POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 10

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 449 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners IV, L.P. ("PVP IV"). Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVP IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 9

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 23,996 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). PVM IV is the general partner of PVPE IV. Each of Flint and McGuire are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVPE IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 8

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,892 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners IV, L.P. ("PVP IV"). Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVP IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 7

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 100,963 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). PVM IV is the general partner of PVPE IV. Each of Flint and McGuire are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVPE IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 6

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,758 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners IV, L.P. ("PVP IV"). Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVP IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 5

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 93,808 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). PVM IV is the general partner of PVPE IV. Each of Flint and McGuire are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVPE IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 4

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,841 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners IV, L.P. ("PVP IV"). Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVP IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · derivative · entry 3

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 98,213 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.exercise_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F1 · derivative.expiration_date: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). PVM IV is the general partner of PVPE IV. Each of Flint and McGuire are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVPE IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · nonDerivative · entry 2

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,940

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners IV, L.P. ("PVP IV"). Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV. Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVP IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-012176 · doc4.xml · nonDerivative · entry 1

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 316,980

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). PVM IV is the general partner of PVPE IV. Each of Flint and McGuire are the managing members of PVM IV and may be deemed to have shared voting and dispositive power over the shares held by PVPE IV. Each of PVM IV, Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 18

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2023-04-03

F15 · price: The reported securities were included within 7,700 Units purchased by PVPSFF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F16 · ownership.nature: Securities held of record by PVPSFF V.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 17

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2018-10-03

F15 · price: The reported securities were included within 7,700 Units purchased by PVPSFF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F16 · ownership.nature: Securities held of record by PVPSFF V.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 16

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,275

Underlying: Common Stock · 5,275 shares

Expires 2023-04-03

F13 · price: The reported securities were included within 5,275 Units purchased by PVPFF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F14 · ownership.nature: Securities held of record by PVPFF V.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 15

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,275

Underlying: Common Stock · 5,275 shares

Expires 2018-10-03

F13 · price: The reported securities were included within 5,275 Units purchased by PVPFF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F14 · ownership.nature: Securities held of record by PVPFF V.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 14

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 15,007

Underlying: Common Stock · 15,007 shares

Expires 2023-04-03

F11 · price: The reported securities were included within 15,007 Units purchased by PVPEF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F12 · ownership.nature: Securities held of record by PVPEF V.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 13

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 15,007

Underlying: Common Stock · 15,007 shares

Expires 2018-10-03

F11 · price: The reported securities were included within 15,007 Units purchased by PVPEF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F12 · ownership.nature: Securities held of record by PVPEF V.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 12

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 769,989

Underlying: Common Stock · 769,989 shares

Expires 2023-04-03

F7 · price: The reported securities were included within 769,989 Units purchased by Polaris Venture Partners V, L.P. ("PVP V").

F8 · ownership.nature: Securities held of record by PVP V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 11

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 769,989

Underlying: Common Stock · 769,989 shares

Expires 2018-10-03

F7 · price: The reported securities were included within 769,989 Units purchased by Polaris Venture Partners V, L.P. ("PVP V").

F8 · ownership.nature: Securities held of record by PVP V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 10

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 6,478

Underlying: Common Stock · 6,478 shares

Expires 2023-04-03

F5 · price: The reported securities were included within 6,478 Units purchased by PVPE IV.

F3 · ownership.nature: Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.

F4 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F6 · ownership.nature: Securities held of record by PVPE IV.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 9

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 6,478

Underlying: Common Stock · 6,478 shares

Expires 2018-10-03

F5 · price: The reported securities were included within 6,478 Units purchased by PVPE IV.

F3 · ownership.nature: Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.

F4 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F6 · ownership.nature: Securities held of record by PVPE IV.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 8

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 345,551

Underlying: Common Stock · 345,551 shares

Expires 2023-04-03

F1 · price: The reported securities were included within 345,551 Units purchased by Polaris Venture Partners IV, L.P. ("PVP IV") for $0.65 per Unit (each, a "Unit"). Each Unit consisted of one share of common stock, one Series A Warrant to purchase one share of common stock at an exercise price of $0.65 per share, and one Series B Warrant to purchase one share of common stock at an exercise price of $0.75 per share.

F2 · ownership.nature: Securities held of record by PVP IV.

