance and market-based vesting conditions were met and the shares underlying this stock option award became fully vested.

SEC source: 0001484612-23-000050 · edgardoc.xml · nonDerivative · entry 2

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 409,489

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from: $20.00 - $20.99 - 8,988 shares; $21.00 - $21.99 - 11,012 shares. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold within the range set forth in this footnote.

SEC source: 0001484612-23-000050 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 429,489

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

SEC source: 0001484612-23-000037 · edgardoc.xml · nonDerivative · entry 1

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 409,489

F1 · price: The sale price of the reporting person's shares represents the weighted average price of all shares sold by a broker on May 16, 2023 on behalf of a group of employees of the Issuer to satisfy the payment of withholding tax liability of such employees.

SEC source: 0001484612-23-000032 · edgardoc.xml · derivative · entry 10

Trigg Leslie · CIK 0001304125 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,418

Underlying: Common Stock · 9,492 shares

Expires 2028-11-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b51 Trading Plan adopted by the reporting person on February 23, 2023.

F4 · derivative.exercise_date: In March 2021, following the expiration of the lock-up period in connection with our initial public offering, the applicable performance and market-based vesting conditions were met and the shares underlying this stock option award became fully vested.