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Kewalramani Reshma

Disclosed activity across 2 companies

Tapewire entity
14888
SEC CIK
0001735944

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
VERTEX PHARMACEUTICALS INC / MAVRTX · Entity 2875Director · CEO & PresidentFebruary 27, 2026March 03, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

VERTEX PHARMACEUTICALS INC / MA

Report date February 27, 2026 · Filed March 03, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect98,278 Ending reported balance After 2026-02-27 transaction · row 13
13 source rows · reconciled sequence

Row 1 · 2026-02-27 · Sale · Disposed 400 · Balance 137,878

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3: Open market sales reported on this line occurred at a weighted average price of $479.75 (range $479.75 to $479.76).

Row 2 · 2026-02-27 · Sale · Disposed 120 · Balance 137,758

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4: Open market sales reported on this line occurred at a weighted average price of $481.50 (range $481.50 to $481.51).

Row 3 · 2026-02-27 · Sale · Disposed 240 · Balance 137,518

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5: Open market sales reported on this line occurred at a weighted average price of $482.84 (range $482.84 to $482.85).

Row 4 · 2026-02-27 · Sale · Disposed 2,510 · Balance 135,008

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6: Open market sales reported on this line occurred at a weighted average price of $487.13 (range $486.64 to $487.55).

Row 5 · 2026-02-27 · Sale · Disposed 3,278 · Balance 131,730

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F7: Open market sales reported on this line occurred at a weighted average price of $488.27 (range $487.82 to $488.56).

Row 6 · 2026-02-27 · Sale · Disposed 460 · Balance 131,270

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F8: Open market sales reported on this line occurred at a weighted average price of $489.32 (range $489.01 to $489.79).

Row 7 · 2026-02-27 · Sale · Disposed 2,725 · Balance 128,545

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F9: Open market sales reported on this line occurred at a weighted average price of $490.54 (range $490.10 to $491.01).

Row 8 · 2026-02-27 · Sale · Disposed 949 · Balance 127,596

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F10: Open market sales reported on this line occurred at a weighted average price of $491.30 (range $491.13 to $491.85).

Row 9 · 2026-02-27 · Sale · Disposed 2,520 · Balance 125,076

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F11: Open market sales reported on this line occurred at a weighted average price of $493.29 (range $492.78 to $493.77).

Row 10 · 2026-02-27 · Sale · Disposed 3,498 · Balance 121,578

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F12: Open market sales reported on this line occurred at a weighted average price of $494.33 (range $493.78 to $494.75).

Row 11 · 2026-02-27 · Sale · Disposed 15,580 · Balance 105,998

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F13: Open market sales reported on this line occurred at a weighted average price of $495.38 (range $494.79 to $495.78).

Row 12 · 2026-02-27 · Sale · Disposed 5,995 · Balance 100,003

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F14: Open market sales reported on this line occurred at a weighted average price of $496.16 (range $495.79 to $496.74).

Row 13 · 2026-02-27 · Sale · Disposed 1,725 · Balance 98,278

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F15: Open market sales reported on this line occurred at a weighted average price of $496.95 (range $496.79 to $497.17).

Filing footnotes · ownership attribution and instrument terms

F1: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3: Open market sales reported on this line occurred at a weighted average price of $479.75 (range $479.75 to $479.76).

F4: Open market sales reported on this line occurred at a weighted average price of $481.50 (range $481.50 to $481.51).

F5: Open market sales reported on this line occurred at a weighted average price of $482.84 (range $482.84 to $482.85).

F6: Open market sales reported on this line occurred at a weighted average price of $487.13 (range $486.64 to $487.55).

F7: Open market sales reported on this line occurred at a weighted average price of $488.27 (range $487.82 to $488.56).

F8: Open market sales reported on this line occurred at a weighted average price of $489.32 (range $489.01 to $489.79).

F9: Open market sales reported on this line occurred at a weighted average price of $490.54 (range $490.10 to $491.01).

F10: Open market sales reported on this line occurred at a weighted average price of $491.30 (range $491.13 to $491.85).

F11: Open market sales reported on this line occurred at a weighted average price of $493.29 (range $492.78 to $493.77).

F12: Open market sales reported on this line occurred at a weighted average price of $494.33 (range $493.78 to $494.75).

F13: Open market sales reported on this line occurred at a weighted average price of $495.38 (range $494.79 to $495.78).

F14: Open market sales reported on this line occurred at a weighted average price of $496.16 (range $495.79 to $496.74).

F15: Open market sales reported on this line occurred at a weighted average price of $496.95 (range $496.79 to $497.17).

Past disclosures · reporting ended (1)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

Ginkgo Bioworks Holdings, Inc.

Report date June 12, 2024 · Filed June 14, 2024

Section 16 reporting ended · disclosed 2024-06-14. Current position is not established by this disclosure.

