organization · Reporting owner

Opaleye Management Inc.

Disclosed activity across 11 companies

Tapewire entity: 1559
SEC CIK: 0001595855

Reported relationships

Latest disclosed role at each company.

Company	Last reported as	Report date	Published
Alpha Cognition Inc.ACOG · Entity 6339	10% owner	October 01, 2026	October 03, 2026
CODEXIS, INC.CDXS · Entity 6428	10% owner	November 26, 2025	December 15, 2025
Grace Therapeutics, Inc.GRCE · Entity 7266	10% owner	October 08, 2026	October 13, 2026
HARROW, INC.HROW · Entity 4740	10% owner	March 03, 2026	March 05, 2026
Protara Therapeutics, Inc.TARA · Entity 6203	10% owner	September 11, 2024	September 13, 2024
Sol-Gel Technologies Ltd.SLGL · Entity 1558	10% owner	September 10, 2026	September 14, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Alpha Cognition Inc.

Report date October 01, 2026 · Filed October 03, 2026

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, no par valueSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	3,222,954	Reported balance After 2026-10-01 transaction · row 1 Account identity is unresolved; indirect or unspecified ownership is not merged. 1 source row Row 1 · 2026-10-01 · Purchase · Acquired 19,050 · Balance 3,222,954 F3: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.645 to $8.70. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, no par valueSEC Table I · non-derivative	IndirectBy Managed Account	100,000	Reported balance Holding disclosure · report date 2026-10-01 · row 2 Holding and transaction disclosures are not merged. 1 source row Row 2 · Balance 100,000 F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. F4: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.645 to $8.70. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F4: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

CODEXIS, INC.

Report date November 26, 2025 · Filed December 15, 2025 · Amendment

Amendment: balances below belong to this corrected disclosure, not necessarily a complete replacement of earlier positions.

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	10,305,000	Reported balance After 2025-11-26 transaction · row 1 Amendment: may correct only part of an earlier disclosure. 1 source row Row 1 · 2025-11-26 · Sale · Disposed 148,318 · Balance 10,305,000 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.7316 - $1.75699 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	10,200,000	Reported balance After 2025-11-28 transaction · row 3 Amendment: may correct only part of an earlier disclosure. 1 source row Row 3 · 2025-11-28 · Sale · Disposed 105,000 · Balance 10,200,000 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.73 - $1.7715 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	9,955,000	Reported balance After 2025-12-01 transaction · row 5 Amendment: may correct only part of an earlier disclosure. 1 source row Row 5 · 2025-12-01 · Sale · Disposed 245,000 · Balance 9,955,000 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.65 - $1.7101 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	191,012	Reported balance After 2025-11-26 transaction · row 2 Amendment: may correct only part of an earlier disclosure. 1 source row Row 2 · 2025-11-26 · Sale · Disposed 5,000 · Balance 191,012 F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.7316 - $1.75699 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	188,522	Reported balance After 2025-11-28 transaction · row 4 Amendment: may correct only part of an earlier disclosure. 1 source row Row 4 · 2025-11-28 · Sale · Disposed 2,490 · Balance 188,522 F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.73 - $1.7715 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	179,989	Reported balance After 2025-12-01 transaction · row 6 Amendment: may correct only part of an earlier disclosure. 1 source row Row 6 · 2025-12-01 · Sale · Disposed 8,533 · Balance 179,989 F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F5: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.65 - $1.7101 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.7316 - $1.75699 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.73 - $1.7715 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F5: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.65 - $1.7101 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Grace Therapeutics, Inc.

Report date October 08, 2026 · Filed October 13, 2026

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.0001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	2,873,289	Last balance in matching sequence After 2026-10-12 transaction · row 3 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 3 source rows Row 1 · 2026-10-08 · Purchase · Acquired 2,077 · Balance 2,860,734 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 2 · 2026-10-09 · Purchase · Acquired 5,340 · Balance 2,866,074 F2: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.05. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 3 · 2026-10-12 · Purchase · Acquired 7,215 · Balance 2,873,289 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.05. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

HARROW, INC.

