RAGUSA ROBERT P

SEC source: 0001222644-26-000004 · form4-09032026_080949.xml · derivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,599

Underlying: Common Stock · 25,599 shares

Expires 2036-08-31

F2 · derivative.exercise_date: One-third of the shares subject to the option will vest on September 1, 2027 and the remainder of the shares subject to the grant will vest in equal monthly installments thereafter through September 1, 2029, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001222644-26-000004 · form4-09032026_080949.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,686

F1 · kind: Represents a restricted stock unit ("RSU") award. The RSUs vest in equal annual installments over 3 years measured from September 1, 2026, subject to the reporting person's continuous service as of each such vesting date.

SEC source: 0001628280-26-024550 · wk-form4_1775775497.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 518,582

F1 · price: Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001628280-26-016216 · wk-form4_1773106552.xml · nonDerivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 642,084

F1 · price: Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001628280-26-016216 · wk-form4_1773106552.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 642,342

F1 · price: Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001628280-26-016216 · wk-form4_1773106552.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 649,545

F1 · price: Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001628280-26-014311 · wk-form4_1772586949.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 650,525

F1 · price: Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001628280-26-014311 · wk-form4_1772586949.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 652,242

F1 · price: Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001214659-26-001343 · marketforms-72067.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,983

F1 · shares: 100% of the Shares subject to the Annual Equity Award will vest upon the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the first annual meeting of stockholders following the date of grant, provided that the Non-Employee Director is a Service Provider on each vesting date.

SEC source: 0001628280-25-055599 · wk-form4_1764969148.xml · nonDerivative · entry 4

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 688,029

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.89 to $97.79 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.

SEC source: 0001628280-25-055599 · wk-form4_1764969148.xml · nonDerivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 689,633

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.88 to $96.82 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.

SEC source: 0001628280-25-055599 · wk-form4_1764969148.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 697,866

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.79 to $95.7850 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.

SEC source: 0001628280-25-055599 · wk-form4_1764969148.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 713,222

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.78 to $94.7750 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.

F2 · balance_after: Includes 641 shares acquired under the Company's ESPP purchased on November 14, 2025.

SEC source: 0001628280-25-045269 · wk-form4_1760653079.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 727,388

F1 · price: Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001699031-25-000099 · wk-form4_1746492275.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 734,627

F1 · price: The price reported in Column 4 is a weighted average price calculated by the broker executing the sell-to-cover transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001699031-25-000066 · wk-form4a_1743713015.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 828,662

F1 · date: This amendment is filed to correct the date of the transaction reported in the original Form 4.

F2 · price: The price reported in Column 4 is a weighted average price calculated by the broker executing the sell-to-cover transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001699031-25-000059 · wk-form4_1741810047.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 828,662

F1 · price: The price reported in Column 4 is a weighted average price calculated by the broker executing the sell-to-cover transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001699031-25-000049 · wk-form4_1741296428.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 836,287

F1 · price: The price reported in Column 4 is a weighted average price calculated by the broker executing the sell-to-cover transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001214659-25-002231 · marketforms-68036.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,888

F1 · shares: 100% of the Shares subject to the Annual Equity Award will vest upon the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the first annual meeting of stockholders following the date of grant, provided that the Non-Employee Director is a Service Provider on each vesting date.

SEC source: 0001699031-25-000008 · wk-form4_1738707584.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 837,281

F1 · shares: Represents an award of 224,620 restricted stock units ("RSUs") which will vest in three substantially equal annual installments, beginning on February 28, 2026, subject to the awardee's continued service through such date. Each RSU represents the right to receive, at settlement, one share of common stock. The RSUs will be settled in common stock upon vesting.

SEC source: 0001628280-24-043069 · wk-form4_1729204370.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 612,661

F1 · price: The price reported in Column 4 is a weighted average price calculated by the broker executing the Sell-To-Cover transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

SEC source: 0001628280-24-042471 · wk-form4_1728347776.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 736,115

F2 · shares: Represents an award of 45,840 RSUs which will vest and become payable on October 3, 2026, subject to the awardee's continuing to be a service provider on such date.

