FEINBERG LARRY N

SEC source: 0001104659-21-013063 · tm215584-1_4.xml · nonDerivative · entry 5

FEINBERG LARRY N · CIK 0000926475 · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F5 · ownership.nature: These securities are owned by Feinberg Family Foundation ("Foundation").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-21-013063 · tm215584-1_4.xml · nonDerivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 105,885

F4 · ownership.nature: These securities are owned by Oracle Investment Management, Inc. Employees Retirement Plan ("Retirement Plan").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 8

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F5 · ownership.nature: These securities are owned by Feinberg Family Foundation ("Foundation").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 7

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F4 · ownership.nature: These securities are owned by Oracle Investment Management, Inc. Employees Retirement Plan ("Retirement Plan").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 6

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 184,300

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 278,300

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,276,500

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-071480 · tm2022210d1_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 655,000

F1 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 5

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 264,141

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 713,896

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072062 · tm2022328d1_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,473,090

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072060 · tm2022328d2_4.xml · derivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 463,298 shares

Expires 2020-06-08

F6 · derivative.expiration_date: The original Warrant expiration date was 2/17/2022, which date was accelerated by the Issuer to 6/8/2020 upon notice to the Reporting Persons.

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-072060 · tm2022328d2_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 6,137,052

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-20-071480 · tm2022210d1_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 805,918

F1 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-19-058583 · tv531499_4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,843

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-19-058583 · tv531499_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,783

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001104659-19-058583 · tv531499_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 12,765

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-036669 · tv526237_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 350,334

F2 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-036669 · tv526237_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,665,050

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 7

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 30,000

F5 · ownership.nature: These securities are owned by Feinberg Family Foundation ("Foundation").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 6

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 135,000

F4 · ownership.nature: These securities are owned by Oracle Investment Management, Inc. Employees Retirement Plan ("Retirement Plan").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 5

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 25,000

F5 · ownership.nature: These securities are owned by Feinberg Family Foundation ("Foundation").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 100,000

F4 · ownership.nature: These securities are owned by Oracle Investment Management, Inc. Employees Retirement Plan ("Retirement Plan").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 550,698

F3 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 379,566

F2 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-033431 · tv524559_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,711,402

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F6 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F7 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-032736 · tv524427_4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 438,585

F1 · ownership.nature: On May 11, 2018, the Issuer effected a 1-for-5 reverse stock split of its common stock (the "Reverse Stock Split"). The amount of securities reported on this Form 4 have been adjusted to reflect the Reverse Stock Split.

F4 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F7 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F8 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-032736 · tv524427_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,000,334

F1 · ownership.nature: On May 11, 2018, the Issuer effected a 1-for-5 reverse stock split of its common stock (the "Reverse Stock Split"). The amount of securities reported on this Form 4 have been adjusted to reflect the Reverse Stock Split.

F3 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F7 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F8 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-032736 · tv524427_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,676,046

F1 · ownership.nature: On May 11, 2018, the Issuer effected a 1-for-5 reverse stock split of its common stock (the "Reverse Stock Split"). The amount of securities reported on this Form 4 have been adjusted to reflect the Reverse Stock Split.

F2 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F7 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners, Ten Fund and Retirement Plan, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners, Ten Fund and Retirement Plan. Mr. Feinberg serves as the Trustee of the Foundation, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by the Foundation.

F8 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-014707 · tv516507_4.xml · nonDerivative · entry 6

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 342,834

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-014707 · tv516507_4.xml · nonDerivative · entry 5

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 329,286

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-014707 · tv516507_4.xml · nonDerivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 855,243

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-014707 · tv516507_4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 834,883

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-014707 · tv516507_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,615,481

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-19-014707 · tv516507_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,520,246

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-066041 · tv509648_4.xml · derivative · entry 6

FEINBERG LARRY N · CIK 0000926475 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,603

Underlying: Common Stock · 5,603 shares

Expires 2023-12-19

F8 · price: The reported securities are included within 112,062 units purchased by Institutional Partners for $1.60625 per unit. Each unit consists of one share of common stock and one warrant to acquire 5% of a share of Common Stock.