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Class A Common StockSEC Table I · non-derivativeDirect186,002 Reported balance After 2024-06-12 transaction · row 1
1 source row

Row 1 · 2024-06-12 · Exercise / conversion · Acquired 105,263 · Balance 186,002

F1: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

Restricted Stock UnitsSEC Table II · derivative / convertible security · Conversion / exercise price $0.00Direct0 Reported balance After 2024-06-12 transaction · row 2 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 2 · 2024-06-12 · Exercise / conversion · Disposed 105,263 · Balance 0

F1: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

F2: In accordance with the Issuer's Non-Employee Director Compensation Program, the RSUs granted on June 16, 2023 vested in full in Class A shares on June 12, 2024, which was the day immediately prior to the date of the Issuer's next Annual Meeting of Shareholders occurring after the grant date, and was subject to the Reporting Person continuing in service as a Non-Employee Director of the Issuer through such date.

Filing footnotes · ownership attribution and instrument terms

F1: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

F2: In accordance with the Issuer's Non-Employee Director Compensation Program, the RSUs granted on June 16, 2023 vested in full in Class A shares on June 12, 2024, which was the day immediately prior to the date of the Issuer's next Annual Meeting of Shareholders occurring after the grant date, and was subject to the Reporting Person continuing in service as a Non-Employee Director of the Issuer through such date.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,725 $496.95 $857,238.75
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 13

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,278

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F15 · price: Open market sales reported on this line occurred at a weighted average price of $496.95 (range $496.79 to $497.17).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 5,995 $496.16 $2,974,479.20
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 12

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,003

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F14 · price: Open market sales reported on this line occurred at a weighted average price of $496.16 (range $495.79 to $496.74).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 15,580 $495.38 $7,718,020.40
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 11

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,998

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F13 · price: Open market sales reported on this line occurred at a weighted average price of $495.38 (range $494.79 to $495.78).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 3,498 $494.33 $1,729,166.34
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 10

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,578

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F12 · price: Open market sales reported on this line occurred at a weighted average price of $494.33 (range $493.78 to $494.75).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 2,520 $493.29 $1,243,090.80
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 9

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,076

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F11 · price: Open market sales reported on this line occurred at a weighted average price of $493.29 (range $492.78 to $493.77).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 949 $491.30 $466,243.70
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 8

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 127,596

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F10 · price: Open market sales reported on this line occurred at a weighted average price of $491.30 (range $491.13 to $491.85).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 2,725 $490.54 $1,336,721.50
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 7

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 128,545

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F9 · price: Open market sales reported on this line occurred at a weighted average price of $490.54 (range $490.10 to $491.01).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 460 $489.32 $225,087.20
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 6

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 131,270

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F8 · price: Open market sales reported on this line occurred at a weighted average price of $489.32 (range $489.01 to $489.79).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 3,278 $488.27 $1,600,549.06
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 5

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 131,730

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F7 · price: Open market sales reported on this line occurred at a weighted average price of $488.27 (range $487.82 to $488.56).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 2,510 $487.13 $1,222,696.30
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 4

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 135,008

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $487.13 (range $486.64 to $487.55).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 240 $482.84 $115,881.60
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 3

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 137,518

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $482.84 (range $482.84 to $482.85).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 120 $481.50 $57,780.00
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 137,758

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $481.50 (range $481.50 to $481.51).

Read SEC document
February 27, 2026 Filed Mar 3, 2026 21:34 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 400 $479.75 $191,900.00
Disclosure

SEC source: 0000875320-26-000129 · wk-form4_1772573657.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 137,878

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025.

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $479.75 (range $479.75 to $479.76).

Read SEC document
February 24, 2026 Filed Feb 26, 2026 23:09 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 4,981 $485.11 $2,416,332.91
Disclosure

SEC source: 0000875320-26-000114 · wk-form4_1772147388.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,278

Read SEC document
February 17, 2026 Filed Feb 19, 2026 21:16 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 6,554 $483.75 $3,170,497.50
Disclosure

SEC source: 0000875320-26-000090 · wk-form4_1771535794.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 143,259

Read SEC document
February 17, 2026 Filed Feb 19, 2026 21:16 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 16,326 $0.00 $0.00
Disclosure

SEC source: 0000875320-26-000090 · wk-form4_1771535794.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,813

F1 · shares: Restricted stock unit award that vests in installments beginning on February 20, 2027.

Read SEC document
February 13, 2026 Filed Feb 18, 2026 21:35 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 13,041 $487.76 $6,360,878.16
Disclosure

SEC source: 0000875320-26-000070 · wk-form4_1771450516.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,487

Read SEC document
February 10, 2026 Filed Feb 12, 2026 22:00 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 8,297 $468.41 $3,886,397.77
Disclosure

SEC source: 0000875320-26-000046 · wk-form4_1770933613.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 146,528

Read SEC document
January 22, 2026 Filed Jan 26, 2026 21:25 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 11,885 $0.00 $0.00
Disclosure

SEC source: 0000875320-26-000018 · wk-form4_1769462741.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,825

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/12/2025 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest in installments beginning on 02/24/2026.