SEC source: 0001628280-24-042471 · wk-form4_1728347776.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 690,275

F1 · shares: Represents an award of 214,240 restricted stock units ("RSUs") which will vest and become payable on April 3, 2026, subject to the awardee's continuing to be a service provider on such date. Each RSU represents the right to receive, at settlement, one share of common stock. The RSUs will be settled in common stock upon vesting.

SEC source: 0001628280-24-030869 · wk-form4_1719953574.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 476,035

F1 · date: On June 24, 2024, Illumina, Inc. (Illumina) completed a pro rata spin-off distribution (the Distribution) of 85.5% of the outstanding shares of the Issuer to the holders of record of Illumina common stock as of June 13, 2024 (the Record Date). In connection with the Distribution, pursuant to the terms of the Employee Matters Agreement, dated as of June 21, 2024, by and between Illumina and the Issuer (the EMA), all outstanding cash-based equity appreciation incentive awards held by the Reporting Person were equitably adjusted and converted into equity-based awards with respect to the common stock of the Issuer, with such equitable adjustments determined based on the value of the award at the time of the Distribution (determined in accordance with the EMA) compared to the market capitalization of the Issuer for the four trading days following the Distribution.

F2 · shares: Represents the grant of restricted stock units (RSUs) of the Issuer upon the conversion of cash-based equity appreciation incentive awards held by the Reporting Person as of the Distribution in connection with the Distribution, in accordance with the terms of the EMA. The RSUs were granted pursuant to the GRAIL, Inc. 2024 Incentive Award Plan in a manner intended to preserve the aggregate intrinsic value of the underlying cash-based equity appreciation incentive awards, on generally the same terms and conditions as applied to the cash-based equity appreciation incentive awards prior to the Distribution (including vesting and payment schedules).

F3 · shares: Includes (i) 242,974 RSUs that vest on October 14, 2024 (ii) 1,890 RSUs that vest on March 4, 2025, (iii) 14,006 RSUs that vest on March 6, 2025, (iv) 172,235 RSUs that vest on April 30, 2025, (v) 14,170 RSUs that vest on October 14, 2025 (vi) 1,891 RSUs that vest on March 4, 2026, (vii) 14,006 RSUs that vest on March 6, 2026 and (viii) 14,006 RSUs that vest on March 6, 2027. Each RSU represents the right to receive, at settlement upon vesting, one share of common stock.

F4 · balance_after: Includes 857 shares of the common stock of the Issuer received in connection with the Distribution in respect of Illumina common stock held as of the Record Date.

SEC source: 0001214659-24-002247 · marketforms-64641.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,416

F1 · shares: 100% of the Shares subject to the Annual Equity Award will vest upon the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the first annual meeting of stockholders following the date of grant, provided that the Non-Employee Director is a Service Provider on each vesting date.

SEC source: 0001214659-23-001882 · marketforms-59388.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,601

F1 · shares: 100% of the Shares subject to the Annual Equity Award will vest upon the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the first annual meeting of stockholders following the date of grant, provided that the Non-Employee Director is a Service Provider on each vesting date.

SEC source: 0001214659-22-002206 · marketforms-55362.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,389

F1 · shares: 100% of the Shares subject to the Annual Equity Award will vest upon the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the first annual meeting of stockholders following the date of grant, provided that the Non-Employee Director is a Service Provider on each vesting date.

SEC source: 0001214659-21-002803 · marketforms-51731.xml · derivative · entry 5

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,588 shares

Expires 2029-07-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 100% of the shares subject to the option vested and became exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-002803 · marketforms-51731.xml · nonDerivative · entry 4

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F3 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $133.61 to $134.47 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002803 · marketforms-51731.xml · nonDerivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,668

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $132.59 to $133.56 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002803 · marketforms-51731.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,187

F1 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $131.44 to $132.37 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002803 · marketforms-51731.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,486

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-21-006523 · form4.xml · derivative · entry 4

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,306 shares

Expires 2021-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Represents shares of stock awarded as a result of the Company achieving at least 100% of the applicable performance criteria pursuant to the reporting person's grant of performance share units on December 11, 2017.