Report date March 03, 2026 · Filed March 05, 2026

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	3,622,000	Last balance in matching sequence After 2026-03-04 transaction · row 3 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 1 · 2026-03-03 · Sale · Disposed 59,000 · Balance 3,756,000 F3: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.50 to $40.66. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 3 · 2026-03-04 · Sale · Disposed 134,000 · Balance 3,622,000 F4: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.12 to $40.50. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	59,428	Last balance in matching sequence After 2026-03-04 transaction · row 4 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 2 · 2026-03-03 · Sale · Disposed 1,309 · Balance 63,691 F3: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.50 to $40.66. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 4 · 2026-03-04 · Sale · Disposed 4,263 · Balance 59,428 F4: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.12 to $40.50. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F3: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.50 to $40.66. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range.

F4: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.12 to $40.50. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range.

F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Protara Therapeutics, Inc.

Report date September 11, 2024 · Filed September 13, 2024

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	1,944,134	Last balance in matching sequence After 2024-09-12 transaction · row 3 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 1 · 2024-09-11 · Sale · Disposed 31,000 · Balance 2,063,935 F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70-$1.74 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. Row 3 · 2024-09-12 · Sale · Disposed 119,801 · Balance 1,944,134 F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70-$1.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed account	45,000	Last balance in matching sequence After 2024-09-12 transaction · row 4 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 2 · 2024-09-11 · Sale · Disposed 1,600 · Balance 51,500 F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70-$1.74 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. Row 4 · 2024-09-12 · Sale · Disposed 6,500 · Balance 45,000 F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70-$1.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

Filing footnotes · ownership attribution and instrument terms

F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70-$1.74 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70-$1.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

Sol-Gel Technologies Ltd.

Report date September 10, 2026 · Filed September 14, 2026

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Ordinary Shares, par value NIS 1.00 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	540,000	Last balance in matching sequence After 2026-09-11 transaction · row 2 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 1 · 2026-09-10 · Purchase · Acquired 1,631 · Balance 538,507 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 2 · 2026-09-11 · Purchase · Acquired 1,493 · Balance 540,000 F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Ordinary Shares, par value NIS 1.00 per shareSEC Table I · non-derivative	IndirectBy Managed Account	15,000	Reported balance Holding disclosure · report date 2026-09-10 · row 3 Holding and transaction disclosures are not merged. 1 source row Row 3 · Balance 15,000 F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. F3: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.

Past disclosures · reporting ended (5)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

Eton Pharmaceuticals, Inc.

Report date July 14, 2026 · Filed July 17, 2026 · Amendment

Section 16 reporting ended · disclosed 2026-07-17. Current position is not established by this disclosure.

Amendment: balances below belong to this corrected disclosure, not necessarily a complete replacement of earlier positions.

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	2,665,000	Reported balance After 2026-07-14 transaction · row 1 Amendment: may correct only part of an earlier disclosure. 1 source row Row 1 · 2026-07-14 · Sale · Disposed 15,000 · Balance 2,665,000 F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	40,000	Reported balance After 2026-07-14 transaction · row 2 Amendment: may correct only part of an earlier disclosure. 1 source row Row 2 · 2026-07-14 · Sale · Disposed 13,315 · Balance 40,000 F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. F4: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F4: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

OCULAR THERAPEUTIX, INC

Report date April 03, 2020 · Filed April 03, 2020

Section 16 reporting ended · disclosed 2020-04-03. Current position is not established by this disclosure.

