ZNTL

SEC source: 0001628280-26-064317 · wk-form4_1790889591.xml · nonDerivative · entry 1

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,059

F1 · kind: The reporting person is voluntarily reporting the acquisition of shares of the Issuer's common stock pursuant to the Issuer's 2020 Employee Stock Purchase Plan ("ESPP") for the ESPP purchase period of April 1, 2026 through September 30, 2026. This transaction is exempt under Rule 16b-3(c).

F2 · price: In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the Issuer's common stock on April 1, 2026.

SEC source: 0001213900-26-091823 · ownership.xml · nonDerivative · entry 1

WALTERS GROUP · CIK 0001177523 · 10% owner

WALTERS WILLIAM THURMAN · CIK 0001689655 · 10% owner

WALTERS SUSAN BERKLEY · CIK 0001689761 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,844,973

F1 · shares: The shares of common stock reported herein (the "Shares") are held directly by The Walters Group (the "TWG"). William T. Walters may be deemed to share voting and dispositive power with respect to the Shares. Susan B. Walters is the general partner and majority member of TWG and may be deemed to share voting and dispositive power with respect to the Shares. Each Reporting Person disclaims Section 16 beneficial ownership of the Shares reported herein except to the extent of its pecuniary interest therein, if any, and the inclusion of these Shares in this report shall not be deemed an admission of beneficial ownership of any of the reported Shares for purposes of Section 16 or any other purpose.

F1 · balance_after: The shares of common stock reported herein (the "Shares") are held directly by The Walters Group (the "TWG"). William T. Walters may be deemed to share voting and dispositive power with respect to the Shares. Susan B. Walters is the general partner and majority member of TWG and may be deemed to share voting and dispositive power with respect to the Shares. Each Reporting Person disclaims Section 16 beneficial ownership of the Shares reported herein except to the extent of its pecuniary interest therein, if any, and the inclusion of these Shares in this report shall not be deemed an admission of beneficial ownership of any of the reported Shares for purposes of Section 16 or any other purpose.

F1 · ownership.direct: The shares of common stock reported herein (the "Shares") are held directly by The Walters Group (the "TWG"). William T. Walters may be deemed to share voting and dispositive power with respect to the Shares. Susan B. Walters is the general partner and majority member of TWG and may be deemed to share voting and dispositive power with respect to the Shares. Each Reporting Person disclaims Section 16 beneficial ownership of the Shares reported herein except to the extent of its pecuniary interest therein, if any, and the inclusion of these Shares in this report shall not be deemed an admission of beneficial ownership of any of the reported Shares for purposes of Section 16 or any other purpose.

SEC source: 0001808098-26-000003 · wk-form4_1781813348.xml · nonDerivative · entry 1

Johnson David Michael · CIK 0001808098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 307,521

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 16, 2027 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001838042-26-000003 · wk-form4_1781813319.xml · nonDerivative · entry 1

Skvarka Jan · CIK 0001838042 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 264,254

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 16, 2027 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001843119-26-000003 · wk-form4_1781813217.xml · nonDerivative · entry 1

Kariuki Enoch · CIK 0001843119 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 194,465

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 16, 2027 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001701440-26-000004 · wk-form4_1781813274.xml · nonDerivative · entry 1

Walker Luke Nathaniel · CIK 0001701440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 201,384

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 16, 2027 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001356256-26-000005 · wk-form4_1781813168.xml · nonDerivative · entry 1

Myers Scott Dunseth · CIK 0001356256 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 395,895

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 16, 2027 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0002018966-26-000005 · wk-form4_1779912686.xml · nonDerivative · entry 1

Campbell Shannon · CIK 0002018966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,200

F1 · balance_after: The restricted stock units ("RSUs") were granted by the Issuer pursuant to the Issuer's Non-Employee Director Compensation Program. One third of the RSUs will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0002018766-26-000006 · wk-form4_1770775823.xml · nonDerivative · entry 3

Vultaggio Vincent · CIK 0002018766 · PAO and PFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 146,506

F2 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 18, 2025.

SEC source: 0001838041-26-000004 · wk-form4_1770775846.xml · nonDerivative · entry 2

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,332

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0002018766-26-000006 · wk-form4_1770775823.xml · nonDerivative · entry 2

Vultaggio Vincent · CIK 0002018766 · PAO and PFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 153,400

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001500189-26-000004 · wk-form4_1770775778.xml · nonDerivative · entry 2

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,133

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001838041-26-000004 · wk-form4_1770775846.xml · nonDerivative · entry 1

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,667

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0002018766-26-000006 · wk-form4_1770775823.xml · nonDerivative · entry 1

Vultaggio Vincent · CIK 0002018766 · PAO and PFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 156,779

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001500189-26-000004 · wk-form4_1770775778.xml · nonDerivative · entry 1

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,022

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0002018766-26-000004 · wk-form4_1770254867.xml · nonDerivative · entry 2

Vultaggio Vincent · CIK 0002018766 · PAO and PFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 186,730

F2 · shares: This sale was effected pursuant to a Rule 10b5-1 trading arrangement adopted by the Reporting Person.

