ZYME

SEC source: 0000950170-24-003099 · ownership.xml · derivative · entry 4

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,334

Underlying: Common Stock · 47,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on January 5, 2024.

F6 · derivative.expiration_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on January 5, 2024.

SEC source: 0000950170-24-003099 · ownership.xml · nonDerivative · entry 2

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,468

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.55 to $10.845, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-003099 · ownership.xml · nonDerivative · entry 1

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,666

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 5, 2023.

SEC source: 0000950170-24-003065 · ownership.xml · derivative · entry 2

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

F3 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

SEC source: 0000950170-24-003065 · ownership.xml · derivative · entry 1

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2034-01-04

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000950170-24-003087 · ownership.xml · derivative · entry 6

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F8 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

F8 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

SEC source: 0000950170-24-003087 · ownership.xml · derivative · entry 5

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-01-04

F7 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000950170-24-003087 · ownership.xml · derivative · entry 4

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Common Stock · 10,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on January 5, 2024.

F6 · derivative.expiration_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on January 5, 2024.

SEC source: 0000950170-24-003087 · ownership.xml · nonDerivative · entry 2

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,934

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.55 to $10.845, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-003087 · ownership.xml · nonDerivative · entry 1

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,497

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 5, 2023.

SEC source: 0000950170-24-003076 · ownership.xml · derivative · entry 6

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F8 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

F8 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

SEC source: 0000950170-24-003076 · ownership.xml · derivative · entry 5

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2034-01-04

F7 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000950170-24-003076 · ownership.xml · derivative · entry 4

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,334

Underlying: Common Stock · 17,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on January 5, 2024.

F6 · derivative.expiration_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on January 5, 2024.

SEC source: 0000950170-24-003076 · ownership.xml · nonDerivative · entry 2

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,706

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.55 to $10.845, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-003076 · ownership.xml · nonDerivative · entry 1

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,166

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 5, 2023.

SEC source: 0000935836-23-000743 · ownership.xml · derivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See note

Disclosed balance after: 5,086,521

Underlying: Common Stock · 5,086,521 shares

Expires not disclosed

F2 · shares: Qualified Fund purchased 4,818,462 of the pre-funded warrants reported in this transaction.

F3 · derivative.expiration_date: The pre-funded warrants do not have an expiration date.

F4 · derivative.underlying_shares: Each pre-funded warrant will be exercisable to purchase one share of Common Stock, except that the pre-funded warrants cannot be exercised if, after giving effect or immediately prior to such exercise, the reporting person, together with its affiliates and any other persons whose beneficial ownership of shares of Common Stock would be aggregated with the reporting person for purposes of Section 13(d) of the Securities Exchange Act of 1934 would beneficially own more than 19.99% of the total number of issued and outstanding shares of Common Stock or voting power of the issuer following such exercise.

F5 · balance_after: After this transaction, Qualified Fund owned 4,818,462 of the pre-funded warrants.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000774 · ownership.xml · derivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See note

Disclosed balance after: 5,086,521

Underlying: Common Stock · 5,086,521 shares

Expires not disclosed

F2 · shares: Qualified Fund purchased 4,818,462 of the pre-funded warrants reported in this transaction.

F3 · derivative.expiration_date: The pre-funded warrants do not have an expiration date.

F4 · derivative.underlying_shares: Each pre-funded warrant will be exercisable to purchase one share of Common Stock, except that the pre-funded warrants cannot be exercised if, after giving effect or immediately prior to such exercise, the reporting person, together with its affiliates and any other persons whose beneficial ownership of shares of Common Stock would be aggregated with the reporting person for purposes of Section 13(d) of the Securities Exchange Act of 1934 would beneficially own more than 19.99% of the total number of issued and outstanding shares of Common Stock or voting power of the issuer following such exercise.

F5 · balance_after: After this transaction, Qualified Fund owned 4,818,462 of the pre-funded warrants.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-069496 · ownership.xml · derivative · entry 3

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,550 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs were granted on December 10, 2021 and vested in two equal annual instalments (on December 12, 2022 and December 11, 2023).

F5 · derivative.expiration_date: The RSUs were granted on December 10, 2021 and vested in two equal annual instalments (on December 12, 2022 and December 11, 2023).

SEC source: 0000950170-23-069496 · ownership.xml · nonDerivative · entry 2

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,997

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $9.11 to $9.16, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-23-069496 · ownership.xml · nonDerivative · entry 1

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,883

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one half of the restricted stock units ("RSUs") granted on December 10, 2021.

SEC source: 0000950170-23-069108 · ownership.xml · derivative · entry 1

Davidson Nancy · CIK 0002002946 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,000

Underlying: Common Stock · 74,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest in 36 equal monthly installments starting one month after grant date of December 7, 2023.

SEC source: 0000950170-23-069104 · ownership.xml · derivative · entry 1

Hillan Kenneth J. · CIK 0001600359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-069112 · ownership.xml · derivative · entry 1

Mahony Susan · CIK 0001463321 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-069121 · ownership.xml · derivative · entry 1

RENTON HOLLINGS · CIK 0001187333 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-069116 · ownership.xml · derivative · entry 1

Neu Kelvin · CIK 0001554699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-069115 · ownership.xml · derivative · entry 1

Cox Troy · CIK 0001696923 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-069126 · ownership.xml · derivative · entry 1

Campoy Carlos · CIK 0001761518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-069111 · ownership.xml · derivative · entry 1

Miller Derek John Michael · CIK 0001971973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

Underlying: Common Stock · 37,000 shares

Expires 2033-12-06

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 7, 2023.

