Curet Myriam

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 7

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,308

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,497

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,298

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,555

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000210 · edgardoc.xml · derivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,257

Underlying: Common Stock · 2,818 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000210 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000210 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,116

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001493152-24-025869 · ownership.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 244,945

F1 · shares: Grant of restricted share units. Each restricted share unit represents a right to receive one share of common stock. The restricted share units vest on the earliest to occur of (i) the fifth anniversary of the date of the award, (ii) the date on which the service of the director on the board of directors terminates, or (iii) a Change of Control (as defined in the award documents).

SEC source: 0001104659-24-057568 · tm2413647-4_4seq1.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,100

F1 · shares: Represents an award of Restricted Stock Units ("RSUs"). Each RSU represents a contingent right to receive one share of common stock. The RSUs shall vest upon the earlier to occur of (a) the first anniversary of the date of grant or (b) the date that is immediately prior to the occurrence of a Change of Control (as defined in the Issuer's 2018 Incentive Award Plan), in each case subject to the Reporting Person's continued employment with the Issuer through the applicable vesting date.

SEC source: 0001035267-24-000139 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 2,500 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000139 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,075

Underlying: Common Stock · 2,818 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $368.86 to $371.98 as follows: 700 shares sold at $368.86 to $369.85; 3,321 shares sold at $369.99 to $370.94; and 1,297 shares sold at $371.03 to $371.98. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,798

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $368.86 to $371.98 as follows: 700 shares sold at $368.86 to $369.85; 3,321 shares sold at $369.99 to $370.94; and 1,297 shares sold at $371.03 to $371.98. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,116

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000097 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000081 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,004

Underlying: Common Stock · 1,003 shares

Expires 2026-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-24-000081 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,253 shares

Expires 2024-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-24-000081 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,903

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000081 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,045

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000081 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 792

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000081 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,301

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000070 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 298

F2 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000070 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,158

Underlying: Common Stock · 9,158 shares

Expires not disclosed

F4 · derivative.exercise_date: Each Restricted Stock Unit, granted pursuant to the 2010 Employee Stock Option Plan, represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 33% on the first anniversary of the date of grant and annually thereafter, over a three year period of time.

F4 · derivative.expiration_date: Each Restricted Stock Unit, granted pursuant to the 2010 Employee Stock Option Plan, represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 33% on the first anniversary of the date of grant and annually thereafter, over a three year period of time.

SEC source: 0001035267-24-000070 · edgardoc.xml · derivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,710

Underlying: Common Stock · 1,710 shares

Expires 2025-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Each RSU granted represents a contingent right to receive one share of Intuitive Surgical common stock. The grant vests 25% on the first anniversary of the date of grant and annually thereafter, over a four year period.

SEC source: 0001035267-24-000070 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,141

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000070 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,008

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on the first anniversary of the grant date. RSUs convert into common stock on the vest date on a one-for-one basis. 25 % of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000045 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F2 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000045 · edgardoc.xml · derivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,514

Underlying: Common Stock · 838 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Constitute restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Issuer common stock upon vesting. 25% of the RSUs shall vest on each anniversary of February 10, 2023, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

F3 · derivative.expiration_date: Constitute restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Issuer common stock upon vesting. 25% of the RSUs shall vest on each anniversary of February 10, 2023, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-24-000045 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 779

F1 · kind: RSUs vest 25% per year over a four year period, commencing on each anniversary of February 10, 2023. RSUs convert into common stock on the vest date on a one-for-one basis. 25% of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000045 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,136

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: RSUs vest 25% per year over a four year period, commencing on each anniversary of February 10, 2023. RSUs convert into common stock on the vest date on a one-for-one basis. 25% of the shares have been released and a portion of the shares were held back to cover the statutory tax withholding requirements. The net shares were deposited into the holders account.

SEC source: 0001035267-24-000015 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 1,500 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000015 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,893

Underlying: Common Stock · 2,818 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000015 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $368.45 to $371.65 as follows: 1,100 shares sold at $368.45 to $369.45; 1.800 shares sold at $369.54 to $370.52; and 1,418 shares sold at $370.65 to $371.65. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000015 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000015 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $368.45 to $371.65 as follows: 1,100 shares sold at $368.45 to $369.45; 1.800 shares sold at $369.54 to $370.52; and 1,418 shares sold at $370.65 to $371.65. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000015 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,007

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001493152-24-000112 · ownership.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,470

F1 · shares: Grant of restricted share units. Each restricted share unit represents a right to receive one share of common stock. The restricted share units vest on the earliest to occur of (i) the fifth anniversary of the date of the award, (ii) the date on which the service of the director on the board of directors terminates, or (iii) a Change of Control (as defined in the award documents).

SEC source: 0001104659-23-129207 · tm2333651-2_4seq1.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,384

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock. The RSUs vest in three equal annual installments on the first three anniversaries of the date of grant, subject to the Reporting Person's continued service on the board of directors of the Issuer through each such vesting date.

SEC source: 0001035267-23-000213 · edgardoc.xml · derivative · entry 9

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Common Stock · 1,500 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-23-000213 · edgardoc.xml · derivative · entry 8

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,711

Underlying: Common Stock · 2,819 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-23-000213 · edgardoc.xml · derivative · entry 7

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,500 shares

Expires 2029-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-23-000213 · edgardoc.xml · nonDerivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-23-000213 · edgardoc.xml · nonDerivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-23-000213 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-23-000213 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-23-000213 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.