F2 · shares: Represents shares of stock awarded as a result of the Company achieving at least 100% of the applicable performance criteria pursuant to the reporting person's grant of performance share units on December 11, 2017.

F2 · derivative.exercise_date: Represents shares of stock awarded as a result of the Company achieving at least 100% of the applicable performance criteria pursuant to the reporting person's grant of performance share units on December 11, 2017.

SEC source: 0001127602-21-006523 · form4.xml · nonDerivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,617

SEC source: 0001127602-21-006523 · form4.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,795

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: Represents shares of stock awarded as a result of the Company achieving at least 100% of the applicable performance criteria pursuant to the reporting person's grant of performance share units on December 11, 2017.

SEC source: 0001127602-21-006523 · form4.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,489

F1 · shares: Represents additional shares of stock awarded as a result of the Company achieving at least 111% of the applicable performance criteria pursuant to the reporting person's grant of performance share units on December 11, 2017.

SEC source: 0001127602-21-005285 · form4.xml · derivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,967

Underlying: Common Stock · 4,967 shares

Expires 2023-12-31

F3 · derivative.exercise_price: Each performance stock unit represents a contingent right to receive one share of common stock based on the Company's earnings per share for the fiscal year ending December 31, 2023. The number of shares issued will range from 0% to 175% of the amount specified above, based on the Company's actual earnings per share for the fiscal year ending December 31,2023, relative to pre-defined objectives, subject to awardee's continuing to be a service provider on such dates.

F3 · derivative.exercise_date: Each performance stock unit represents a contingent right to receive one share of common stock based on the Company's earnings per share for the fiscal year ending December 31, 2023. The number of shares issued will range from 0% to 175% of the amount specified above, based on the Company's actual earnings per share for the fiscal year ending December 31,2023, relative to pre-defined objectives, subject to awardee's continuing to be a service provider on such dates.

SEC source: 0001127602-21-005285 · form4.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,795

F1 · shares: Grant of restricted stock units shall vest as follows: 25% of the shares subject to the award shall vest on each of November 5, 2021, November 5, 2022, November 5, 2023, and November 5, 2024, subject to awardee's continuing status as a service provider on such dates.

F2 · balance_after: Balance includes 47 shares acquired through Employee Stock Purchase Plan.

SEC source: 0001214659-21-001432 · marketforms-51434.xml · derivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F3 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001432 · marketforms-51434.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 8

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,092

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 7

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,142

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F7 · price: Weighted average sale price representing 120 shares sold ranging from $318.39 to $319.37 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 6

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,262

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F6 · price: Weighted average sale price representing 834 shares sold ranging from $317.12 to $318.02 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 5

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,096

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F5 · price: Weighted average sale price representing 150 shares sold ranging from $315.28 to $316 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 4

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,246

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F4 · price: Weighted average sale price representing 580 shares sold ranging from $314.25 to $315.21 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,826

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 2

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,876

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F3 · price: Weighted average sale price representing 926 shares sold ranging from $312.01 to $312.85 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127602-20-030334 · form4.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,802

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F2 · price: Weighted average sale price representing 180 shares sold ranging from $311 to $311.99 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127602-20-028501 · form4.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,982

SEC source: 0001127602-20-024654 · form4.xml · nonDerivative · entry 5

RAGUSA ROBERT P · CIK 0001222644 · SVP, Global Quality & Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,103

F1 · shares: The sale was made pursuant to a 10b5-1 plan.

F7 · price: Weighted average sale price representing 633 shares sold ranging from $357.23 to $358.105 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request. Canc