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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
December 09, 2019 Filed Dec 10, 2019 21:49 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionCommon Stock 5,000 $109.14 $545,700.00
Disclosure

SEC source: 0001209191-19-059883 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,416

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 26, 2019 Filed Nov 26, 2019 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (Right to buy) · Derivative 3,910 $0.00 Strike: $187.53 $0.00
Disclosure

SEC source: 0001209191-19-058097 · doc4.xml · derivative · entry 3

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,945

Underlying: Common Stock · 3,910 shares

Expires 2029-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/06/2019.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 3,910 $219.37 $857,736.70
Disclosure

SEC source: 0001209191-19-058097 · doc4.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,553

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionCommon Stock 3,910 $187.53 $733,242.30
Disclosure

SEC source: 0001209191-19-058097 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,463

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:12 UTC Exercise / conversionStock Option (Right to buy) · Derivative 4,692 $0.00 Strike: $187.53 $0.00
Disclosure

SEC source: 0001209191-19-058099 · doc4.xml · derivative · entry 3

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,334

Underlying: Common Stock · 4,692 shares

Expires 2029-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/06/2019.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:12 UTC SaleCommon Stock 4,692 $219.37 $1,029,284.04
Disclosure

SEC source: 0001209191-19-058099 · doc4.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,098

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:12 UTC Exercise / conversionCommon Stock 4,692 $187.53 $879,890.76
Disclosure

SEC source: 0001209191-19-058099 · doc4.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,790

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:13 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionStock Option (Right to buy) · Derivative 5,000 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-19-058101 · doc4.xml · derivative · entry 5

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,500

Underlying: Common Stock · 5,000 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:13 UTC
Sachdev AmitEVP, Chief Patient Officer
SaleCommon Stock 5,000 $220.00 $1,100,000.00
Disclosure

SEC source: 0001209191-19-058101 · doc4.xml · nonDerivative · entry 2

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,416

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

Read SEC document
November 25, 2019 Filed Nov 26, 2019 21:13 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionCommon Stock 5,000 $109.14 $545,700.00
Disclosure

SEC source: 0001209191-19-058101 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,416

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:19 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 5,000 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-19-057609 · doc4.xml · derivative · entry 5

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,500

Underlying: Common Stock · 5,000 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:19 UTC
Sachdev AmitEVP, Chief Patient Officer
SaleCommon Stock 5,000 $215.00 $1,075,000.00
Disclosure

SEC source: 0001209191-19-057609 · doc4.xml · nonDerivative · entry 2

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,416

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:19 UTC
Sachdev AmitEVP, Chief Patient Officer
Exercise / conversionCommon Stock 5,000 $109.14 $545,700.00
Disclosure

SEC source: 0001209191-19-057609 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,416

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 32,502 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · derivative · entry 8

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 32,502 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Fully vested.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 64,032 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · derivative · entry 7

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 64,032 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Fully vested.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 10,615 $212.75 $2,258,341.25
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · nonDerivative · entry 5

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,346

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

F3 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $212.75 (range $212.30 to $212.97).

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 23,033 $211.43 $4,869,867.19
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · nonDerivative · entry 4

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,961

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

F3 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $211.43 (range $211.08 to $211.97).

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 62,886 $210.41 $13,231,843.26
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · nonDerivative · entry 3

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,994

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $210.41 (range $210.06 to $210.83).

F3 · price: Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 32,502 $131.89 $4,286,688.78
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · nonDerivative · entry 2

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 202,880

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 19, 2019 Filed Nov 21, 2019 21:21 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 64,032 $109.14 $6,988,452.48
Disclosure

SEC source: 0001209191-19-057610 · doc4.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,378

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 18, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 1,493 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · derivative · entry 13

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,502

Underlying: Common Stock · 1,493 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
November 18, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 2,941 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · derivative · entry 12

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,032

Underlying: Common Stock · 2,941 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
November 18, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 1,493 $210.00 $313,530.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 8

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,346

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
November 18, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 1,493 $131.89 $196,911.77
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 7

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,839

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 18, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 2,941 $210.00 $617,610.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 6

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,346

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
November 18, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 2,941 $109.14 $320,980.74
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 5

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,287

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 18, 2019 Filed Nov 20, 2019 21:10 UTC GiftCommon Stock 239 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-057431 · doc4.xml · nonDerivative · entry 1

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,885

F1 · shares: This transaction represents a gift/charitable donation effective November 18, 2019, in which no value was received in return.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:07 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 60 $205.95 $12,357.00
Disclosure

SEC source: 0001209191-19-057119 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,553