SEC source: 0002018766-26-000004 · wk-form4_1770254867.xml · nonDerivative · entry 1

Vultaggio Vincent · CIK 0002018766 · PAO and PFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 187,286

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0002018766-26-000002 · wk-form4_1768008966.xml · derivative · entry 1

Vultaggio Vincent · CIK 0002018766 · PAO and PFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Stock Option · 100,000 shares

Expires 2036-01-07

F1 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001664928-26-000003 · wk-form4_1768008932.xml · derivative · entry 1

Bucher James B · CIK 0001664928 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2036-01-07

F1 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001838041-26-000002 · wk-form4_1768008888.xml · derivative · entry 1

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 365,000

Underlying: Common Stock · 365,000 shares

Expires 2036-01-07

F1 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001500189-26-000002 · wk-form4_1768008785.xml · derivative · entry 1

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 775,000

Underlying: Common Stock · 775,000 shares

Expires 2036-01-07

F1 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001213900-26-002567 · ownership.xml · nonDerivative · entry 1

WALTERS GROUP · CIK 0001177523 · 10% owner

WALTERS WILLIAM THURMAN · CIK 0001689655 · 10% owner

WALTERS SUSAN BERKLEY · CIK 0001689761 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,509,973

F1 · shares: The shares of common stock reported herein (the "Shares") are held directly by The Walters Group (the "TWG"). William T. Walters may be deemed to share voting and dispositive power with respect to the Shares. Susan B. Walters is the general partner and majority member of TWG and may be deemed to share voting and dispositive power with respect to the Shares. Each Reporting Person disclaims Section 16 beneficial ownership of the Shares reported herein except to the extent of its pecuniary interest therein, if any, and the inclusion of these Shares in this report shall not be deemed an admission of beneficial ownership of any of the reported Shares for purposes of Section 16 or any other purpose.

F1 · balance_after: The shares of common stock reported herein (the "Shares") are held directly by The Walters Group (the "TWG"). William T. Walters may be deemed to share voting and dispositive power with respect to the Shares. Susan B. Walters is the general partner and majority member of TWG and may be deemed to share voting and dispositive power with respect to the Shares. Each Reporting Person disclaims Section 16 beneficial ownership of the Shares reported herein except to the extent of its pecuniary interest therein, if any, and the inclusion of these Shares in this report shall not be deemed an admission of beneficial ownership of any of the reported Shares for purposes of Section 16 or any other purpose.

F1 · ownership.direct: The shares of common stock reported herein (the "Shares") are held directly by The Walters Group (the "TWG"). William T. Walters may be deemed to share voting and dispositive power with respect to the Shares. Susan B. Walters is the general partner and majority member of TWG and may be deemed to share voting and dispositive power with respect to the Shares. Each Reporting Person disclaims Section 16 beneficial ownership of the Shares reported herein except to the extent of its pecuniary interest therein, if any, and the inclusion of these Shares in this report shall not be deemed an admission of beneficial ownership of any of the reported Shares for purposes of Section 16 or any other purpose.

SEC source: 0000902664-25-005288 · ownership.xml · nonDerivative · entry 1

Matrix Capital Management Company, LP · CIK 0001410830 · 10% owner

GOEL DAVID E. · CIK 0001548144 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 6,459,973

F1 · ownership.nature: The securities reported herein are held by Matrix Capital Management Master Fund, LP (the "Matrix Fund"). Matrix Capital Management Company, LP (the "Investment Manager"), a Delaware limited partnership, is the investment advisor to the Matrix Fund. Mr. David E. Goel ("Mr. Goel", and together with the Investment Manager, the "Reporting Persons"), serves as the Managing General Partner of the Investment Manager.

F2 · ownership.nature: The filing of this statement shall not be deemed an admission that either of the Reporting Persons is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its or his pecuniary interest therein.

SEC source: 0001664928-25-000008 · wk-form4_1759358422.xml · derivative · entry 1

Bucher James B · CIK 0001664928 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2025-09-30

F1 · derivative.exercise_date: The options will vest over a four-year period as follows: 25% of the options will vest on October 1, 2026, with the remaining 75% vesting in substantially equal monthly installments thereafter until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000133 · wk-form4_1750277742.xml · nonDerivative · entry 1

Johnson David Michael · CIK 0001808098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,421

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 17, 2026 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001725160-25-000137 · wk-form4_1750277940.xml · nonDerivative · entry 1

Walker Luke Nathaniel · CIK 0001701440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,284

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 17, 2026 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001725160-25-000135 · wk-form4_1750277814.xml · nonDerivative · entry 1

Skvarka Jan · CIK 0001838042 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 207,154

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 17, 2026 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001725160-25-000131 · wk-form4_1750277634.xml · nonDerivative · entry 1

Kariuki Enoch · CIK 0001843119 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,365

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 17, 2026 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001725160-25-000129 · wk-form4_1750277537.xml · nonDerivative · entry 1

Myers Scott Dunseth · CIK 0001356256 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 338,795

F1 · shares: Represents restricted stock units granted pursuant to the Issuer's Non-Employee Director Compensation Program, each of which represents a contingent right to receive one share of common stock, and which will vest on the first to occur of (a) June 17, 2026 or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date.

