ZYME

SEC source: 0000950170-25-004358 · ownership.xml · derivative · entry 2

PATTERSON LEONE D · CIK 0001233539 · EVP, Chief Bus & Fin Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,000

Underlying: Common Stock · 53,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

SEC source: 0000950170-25-004358 · ownership.xml · derivative · entry 1

PATTERSON LEONE D · CIK 0001233539 · EVP, Chief Bus & Fin Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,000

Underlying: Common Stock · 79,000 shares

Expires 2035-01-09

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000950170-25-004336 · ownership.xml · derivative · entry 2

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 192,000

Underlying: Common Stock · 192,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

SEC source: 0000950170-25-004336 · ownership.xml · derivative · entry 1

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 288,000

Underlying: Common Stock · 288,000 shares

Expires 2035-01-09

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000935836-25-000048 · ownership.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 15,411,078

F4 · shares: Qualified Fund purchased 191,791 of the shares purchased in this transaction.

F5 · balance_after: After this transaction, Qualified Fund held 14,442,664 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-25-004346 · ownership.xml · derivative · entry 2

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,000

Underlying: Common Stock · 53,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

SEC source: 0000950170-25-004346 · ownership.xml · derivative · entry 1

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,000

Underlying: Common Stock · 79,000 shares

Expires 2035-01-09

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000950170-25-004352 · ownership.xml · derivative · entry 2

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,000

Underlying: Common Stock · 53,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

SEC source: 0000950170-25-004352 · ownership.xml · derivative · entry 1

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,000

Underlying: Common Stock · 79,000 shares

Expires 2035-01-09

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000935836-25-000048 · ownership.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 15,206,980

F2 · shares: Qualified Fund purchased 19,752 of the shares purchased in this transaction.

F3 · balance_after: After this transaction, Qualified Fund held 14,250,873 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-25-002497 · ownership.xml · derivative · entry 6

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,334

Underlying: Common Stock · 66,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F7 · derivative.exercise_date: The RSUS were granted on January 5, 2024 and vest in three equal annual installments beginning on the first anniversary of January 5, 2024.

F7 · derivative.expiration_date: The RSUS were granted on January 5, 2024 and vest in three equal annual installments beginning on the first anniversary of January 5, 2024.

SEC source: 0000950170-25-002497 · ownership.xml · derivative · entry 5

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,668

Underlying: Common Stock · 47,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on the first anniversary of January 5, 2023.

F6 · derivative.expiration_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on the first anniversary of January 5, 2023.

SEC source: 0000950170-25-002497 · ownership.xml · nonDerivative · entry 4

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,803

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.44 to $15.14, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-002497 · ownership.xml · nonDerivative · entry 3

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,209

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Represents shares of common stock issued upon vesting of one third of the RSUs granted on January 5, 2024.

SEC source: 0000950170-25-002497 · ownership.xml · nonDerivative · entry 2

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,543

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.44 to $15.14, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-002497 · ownership.xml · nonDerivative · entry 1

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,428

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 5, 2023.

SEC source: 0000950170-25-002490 · ownership.xml · derivative · entry 3

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUS were granted on January 5, 2024 and vest in three equal annual installments beginning on the first anniversary of January 5, 2024.

F5 · derivative.expiration_date: The RSUS were granted on January 5, 2024 and vest in three equal annual installments beginning on the first anniversary of January 5, 2024.

SEC source: 0000950170-25-002490 · ownership.xml · nonDerivative · entry 2

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,890

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.44 to $15.14, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-002490 · ownership.xml · nonDerivative · entry 1

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 5, 2024.

SEC source: 0000950170-25-002501 · ownership.xml · derivative · entry 6

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 20,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F7 · derivative.exercise_date: The RSUS were granted on January 5, 2024 and vest in three equal annual installments beginning on the first anniversary of January 5, 2024.

F7 · derivative.expiration_date: The RSUS were granted on January 5, 2024 and vest in three equal annual installments beginning on the first anniversary of January 5, 2024.

SEC source: 0000950170-25-002501 · ownership.xml · derivative · entry 5

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,168

Underlying: Common Stock · 17,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on the first anniversary of January 5, 2023.

F6 · derivative.expiration_date: The RSUS were granted on January 5, 2023 and vest in three equal annual installments beginning on the first anniversary of January 5, 2023.

SEC source: 0000950170-25-002501 · ownership.xml · nonDerivative · entry 4

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,333

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.44 to $15.14, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-002501 · ownership.xml · nonDerivative · entry 3

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,741

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Represents shares of common stock issued upon vesting of one third of the RSUs granted on January 5, 2024.

SEC source: 0000950170-25-002501 · ownership.xml · nonDerivative · entry 2

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,741

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.44 to $15.14, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-002501 · ownership.xml · nonDerivative · entry 1

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,533

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 5, 2023.

SEC source: 0000935836-25-000007 · ownership.xml · nonDerivative · entry 3

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 15,185,959

F6 · shares: Qualified Fund purchased 152,346 of the shares purchased in this transaction.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $14.7789 to $14.78, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote 7.

F8 · balance_after: After this transaction, Qualified Fund held 14,231,121 shares of the Issuer's Common Stock

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-25-000007 · ownership.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 15,028,079

F4 · shares: Qualified Fund purchased 61,501 of the shares purchased in this transaction.

