First Eagle Value in Biotechnology Master Fund, Ltd.

SEC source: 0001567619-19-013856 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 26,476,546

F1 · security: This Form 4 is filed by 21 April Fund, LP ("April LP"), 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April LP, April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · shares: Pursuant to a prospectus supplement, dated June 20, 2019, DURECT Corporation (the "Company") offered 29,000,000 shares of its common stock, par value $0.0001 per share (the "Common Stock") to certain investors of the Company. Pursuant to the terms that certain Securities Purchase Agreement, dated June 20, 2019, by and among the Company, April LP, April Ltd. and certain other persons, April LP and April Ltd purchased an aggregate of 4,000,000 shares of the Common Stock of the 29,000,000 made available in the offering at a price of $0.52 per share. The 4,000,000 shares of Common Stock represent 1,300,000 shares of Common Stock directly held by April LP and 2,700,000 shares of Common Stock directly held by April Ltd.

F3 · balance_after: Represents 4,726,893, 16,067,709, 5,586,944 and 95,000 shares of Common Stock held directly by 21 April LP, 21 April Ltd., FEVIBM and certain separately managed accounts, including accounts for which FEIM serves as registered investment adviser (the "Separately Managed Accounts"), respectively.

F4 · ownership.nature: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) the investment adviser to certain of the Separately Managed Accounts. FEHI disclaims beneficial ownership of the shares of Common Stock held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the beneficial owner of any such securities.

SEC source: 0001567619-19-009760 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,362,072

Underlying: Common Stock · 16,505 shares

Expires 2021-04-30

F1 · security: See Exhibit 99.1.

F4 · security: See Exhibit 99.1.

F5 · derivative.exercise_price: See Exhibit 99.1.

F7 · kind: See Exhibit 99.1.

F5 · shares: See Exhibit 99.1.

F7 · shares: See Exhibit 99.1.

F6 · derivative.exercise_date: See Exhibit 99.1.

F5 · derivative.underlying_shares: See Exhibit 99.1.

F5 · balance_after: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F3 · ownership.nature: See Exhibit 99.1.

SEC source: 0001567619-18-005067 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,276,076

Underlying: Common Stock · 27,076 shares

Expires 2021-04-30

F1 · security: See Exhibit 99.1.

F4 · security: See Exhibit 99.1.

F5 · derivative.exercise_price: See Exhibit 99.1.

F7 · kind: See Exhibit 99.1.

F5 · shares: See Exhibit 99.1.

F7 · shares: See Exhibit 99.1.

F7 · price: See Exhibit 99.1.

F6 · derivative.exercise_date: See Exhibit 99.1.

F5 · derivative.underlying_shares: See Exhibit 99.1.

F5 · balance_after: See Exhibit 99.1.

F2 · ownership.nature: See Exhibit 99.1.

F3 · ownership.nature: See Exhibit 99.1.

SEC source: 0001140361-18-021276 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,135,000

Underlying: Common Stock · 601,728 shares

Expires 2021-04-30

F1 · security: See Exhibit 99.1

F4 · security: See Exhibit 99.1

F5 · derivative.exercise_price: See Exhibit 99.1

F7 · kind: See Exhibit 99.1

F7 · shares: See Exhibit 99.1

F7 · price: See Exhibit 99.1

F6 · derivative.exercise_date: See Exhibit 99.1

F5 · derivative.underlying_shares: See Exhibit 99.1

F5 · balance_after: See Exhibit 99.1

F2 · ownership.nature: See Exhibit 99.1

F3 · ownership.nature: See Exhibit 99.1

SEC source: 0001140361-18-008694 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,396,477

F5 · ownership.nature: Represents 2,864,282, 299,662 and 1,232,533 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-008694 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,381,686

F4 · ownership.nature: Represents 2,851,236, 299,662 and 1,230,788 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-008694 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,375,186

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,845,503, 299,662 and 1,230,021 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006973 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,373,086

F4 · ownership.nature: Represents 2,843,651, 299,662 and 1,229,773 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006973 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,360,414

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,832,474, 299,662 and 1,228,278 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006264 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,337,814

F4 · ownership.nature: Represents 2,812,541, 299,662 and 1,225,611 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-006264 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,320,314