SEC source: 0001725160-25-000094 · wk-form4_1746047232.xml · nonDerivative · entry 1

Myers Scott Dunseth · CIK 0001356256 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 281,192

SEC source: 0001725160-25-000047 · wk-form4_1739397624.xml · nonDerivative · entry 1

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,629

SEC source: 0001725160-25-000040 · wk-form4_1738798313.xml · derivative · entry 3

Paul Andrea · CIK 0001863130 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,714

Underlying: Common Stock · 124,714 shares

Expires 2035-02-02

F3 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000040 · wk-form4_1738798313.xml · nonDerivative · entry 2

Paul Andrea · CIK 0001863130 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,070,784

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001725160-25-000040 · wk-form4_1738798313.xml · nonDerivative · entry 1

Paul Andrea · CIK 0001863130 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,084,014

F1 · shares: Represents restricted stock units, each of which represent a contingent right to receive one share of common stock, and which will vest in substantially equal annual installments over a two year period following the grant date, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000043 · wk-form4_1738798376.xml · derivative · entry 3

Vultaggio Vincent · CIK 0002018766 · PAO and Interim PFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,633

Underlying: Common Stock · 35,633 shares

Expires 2035-02-02

F3 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000043 · wk-form4_1738798376.xml · nonDerivative · entry 2

Vultaggio Vincent · CIK 0002018766 · PAO and Interim PFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 189,826

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001725160-25-000043 · wk-form4_1738798376.xml · nonDerivative · entry 1

Vultaggio Vincent · CIK 0002018766 · PAO and Interim PFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 192,441

F1 · shares: Represents restricted stock units, each of which represent a contingent right to receive one share of common stock, and which will vest in substantially equal annual installments over a two year period following the grant date, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000041 · wk-form4_1738798344.xml · derivative · entry 3

Lackner Mark · CIK 0001777413 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,714

Underlying: Common Stock · 124,714 shares

Expires 2035-02-02

F3 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000041 · wk-form4_1738798344.xml · nonDerivative · entry 2

Lackner Mark · CIK 0001777413 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 512,856

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001725160-25-000041 · wk-form4_1738798344.xml · nonDerivative · entry 1

Lackner Mark · CIK 0001777413 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 527,224

F1 · shares: Represents restricted stock units, each of which represent a contingent right to receive one share of common stock, and which will vest in substantially equal annual installments over a two year period following the grant date, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000036 · wk-form4_1738798191.xml · derivative · entry 2

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,388

Underlying: Common Stock · 59,388 shares

Expires 2035-02-02

F2 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000036 · wk-form4_1738798191.xml · nonDerivative · entry 1

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,888

F1 · shares: Represents restricted stock units, each of which represent a contingent right to receive one share of common stock, and which will vest in substantially equal annual installments over a two year period following the grant date, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000037 · wk-form4_1738798229.xml · derivative · entry 2

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,629

Underlying: Common Stock · 16,629 shares

Expires 2035-02-02

F2 · derivative.exercise_date: The options will vest over four years in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000037 · wk-form4_1738798229.xml · nonDerivative · entry 1

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,629

F1 · shares: Represents restricted stock units, each of which represent a contingent right to receive one share of common stock, and which will vest in substantially equal annual installments over a two year period following the grant date, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-25-000030 · wk-form4_1738705494.xml · nonDerivative · entry 1

Skvarka Jan · CIK 0001838042 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,551

SEC source: 0001725160-25-000029 · wk-form4_1738705431.xml · nonDerivative · entry 1

Walker Luke Nathaniel · CIK 0001701440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,681

SEC source: 0001725160-25-000028 · wk-form4_1738705022.xml · nonDerivative · entry 1

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,500

SEC source: 0001725160-25-000002 · wk-form4_1735942617.xml · nonDerivative · entry 1

Lackner Mark · CIK 0001777413 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,317

F1 · kind: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units previously granted to the Reporting Person.

SEC source: 0001725160-24-000190 · wk-form4_1733270555.xml · derivative · entry 1

Bruns Ingmar · CIK 0001838041 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 712,650

Underlying: Common Stock · 712,650 shares

Expires 2034-12-02

F1 · derivative.exercise_date: The options will vest over a four-year period as follows: 25% of the options will vest on November 13, 2025, with the remaining 75% vesting in substantially equal monthly installments thereafter until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.

SEC source: 0001725160-24-000189 · wk-form4_1733270528.xml · derivative · entry 1

EASTLAND JULIA MARIE · CIK 0001500189 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,028,800

Underlying: Common Stock · 3,028,800 shares

Expires 2034-12-02

F1 · derivative.exercise_date: The options will vest over a four-year period following the vesting commencement date of November 13, 2024, in substantially equal monthly installments until the options are fully vested, subject to the Reporting Person's continued service with the Issuer.