SEC source: 0000950170-23-031230 · ownership.xml · derivative · entry 1

Campoy Carlos · CIK 0001761518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-06-29

F1 · derivative.exercise_date: Stock options vest in 36 equal monthly installments starting one month after grant date of June 30, 2023.

SEC source: 0000935836-23-000469 · ownership.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 13,437,473

F2 · shares: Qualified Fund purchased 3,157,542 of the shares purchased in this transaction.

F3 · balance_after: After this transaction, Qualified Fund directly owned 12,658,224 shares of the Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group withn the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-23-011069 · doc4.xml · derivative · entry 1

Miller Derek John Michael · CIK 0001971973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-04-09

F1 · derivative.exercise_date: Stock options vest in 36 equal monthly installments starting one month after grant date of April 10, 2023.

SEC source: 0000935836-23-000348 · form4.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See note

Disclosed balance after: 10,087,473

F2 · shares: Qualified Fund purchased 188,520 of the shares purchased in this transaction.

F3 · balance_after: After this transaction, Qualified Fund directly owned 9,500,682 shares of the Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-23-008432 · doc4.xml · derivative · entry 6

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,709

Underlying: Common Stock · 2,708 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F7 · derivative.exercise_date: The RSUs were granted on March 10, 2021 and vest in three equal annual instalments beginning on March 10, 2022.

F7 · derivative.expiration_date: The RSUs were granted on March 10, 2021 and vest in three equal annual instalments beginning on March 10, 2022.

SEC source: 0000899243-23-008432 · doc4.xml · derivative · entry 5

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUs were granted on March 10, 2020 and vest in three equal annual instalments beginning on March 10, 2021.

F6 · derivative.expiration_date: The RSUs were granted on March 10, 2020 and vest in three equal annual instalments beginning on March 10, 2021.

SEC source: 0000899243-23-008432 · doc4.xml · nonDerivative · entry 3

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,032

F3 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.815 to $7.86, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-23-008432 · doc4.xml · nonDerivative · entry 2

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,009

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Represents shares of common stock issued upon vesting of one third of the RSUs granted on March 10, 2021.

SEC source: 0000899243-23-008432 · doc4.xml · nonDerivative · entry 1

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,301

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on March 10, 2020.

SEC source: 0001567619-23-001148 · doc1.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 9,887,473

F4 · shares: Qualified Fund purchased 153,906 shares of the Common Stock acquired in this transaction.

F5 · balance_after: After this transaction, Qualified Fund directly owned 9,312,162 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0001567619-23-001148 · doc1.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 9,724,073

F2 · shares: Qualified Fund purchased 135,728 shares of the Common Stock acquired in this transaction.

F3 · balance_after: After this transaction, Qualified Fund directly owned 9,158,256 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0001567619-23-000997 · doc1.xml · nonDerivative · entry 3

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 9,579,973

F6 · shares: Qualified Fund purchased 191,206 shares of the Common Stock acquired in this transaction.

F7 · balance_after: After this transaction, Qualified Fund directly owned 9,022,528 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0001567619-23-000997 · doc1.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 9,376,973

F4 · shares: Qualified Fund purchased 414,436 shares of the Common Stock acquired in this transaction.

F5 · balance_after: After this transaction, Qualified Fund directly owned 8,831,322 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0001567619-23-000997 · doc1.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 8,936,973

F2 · shares: Qualified Fund purchased 322,224 shares of the Common Stock acquired in this transaction.

F3 · balance_after: After this transaction, Qualified Fund directly owned 8,416,886 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0001567619-23-000896 · doc1.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 8,594,873

F4 · shares: Qualified Fund purchased 100,124 shares of the Common Stock acquired in this transaction.

F5 · balance_after: After this transaction, Qualified Fund directly owned 8,094,662 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0001567619-23-000896 · doc1.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 8,488,573

F2 · shares: Qualified Fund purchased 861,156 shares of the Common Stock acquired in this transaction.

F3 · balance_after: After this transaction, Qualified Fund directly owned 7,994,538 shares of Common Stock.

F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-23-001217 · doc4.xml · derivative · entry 2

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,000

Underlying: Common Stock · 143,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2024.

F3 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2024.

SEC source: 0000899243-23-001217 · doc4.xml · derivative · entry 1

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,000

Underlying: Common Stock · 215,000 shares

Expires 2033-01-04

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000899243-23-001218 · doc4.xml · derivative · entry 2

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,500

Underlying: Common Stock · 31,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2024.

F3 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2024.

SEC source: 0000899243-23-001218 · doc4.xml · derivative · entry 1

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Common Stock · 47,000 shares

Expires 2033-01-04

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000899243-23-001219 · doc4.xml · derivative · entry 2

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,500

Underlying: Common Stock · 58,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2024.

F3 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2024.

SEC source: 0000899243-23-001219 · doc4.xml · derivative · entry 1

Klompas Neil A · CIK 0001761857 · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,500

Underlying: Common Stock · 87,500 shares

Expires 2033-01-04

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.