Read SEC document
January 22, 2026 Filed Jan 26, 2026 21:25 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 26,972 $0.00 $0.00
Disclosure

SEC source: 0000875320-26-000018 · wk-form4_1769462741.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,940

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2023 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest on 02/13/2026.

Read SEC document
August 06, 2025 Filed Aug 7, 2025 20:23 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 PurchaseCommon Stock 5,710 $389.95 $2,226,614.50
Disclosure

SEC source: 0000875320-25-000220 · wk-form4_1754598207.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,968

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price.

F3 · price: Open market purchases reported on this line occurred at a weighted average price of $389.95 (range $389.72 to $390.53).

Read SEC document
August 06, 2025 Filed Aug 7, 2025 20:23 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 PurchaseCommon Stock 4,290 $389.08 $1,669,153.20
Disclosure

SEC source: 0000875320-25-000220 · wk-form4_1754598207.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,258

F1 · price: Open market purchases reported on this line occurred at a weighted average price of $389.08 (range $388.71 to $389.43).

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price.

Read SEC document
February 26, 2025 Filed Feb 28, 2025 21:43 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 14,079 $479.61 $6,752,429.19
Disclosure

SEC source: 0000875320-25-000131 · wk-form4_1740779025.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,915

Read SEC document
February 24, 2025 Filed Feb 26, 2025 21:12 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 9,386 $483.28 $4,536,066.08
Disclosure

SEC source: 0000875320-25-000111 · wk-form4_1740604345.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,994

Read SEC document
February 14, 2025 Filed Feb 19, 2025 21:31 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 6,553 $463.46 $3,037,053.38
Disclosure

SEC source: 0000875320-25-000089 · wk-form4_1740000707.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 129,380

Read SEC document
February 12, 2025 Filed Feb 14, 2025 21:13 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 19,015 $0.00 $0.00
Disclosure

SEC source: 0000875320-25-000067 · wk-form4_1739567593.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,933

F1 · shares: Restricted stock unit award that vests in installments beginning on 02/24/2026.

Read SEC document
February 10, 2025 Filed Feb 12, 2025 21:46 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 8,300 $467.98 $3,884,234.00
Disclosure

SEC source: 0000875320-25-000044 · wk-form4_1739396757.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,918

Read SEC document
February 04, 2025 Filed Feb 6, 2025 21:37 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 20,328 $0.00 $0.00
Disclosure

SEC source: 0000875320-25-000018 · wk-form4_1738877851.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,218

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

Read SEC document
February 04, 2025 Filed Feb 6, 2025 21:37 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 29,118 $0.00 $0.00
Disclosure

SEC source: 0000875320-25-000018 · wk-form4_1738877851.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,890

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

Read SEC document
November 08, 2024 Filed Nov 12, 2024 21:08 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 15,198 $515.00 $7,826,970.00
Disclosure

SEC source: 0000875320-24-000225 · wk-form4_1731445703.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,772

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

Read SEC document
July 30, 2024 Filed Aug 1, 2024 20:17 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 15,202 $505.00 $7,677,010.00
Disclosure

SEC source: 0000875320-24-000195 · wk-form4_1722543438.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 90,970

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

Read SEC document
July 22, 2024 Filed Jul 24, 2024 20:05 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 15,202 $497.00 $7,555,394.00
Disclosure

SEC source: 0000875320-24-000187 · wk-form4_1721851538.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,172

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

Read SEC document
June 12, 2024 Filed Jun 14, 2024 16:24 UTC Ginkgo Bioworks Holdings, Inc. DNA · Entity 5530 Exercise / conversionRestricted Stock Units · Derivative 105,263 Not disclosed Strike: $0.00 Not disclosed
Disclosure

SEC source: 0001127602-24-018713 · form4.xml · derivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Class A Common Stock · 105,263 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

F1 · kind: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

F2 · derivative.exercise_date: In accordance with the Issuer's Non-Employee Director Compensation Program, the RSUs granted on June 16, 2023 vested in full in Class A shares on June 12, 2024, which was the day immediately prior to the date of the Issuer's next Annual Meeting of Shareholders occurring after the grant date, and was subject to the Reporting Person continuing in service as a Non-Employee Director of the Issuer through such date.

F2 · derivative.expiration_date: In accordance with the Issuer's Non-Employee Director Compensation Program, the RSUs granted on June 16, 2023 vested in full in Class A shares on June 12, 2024, which was the day immediately prior to the date of the Issuer's next Annual Meeting of Shareholders occurring after the grant date, and was subject to the Reporting Person continuing in service as a Non-Employee Director of the Issuer through such date.

