VRTX

SEC source: 0000875320-24-000212 · wk-form4_1725480803.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,994

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 05/10/2024.

SEC source: 0000875320-24-000204 · wk-form4_1723493293.xml · derivative · entry 3

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 646

Underlying: Common Stock · 1,292 shares

Expires 2028-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000204 · wk-form4_1723493293.xml · nonDerivative · entry 2

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,435

F1 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1, which was entered into on 05/09/2024.

SEC source: 0000875320-24-000204 · wk-form4_1723493293.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,727

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-24-000202 · wk-form4_1723147577.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,259

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 02/27/2024.

SEC source: 0000875320-24-000200 · wk-form4_1722629400.xml · derivative · entry 3

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,295 shares

Expires 2027-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000200 · wk-form4_1722629400.xml · nonDerivative · entry 2

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,000

F1 · kind: Transaction made pursuant to Mr. Sachs' company approved trading plan under Rule 10b5-1, which was entered into on 02/12/2024.

SEC source: 0000875320-24-000200 · wk-form4_1722629400.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,295

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-24-000195 · wk-form4_1722543438.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 90,970

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

SEC source: 0000875320-24-000189 · wk-form4_1721937956.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,539

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 02/27/2024.

SEC source: 0000875320-24-000187 · wk-form4_1721851538.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,172

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

SEC source: 0000875320-24-000185 · wk-form4_1721247199.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,943.012

Underlying: Common Stock · 89.264 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-24-000183 · wk-form4_1720814825.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,819

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 02/27/2024.

SEC source: 0000875320-24-000181 · wk-form4_1719605071.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,099

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 02/27/2024.

SEC source: 0000875320-24-000174 · wk-form4_1718309345.xml · nonDerivative · entry 2

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,972

F1 · kind: Transaction made pursuant to Mr. Atkinson's company approved trading plan under Rule 10b5-1, which was entered into on 02/22/2024.

SEC source: 0000875320-24-000176 · wk-form4_1718309487.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,379

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 02/27/2024.

SEC source: 0000875320-24-000174 · wk-form4_1718309345.xml · nonDerivative · entry 1

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,260

SEC source: 0000875320-24-000172 · wk-form4_1717790851.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: No plan indicated

Ownership: Indirect · Held in Trust

Disclosed balance after: 0

SEC source: 0000875320-24-000168 · wk-form4_1717618128.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,098

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 02/29/2024.

SEC source: 0000875320-24-000170 · wk-form4_1717618308.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,137

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1, which was entered into on 02/26/2024.

SEC source: 0000875320-24-000166 · wk-form4_1717445345.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,273

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 02/29/2024.

SEC source: 0000875320-24-000166 · wk-form4_1717445345.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,523

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 02/29/2024.

SEC source: 0000875320-24-000164 · wk-form4_1717186773.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,659

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 02/27/2024.

SEC source: 0000875320-24-000162 · wk-form4_1717099663.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,387

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1, which was entered into on 02/26/2024.

SEC source: 0000875320-24-000160 · wk-form4_1717013304.xml · derivative · entry 3

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,565 shares

Expires 2029-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000160 · wk-form4_1717013304.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,374

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

SEC source: 0000875320-24-000160 · wk-form4_1717013304.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,939

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-24-000158 · wk-form4_1716581569.xml · derivative · entry 3

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,073 shares

Expires 2026-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000158 · wk-form4_1716581569.xml · nonDerivative · entry 2

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,000

F1 · kind: Transaction made pursuant to Mr. Sachs' company approved trading plan under Rule 10b5-1, which was entered into on 02/12/2024.

SEC source: 0000875320-24-000158 · wk-form4_1716581569.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,073

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-24-000156 · wk-form4_1716409296.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,374

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

SEC source: 0000875320-24-000148 · wk-form4_1715977097.xml · nonDerivative · entry 1

Schneider Jennifer · CIK 0001783060 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 922

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-24-000150 · wk-form4_1715977306.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,813

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1, which was entered into on 5/10/2023.

SEC source: 0000875320-24-000152 · wk-form4_1715977463.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,691

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1, which was entered into on 02/28/2023.

SEC source: 0000875320-24-000154 · wk-form4_1715977634.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,325

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1, which was entered into on 05/09/2023.

SEC source: 0000875320-24-000144 · wk-form4_1715890307.xml · nonDerivative · entry 1

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,084

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 05/19/2021 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 05/14/2024 and the shares will vest on 06/10/2024.

SEC source: 0000875320-24-000117 · wk-form4_1714766716.xml · nonDerivative · entry 2

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,435

F2 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1, which was entered into on 05/10/2023.

SEC source: 0000875320-24-000117 · wk-form4_1714766716.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,902

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-24-000119 · wk-form4_1714766934.xml · nonDerivative · entry 1

CARNEY LLOYD · CIK 0001204424 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,319

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-24-000121 · wk-form4_1714767073.xml · derivative · entry 1

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,142

Underlying: Common Stock · 3,142 shares

Expires 2034-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000123 · wk-form4_1714767244.xml · derivative · entry 1

Kearney Terrence C · CIK 0001289098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,142

Underlying: Common Stock · 3,142 shares

Expires 2034-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000125 · wk-form4_1714767388.xml · derivative · entry 1

Lagarde Michel · CIK 0001518973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,142

Underlying: Common Stock · 3,142 shares

Expires 2034-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000127 · wk-form4_1714767498.xml · derivative · entry 4

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,990.483

Underlying: Common Stock · 1,168 shares

Expires not disclosed

F3 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2023, Ms. McKenzie deferred the receipt of 1,168 shares of common stock and received instead 1,168 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 1,168 shares of common stock in exchange for an equal number of deferred stock units.

F3 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

F3 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

SEC source: 0000875320-24-000127 · wk-form4_1714767498.xml · nonDerivative · entry 2

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,436

F2 · price: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2023, Ms. McKenzie deferred the receipt of 1,168 shares of common stock and received instead 1,168 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 1,168 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-24-000127 · wk-form4_1714767498.xml · nonDerivative · entry 1

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,604

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-24-000129 · wk-form4_1714767664.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,142

Underlying: Common Stock · 3,142 shares

Expires 2034-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000131 · wk-form4_1714767803.xml · derivative · entry 2

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,571

Underlying: Common Stock · 1,571 shares

Expires 2034-04-30

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000131 · wk-form4_1714767803.xml · nonDerivative · entry 1

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,637

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-24-000133 · wk-form4_1714767971.xml · derivative · entry 3

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,402.996

Underlying: Common Stock · 1,168 shares

Expires not disclosed

F3 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Mr. Upadhyay on May 1, 2023, Mr. Upadhyay deferred the receipt of 1,168 shares of common stock and received instead 1,168 deferred stock units pursuant to our deferred compensation plan. As a result, Mr. Upadhyay is reporting the disposition of 1,168 shares of common stock in exchange for an equal number of deferred stock units.

F3 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F3 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-24-000133 · wk-form4_1714767971.xml · nonDerivative · entry 2

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,559

F2 · price: Upon the vesting of restricted stock units granted to Mr. Upadhyay on May 1, 2023, Mr. Upadhyay deferred the receipt of 1,168 shares of common stock and received instead 1,168 deferred stock units pursuant to our deferred compensation plan. As a result, Mr. Upadhyay is reporting the disposition of 1,168 shares of common stock in exchange for an equal number of deferred stock units.