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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
November 01, 2019 Filed Nov 4, 2019 21:15 UTC SaleCommon Stock 3,159 $200.00 $631,800.00
Disclosure

SEC source: 0001209191-19-054882 · doc4.xml · nonDerivative · entry 2

Kearney Terrence C · CIK 0001289098 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,811

F1 · kind: Transaction made pursuant to Mr. Kearney's company approved trading plan under Rule 10b5-1.

Read SEC document
October 31, 2019 Filed Nov 4, 2019 21:13 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 8,879 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-19-054876 · doc4.xml · derivative · entry 8

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,210

Underlying: Common Stock · 8,879 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Fully vested.

Read SEC document
October 31, 2019 Filed Nov 4, 2019 21:13 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 8,879 $200.00 $1,775,800.00
Disclosure

SEC source: 0001209191-19-054876 · doc4.xml · nonDerivative · entry 2

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,287

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
October 31, 2019 Filed Nov 4, 2019 21:13 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 8,879 $131.89 $1,171,051.31
Disclosure

SEC source: 0001209191-19-054876 · doc4.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,166

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 31, 2019 Filed Nov 4, 2019 21:15 UTC SaleCommon Stock 1,841 $200.00 $368,200.00
Disclosure

SEC source: 0001209191-19-054882 · doc4.xml · nonDerivative · entry 1

Kearney Terrence C · CIK 0001289098 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,970

F1 · kind: Transaction made pursuant to Mr. Kearney's company approved trading plan under Rule 10b5-1.

Read SEC document
October 30, 2019 Filed Oct 31, 2019 20:36 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 3,057 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0001209191-19-054635 · doc4.xml · derivative · entry 3

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,096

Underlying: Common Stock · 3,057 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/06/2018.

Read SEC document
October 30, 2019 Filed Oct 31, 2019 20:36 UTC SaleCommon Stock 3,057 $199.00 $608,343.00
Disclosure

SEC source: 0001209191-19-054635 · doc4.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,098

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1.

Read SEC document
October 30, 2019 Filed Oct 31, 2019 20:36 UTC Exercise / conversionCommon Stock 3,057 $155.57 $475,577.49
Disclosure

SEC source: 0001209191-19-054635 · doc4.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,155

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 25, 2019 Filed Oct 29, 2019 20:54 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 4,311 $0.00 Strike: $91.05 $0.00
Disclosure

SEC source: 0001209191-19-054333 · doc4.xml · derivative · entry 5

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,311

Underlying: Common Stock · 4,311 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/02/2016.

Read SEC document
October 25, 2019 Filed Oct 29, 2019 20:54 UTC
Sachdev AmitEVP, Chief Patient Officer
SaleCommon Stock 4,311 $195.01 $840,688.11
Disclosure

SEC source: 0001209191-19-054333 · doc4.xml · nonDerivative · entry 2

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,416

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $195.01 (range $195.00 to $195.04).

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
October 25, 2019 Filed Oct 29, 2019 20:54 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionCommon Stock 4,311 $91.05 $392,516.55
Disclosure

SEC source: 0001209191-19-054333 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,727

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:13 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (Right to Buy) · Derivative 3,669 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0001209191-19-053923 · doc4.xml · derivative · entry 3

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,229

Underlying: Common Stock · 3,669 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/06/2018.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:13 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 3,669 $194.37 $713,143.53
Disclosure

SEC source: 0001209191-19-053923 · doc4.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,553

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:13 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionCommon Stock 3,669 $155.57 $570,786.33
Disclosure

SEC source: 0001209191-19-053923 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,222

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:18 UTC SaleCommon Stock 638 $189.00 $120,582.00
Disclosure

SEC source: 0001209191-19-053925 · doc4.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,098

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:23 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 35,411 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-19-053936 · doc4.xml · derivative · entry 7

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,089

Underlying: Common Stock · 35,411 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:23 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 72,420 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-19-053936 · doc4.xml · derivative · entry 6

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,580

Underlying: Common Stock · 72,420 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:23 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 35,411 $190.00 $6,728,090.00
Disclosure