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,797,106, 299,662 and 1,223,546 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-005487 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,316,514

F5 · ownership.nature: Represents 2,793,754, 299,662 and 1,223,098 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-005487 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,270,680

F4 · ownership.nature: Represents 2,753,328, 299,662 and 1,217,690 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-005487 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,265,680

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,748,918, 299,662 and 1,217,100 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004930 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,230,182

F5 · ownership.nature: Represents 2,717,609, 299,662 and 1,212,911 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004930 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,219,882

F4 · ownership.nature: Represents 2,708,524, 299,662 and 1,211,696 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004372 · doc1.xml · nonDerivative · entry 5

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,184,274

F7 · price: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F7 · acquired: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F8 · ownership.nature: Represents 2,677,118, 299,662 and 1,207,494 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004826 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,210,186

F1 · security: This Form 4 is filed by 21 April Fund, LP ("April LP"), 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April LP, April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · price: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F2 · acquired: As of February 1, 2018, certain separately managed accounts terminated their relationship with, and are no longer advised by, FEIM. The positions held in such accounts are therefore no longer included herein.

F3 · ownership.nature: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) FEIM is investment adviser to certain of the Separately Managed Accounts. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004930 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,184,674

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,677,471, 299,662 and 1,207,541 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004372 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,477,920

F6 · ownership.nature: Represents 2,677,118, 299,662 and 1,501,140 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004372 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,435,920

F5 · ownership.nature: Represents 2,640,074, 299,662 and 1,496,184 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004372 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,416,435

F4 · ownership.nature: Represents 2,622,888, 299,662 and 1,493,885 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-18-004372 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,403,035

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,611,069, 299,662 and 1,492,304 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-019221 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,389,737

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F7 · ownership.nature: Represents 2,599,340, 299,662 and 1,490,735 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-019221 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,408,812

F6 · ownership.nature: Represents 2,599,340, 299,662 and 1,509,810 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-019221 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,422,317

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F5 · ownership.nature: Represents 2,599,340, 313,167 and 1,509,810 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-019221 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,442,794

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,599,340, 313,167 and 1,530,287 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-018386 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,457,291

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F7 · ownership.nature: Represents 2,599,340, 327,664 and 1,530,287 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-018386 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,460,628

F6 · ownership.nature: Represents 2,599,340, 327,664 and 1,533,624 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-018386 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,462,991

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F5 · ownership.nature: Represents 2,599,340, 330,027 and 1,533,624 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-018386 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,481,426

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,599,340, 330,027 and 1,552,059 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017790 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,494,478

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F7 · ownership.nature: Represents 2,599,340, 343,079 and 1,552,059 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017790 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,512,119

F6 · ownership.nature: Represents 2,599,340, 343,079 and 1,569,700 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017790 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,524,609

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F5 · ownership.nature: Represents 2,599,340, 355,569 and 1,569,700 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017790 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,526,424

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,599,340, 355,569 and 1,571,515 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017253 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,527,709

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F7 · ownership.nature: Represents 2,599,340, 356,854 and 1,571,515 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017253 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,558,847

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F6 · ownership.nature: Represents 2,599,340, 356,854 and 1,602,653 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017253 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,580,894

F4 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F5 · ownership.nature: Represents 2,599,340, 378,901 and 1,602,653 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-017253 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,618,148

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,599,340, 378,901 and 1,639,907 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-016840 · doc1.xml · nonDerivative · entry 6

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,644,524

F7 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F9 · ownership.nature: Represents 2,599,340, 405,277 and 1,639,907 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-016840 · doc1.xml · nonDerivative · entry 5

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,783,141

F7 · shares: These shares are indirectly beneficially owned by certain Separately Managed Accounts.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F8 · ownership.nature: Represents 2,599,340, 405,277 and 1,778,524 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-016840 · doc1.xml · nonDerivative · entry 4

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,788,996

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F6 · ownership.nature: Represents 2,599,340, 405,277 and 1,784,379 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-016840 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,887,139

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F5 · ownership.nature: Represents 2,599,340, 503,420 and 1,784,379 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-016840 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,891,284

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F4 · ownership.nature: Represents 2,599,340, 507,565 and 1,784,379 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-17-016840 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,901,284