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.0001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	4,915,000	Reported balance Holding disclosure · report date 2020-04-03 · row 1 Holding and transaction disclosures are not merged. 1 source row Row 1 · Balance 4,915,000 F1: No transactions are being reported in connection with this Form 4. The stock ownership listed was previously reported on a Form 3, Form 4 and Schedule 13G/A filed with the SEC. Based on the total number of shares of common stock reported issued and outstanding by the Issuer in its annual report on Form 10-K, filed with the SEC on March 12, 2020, the Reporting Person no longer owns in excess of 10% of the Issuer's common stock, and this Form 4 is being filed solely to reflect that the Reporting Person is no longer subject to Section 16 reporting obligations in connection with its holdings of the Issuer. F2: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. ("Opaleye") may be deemed to beneficially own the securities owned directly by the Fund.
Common Stock, par value $0.0001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	207,500	Reported balance Holding disclosure · report date 2020-04-03 · row 2 Holding and transaction disclosures are not merged. 1 source row Row 2 · Balance 207,500 F1: No transactions are being reported in connection with this Form 4. The stock ownership listed was previously reported on a Form 3, Form 4 and Schedule 13G/A filed with the SEC. Based on the total number of shares of common stock reported issued and outstanding by the Issuer in its annual report on Form 10-K, filed with the SEC on March 12, 2020, the Reporting Person no longer owns in excess of 10% of the Issuer's common stock, and this Form 4 is being filed solely to reflect that the Reporting Person is no longer subject to Section 16 reporting obligations in connection with its holdings of the Issuer. F3: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.
American-style call optionSEC Table II · derivative / convertible security · Conversion / exercise price $7.50 · Expires 2020-06-19	IndirectBy Opaleye, L.P.	1,000	Reported balance Holding disclosure · report date 2020-04-03 · row 3 Instrument identity requires review; Table II rows are not merged. 1 source row Row 3 · Balance 1,000 F1: No transactions are being reported in connection with this Form 4. The stock ownership listed was previously reported on a Form 3, Form 4 and Schedule 13G/A filed with the SEC. Based on the total number of shares of common stock reported issued and outstanding by the Issuer in its annual report on Form 10-K, filed with the SEC on March 12, 2020, the Reporting Person no longer owns in excess of 10% of the Issuer's common stock, and this Form 4 is being filed solely to reflect that the Reporting Person is no longer subject to Section 16 reporting obligations in connection with its holdings of the Issuer. F2: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. ("Opaleye") may be deemed to beneficially own the securities owned directly by the Fund.

Filing footnotes · ownership attribution and instrument terms

F1: No transactions are being reported in connection with this Form 4. The stock ownership listed was previously reported on a Form 3, Form 4 and Schedule 13G/A filed with the SEC. Based on the total number of shares of common stock reported issued and outstanding by the Issuer in its annual report on Form 10-K, filed with the SEC on March 12, 2020, the Reporting Person no longer owns in excess of 10% of the Issuer's common stock, and this Form 4 is being filed solely to reflect that the Reporting Person is no longer subject to Section 16 reporting obligations in connection with its holdings of the Issuer.

F2: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. ("Opaleye") may be deemed to beneficially own the securities owned directly by the Fund.

F3: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SANUWAVE Health, Inc.

Report date April 30, 2026 · Filed May 04, 2026

Section 16 reporting ended · disclosed 2026-05-04. Current position is not established by this disclosure.

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	853,569	Last balance in matching sequence After 2026-05-01 transaction · row 3 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 1 · 2026-04-30 · Sale · Disposed 24,000 · Balance 863,650 F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.10-$16.775 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 3 · 2026-05-01 · Sale · Disposed 10,081 · Balance 853,569 F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00-$16.28 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed account	5,000	Last balance in matching sequence After 2026-05-01 transaction · row 4 Source-order balances reconcile. Account continuity and personal attribution are not independently verified. 2 source rows Row 2 · 2026-04-30 · Sale · Disposed 1,000 · Balance 5,500 F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.10-$16.775 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Row 4 · 2026-05-01 · Sale · Disposed 500 · Balance 5,000 F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00-$16.28 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F5: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Filing footnotes · ownership attribution and instrument terms

F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.10-$16.775 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00-$16.28 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

TELA Bio, Inc.

Report date April 20, 2023 · Filed April 20, 2023

Section 16 reporting ended · disclosed 2023-04-20. Current position is not established by this disclosure.

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed Account	124,813	Reported balance Holding disclosure · report date 2023-04-20 · row 1 Holding and transaction disclosures are not merged. 1 source row Row 1 · Balance 124,813 F1: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to own the securities owned directly by the Managed Account.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	1,948,000	Reported balance Holding disclosure · report date 2023-04-20 · row 2 Holding and transaction disclosures are not merged. 1 source row Row 2 · Balance 1,948,000 F2: Represents securities directly owned by Opaleye, L.P. ("the fund"). As the investment manager of the Fund, Opaleye Management may be deemed to own the securities owned directly by the Fund.