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:09 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 19 $205.95 $3,913.05
Disclosure

SEC source: 0001209191-19-057126 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,240

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:11 UTC SaleCommon Stock 61 $205.95 $12,562.95
Disclosure

SEC source: 0001209191-19-057132 · doc4.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,098

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 1,683 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · derivative · entry 11

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,995

Underlying: Common Stock · 1,683 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionStock Option (Right to Buy) · Derivative 3,317 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · derivative · entry 10

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,973

Underlying: Common Stock · 3,317 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 1,683 $210.00 $353,430.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 4

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,346

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 1,683 $131.89 $221,970.87
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 3

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,029

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
SaleCommon Stock 3,317 $210.00 $696,570.00
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 2

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,346

F1 · kind: Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:12 UTC
LEIDEN JEFFREY MDirector · CEO & President
Exercise / conversionCommon Stock 3,317 $109.14 $362,017.38
Disclosure

SEC source: 0001209191-19-057137 · doc4.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,663

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:15 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 84 $205.95 $17,299.80
Disclosure

SEC source: 0001209191-19-057142 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,003

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:16 UTC
Sachdev AmitEVP, Chief Patient Officer
SaleCommon Stock 57 $205.95 $11,739.15
Disclosure

SEC source: 0001209191-19-057148 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,416

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 21:17 UTC SaleCommon Stock 5 $205.95 $1,029.75
Disclosure

SEC source: 0001209191-19-057152 · doc4.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · SVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,252

F1 · kind: Transaction made pursuant to Ms. Tatsis' company-approved trading plan under Rule 10b5-1.

Read SEC document
November 13, 2019 Filed Nov 15, 2019 21:03 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 8,560 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0001209191-19-056706 · doc4.xml · derivative · entry 4

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,006

Underlying: Common Stock · 8,560 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 2/6/2018.

Read SEC document
November 13, 2019 Filed Nov 15, 2019 21:03 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 8,560 $205.57 $1,759,679.20
Disclosure

SEC source: 0001209191-19-056706 · doc4.xml · nonDerivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,240

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 13, 2019 Filed Nov 15, 2019 21:03 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionCommon Stock 8,560 $155.57 $1,331,679.20
Disclosure

SEC source: 0001209191-19-056706 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,800

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 13, 2019 Filed Nov 15, 2019 21:05 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionStock Option (Right to Buy) · Derivative 4,892 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0001209191-19-056709 · doc4.xml · derivative · entry 3

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,006

Underlying: Common Stock · 4,892 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 2/6/2018.

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November 13, 2019 Filed Nov 15, 2019 21:05 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 4,892 $205.50 $1,005,306.00
Disclosure

SEC source: 0001209191-19-056709 · doc4.xml · nonDerivative · entry 2

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,003

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

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November 13, 2019 Filed Nov 15, 2019 21:05 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionCommon Stock 4,892 $155.57 $761,048.44
Disclosure

SEC source: 0001209191-19-056709 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,895

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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November 13, 2019 Filed Nov 15, 2019 21:07 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 2,853 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0001209191-19-056713 · doc4.xml · derivative · entry 3

Tatsis Ourania · CIK 0001789815 · SVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,669

Underlying: Common Stock · 2,853 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vests in 16 quarterly installments from 2/6/2018.

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November 13, 2019 Filed Nov 15, 2019 21:07 UTC SaleCommon Stock 2,853 $205.59 $586,548.27
Disclosure

SEC source: 0001209191-19-056713 · doc4.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · SVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,252

F1 · kind: Transaction made pursuant to Ms. Tatsis' company-approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $205.59 (range $205.57 to $205.76).

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

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November 13, 2019 Filed Nov 15, 2019 21:07 UTC Exercise / conversionCommon Stock 2,853 $155.57 $443,841.21
Disclosure

SEC source: 0001209191-19-056713 · doc4.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · SVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,105

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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November 08, 2019 Filed Nov 13, 2019 21:08 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 509 $0.00 Strike: $155.57 $0.00
Disclosure

SEC source: 0001209191-19-056327 · doc4.xml · derivative · entry 3

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,587

Underlying: Common Stock · 509 shares

Expires 2028-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 2/6/2018.

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November 08, 2019 Filed Nov 13, 2019 21:08 UTC SaleCommon Stock 509 $199.00 $101,291.00
Disclosure

SEC source: 0001209191-19-056327 · doc4.xml · nonDerivative · entry 2

Kewalramani Reshma · CIK 0001735944 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,098

F1 · kind: Transaction made pursuant to Dr. Kewalramani's company-approved trading plan under Rule 10b5-1.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.