F5 · balance_after: After this transaction, Qualified Fund held 14,078,775 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-25-000007 · ownership.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 14,881,578

F2 · shares: Qualified Fund purchased 55,513 of the shares purchased in this transaction.

F3 · balance_after: After this transaction, Qualified Fund held 14,017,274 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000785 · ownership.xml · nonDerivative · entry 3

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 14,822,590

F7 · shares: Qualified Fund purchased 95,672 of the shares purchased in this transaction.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $14.2405 to $14.50, inclusive.

F9 · balance_after: After this transaction, Qualified Fund held 13,961,761 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000785 · ownership.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 14,720,931

F5 · shares: Qualified Fund purchased 15,707 of the shares purchased in this transaction.

F6 · balance_after: After this transaction, Qualified Fund held 13,866,089 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000785 · ownership.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 14,704,239

F2 · shares: Qualified Fund purchased 11,254 of the shares purchased in this transaction.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $13.9473 and $14.14 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes 3 and 8.

F4 · balance_after: After this transaction, Qualified Fund held 13,850,382 shares of the Issuer's Common Stock.

F1 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000780 · ownership.xml · nonDerivative · entry 3

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 14,692,281

F1 · security: This transaction was inadvertently omitted from the Form 4 filed on 12/23/2024.

F9 · shares: Qualified Fund purchased 236,691 of the shares purchased in this transaction.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $14.1957 to $14.2713, inclusive.

F11 · balance_after: After this transaction, Qualified Fund held 13,839,128 shares of the Issuer's Common Stock.

F2 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000780 · ownership.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 14,440,779

F1 · security: This transaction was inadvertently omitted from the Form 4 filed on 12/23/2024.

F6 · shares: Qualified Fund purchased 662,995 of the shares purchased in this transaction.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $13.6517 to $14.1388, inclusive.

F8 · balance_after: After this transaction, Qualified Fund held 13,602,437 shares of the Issuer's Common Stock.

F2 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000935836-24-000780 · ownership.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 13,736,291

F1 · security: This transaction was inadvertently omitted from the Form 4 filed on 12/23/2024.

F3 · shares: Qualified Fund purchased 281,218 of the shares purchased in this transaction.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $13.3758 to $13.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes 4, 7 and 10.

F5 · balance_after: After this transaction, Qualified Fund held 12,939,442 shares of the Issuer's Common Stock.

F2 · ownership.nature: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-24-135923 · ownership.xml · derivative · entry 1

Davidson Nancy · CIK 0002002946 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135919 · ownership.xml · derivative · entry 1

Gallagher Neil · CIK 0001972849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135921 · ownership.xml · derivative · entry 1

Mahony Susan · CIK 0001463321 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135928 · ownership.xml · derivative · entry 1

Neu Kelvin · CIK 0001554699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135922 · ownership.xml · derivative · entry 1

Cox Troy · CIK 0001696923 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135948 · ownership.xml · derivative · entry 1

Campoy Carlos · CIK 0001761518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135932 · ownership.xml · derivative · entry 1

Cesano Alessandra · CIK 0001827015 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-135950 · ownership.xml · derivative · entry 1

Miller Derek John Michael · CIK 0001971973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,000

Underlying: Common Stock · 31,000 shares

Expires 2034-12-09

F1 · derivative.exercise_date: Stock options vest on date of next annual general meeting following grant date of December 10, 2024.

SEC source: 0000950170-24-102982 · ownership.xml · derivative · entry 1

PATTERSON LEONE D · CIK 0001233539 · EVP, Chief Bus & Fin Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 360,000

Underlying: Common Stock · 360,000 shares

Expires 2034-08-31

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares on first anniversary of grant date and (ii) remainder of underlying shares in 36 equal monthly installments on last day of month following first anniversary of grant date.

SEC source: 0000950170-24-040632 · ownership.xml · derivative · entry 1

Gallagher Neil · CIK 0001972849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,000

Underlying: Common Stock · 74,000 shares

Expires 2034-04-01

F1 · derivative.exercise_date: Stock options vest in 36 equal monthly installments starting one month after grant date of April 2, 2024.

SEC source: 0000950170-24-013427 · ownership.xml · derivative · entry 1

Cesano Alessandra · CIK 0001827015 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,000

Underlying: Common Stock · 74,000 shares

Expires 2034-02-07

F1 · derivative.exercise_date: Stock options vest in 36 equal monthly installments starting one month after grant date of February 8, 2024.

SEC source: 0000950170-24-003099 · ownership.xml · nonDerivative · entry 3

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,762

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.49 to $11.58, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-003087 · ownership.xml · nonDerivative · entry 3

Astle Christopher · CIK 0001915257 · SVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,503

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.49 to $11.58, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-003076 · ownership.xml · nonDerivative · entry 3

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,367

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.49 to $11.58, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-003099 · ownership.xml · derivative · entry 6

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F8 · derivative.exercise_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

F8 · derivative.expiration_date: The RSUs vest in three equal annual installments beginning on January 5, 2025.

SEC source: 0000950170-24-003099 · ownership.xml · derivative · entry 5

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2034-01-04

F7 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.