Curet Myriam

SEC source: 0001035267-23-000213 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,008

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001209191-23-050223 · doc4.xml · derivative · entry 2

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Stock · 85,000 shares

Expires 2031-09-18

F2 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 19, 2023.

SEC source: 0001209191-23-050223 · doc4.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,418

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax obligations in connection with the vesting of certain RSUs held by the reporting person. This sale is mandated by the reporting person's previous election under the Issuer's equity incentive plans to require the satisfaction of tax obligations to be funded by a "sell to cover" transaction.

SEC source: 0001035267-23-000175 · edgardoc.xml · derivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,028

Underlying: Common Stock · 5,028 shares

Expires 2030-08-09

F1 · derivative.exercise_date: 7/48th of the shares subject to the option vest on the one-month anniversary measured from August 10, 2023, and 1/48th of the total number of shares vest in forty-one (41) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-23-023298 · ownership.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,535

F1 · shares: Grant of restricted share units. Each restricted share unit represents a right to receive one share of common stock. The restricted share units vest on the earliest to occur of (i) the fifth anniversary of the date of the award, (ii) the date on which the service of the director on the board of directors terminates, or (iii) a Change of Control (as defined in the award documents).

SEC source: 0001035267-23-000137 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 189

F1 · kind: The filer gifted shares to Byrn Mawr College.

SEC source: 0001035267-23-000094 · edgardoc.xml · derivative · entry 8

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,000 shares

Expires 2028-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-23-000094 · edgardoc.xml · derivative · entry 7

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,500

Underlying: Common Stock · 2,000 shares

Expires 2029-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-23-000094 · edgardoc.xml · nonDerivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 327

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000094 · edgardoc.xml · nonDerivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 832

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $296.54 to $299.27 as follows: 232 shares sold at $296.54 - $297.32; 666 shares sold at $297.57 - $298.50; 220 shares sold at $298.62 - $299.27. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-23-000094 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,950

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000094 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,950

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000094 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,950

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000094 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,950

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000075 · edgardoc.xml · nonDerivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,950

F2 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000075 · edgardoc.xml · derivative · entry 9

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,352

Underlying: Common Stock · 3,352 shares

Expires not disclosed

F5 · derivative.exercise_date: Constitute restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Issuer common stock upon vesting. 25% of the RSUs shall vest on each anniversary of February 10, 2023, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

F5 · derivative.expiration_date: Constitute restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Issuer common stock upon vesting. 25% of the RSUs shall vest on each anniversary of February 10, 2023, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-23-000075 · edgardoc.xml · derivative · entry 8

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,007

Underlying: Common Stock · 1,003 shares

Expires 2026-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-23-000075 · edgardoc.xml · derivative · entry 7

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,253

Underlying: Common Stock · 2,256 shares

Expires 2024-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-23-000075 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,028

Underlying: Common Stock · 5,028 shares

Expires 2030-02-27

F3 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-23-000075 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,203

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000075 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,701

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000075 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,698

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000075 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,701

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000053 · edgardoc.xml · derivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,420

Underlying: Common Stock · 1,710 shares

Expires 2025-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-23-000053 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,445

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000053 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,037

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000035 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 327

F2 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-23-000035 · edgardoc.xml · derivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,749 shares

Expires 2023-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Each Restricted Stock Unit, granted pursuant to the 2010 Employee Stock Option Plan, represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period of time.

SEC source: 0001035267-23-000035 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,451

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-23-000035 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,076

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001493152-23-000125 · ownership.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,916

F1 · shares: Grant of restricted share units. Each restricted share unit represents a right to receive one share of common stock. The restricted share units vest on the earliest to occur of (i) the fifth anniversary of the date of the award, (ii) the date on which the service of the director on the board of directors terminates, or (iii) a Change of Control (as defined in the award documents).

SEC source: 0001035267-22-000178 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2028-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-22-000178 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,500

Underlying: Common Stock · 2,000 shares

Expires 2029-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-22-000178 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-22-000178 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,217

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-22-000178 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-22-000178 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,217

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-22-000171 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 6,000 shares

Expires 2028-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-22-000171 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,500

Underlying: Common Stock · 2,000 shares

Expires 2029-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-22-000171 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $207.08 to $212.46 as follows: 1,290 shares sold at $207.08 to $208.08; 1,411 shares sold at $208.09 to $209.09; 1,600 shares sold at $209.49 to $210.41; 3,319 shares sold at $210.50 to $211.45 and 380 shares sold at $211.70 to $212.46. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-22-000171 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,217

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001035267-22-000171 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $207.08 to $212.46 as follows: 1,290 shares sold at $207.08 to $208.08; 1,411 shares sold at $208.09 to $209.09; 1,600 shares sold at $209.49 to $210.41; 3,319 shares sold at $210.50 to $211.45 and 380 shares sold at $211.70 to $212.46. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-22-000171 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,217

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 10, 2023.

SEC source: 0001209191-22-051305 · doc4.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,777

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax obligations in connection with the vesting of certain RSUs held by the reporting person. This sale is mandated by the reporting person's previous election under the Issuer's equity incentive plans to require the satisfaction of tax obligations to be funded by a "sell to cover" transaction.

SEC source: 0001209191-22-050813 · doc4.xml · derivative · entry 2

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2030-09-15

F3 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 16, 2022.

SEC source: 0001209191-22-050813 · doc4.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,975

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 16, 2022.

SEC source: 0001035267-22-000146 · edgardoc.xml · derivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,015

Underlying: Common Stock · 6,015 shares

Expires 2029-08-28

F1 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-22-000133 · edgardoc.xml · derivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 9,000 shares

Expires 2028-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were exercised and sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 9, 2022.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-22-000133 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217

F1 · kind: These shares were exercised and sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 9, 2022.

SEC source: 0001035267-22-000133 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,217

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were exercised and sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 9, 2022.