Filing footnotes · ownership attribution and instrument terms

F1: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to own the securities owned directly by the Managed Account.

F2: Represents securities directly owned by Opaleye, L.P. ("the fund"). As the investment manager of the Fund, Opaleye Management may be deemed to own the securities owned directly by the Fund.

Tracon Pharmaceuticals, Inc.

Report date November 10, 2023 · Filed November 14, 2023

Section 16 reporting ended · disclosed 2023-11-14. Current position is not established by this disclosure.

Security / award	Ownership account	Disclosed shares / units	Disclosure context
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Opaleye, L.P.	0	Reported balance After 2023-11-10 transaction · row 1 Account identity is unresolved; indirect or unspecified ownership is not merged. 1 source row Row 1 · 2023-11-10 · Sale · Disposed 4,324,008 · Balance 0 F3: This transaction was executed in multiple trades at prices ranging from $0.21 to $0.375; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased. F1: Represents securities owned directly by Opaleye, L.P. (The "Fund"). As the investment manager of the Fund.
Common Stock, par value $0.001 per shareSEC Table I · non-derivative	IndirectBy Managed account	0	Reported balance After 2023-11-10 transaction · row 2 Account identity is unresolved; indirect or unspecified ownership is not merged. 1 source row Row 2 · 2023-11-10 · Sale · Disposed 440,000 · Balance 0 F3: This transaction was executed in multiple trades at prices ranging from $0.21 to $0.375; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased. F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to own the securities owned directly by the Managed Account beneficially.
Prefunded WarrantsSEC Table II · derivative / convertible security · Conversion / exercise price $0.01 · Expires 2030-08-27	IndirectBy Opaleye,L.P.	1,667,974	Reported balance Holding disclosure · report date 2023-11-10 · row 3 Instrument identity requires review; Table II rows are not merged. 1 source row Row 3 · Balance 1,667,974 F4: The warrants may not be exercised to the extent that such exercise would cause the reporting person and its affiliates to beneficially own more than 19.99% of the Issuer's then outstanding common stock. F1: Represents securities owned directly by Opaleye, L.P. (The "Fund"). As the investment manager of the Fund.
Prefunded WarrantsSEC Table II · derivative / convertible security · Conversion / exercise price $0.01 · Expires 2030-08-31	IndirectBy Opaleye,L.P.	1,358,993	Reported balance Holding disclosure · report date 2023-11-10 · row 4 Instrument identity requires review; Table II rows are not merged. 1 source row Row 4 · Balance 1,358,993 F4: The warrants may not be exercised to the extent that such exercise would cause the reporting person and its affiliates to beneficially own more than 19.99% of the Issuer's then outstanding common stock. F1: Represents securities owned directly by Opaleye, L.P. (The "Fund"). As the investment manager of the Fund.
Prefunded WarrantsSEC Table II · derivative / convertible security · Conversion / exercise price $0.01 · Expires 2032-06-21	IndirectBy Opaleye, L.P.	2,205,018	Reported balance Holding disclosure · report date 2023-11-10 · row 5 Instrument identity requires review; Table II rows are not merged. 1 source row Row 5 · Balance 2,205,018 F4: The warrants may not be exercised to the extent that such exercise would cause the reporting person and its affiliates to beneficially own more than 19.99% of the Issuer's then outstanding common stock. F1: Represents securities owned directly by Opaleye, L.P. (The "Fund"). As the investment manager of the Fund.
Prefunded WarrantsSEC Table II · derivative / convertible security · Conversion / exercise price $0.01 · Expires 2033-03-09	IndirectBy Opaleye, L.P.	2,013,999	Reported balance Holding disclosure · report date 2023-11-10 · row 6 Instrument identity requires review; Table II rows are not merged. 1 source row Row 6 · Balance 2,013,999 F4: The warrants may not be exercised to the extent that such exercise would cause the reporting person and its affiliates to beneficially own more than 19.99% of the Issuer's then outstanding common stock. F1: Represents securities owned directly by Opaleye, L.P. (The "Fund"). As the investment manager of the Fund.