SEC source: 0001209191-19-053936 · doc4.xml · nonDerivative · entry 4

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,287

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:23 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 35,411 $131.89 $4,670,356.79
Disclosure

SEC source: 0001209191-19-053936 · doc4.xml · nonDerivative · entry 3

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,698

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:23 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 72,420 $190.00 $13,759,800.00
Disclosure

SEC source: 0001209191-19-053936 · doc4.xml · nonDerivative · entry 2

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,287

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:23 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 72,420 $109.14 $7,903,918.80
Disclosure

SEC source: 0001209191-19-053936 · doc4.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 178,707

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:26 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 20,000 $0.00 Strike: $72.14 $0.00
Disclosure

SEC source: 0001209191-19-053941 · doc4.xml · derivative · entry 3

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2024-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:26 UTC SaleCommon Stock 20,000 $190.00 $3,800,000.00
Disclosure

SEC source: 0001209191-19-053941 · doc4.xml · nonDerivative · entry 2

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,124

F1 · kind: Transaction made pursuant to Ms. McGlynn's company-approved trading plan under Rule 10b5-1.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:26 UTC Exercise / conversionCommon Stock 20,000 $72.14 $1,442,800.00
Disclosure

SEC source: 0001209191-19-053941 · doc4.xml · nonDerivative · entry 1

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,124

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:28 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 3,883 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-19-053945 · doc4.xml · derivative · entry 5

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,650

Underlying: Common Stock · 3,883 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:28 UTC
Sachdev AmitEVP, Chief Patient Officer
SaleCommon Stock 3,883 $190.27 $738,818.41
Disclosure

SEC source: 0001209191-19-053945 · doc4.xml · nonDerivative · entry 2

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,416

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $190.27 (range $190.00 to $190.60).

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
October 22, 2019 Filed Oct 24, 2019 23:28 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionCommon Stock 3,883 $86.52 $335,957.16
Disclosure

SEC source: 0001209191-19-053945 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,299

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 17, 2019 Filed Oct 21, 2019 20:29 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionStock Option (Right to Buy) · Derivative 4,250 $0.00 Strike: $122.45 $0.00
Disclosure

SEC source: 0001209191-19-053698 · doc4.xml · derivative · entry 3

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,250

Underlying: Common Stock · 4,250 shares

Expires 2026-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 01/04/2016.

Read SEC document
October 17, 2019 Filed Oct 21, 2019 20:29 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 4,250 $177.80 $755,650.00
Disclosure

SEC source: 0001209191-19-053698 · doc4.xml · nonDerivative · entry 2

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,003

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

Read SEC document
October 17, 2019 Filed Oct 21, 2019 20:29 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionCommon Stock 4,250 $122.45 $520,412.50
Disclosure

SEC source: 0001209191-19-053698 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,253

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 15, 2019 Filed Oct 17, 2019 20:07 UTC GrantDeferred Stock Units · Derivative 263.533 $175.50 $46,250.04
Disclosure

SEC source: 0001209191-19-053410 · doc4.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,898.816

Underlying: Common Stock · 263.533 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

Read SEC document
October 14, 2019 Filed Oct 16, 2019 20:14 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionStock Option (Right to Buy) · Derivative 2,125 $0.00 Strike: $90.29 $0.00
Disclosure

SEC source: 0001209191-19-053284 · doc4.xml · derivative · entry 5

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,375

Underlying: Common Stock · 2,125 shares

Expires 2026-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option vests in 16 quarterly installments from 07/12/2016.

Read SEC document
October 14, 2019 Filed Oct 16, 2019 20:14 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 100 $175.10 $17,510.00
Disclosure

SEC source: 0001209191-19-053284 · doc4.xml · nonDerivative · entry 4

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,003

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

Read SEC document
October 14, 2019 Filed Oct 16, 2019 20:14 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 1,136 $174.46 $198,186.56
Disclosure

SEC source: 0001209191-19-053284 · doc4.xml · nonDerivative · entry 3

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,103

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

F3 · price: Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $174.46 (range $174.07 to $174.90).

Read SEC document
October 14, 2019 Filed Oct 16, 2019 20:14 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 889 $173.44 $154,188.16
Disclosure

SEC source: 0001209191-19-053284 · doc4.xml · nonDerivative · entry 2

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,239

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $173.44 (range $172.81 to $173.77).