Read SEC document
June 12, 2024 Filed Jun 14, 2024 16:24 UTC Ginkgo Bioworks Holdings, Inc. DNA · Entity 5530 Exercise / conversionClass A Common Stock 105,263 Not disclosed Not disclosed
Disclosure

SEC source: 0001127602-24-018713 · form4.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 186,002

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's Class A Common Stock.

Read SEC document
May 24, 2024 Filed May 29, 2024 20:08 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option (Right to Buy) · Derivative 1,565 $0.00 Strike: $187.53 $0.00
Disclosure

SEC source: 0000875320-24-000160 · wk-form4_1717013304.xml · derivative · entry 3

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,565 shares

Expires 2029-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
May 24, 2024 Filed May 29, 2024 20:08 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 1,565 $457.00 $715,205.00
Disclosure

SEC source: 0000875320-24-000160 · wk-form4_1717013304.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,374

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

Read SEC document
May 24, 2024 Filed May 29, 2024 20:08 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 1,565 $187.53 $293,484.45
Disclosure

SEC source: 0000875320-24-000160 · wk-form4_1717013304.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,939

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 20, 2024 Filed May 22, 2024 20:21 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 15,202 $447.00 $6,795,294.00
Disclosure

SEC source: 0000875320-24-000156 · wk-form4_1716409296.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,374

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

Read SEC document
February 23, 2024 Filed Feb 27, 2024 21:55 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 9,386 $431.79 $4,052,780.94
Disclosure

SEC source: 0000875320-24-000105 · wk-form4_1709070906.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 136,507

Read SEC document
February 20, 2024 Filed Feb 21, 2024 21:29 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 7,019 $420.58 $2,952,051.02
Disclosure

SEC source: 0000875320-24-000074 · wk-form4_1708550975.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 145,893

Read SEC document
February 16, 2024 Filed Feb 21, 2024 21:29 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 9,359 $424.01 $3,968,309.59
Disclosure

SEC source: 0000875320-24-000074 · wk-form4_1708550975.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,912

Read SEC document
February 09, 2024 Filed Feb 13, 2024 22:07 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Tax withholdingCommon Stock 8,255 $422.74 $3,489,718.70
Disclosure

SEC source: 0000875320-24-000051 · wk-form4_1707862030.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,271

Read SEC document
February 07, 2024 Filed Feb 8, 2024 21:38 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 20,327 $0.00 $0.00
Disclosure

SEC source: 0000875320-24-000026 · wk-form4_1707428268.xml · nonDerivative · entry 3

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 170,526

F3 · shares: Restricted stock unit award that vests in installments beginning on 02/17/2025.

Read SEC document
February 06, 2024 Filed Feb 8, 2024 21:38 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 26,972 $0.00 $0.00
Disclosure

SEC source: 0000875320-24-000026 · wk-form4_1707428268.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,199

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2023 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/06/2024 and the shares will vest in installments beginning on 02/10/2024.

Read SEC document
February 06, 2024 Filed Feb 8, 2024 21:38 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 GrantCommon Stock 14,516 $0.00 $0.00
Disclosure

SEC source: 0000875320-24-000026 · wk-form4_1707428268.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 123,227

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/03/2021 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/06/2024 and the shares will vest on 02/20/2024.

Read SEC document
December 15, 2023 Filed Dec 19, 2023 21:15 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option (Right to Buy) · Derivative 14,077 $0.00 Strike: $187.53 $0.00
Disclosure

SEC source: 0000875320-23-000062 · wk-form4_1703020525.xml · derivative · entry 5

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,565

Underlying: Common Stock · 14,077 shares

Expires 2029-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
December 15, 2023 Filed Dec 19, 2023 21:15 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionStock Option (Right to Buy) · Derivative 3,058 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0000875320-23-000062 · wk-form4_1703020525.xml · derivative · entry 4

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,058 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
December 15, 2023 Filed Dec 19, 2023 21:15 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 SaleCommon Stock 17,135 $407.00 $6,973,945.00
Disclosure

SEC source: 0000875320-23-000062 · wk-form4_1703020525.xml · nonDerivative · entry 3

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,711

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 08/11/2023.

Read SEC document
December 15, 2023 Filed Dec 19, 2023 21:15 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 14,077 $187.53 $2,639,859.81
Disclosure

SEC source: 0000875320-23-000062 · wk-form4_1703020525.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,846

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 15, 2023 Filed Dec 19, 2023 21:15 UTC VERTEX PHARMACEUTICALS INC / MA VRTX · Entity 2875 Exercise / conversionCommon Stock 3,058 $155.57 $475,733.06
Disclosure

SEC source: 0000875320-23-000062 · wk-form4_1703020525.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,769

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.