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ALAM JOHN J

Disclosed activity across 2 companies

Tapewire entity
17122
SEC CIK
0001197014

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
CervoMed Inc.CRVO · Entity 7338Director · CEO & President · 10% ownerJune 08, 2026June 10, 2026
VERTEX PHARMACEUTICALS INC / MAVRTX · Entity 2875EVP, Med. Dev. Group & CMOOctober 01, 2008October 02, 2008

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

CervoMed Inc.

Report date June 08, 2026 · Filed June 10, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $2.91 · Expires 2036-06-08IndirectBy Spouse8,150 Reported balance After 2026-06-08 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-06-08 · Grant · Acquired 8,150 · Balance 8,150

F1: Consists of an option to purchase shares of common stock granted to Sylvie Gregoire, PharmD., the Reporting Person's spouse and a non-employee director of the Issuer. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

F2: The shares of common stock underlying the award will vest on a monthly basis over a one-year period in substantially equal 1/12th increments on the last day of each month beginning on June 30, 2026, subject to the Dr. Gregoire's continued service through the applicable vesting date.

Filing footnotes · ownership attribution and instrument terms

F1: Consists of an option to purchase shares of common stock granted to Sylvie Gregoire, PharmD., the Reporting Person's spouse and a non-employee director of the Issuer. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

F2: The shares of common stock underlying the award will vest on a monthly basis over a one-year period in substantially equal 1/12th increments on the last day of each month beginning on June 30, 2026, subject to the Dr. Gregoire's continued service through the applicable vesting date.

VERTEX PHARMACEUTICALS INC / MA

Report date October 01, 2008 · Filed October 02, 2008

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect136,792 Ending reported balance After 2008-10-01 transaction · row 2
2 source rows · reconciled sequence

Row 1 · 2008-10-01 · Exercise / conversion · Acquired 4,253 · Balance 141,045

Row 2 · 2008-10-01 · Sale · Disposed 4,253 · Balance 136,792

F1: Transaction for sales of common stock made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

F2: Open market sales reported on this line occurred at a weighted average price of $32.65 (range $32.30 to $33.08).

F3: Dr. Alam undertakes to provide (upon request by the SEC staff, the issuer or security holder of the issuer) full information regarding the number of shares sold at each separate price.

Stock OptionSEC Table II · derivative / convertible security · Conversion / exercise price $13.63 · Expires 2008-12-09Direct12,761 Reported balance After 2008-10-01 transaction · row 4 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 4 · 2008-10-01 · Exercise / conversion · Disposed 4,253 · Balance 12,761

F4: Fully vested.

Common StockSEC Table I · non-derivativeIndirect401(k)5,140 Reported balance Holding disclosure · report date 2008-10-01 · row 3 Holding and transaction disclosures are not merged.
1 source row

Row 3 · Balance 5,140

Filing footnotes · ownership attribution and instrument terms

F1: Transaction for sales of common stock made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

F2: Open market sales reported on this line occurred at a weighted average price of $32.65 (range $32.30 to $33.08).

F3: Dr. Alam undertakes to provide (upon request by the SEC staff, the issuer or security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4: Fully vested.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
January 03, 2007 Filed Jan 4, 2007 21:26 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 496,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:26 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 497,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:26 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 500 $37.61 $18,805.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:26 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,000 $37.12 $37,120.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:26 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:26 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 498,495

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 498,995

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 500 $37.56 $18,780.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,000 $37.56 $37,560.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 499,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 500 $37.78 $18,890.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,000 $37.78 $37,780.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 13, 2006 Filed Dec 14, 2006 15:36 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 480 $38.85 $18,648.00
Disclosure

SEC source: 0000875320-06-000118 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 14, 2006 15:36 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $38.54 $57,810.00
Disclosure

SEC source: 0000875320-06-000118 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,356

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 501,495

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 501,995

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 ;years from 9/26/1997.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 480 $38.85 $18,648.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $38.54 $57,810.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 06, 2006 Filed Dec 7, 2006 17:56 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 502,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 06, 2006 Filed Dec 7, 2006 17:56 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · derivative · entry 5

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 503,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
December 06, 2006 Filed Dec 7, 2006 17:56 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $44.69 $67,035.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 06, 2006 Filed Dec 7, 2006 17:56 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 06, 2006 Filed Dec 7, 2006 17:56 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 29, 2006 Filed Nov 30, 2006 20:01 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000104 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 504,495

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
November 29, 2006 Filed Nov 30, 2006 20:01 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000104 · edgar.xml · derivative · entry 5

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 504,995

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
November 29, 2006 Filed Nov 30, 2006 20:01 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $44.21 $66,315.00
Disclosure

SEC source: 0000875320-06-000104 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
November 29, 2006 Filed Nov 30, 2006 20:01 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000104 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 29, 2006 Filed Nov 30, 2006 20:01 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000104 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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November 22, 2006 Filed Nov 27, 2006 15:54 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,500 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000101 · edgar.xml · derivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 505,995

Underlying: Common Stock · 1,500 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

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November 22, 2006 Filed Nov 27, 2006 15:54 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $44.36 $66,540.00
Disclosure

SEC source: 0000875320-06-000101 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,563

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
November 22, 2006 Filed Nov 27, 2006 15:54 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,500 $18.47 $27,705.00
Disclosure

SEC source: 0000875320-06-000101 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,063

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 15, 2006 Filed Nov 16, 2006 21:23 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,500 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000097 · edgar.xml · derivative · entry 5

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 507,495

Underlying: Common Stock · 1,500 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
November 15, 2006 Filed Nov 16, 2006 21:23 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 707 $44.01 $31,115.07
Disclosure

SEC source: 0000875320-06-000097 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
November 15, 2006 Filed Nov 16, 2006 21:23 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $43.55 $65,325.00
Disclosure

SEC source: 0000875320-06-000097 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,563

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
November 15, 2006 Filed Nov 16, 2006 21:23 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,500 $18.47 $27,705.00
Disclosure

SEC source: 0000875320-06-000097 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,063

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 08, 2006 Filed Nov 9, 2006 19:09 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,500 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000092 · edgar.xml · derivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 508,995

Underlying: Common Stock · 1,500 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
November 08, 2006 Filed Nov 9, 2006 19:09 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,500 $41.49 $62,235.00
Disclosure

SEC source: 0000875320-06-000092 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
November 08, 2006 Filed Nov 9, 2006 19:09 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,500 $18.47 $27,705.00
Disclosure

SEC source: 0000875320-06-000092 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 01, 2006 Filed Nov 2, 2006 21:02 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 3,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000091 · edgar.xml · derivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 510,495

Underlying: Common Stock · 3,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
November 01, 2006 Filed Nov 2, 2006 21:02 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 3,000 $40.33 $120,990.00
Disclosure

SEC source: 0000875320-06-000091 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
November 01, 2006 Filed Nov 2, 2006 21:02 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 3,000 $18.47 $55,410.00
Disclosure

SEC source: 0000875320-06-000091 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 18, 2006 Filed Oct 19, 2006 17:49 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option · Derivative 1,500 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000086 · edgar.xml · derivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 513,495

Underlying: Common Stock · 1,500 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.