F1 · security: This Form 4 is filed by 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) the registered investment adviser to FEVIBM as well as to April Ltd. (collectively, the "Funds"), (ii) a subsidiary of FEHI and (iii) investment adviser to certain separately managed accounts which, together with certain separate accounts managed by Michael M. Kellen in his individual capacity holding shares reported by FEIM for which FEIM disclaims beneficial ownership are defined herein as the "Separately Managed Accounts". FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F3 · ownership.nature: Represents 2,599,340, 517,565 and 1,784,379 shares held directly by 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-16-088916 · doc1.xml · derivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 259,117

Underlying: Common Stock · 259,117 shares

Expires 2021-07-14

F1 · security: See Exhibit 99.1.

F2 · derivative.exercise_price: See Exhibit 99.1.

F3 · shares: See Exhibit 99.1.

F2 · price: See Exhibit 99.1.

F4 · derivative.exercise_date: See Exhibit 99.1.

F3 · derivative.underlying_shares: See Exhibit 99.1.

F3 · balance_after: See Exhibit 99.1.

F5 · ownership.nature: See Exhibit 99.1.

F6 · ownership.nature: See Exhibit 99.1.

SEC source: 0001140361-16-084885 · doc1.xml · nonDerivative · entry 3

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 22,476,546

F2 · shares: These shares are indirectly beneficially owned by certain separately managed accounts, including accounts for which FEIM serves as registered investment adviser (the "Separately Managed Accounts").

F3 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) FEIM is investment adviser to certain of the Separately Managed Accounts. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F6 · ownership.nature: Represents 3,426,893, 13,367,709, 5,586,944 and 95,000 shares held directly by 21 April LP, 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-16-084885 · doc1.xml · nonDerivative · entry 2

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 22,456,546

F2 · shares: These shares are indirectly beneficially owned by certain separately managed accounts, including accounts for which FEIM serves as registered investment adviser (the "Separately Managed Accounts").

F3 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) FEIM is investment adviser to certain of the Separately Managed Accounts. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F5 · ownership.nature: Represents 3,426,893, 13,367,709, 5,586,944 and 75,000 shares held directly by 21 April LP, 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-16-084885 · doc1.xml · nonDerivative · entry 1

First Eagle Investment Management, LLC · CIK 0001325447 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 22,431,546

F1 · security: This Form 4 is filed by 21 April Fund, LP ("April LP"), 21 April Ltd. ("April Ltd."), First Eagle Investment Management, LLC ("FEIM"), First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM") and First Eagle Holdings, Inc. ("FEHI" and, collectively with April LP, April Ltd., FEIM and FEVIBM, the "Entities"). The Entities disclaim status as a "group" for purposes of this Form 4.

F2 · shares: These shares are indirectly beneficially owned by certain separately managed accounts, including accounts for which FEIM serves as registered investment adviser (the "Separately Managed Accounts").

F3 · balance_after: The shares of Common Stock reported herein are indirectly beneficially owned by FEHI and FEIM, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940. FEIM is (i) a general partner of April LP, (ii) the registered investment adviser to FEVIBM as well as to April LP and April Ltd. (collectively, the "Funds"), (iii) a subsidiary of FEHI and (iv) FEIM is investment adviser to certain of the Separately Managed Accounts. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F4 · ownership.nature: Represents 3,426,893, 13,367,709, 5,586,944 and 50,000 shares held directly by 21 April LP, 21 April Ltd., FEVIBM and the Separately Managed Accounts, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

SEC source: 0001140361-16-080886 · doc1.xml · nonDerivative · entry 3

21 APRIL FUND, LTD. · CIK 0001459708 · 10% owner

21 APRIL FUND, L.P. · CIK 0001459688 · 10% owner

First Eagle Value in Biotechnology Master Fund, Ltd. · CIK 0001457518 · 10% owner

First Eagle Holdings, Inc. · CIK 0001637141 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,381,546

F5 · shares: Represents 40,809 and 159,191 shares purchased by 21 April LP and 21 April Ltd., respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.

F6 · ownership.direct: Represents 3,426,893, 13,367,709, and 5,586,944 shares held directly by 21 April LP, 21 April Ltd. and FEVIBM, respectively. FEHI disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that FEHI is the Section 16 beneficial owner of any such securities.