VRTX

SEC source: 0000875320-25-000065 · wk-form4_1739567507.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,853

F1 · shares: Restricted stock unit award that vests in installments beginning on 02/24/2026.

SEC source: 0000875320-25-000067 · wk-form4_1739567593.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,933

F1 · shares: Restricted stock unit award that vests in installments beginning on 02/24/2026.

SEC source: 0000875320-25-000071 · wk-form4_1739567825.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,617

F1 · shares: Restricted stock unit award that fully vested upon grant.

SEC source: 0000875320-25-000069 · wk-form4_1739567669.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,802

F1 · shares: Restricted stock unit award that vests in installments beginning on 02/24/2026.

SEC source: 0000875320-25-000073 · wk-form4_1739567930.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,232

F1 · shares: Restricted stock unit award that vests in installments beginning on 02/24/2026.

SEC source: 0000875320-25-000075 · wk-form4_1739568057.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,534

F1 · shares: Restricted stock unit award that vests in installments beginning on 02/24/2026.

SEC source: 0000875320-25-000033 · wk-form4_1739395442.xml · nonDerivative · entry 2

Ambrose Kristen · CIK 0001856587 · SVP & Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,953

F1 · kind: Transaction made pursuant to Ms. Ambrose's company approved trading plan under Rule 10b5-1, which was entered into on 08/08/2024.

SEC source: 0000875320-25-000037 · wk-form4_1739395783.xml · nonDerivative · entry 2

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,225

F1 · kind: Transaction made pursuant to Mr. Atkinson's company approved trading plan under Rule 10b5-1, which was entered into on 02/22/2024.

SEC source: 0000875320-25-000039 · wk-form4_1739396180.xml · nonDerivative · entry 2

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,330

F1 · kind: Transaction made pursuant to Mr. Biller's company approved trading plan under Rule 10b5-1, which was entered into on 02/13/2024.

F2 · price: Mr. Biller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $459.87 (range $459.83 to $460.00).

SEC source: 0000875320-25-000048 · wk-form4_1739397030.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,021

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 02/29/2024.

SEC source: 0000875320-25-000031 · wk-form4_1739395266.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,099

SEC source: 0000875320-25-000033 · wk-form4_1739395442.xml · nonDerivative · entry 1

Ambrose Kristen · CIK 0001856587 · SVP & Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,329

SEC source: 0000875320-25-000035 · wk-form4_1739395597.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,543

SEC source: 0000875320-25-000037 · wk-form4_1739395783.xml · nonDerivative · entry 1

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,972

SEC source: 0000875320-25-000039 · wk-form4_1739396180.xml · nonDerivative · entry 1

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,763

SEC source: 0000875320-25-000041 · wk-form4_1739396310.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,307

SEC source: 0000875320-25-000044 · wk-form4_1739396757.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,918

SEC source: 0000875320-25-000046 · wk-form4_1739396879.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,591

SEC source: 0000875320-25-000048 · wk-form4_1739397030.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,331

SEC source: 0000875320-25-000050 · wk-form4_1739397137.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,879

SEC source: 0000875320-25-000005 · wk-form4_1738876056.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,241

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000005 · wk-form4_1738876056.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,127

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000007 · wk-form4_1738876523.xml · nonDerivative · entry 2

Ambrose Kristen · CIK 0001856587 · SVP & Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,920

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000007 · wk-form4_1738876523.xml · nonDerivative · entry 1

Ambrose Kristen · CIK 0001856587 · SVP & Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,066

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000009 · wk-form4_1738876713.xml · nonDerivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,763

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000009 · wk-form4_1738876713.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,315

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000011 · wk-form4_1738876909.xml · nonDerivative · entry 2

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,848

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000011 · wk-form4_1738876909.xml · nonDerivative · entry 1

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,104

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000014 · wk-form4_1738877513.xml · nonDerivative · entry 1

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,395

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000016 · wk-form4_1738877728.xml · nonDerivative · entry 2

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,449

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000016 · wk-form4_1738877728.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,521

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000018 · wk-form4_1738877851.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,218

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000018 · wk-form4_1738877851.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,890

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000020 · wk-form4_1738877930.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,408

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/17/2025.

SEC source: 0000875320-25-000022 · wk-form4_1738878100.xml · nonDerivative · entry 2

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,647

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000022 · wk-form4_1738878100.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,533

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000024 · wk-form4_1738878214.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,474

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000024 · wk-form4_1738878214.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,360

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000026 · wk-form4_1738878299.xml · nonDerivative · entry 2

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,528

F2 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/07/2024 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest in installments beginning on 02/17/2025.

SEC source: 0000875320-25-000026 · wk-form4_1738878299.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,414

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/04/2025 and the shares will vest on 02/26/2025.

SEC source: 0000875320-25-000002 · wk-form4_1737147865.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,144.986

Underlying: Common Stock · 111.654 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-24-000229 · wk-form4_1732050530.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,813

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1, which was entered into on 8/8/2024.

SEC source: 0000875320-24-000227 · wk-form4_1731532506.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,137

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1, which was entered into on 08/08/2024.

SEC source: 0000875320-24-000225 · wk-form4_1731445703.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,772

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 02/07/2024.

SEC source: 0000875320-24-000216 · wk-form4_1729195965.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,033.332

Underlying: Common Stock · 90.32 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-24-000214 · wk-form4_1727986328.xml · nonDerivative · entry 2

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,651

F1 · kind: Transaction made pursuant to Mr. Biller's company approved trading plan under Rule 10b5-1, which was entered into on 02/13/2024.

SEC source: 0000875320-24-000214 · wk-form4_1727986328.xml · nonDerivative · entry 1

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,650

SEC source: 0000875320-24-000211 · wk-form4_1725480753.xml · derivative · entry 3

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 646 shares

Expires 2028-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-24-000211 · wk-form4_1725480753.xml · nonDerivative · entry 2

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,435

F1 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1, which was entered into on 05/09/2024.

SEC source: 0000875320-24-000211 · wk-form4_1725480753.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,081

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.