VRTX

SEC source: 0000875320-25-000244 · wk-form4_1764969166.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,793

F1 · kind: Transaction made pursuant to Dr. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 08/21/2025.

F2 · balance_after: Open market sales reported on this line occurred at a weighted average price of $449.99 (range $449.99 to $450.00).

F3 · balance_after: Dr. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

SEC source: 0000875320-25-000247 · wk-form4_1764969405.xml · nonDerivative · entry 2

WAGNER CHARLES F JR · CIK 0001223348 · EVP, CO & FO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,725

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1, which was entered into on 5/9/2025.

SEC source: 0000875320-25-000247 · wk-form4_1764969405.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP, CO & FO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,725

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1, which was entered into on 5/9/2025.

SEC source: 0000875320-25-000238 · wk-form4_1763672580.xml · nonDerivative · entry 1

CARNEY LLOYD · CIK 0001204424 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,315

SEC source: 0000875320-25-000236 · wk-form4_1763586372.xml · nonDerivative · entry 1

Atkinson Edward Morrow III · CIK 0001914164 · EVP, Chief Technical Ops. Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,852

F1 · kind: Transaction made pursuant to Mr. Atkinson's company approved trading plan under Rule 10b5-1, which was entered into on 08/11/2025.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · derivative · entry 12

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,781

Underlying: Common Stock · 39,769 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · derivative · entry 11

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1

Underlying: Common Stock · 13,835 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 8

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,026

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 7

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,066

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.

F2 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $441.35 (range $441.00 to $441.99).

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 6

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,396

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.

F2 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $440.30 (range $440.00 to $440.99).

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 5

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 77,630

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 4

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,861

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · derivative · entry 10

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,836

Underlying: Common Stock · 19,688 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 3

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,026

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.

F2 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $441.05 (range $441.00 to $441.10).

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 2

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,186

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.

F2 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $440.22 (range $440.00 to $440.99).

SEC source: 0000875320-25-000234 · wk-form4_1763413922.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,714

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000875320-25-000226 · wk-form4_1760731442.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,457.433

Underlying: Common Stock · 115.766 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0001533149-25-000003 · wk-form4_1760731543.xml · derivative · entry 1

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,638.332

Underlying: Common Stock · 86.825 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-25-000224 · wk-form4_1759522036.xml · nonDerivative · entry 2

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,653

F1 · kind: Transaction made pursuant to Mr. Biller's company approved trading plan under Rule 10b5-1, which was entered into on 02/24/2025.

SEC source: 0000875320-25-000224 · wk-form4_1759522036.xml · nonDerivative · entry 1

Biller Jonathan · CIK 0001744749 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,347

SEC source: 0000875320-25-000222 · wk-form4_1756497726.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,565

F1 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1, which was entered into on 05/27/2025.

SEC source: 0000875320-25-000218 · wk-form4_1754597921.xml · nonDerivative · entry 2

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

F2 · price: Mr. Sachs undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price.

F3 · price: Open market purchases reported on this line occurred at a weighted average price of $389.84 (range $389.61 to $390.00).

SEC source: 0000875320-25-000218 · wk-form4_1754597921.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,634

F1 · price: Open market purchases reported on this line occurred at a weighted average price of $389.36 (range $388.61 to $389.60).

F2 · price: Mr. Sachs undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price.

SEC source: 0000875320-25-000220 · wk-form4_1754598207.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,968

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price.

F3 · price: Open market purchases reported on this line occurred at a weighted average price of $389.95 (range $389.72 to $390.53).

SEC source: 0000875320-25-000220 · wk-form4_1754598207.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,258

F1 · price: Open market purchases reported on this line occurred at a weighted average price of $389.08 (range $388.71 to $389.43).

F2 · price: Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price.

SEC source: 0000875320-25-000208 · wk-form4_1752782649.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,341.667

Underlying: Common Stock · 101.206 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-25-000210 · wk-form4_1752782953.xml · derivative · entry 1

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,551.507

Underlying: Common Stock · 75.904 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-25-000204 · wk-form4_1751487400.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,368

SEC source: 0000875320-25-000201 · wk-form4_1747688856.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,281

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1, which was entered into on 8/8/2024.