Filing footnotes · ownership attribution and instrument terms

F1: Represents securities owned directly by Opaleye, L.P. (The "Fund"). As the investment manager of the Fund.

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to own the securities owned directly by the Managed Account beneficially.

F3: This transaction was executed in multiple trades at prices ranging from $0.21 to $0.375; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F4: The warrants may not be exercised to the extent that such exercise would cause the reporting person and its affiliates to beneficially own more than 19.99% of the Issuer's then outstanding common stock.

Transaction history

JSON API

Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction date	Company	Activity / security	Shares / units	Reported price	Reported value	Details
October 12, 2026 Filed Oct 13, 2026 21:45 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	7,215	$2.02	$14,574.30	Disclosure SEC source: 0001493152-26-046899 · ownership.xml · nonDerivative · entry 3 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,873,289 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
October 09, 2026 Filed Oct 13, 2026 21:45 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	5,340	$2.04	$10,918.16	Disclosure SEC source: 0001493152-26-046899 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,866,074 F2 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.05. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
October 08, 2026 Filed Oct 13, 2026 21:45 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	2,077	$2.02	$4,190.35	Disclosure SEC source: 0001493152-26-046899 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,860,734 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
October 05, 2026 Filed Oct 5, 2026 22:46 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	1,694	$2.06	$3,489.64	Disclosure SEC source: 0001493152-26-045809 · ownership.xml · nonDerivative · entry 3 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,858,657 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
October 02, 2026 Filed Oct 5, 2026 22:46 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	20,000	$2.07	$41,368.00	Disclosure SEC source: 0001493152-26-045809 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,856,963 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.07. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
October 01, 2026 Filed Oct 3, 2026 00:05 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	19,050	$8.69	$165,634.04	Disclosure SEC source: 0001493152-26-045511 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,222,954 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.645 to $8.70. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
October 01, 2026 Filed Oct 5, 2026 22:46 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	38,796	$2.04	$78,961.50	Disclosure SEC source: 0001493152-26-045809 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,836,963 F2 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.00 to $2.04. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 29, 2026 Filed Oct 2, 2026 00:30 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	7,849	$2.09	$16,404.41	Disclosure SEC source: 0001493152-26-045358 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,798,167 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F2 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 25, 2026 Filed Sep 28, 2026 23:57 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	13,426	$8.47	$113,718.22	Disclosure SEC source: 0001493152-26-044690 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,203,904 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 24, 2026 Filed Sep 28, 2026 23:57 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	18,337	$8.57	$157,082.08	Disclosure SEC source: 0001493152-26-044690 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,190,478 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.52 to $8.57. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 23, 2026 Filed Oct 2, 2026 00:05 UTC Amendment	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	5,318	$2.10	$11,167.80	Disclosure SEC source: 0001493152-26-045347 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,790,318 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F2 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 23, 2026 Filed Sep 23, 2026 22:19 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	5,318	$2.10	$11,167.80	Disclosure SEC source: 0001493152-26-043996 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,855,318 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F2 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 21, 2026 Filed Oct 2, 2026 00:05 UTC Amendment	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	9,771	$2.10	$20,519.10	Disclosure SEC source: 0001493152-26-045347 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,785,000 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F2 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 21, 2026 Filed Sep 23, 2026 22:19 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	9,771	$2.10	$20,519.10	Disclosure SEC source: 0001493152-26-043996 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,850,000 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F2 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 16, 2026 Filed Sep 16, 2026 21:57 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	27,141	$8.40	$227,984.40	Disclosure SEC source: 0001493152-26-042969 · ownership.xml · nonDerivative · entry 4 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,172,141 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F6 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 16, 2026 Filed Sep 16, 2026 21:57 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	53,029	$8.57	$454,607.01	Disclosure SEC source: 0001493152-26-042969 · ownership.xml · nonDerivative · entry 3 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,145,000 F5 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.46 to $8.70. