Raifeld Pavel

SEC source: 0001193125-26-363608 · ownership.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 284,799

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001193125-26-236910 · ownership.xml · nonDerivative · entry 2

Raifeld Pavel · CIK 0001813426 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,929

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001193125-26-236910 · ownership.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 287,059

F1 · shares: Includes 1,123 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 15, 2026.

SEC source: 0001193125-26-209009 · ownership.xml · derivative · entry 2

Raifeld Pavel · CIK 0001813426 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 312,500

Underlying: Common Stock · 312,500 shares

Expires 2036-05-03

F1 · derivative.exercise_date: The Reporting Person was conditionally granted time-vested restricted stock units ("RSUs") and non-statutory stock options ("Options"). The RSUs and Options were granted subject to stockholder approval of the Issuer's 2026 Equity Incentive Plan at the Issuer's 2026 annual meeting of stockholders on May 4, 2026, as disclosed in the Issuer's Schedule 14A filed with the Securities and Exchange Commission ("SEC") on March 24, 2026.

F2 · derivative.exercise_date: Twenty-five percent of each of the RSUs and Options vest on February 20, 2027 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) with respect to the Options, in the event of a "change in control" (as defined in the Issuer's 2026 Equity Incentive Plan) in which the options are not assumed or replaced, provided that the Reporting Person has not experienced a termination prior to such "change in control," or (ii) with respect to the Options and the RSUs, in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control" where such awards are assumed or substituted, subject to an effective release of claims.

SEC source: 0001193125-26-209009 · ownership.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,936

F1 · shares: The Reporting Person was conditionally granted time-vested restricted stock units ("RSUs") and non-statutory stock options ("Options"). The RSUs and Options were granted subject to stockholder approval of the Issuer's 2026 Equity Incentive Plan at the Issuer's 2026 annual meeting of stockholders on May 4, 2026, as disclosed in the Issuer's Schedule 14A filed with the Securities and Exchange Commission ("SEC") on March 24, 2026.

F2 · shares: Twenty-five percent of each of the RSUs and Options vest on February 20, 2027 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) with respect to the Options, in the event of a "change in control" (as defined in the Issuer's 2026 Equity Incentive Plan) in which the options are not assumed or replaced, provided that the Reporting Person has not experienced a termination prior to such "change in control," or (ii) with respect to the Options and the RSUs, in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control" where such awards are assumed or substituted, subject to an effective release of claims.

SEC source: 0001193125-26-067024 · ownership.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 159,290

F1 · balance_after: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-25-107234 · tm2530357-2_4seq1.xml · nonDerivative · entry 2

Raifeld Pavel · CIK 0001813426 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,276

F2 · balance_after: The Reporting Person was granted a time-vested restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU vest on November 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the RSU is not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001104659-25-107234 · tm2530357-2_4seq1.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,840

F1 · balance_after: Includes 1.860 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 15, 2025.

SEC source: 0000899140-25-000472 · form4.xml · derivative · entry 3

Raifeld Pavel · CIK 0001813426 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,068,750

Underlying: Common Stock · 243,750 shares

Expires 2035-03-13

F3 · derivative.exercise_date: Twenty-five percent of the options vest on February 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

F3 · balance_after: Twenty-five percent of the options vest on February 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0000899140-25-000472 · form4.xml · nonDerivative · entry 2

Raifeld Pavel · CIK 0001813426 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,980

F2 · balance_after: The Reporting Person was granted a time-vested restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU vest on February 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the RSU is not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001104659-24-031999 · tm248180-3_4seq1.xml · derivative · entry 4

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 825,000

Underlying: Common Stock · 150,000 shares

Expires 2034-03-05

F2 · derivative.exercise_date: 25% of the options will vest on February 20, 2025 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Mr. Raifeld's continuous service through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that Mr. Raifeld experiences a termination of employment by the Innoviva, Inc. without "cause" or by Mr. Raifeld for "good reason" (each as defined in Mr. Raifeld's employment agreement) within 24 months following a "change in control," subject to an effective release of claims.

SEC source: 0001104659-24-031999 · tm248180-3_4seq1.xml · derivative · entry 3

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 675,000

Underlying: Common Stock · 100,000 shares

Expires 2034-03-05

F2 · derivative.exercise_date: 25% of the options will vest on February 20, 2025 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Mr. Raifeld's continuous service through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that Mr. Raifeld experiences a termination of employment by the Innoviva, Inc. without "cause" or by Mr. Raifeld for "good reason" (each as defined in Mr. Raifeld's employment agreement) within 24 months following a "change in control," subject to an effective release of claims.

SEC source: 0001104659-24-031999 · tm248180-3_4seq1.xml · derivative · entry 2

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 575,000

Underlying: Common Stock · 75,000 shares

Expires 2034-03-05

F2 · derivative.exercise_date: 25% of the options will vest on February 20, 2025 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Mr. Raifeld's continuous service through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that Mr. Raifeld experiences a termination of employment by the Innoviva, Inc. without "cause" or by Mr. Raifeld for "good reason" (each as defined in Mr. Raifeld's employment agreement) within 24 months following a "change in control," subject to an effective release of claims.

SEC source: 0001567619-23-005055 · doc1.xml · nonDerivative · entry 1

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,799

F1 · shares: The price reported in Column 4 is a weighted average price. These shares were acquired in multiple transactions in the open market at prices ranging from $10.865 to $10.87, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote 1 to this Form 4.

F1 · price: The price reported in Column 4 is a weighted average price. These shares were acquired in multiple transactions in the open market at prices ranging from $10.865 to $10.87, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote 1 to this Form 4.

F2 · balance_after: Includes (1) 2,266 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 13, 2022, and (2) 3,000 shares of common stock acquired in multiple transactions in the open market on March 10, 2023, as described in greater detail in footnote 1 to this Form 4.

SEC source: 0001567619-22-009512 · doc1.xml · derivative · entry 2

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Stock · 150,000 shares

Expires 2032-05-01

F2 · derivative.exercise_date: 25% of the options will vest on May 20, 2023 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Mr. Raifeld's continuous service through the applicable vesting date, with accelerated vesting in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) or in the event that Mr. Raifeld experiences an "involuntary termination" (as defined in Mr. Raifeld's option agreement) within 24 months following a "change in control."

SEC source: 0001567619-21-011166 · doc1.xml · derivative · entry 2

Raifeld Pavel · CIK 0001813426 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 100,000 shares

Expires 2031-05-21

F2 · derivative.exercise_date: 25% of the options will vest on May 20, 2022 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Mr. Raifeld's continuous service through the applicable vesting date, with accelerated vesting in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) or in the event that Mr. Raifeld experiences an "involuntary termination" (as defined in Mr. Raifeld's option agreement) within 24 months following a "change in control."