F3 · price: Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
October 14, 2019 Filed Oct 16, 2019 20:14 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionCommon Stock 2,125 $90.29 $191,866.25
Disclosure

SEC source: 0001209191-19-053284 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,128

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 02, 2019 Filed Oct 3, 2019 20:25 UTC SaleCommon Stock 444 $167.69 $74,454.36
Disclosure

SEC source: 0001209191-19-052177 · doc4.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · SVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,252

F1 · kind: Transaction made pursuant to Ms. Tatsis' company-approved trading plan under Rule 10b5-1.

Read SEC document
October 02, 2019 Filed Oct 4, 2019 20:11 UTC Exercise / conversionStock Options (Right to Buy) · Derivative 5,818 $0.00 Strike: $126.68 $0.00
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · derivative · entry 7

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,729

Underlying: Common Stock · 5,818 shares

Expires 2025-06-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Fully vested.

Read SEC document
October 02, 2019 Filed Oct 4, 2019 20:11 UTC Exercise / conversionStock Options (Right to Buy) · Derivative 1,270 $0.00 Strike: $125.71 $0.00
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · derivative · entry 6

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,907

Underlying: Common Stock · 1,270 shares

Expires 2027-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Fully vested.

Read SEC document
October 02, 2019 Filed Oct 4, 2019 20:11 UTC SaleCommon Stock 1,232 $167.88 $206,828.16
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · nonDerivative · entry 5

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,249

F1 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1.

F3 · price: Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $167.88 (range $167.50 to $168.36).

Read SEC document
October 02, 2019 Filed Oct 4, 2019 20:11 UTC SaleCommon Stock 5,187 $166.82 $865,295.34
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · nonDerivative · entry 4

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,481

F1 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1.

F3 · price: Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $166.82 (range $166.40 to $167.35).

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October 02, 2019 Filed Oct 4, 2019 20:11 UTC SaleCommon Stock 1,960 $166.08 $325,516.80
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · nonDerivative · entry 3

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,668

F1 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $166.08 (range $165.39 to $166.38).

F3 · price: Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

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October 02, 2019 Filed Oct 4, 2019 20:11 UTC Exercise / conversionCommon Stock 5,818 $126.68 $737,024.24
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · nonDerivative · entry 2

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,628

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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October 02, 2019 Filed Oct 4, 2019 20:11 UTC Exercise / conversionCommon Stock 1,270 $125.71 $159,651.70
Disclosure

SEC source: 0001209191-19-052541 · doc4.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,810

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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October 01, 2019 Filed Oct 3, 2019 20:25 UTC SaleCommon Stock 188 $169.11 $31,792.68
Disclosure

SEC source: 0001209191-19-052177 · doc4.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · SVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,696

F1 · kind: Transaction made pursuant to Ms. Tatsis' company-approved trading plan under Rule 10b5-1.

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August 19, 2019 Filed Aug 20, 2019 20:30 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionCommon Stock (right to buy) · Derivative 4,659 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-19-046807 · doc4.xml · derivative · entry 11

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,980

Underlying: Common Stock · 4,659 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

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August 19, 2019 Filed Aug 20, 2019 20:30 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (right to buy) · Derivative 3,592 $0.00 Strike: $91.05 $0.00
Disclosure

SEC source: 0001209191-19-046807 · doc4.xml · derivative · entry 10

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,592

Underlying: Common Stock · 3,592 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/02/2016.

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August 19, 2019 Filed Aug 20, 2019 20:30 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (right to buy) · Derivative 4,250 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-19-046807 · doc4.xml · derivative · entry 9

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,250 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

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August 19, 2019 Filed Aug 20, 2019 20:30 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 2,330 $186.37 $434,242.10
Disclosure

SEC source: 0001209191-19-046807 · doc4.xml · nonDerivative · entry 8

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,553

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

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August 19, 2019 Filed Aug 20, 2019 20:30 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 2,329 $186.41 $434,148.89
Disclosure

SEC source: 0001209191-19-046807 · doc4.xml · nonDerivative · entry 7

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,883

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.