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person · Reporting owner

Krishnan Krish S

Disclosed activity across 1 company

Tapewire entity
10295
SEC CIK
0001298709

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Krystal Biotech, Inc.KRYS · Entity 3500Director · President and CEO · 10% ownerSeptember 04, 2026September 04, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Krystal Biotech, Inc.

Report date September 04, 2026 · Filed September 04, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect1,347,543 Ending reported balance After 2026-09-04 transaction · row 13
13 source rows · reconciled sequence

Row 1 · 2026-09-04 · Sale · Disposed 520 · Balance 1,372,023

F1: The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

F2: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3: The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 2 · 2026-09-04 · Sale · Disposed 2,029 · Balance 1,369,994

F4: The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 3 · 2026-09-04 · Sale · Disposed 3,297 · Balance 1,366,697

F5: The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 4 · 2026-09-04 · Sale · Disposed 3,981 · Balance 1,362,716

F6: The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 5 · 2026-09-04 · Sale · Disposed 3,143 · Balance 1,359,573

F7: The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 6 · 2026-09-04 · Sale · Disposed 3,357 · Balance 1,356,216

F8: The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 7 · 2026-09-04 · Sale · Disposed 2,266 · Balance 1,353,950

F9: The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 8 · 2026-09-04 · Sale · Disposed 1,214 · Balance 1,352,736

F10: The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 9 · 2026-09-04 · Sale · Disposed 2,010 · Balance 1,350,726

F11: The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 10 · 2026-09-04 · Sale · Disposed 573 · Balance 1,350,153

F12: The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 11 · 2026-09-04 · Sale · Disposed 1,358 · Balance 1,348,795

F13: The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 12 · 2026-09-04 · Sale · Disposed 847 · Balance 1,347,948

F14: The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Row 13 · 2026-09-04 · Sale · Disposed 405 · Balance 1,347,543

F15: The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Common StockSEC Table I · non-derivativeIndirectBy SMK Trust FBO KSK90,000 Reported balance Holding disclosure · report date 2026-09-04 · row 14 Holding and transaction disclosures are not merged.
1 source row

Row 14 · Balance 90,000

F16: Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.

Common StockSEC Table I · non-derivativeIndirectBy Krish Srinivas Krishnan Trust77,710 Reported balance Holding disclosure · report date 2026-09-04 · row 15 Holding and transaction disclosures are not merged.
1 source row

Row 15 · Balance 77,710

F17: Held by the Krish Srinivas Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.

Common StockSEC Table I · non-derivativeIndirectBy Krishnan Family Trust50,000 Reported balance Holding disclosure · report date 2026-09-04 · row 16 Holding and transaction disclosures are not merged.
1 source row

Row 16 · Balance 50,000

F18: Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.

Filing footnotes · ownership attribution and instrument terms

F1: The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

F2: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3: The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F4: The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F5: The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F6: The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F7: The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8: The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F9: The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10: The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F11: The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12: The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F13: The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14: The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F15: The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F16: Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.

F17: Held by the Krish Srinivas Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.

F18: Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 200 $222.38 $44,475.00
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 19

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,413,711

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F21 · price: The transaction was executed in multiple trades ranging from $222.34 to $222.41. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 10,461 $221.82 $2,320,470.53
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 18

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,413,911

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F20 · price: The transaction was executed in multiple trades ranging from $221.21 to $222.15. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 2,627 $220.52 $579,300.52
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 17

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,424,372

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F19 · price: The transaction was executed in multiple trades ranging from $220.21 to $221.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 5,419 $219.68 $1,190,422.62
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 16

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,426,999

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F18 · price: The transaction was executed in multiple trades ranging from $219.21 to $220.20. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 3,593 $218.83 $786,244.69
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 15

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,432,418

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F17 · price: The transaction was executed in multiple trades ranging from $218.21 to $219.20. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,400 $216.97 $303,753.52
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 14

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,436,011

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F16 · price: The transaction was executed in multiple trades ranging from $216.60 to $217.53. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 600 $215.49 $129,295.98
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 13

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,437,411

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F15 · price: The transaction was executed in multiple trades ranging from $215.34 to $215.80. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 700 $214.25 $149,975.21
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 12

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,438,011

F12 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F13 · price: The transaction was executed in multiple trades ranging from $213.87 to $214.68. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F14 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 700 $222.20 $155,539.02
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,483,056

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F9 · price: The transaction was executed in multiple trades ranging from $222.14 to $222.30. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 10,505 $221.78 $2,329,771.59
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,483,756

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F8 · price: The transaction was executed in multiple trades ranging from $221.14 to $222.11. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 2,625 $220.34 $578,394.60
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 6

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,494,261

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F7 · price: The transaction was executed in multiple trades ranging from $220.14 to $221.11. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 5,693 $219.55 $1,249,916.94
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 5

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,496,886

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F6 · price: The transaction was executed in multiple trades ranging from $219.14 to $220.13. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 2,577 $218.72 $563,637.83
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,502,579

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F5 · price: The transaction was executed in multiple trades ranging from $218.11 to $219.07. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,600 $217.04 $347,271.68
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,505,156

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F4 · price: The transaction was executed in multiple trades ranging from $216.73 to $217.63. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

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December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 344 $215.48 $74,125.60
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,506,756

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F3 · price: The transaction was executed in multiple trades ranging from $214.99 to $215.80. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 23:53 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 956 $214.28 $204,851.39
Disclosure

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,507,100

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F2 · price: The transaction was executed in multiple trades ranging from $213.93 to $214.67. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
July 16, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,529 $150.00 $229,350.00
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,438,711