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F6 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 15, 2026 Filed Sep 16, 2026 21:57 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	3,375	$8.54	$28,830.60	Disclosure SEC source: 0001493152-26-042969 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,091,971 F4 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.53 to $8.57. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F6 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 14, 2026 Filed Sep 16, 2026 21:57 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	40,373	$8.70	$351,083.61	Disclosure SEC source: 0001493152-26-042969 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,088,596 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.664 to $8.72. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F6 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 11, 2026 Filed Sep 14, 2026 21:23 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	1,493	$65.95	$98,455.89	Disclosure SEC source: 0001493152-26-042615 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 540,000 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 10, 2026 Filed Sep 14, 2026 21:23 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	1,631	$66.80	$108,942.65	Disclosure SEC source: 0001493152-26-042615 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 538,507 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 09, 2026 Filed Sep 10, 2026 20:05 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	5,836	$2.09	$12,196.66	Disclosure SEC source: 0001493152-26-042152 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,775,229 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.085 to $2.09. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 09, 2026 Filed Sep 9, 2026 23:18 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	3,097	$68.71	$212,779.39	Disclosure SEC source: 0001493152-26-042023 · ownership.xml · nonDerivative · entry 5 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 536,876 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 08, 2026 Filed Sep 10, 2026 20:05 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	9,393	$2.10	$19,699.00	Disclosure SEC source: 0001493152-26-042152 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,769,393 F2 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.095 to $2.10. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 08, 2026 Filed Sep 9, 2026 23:18 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	471	$69.37	$32,673.27	Disclosure SEC source: 0001493152-26-042023 · ownership.xml · nonDerivative · entry 4 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 533,779 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 08, 2026 Filed Sep 9, 2026 23:18 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	3,390	$68.74	$233,029.62	Disclosure SEC source: 0001493152-26-042023 · ownership.xml · nonDerivative · entry 3 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 533,308 F3 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.50-$68.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 04, 2026 Filed Sep 9, 2026 23:18 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	2,100	$68.98	$144,858.00	Disclosure SEC source: 0001493152-26-042023 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 529,918 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 04, 2026 Filed Sep 9, 2026 23:18 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	918	$69.52	$63,819.36	Disclosure SEC source: 0001493152-26-042023 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 527,818 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.42-$68.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Read SEC document
September 02, 2026 Filed Sep 3, 2026 20:05 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	900	$68.95	$62,054.01	Disclosure SEC source: 0001493152-26-041363 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 526,900 F3 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.94-$68.95 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
September 01, 2026 Filed Sep 3, 2026 20:05 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	783	$69.52	$54,434.16	Disclosure SEC source: 0001493152-26-041363 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 526,000 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 31, 2026 Filed Aug 31, 2026 22:24 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	217	$69.10	$14,994.70	Disclosure SEC source: 0001493152-26-040895 · ownership.xml · nonDerivative · entry 5 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 525,217 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 31, 2026 Filed Aug 31, 2026 22:24 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	5,000	$68.24	$341,175.00	Disclosure SEC source: 0001493152-26-040895 · ownership.xml · nonDerivative · entry 4 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 525,000 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 28, 2026 Filed Aug 31, 2026 22:24 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	5,000	$68.81	$344,050.00	Disclosure SEC source: 0001493152-26-040895 · ownership.xml · nonDerivative · entry 3 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 520,000 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 28, 2026 Filed Aug 31, 2026 22:24 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	20,113	$68.42	$1,376,137.49	Disclosure SEC source: 0001493152-26-040895 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 515,000 F4 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $66.15-$69.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 28, 2026 Filed Aug 31, 2026 22:24 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	10,000	$71.40	$713,969.00	Disclosure SEC source: 0001493152-26-040895 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 494,887 F3 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $69.145-$74.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 14, 2026 Filed Aug 19, 2026 11:44 UTC	Grace Therapeutics, Inc. GRCE · Entity 7266	PurchaseCommon Stock, par value $0.0001 per share	11,608	$2.09	$24,206.16	Disclosure SEC source: 0001493152-26-039124 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,760,000 F2 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.05 to $2.09. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 12, 2026 Filed Aug 14, 2026 20:05 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	951	$71.50	$67,996.50	Disclosure SEC source: 0001493152-26-038304 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 494,887 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