F3 · ownership.nature: Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.

F4 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-18-009612 · doc4.xml · derivative · entry 7

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 345,551

Underlying: Common Stock · 345,551 shares

Expires 2018-10-03

F1 · price: The reported securities were included within 345,551 Units purchased by Polaris Venture Partners IV, L.P. ("PVP IV") for $0.65 per Unit (each, a "Unit"). Each Unit consisted of one share of common stock, one Series A Warrant to purchase one share of common stock at an exercise price of $0.65 per share, and one Series B Warrant to purchase one share of common stock at an exercise price of $0.75 per share.

F2 · ownership.nature: Securities held of record by PVP IV.

F3 · ownership.nature: Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.

F4 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-18-009612 · doc4.xml · nonDerivative · entry 6

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 34,587

F15 · price: The reported securities were included within 7,700 Units purchased by PVPSFF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F16 · ownership.nature: Securities held of record by PVPSFF V.

SEC source: 0000899243-18-009612 · doc4.xml · nonDerivative · entry 5

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 23,875

F13 · price: The reported securities were included within 5,275 Units purchased by PVPFF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F14 · ownership.nature: Securities held of record by PVPFF V.

SEC source: 0000899243-18-009612 · doc4.xml · nonDerivative · entry 4

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 67,729

F11 · price: The reported securities were included within 15,007 Units purchased by PVPEF V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F12 · ownership.nature: Securities held of record by PVPEF V.

SEC source: 0000899243-18-009612 · doc4.xml · nonDerivative · entry 3

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,468,190

F7 · price: The reported securities were included within 769,989 Units purchased by Polaris Venture Partners V, L.P. ("PVP V").

F8 · ownership.nature: Securities held of record by PVP V.

F9 · ownership.nature: Polaris Venture Management Co. V, LLC ("PVM V") is the general partner of PVP V, Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"), Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V") and Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPEF V"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power over the shares held by each of PVP V, PVPFF V, PFPSFF V and PVPEF V.

F10 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-18-009612 · doc4.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 29,178

F5 · price: The reported securities were included within 6,478 Units purchased by PVPE IV.

F3 · ownership.nature: Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.

F4 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F6 · ownership.nature: Securities held of record by PVPE IV.

SEC source: 0000899243-18-009612 · doc4.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director · 10% owner

Flint Jonathan A · CIK 0001295676 · 10% owner

Polaris Venture Management Co IV LLC · CIK 0001295438 · 10% owner

POLARIS VENTURE PARTNERS ENTREPRENEURS FUND IV LP · CIK 0001170720 · 10% owner

POLARIS VENTURE PARTNERS IV LP · CIK 0001157864 · 10% owner

Polaris Venture Management Co. V, L.L.C. · CIK 0001439589 · 10% owner

Polaris Venture Partners Entrepreneurs' Fund V, L.P. · CIK 0001439587 · 10% owner

Polaris Venture Partners V, L.P. · CIK 0001439590 · 10% owner

Polaris Venture Partners Founders' Fund V, L.P. · CIK 0001439588 · 10% owner

Polaris Venture Partners Special Founders' Fund V, L.P. · CIK 0001439586 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,556,676

F1 · price: The reported securities were included within 345,551 Units purchased by Polaris Venture Partners IV, L.P. ("PVP IV") for $0.65 per Unit (each, a "Unit"). Each Unit consisted of one share of common stock, one Series A Warrant to purchase one share of common stock at an exercise price of $0.65 per share, and one Series B Warrant to purchase one share of common stock at an exercise price of $0.75 per share.

F2 · ownership.nature: Securities held of record by PVP IV.

F3 · ownership.nature: Polaris Venture Management Co. IV, L.L.C. ("PVM IV") is the general partner of PVP IV and Polaris Venture Partners Entrepreneurs' Fund IV, L.P. ("PVPE IV"). Each of Jonathan A. Flint and Terrance G. McGuire are the managing members of PVM IV. PVM IV disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM IV is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Jonathan A. Flint and Terrance G. McGuire, in their respective capacities with regard to PVM IV, may be deemed to have shared voting and dispositive power over the shares held by each of PVP IV and PVPE IV.

F4 · ownership.nature: Each of Messrs. Flint and McGuire disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.