SEC source: 0000875320-25-000196 · wk-form4_1747339820.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,611

F1 · shares: Represents earned performance shares with respect to a performance stock unit award granted on 12/06/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 05/13/2025 and the shares will vest on 07/01/2025.

SEC source: 0000875320-25-000173 · wk-form4_1746476052.xml · nonDerivative · entry 2

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,831

F2 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1, which was entered into on 05/09/2024.

SEC source: 0000875320-25-000173 · wk-form4_1746476052.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,231

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000175 · wk-form4_1746476153.xml · nonDerivative · entry 1

CARNEY LLOYD · CIK 0001204424 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,115

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000179 · wk-form4_1746476447.xml · derivative · entry 1

Lagarde Michel · CIK 0001518973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,398

Underlying: Common Stock · 2,398 shares

Expires 2035-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000177 · wk-form4_1746476345.xml · derivative · entry 2

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,199

Underlying: Common Stock · 1,199 shares

Expires 2035-04-30

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000177 · wk-form4_1746476345.xml · nonDerivative · entry 1

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,872

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000182 · wk-form4_1746478338.xml · derivative · entry 4

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,991.483

Underlying: Common Stock · 1,001 shares

Expires not disclosed

F3 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2024, Ms. McKenzie deferred the receipt of 1,001 shares of common stock and received instead 1,001 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 1,001 shares of common stock in exchange for an equal number of deferred stock units.

F3 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

F3 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

SEC source: 0000875320-25-000182 · wk-form4_1746478338.xml · nonDerivative · entry 2

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,231

F2 · price: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2024, Ms. McKenzie deferred the receipt of 1,001 shares of common stock and received instead 1,001 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 1,001 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-25-000182 · wk-form4_1746478338.xml · nonDerivative · entry 1

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,232

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000184 · wk-form4_1746478539.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,398

Underlying: Common Stock · 2,398 shares

Expires 2035-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000186 · wk-form4_1746478668.xml · nonDerivative · entry 1

Schneider Jennifer · CIK 0001783060 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,718

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000188 · wk-form4_1746478751.xml · derivative · entry 2

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,199

Underlying: Common Stock · 1,199 shares

Expires 2035-04-30

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-25-000188 · wk-form4_1746478751.xml · nonDerivative · entry 1

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,035

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000190 · wk-form4_1746478850.xml · derivative · entry 3

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,475.603

Underlying: Common Stock · 1,001 shares

Expires not disclosed

F3 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Mr. Upadhyay on May 1, 2024, Mr. Upadhyay deferred the receipt of 1,001 shares of common stock and received instead 1,001 deferred stock units pursuant to our deferred compensation plan. As a result, Mr. Upadhyay is reporting the disposition of 1,001 shares of common stock in exchange for an equal number of deferred stock units.

F3 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F3 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-25-000190 · wk-form4_1746478850.xml · nonDerivative · entry 2

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,354

F2 · price: Upon the vesting of restricted stock units granted to Mr. Upadhyay on May 1, 2024, Mr. Upadhyay deferred the receipt of 1,001 shares of common stock and received instead 1,001 deferred stock units pursuant to our deferred compensation plan. As a result, Mr. Upadhyay is reporting the disposition of 1,001 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-25-000190 · wk-form4_1746478850.xml · nonDerivative · entry 1

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,355

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-25-000166 · wk-form4_1744920530.xml · derivative · entry 1

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,474.603

Underlying: Common Stock · 71.607 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-25-000164 · wk-form4_1744920427.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,240.461

Underlying: Common Stock · 95.475 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-25-000152 · wk-form4_1742242135.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,281

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1, which was entered into on 8/8/2024.

SEC source: 0000875320-25-000144 · wk-form4_1741810093.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,512

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1, which was entered into on 8/8/2024.