August 03, 2026 Filed Aug 4, 2026 20:50 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	50,000	$8.00	$400,000.00	Disclosure SEC source: 0001493152-26-036015 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 3,048,223 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 31, 2026 Filed Aug 4, 2026 20:50 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	2,900	$7.92	$22,975.54	Disclosure SEC source: 0001493152-26-036015 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,998,223 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.855 to $7.95. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 24, 2026 Filed Jul 28, 2026 20:05 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	130	$7.90	$1,027.00	Disclosure SEC source: 0001493152-26-035000 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,995,323 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F3 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 23, 2026 Filed Jul 24, 2026 20:05 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	49,849	$7.80	$388,587.91	Disclosure SEC source: 0001493152-26-034560 · ownership.xml · nonDerivative · entry 3 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,995,193 F4 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.655 to $7.8667. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 22, 2026 Filed Jul 24, 2026 20:05 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	10,000	$7.83	$78,337.00	Disclosure SEC source: 0001493152-26-034560 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Managed Account Disclosed balance after: 100,000 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.75 to $7.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. F5 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 22, 2026 Filed Jul 24, 2026 20:05 UTC	Alpha Cognition Inc. ACOG · Entity 6339	PurchaseCommon Stock, no par value	140,237	$7.83	$1,098,574.59	Disclosure SEC source: 0001493152-26-034560 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,945,344 F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.75 to $7.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 14, 2026 Filed Jul 15, 2026 20:05 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	920	$73.43	$67,555.97	Disclosure SEC source: 0001493152-26-033354 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 493,936 F4 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.34-$73.50 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 14, 2026 Filed Jul 16, 2026 21:14 UTC	Eton Pharmaceuticals, Inc. ETON · Entity 4598	SaleCommon Stock, par value $0.001 per share	13,315	$37.54	$499,886.38	Disclosure SEC source: 0001493152-26-033577 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Managed Account Disclosed balance after: 40,000 F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 14, 2026 Filed Jul 16, 2026 21:14 UTC	Eton Pharmaceuticals, Inc. ETON · Entity 4598	SaleCommon Stock, par value $0.001 per share	15,000	$37.54	$563,146.50	Disclosure SEC source: 0001493152-26-033577 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,665,000 F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 14, 2026 Filed Jul 17, 2026 23:12 UTC Amendment	Eton Pharmaceuticals, Inc. ETON · Entity 4598	SaleCommon Stock, par value $0.001 per share	13,315	$37.54	$499,886.38	Disclosure SEC source: 0001493152-26-033818 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Managed Account Disclosed balance after: 40,000 F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 14, 2026 Filed Jul 17, 2026 23:12 UTC Amendment	Eton Pharmaceuticals, Inc. ETON · Entity 4598	SaleCommon Stock, par value $0.001 per share	15,000	$37.54	$563,146.50	Disclosure SEC source: 0001493152-26-033818 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 2,665,000 F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 13, 2026 Filed Jul 15, 2026 20:05 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	775	$73.89	$57,262.66	Disclosure SEC source: 0001493152-26-033354 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 493,016 F3 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.75-$73.95 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F5 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 10, 2026 Filed Jul 10, 2026 20:41 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	229	$73.95	$16,934.55	Disclosure SEC source: 0001493152-26-032859 · ownership.xml · nonDerivative · entry 2 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 492,241 F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document
July 08, 2026 Filed Jul 10, 2026 20:41 UTC	Sol-Gel Technologies Ltd. SLGL · Entity 1558	PurchaseOrdinary Shares, par value NIS 1.00 per share	300	$73.69	$22,107.00	Disclosure SEC source: 0001493152-26-032859 · ownership.xml · nonDerivative · entry 1 Opaleye Management Inc. · CIK 0001595855 · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Opaleye, L.P. Disclosed balance after: 492,012 F3 · price: The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.475-$73.845 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. F4 · ownership.nature: Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.