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-066041 · tv509648_4.xml · derivative · entry 5

FEINBERG LARRY N · CIK 0000926475 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 14,163

Underlying: Common Stock · 14,163 shares

Expires 2023-12-19

F7 · price: The reported securities are included within 283,268 units purchased by Ten Fund for $1.60625 per unit. Each unit consists of one share of common stock and one warrant to acquire 5% of a share of Common Stock.

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-066041 · tv509648_4.xml · derivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 42,490

Underlying: Common Stock · 42,490 shares

Expires 2023-12-19

F6 · price: The reported securities are included within 849,805 units purchased by Partners for $1.60625 per unit. Each unit consists of one share of common stock and one warrant to acquire 5% of a share of Common Stock.

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-066041 · tv509648_4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 329,158

F3 · ownership.nature: These securities are owned by Oracle Institutional Partners, L.P. ("Institutional Partners")

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-066041 · tv509648_4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 834,691

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-066041 · tv509648_4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,519,346

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund.

F5 · ownership.nature: Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities. The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-029229 · tv494349_form4.xml · nonDerivative · entry 4

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 551,423

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities.

F5 · ownership.nature: The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-029229 · tv494349_form4.xml · nonDerivative · entry 3

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,669,541

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities.

F5 · ownership.nature: The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-029229 · tv494349_form4.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 551,167

F2 · ownership.nature: These securities are owned by Oracle Ten Fund, L.P. ("Ten Fund").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities.

F5 · ownership.nature: The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001144204-18-029229 · tv494349_form4.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,668,323

F1 · ownership.nature: These securities are owned by Oracle Partners, LP. ("Partners").

F4 · ownership.nature: Larry N. Feinberg serves as the managing member of Oracle Associates, LLC, the general partner of Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the indirect beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Mr. Feinberg is the sole shareholder, director and president of Oracle Investment Management, Inc., which serves as investment manager to Partners, Institutional Partners and Ten Fund, and accordingly, may be deemed to be the beneficial owner of the shares beneficially owned by Partners, Institutional Partners and Ten Fund. Each of the Reporting Persons identified in this statement disclaims beneficial ownership of the securities described in this statement, except to the extent of their individual respective pecuniary interest in such securities.

F5 · ownership.nature: The filing of this statement shall not be deemed an admission that any of the Reporting Persons identified in this statement are, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any securities specified in this statement other than those directly beneficially owned by them.

SEC source: 0001140361-17-045190 · doc1.xml · nonDerivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Oracle Associates LLC · CIK 0001317217 · 10% owner

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 30,866,265

F1 · ownership.nature: See Exhibit 99.1.

SEC source: 0001140361-17-045190 · doc1.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Oracle Associates LLC · CIK 0001317217 · 10% owner

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 20,120,650

F1 · ownership.nature: See Exhibit 99.1.

SEC source: 0001140361-17-034022 · doc1.xml · derivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner · * See Remarks

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner · * See Remarks

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner · * See Remarks

Oracle Associates LLC · CIK 0001317217 · 10% owner · * See Remarks

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 583,333 shares

Expires 2017-08-31

F2 · price: See Exhibit 99.1, Note 2.

F1 · ownership.nature: See Exhibit 99.1, Note1.

SEC source: 0001140361-17-034022 · doc1.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner · * See Remarks

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner · * See Remarks

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner · * See Remarks

Oracle Associates LLC · CIK 0001317217 · 10% owner · * See Remarks

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 9,825,289

F1 · ownership.nature: See Exhibit 99.1, Note1.

SEC source: 0001140361-17-033837 · doc1.xml · derivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner · * See Remarks

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner · * See Remarks

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner · * See Remarks

Oracle Associates LLC · CIK 0001317217 · 10% owner · * See Remarks

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 583,333

Underlying: Common Stock · 583,333 shares

Expires 2017-08-31

F3 · derivative.exercise_price: See Exhibit 99.1, Note 3.

F2 · kind: See Exhibit 99.1, Note 2.

F2 · price: See Exhibit 99.1, Note 2.

F3 · derivative.expiration_date: See Exhibit 99.1, Note 3.

F1 · ownership.nature: See Exhibit 99.1, Note1.