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

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July 16, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,389 $150.00 $208,350.00
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,508,056

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

Read SEC document
July 15, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 800 $151.79 $121,432.00
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,440,240

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 15, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 2,236 $150.68 $336,929.20
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,441,040

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F9 · price: The transaction was executed in multiple trades ranging from $150.21 to $151.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 15, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 900 $151.79 $136,611.00
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,509,445

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

Read SEC document
July 15, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 2,184 $150.68 $329,088.83
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,510,345

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in multiple trades ranging from $150.21 to $151.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
July 14, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 100 $151.00 $15,100.00
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,443,276

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 14, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 13,335 $150.29 $2,004,125.15
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,443,376

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F7 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 14, 2025 Filed Jul 16, 2025 22:41 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 13,400 $150.30 $2,014,014.64
Disclosure

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,512,529

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F2 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
July 10, 2025 Filed Jul 11, 2025 21:44 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 300 $151.39 $45,416.01
Disclosure

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,456,711

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F4 · price: The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 10, 2025 Filed Jul 11, 2025 21:44 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 6,500 $150.23 $976,463.80
Disclosure

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,457,011

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F3 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 10, 2025 Filed Jul 11, 2025 21:44 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 300 $151.39 $45,416.01
Disclosure

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,525,929

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F4 · price: The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price.

Read SEC document
July 10, 2025 Filed Jul 11, 2025 21:44 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 6,627 $150.22 $995,497.34
Disclosure

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,526,229

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F3 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 21:44 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 200 $150.14 $30,027.80
Disclosure

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 6

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,463,511

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F7 · price: The transaction was executed in multiple trades ranging from $150.1200 to $150.1600. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 21:44 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 200 $150.07 $30,014.00
Disclosure

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,532,856

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F2 · price: The transaction was executed in two trades of 100 shares each at $150 and $150.14, respectively. The price reported above reflects the average sale price.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,331 $179.55 $238,976.52
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 12

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,463,711

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F14 · price: The transaction was executed in multiple trades ranging from $179.33 to $179.70. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 6,514 $178.76 $1,164,415.28
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,465,042

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F13 · price: The transaction was executed in multiple trades ranging from $178.31 to $179.26. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 10,937 $177.66 $1,943,026.95
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,471,556

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F12 · price: The transaction was executed in multiple trades ranging from $177.30 to $178.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 4,579 $176.88 $809,923.90
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,482,493

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F11 · price: The transaction was executed in multiple trades ranging from $176.30 to $177.29. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,639 $175.97 $288,418.76
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,487,072

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F9 · price: The transaction was executed in multiple trades ranging from $175.30 to $176.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,256 $179.57 $225,544.32
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 5

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,533,056

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F6 · price: The transaction was executed in multiple trades ranging from $179.29 to $179.74. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 6,769 $178.77 $1,210,076.53
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,534,312

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F5 · price: The transaction was executed in multiple trades ranging from $178.29 to $179.27. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 10,931 $177.62 $1,941,611.22
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,541,081

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F4 · price: The transaction was executed in multiple trades ranging from $177.28 to $178.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Read SEC document
March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 4,944 $176.80 $874,122.93
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,552,012

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F3 · price: The transaction was executed in multiple trades ranging from $176.28 to $177.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

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March 13, 2025 Filed Mar 13, 2025 22:04 UTC Krystal Biotech, Inc. KRYS · Entity 3500 SaleCommon Stock 1,100 $175.83 $193,408.16
Disclosure

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,556,956

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F2 · price: The transaction was executed in multiple trades ranging from $175.23 to $176.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 GrantRestricted Stock Units · Derivative 22,900 $0.00 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 19

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,900

Underlying: Common Stock · 22,900 shares

Expires not disclosed

F19 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.

F20 · shares: The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates.

F21 · derivative.exercise_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

F21 · derivative.expiration_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 GrantStock Option (Right to Buy) · Derivative 39,300 $0.00 Strike: $179.25 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 18

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,300

Underlying: Common Stock · 39,300 shares

Expires 2035-02-28

F18 · derivative.exercise_date: The option vests in four equal annual installments beginning on February 28, 2026.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Exercise / conversionPerformance Stock Units · Derivative 26,250 $0.00 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 17

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,250

Underlying: Common Stock · 26,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_price: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

F8 · derivative.exercise_date: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

F8 · derivative.expiration_date: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Exercise / conversionRestricted Stock Units · Derivative 8,750 $0.00 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 16

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,250

Underlying: Common Stock · 8,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

F6 · derivative.exercise_date: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

F6 · derivative.expiration_date: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Exercise / conversionPerformance Stock Units · Derivative 12,500 $0.00 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 15

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

F3 · derivative.exercise_date: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

F3 · derivative.expiration_date: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Tax withholdingCommon Stock 10,414 $179.25 $1,866,709.50
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,491,997

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F15 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 22,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Exercise / conversionCommon Stock 22,500 $0.00 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,502,411

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F14 · shares: 45,000 PSUs were granted on February 29, 2024, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Tax withholdingCommon Stock 3,471 $179.25 $622,176.75
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,479,911

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F13 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 7,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

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February 28, 2025 Filed Feb 28, 2025 23:58 UTC Krystal Biotech, Inc. KRYS · Entity 3500 Exercise / conversionCommon Stock 7,500 $0.00 $0.00
Disclosure

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,483,382

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · shares: 15,000 PSUs were granted on February 28, 2023, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2024, and the other 7,500 PSUs vested on February 28, 2025.

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.