Tapewire

Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
April 04, 2022 Filed Apr 6, 2022 20:59 UTC
Lee YuchunDirector
SaleCommon Stock 983 $268.36 $263,797.88
Disclosure

SEC source: 0000899243-22-014117 · doc4.xml · nonDerivative · entry 4

Lee Yuchun · CIK 0001334365 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,875

F1 · kind: Transaction made pursuant to Mr. Lee's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Lee undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $268.36 (range $267.97 to $268.81).

Read SEC document
April 04, 2022 Filed Apr 6, 2022 20:59 UTC
Lee YuchunDirector
SaleCommon Stock 917 $267.23 $245,049.91
Disclosure

SEC source: 0000899243-22-014117 · doc4.xml · nonDerivative · entry 3

Lee Yuchun · CIK 0001334365 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,858

F1 · kind: Transaction made pursuant to Mr. Lee's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Lee undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $267.23 (range $266.85 to $267.79).

Read SEC document
April 04, 2022 Filed Apr 6, 2022 20:59 UTC
Lee YuchunDirector
SaleCommon Stock 100 $265.83 $26,583.00
Disclosure

SEC source: 0000899243-22-014117 · doc4.xml · nonDerivative · entry 2

Lee Yuchun · CIK 0001334365 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,775

F1 · kind: Transaction made pursuant to Mr. Lee's company approved trading plan under Rule 10b5-1.

Read SEC document
April 04, 2022 Filed Apr 6, 2022 20:59 UTC
Lee YuchunDirector
Exercise / conversionCommon Stock 2,000 $81.54 $163,080.00
Disclosure

SEC source: 0000899243-22-014117 · doc4.xml · nonDerivative · entry 1

Lee Yuchun · CIK 0001334365 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,875

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 04, 2022 Filed Apr 6, 2022 21:02 UTC
Sanna BastianoEVP, Cell & Genetic Therapies
SaleCommon Stock 257 $268.43 $68,986.51
Disclosure

SEC source: 0000899243-22-014120 · doc4.xml · nonDerivative · entry 2

Sanna Bastiano · CIK 0001829069 · EVP, Cell & Genetic Therapies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,506

F1 · kind: Transaction made pursuant to Mr. Sanna's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Sanna undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $268.43 (range $267.81 to $268.78).

Read SEC document
April 04, 2022 Filed Apr 6, 2022 21:02 UTC
Sanna BastianoEVP, Cell & Genetic Therapies
SaleCommon Stock 305 $267.10 $81,465.50
Disclosure

SEC source: 0000899243-22-014120 · doc4.xml · nonDerivative · entry 1

Sanna Bastiano · CIK 0001829069 · EVP, Cell & Genetic Therapies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,763

F1 · kind: Transaction made pursuant to Mr. Sanna's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Sanna undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $267.10 (range $266.66 to $267.57).

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:05 UTC
Sanna BastianoEVP, Cell & Genetic Therapies
Tax withholdingCommon Stock 1,344 $263.09 $353,592.96
Disclosure

SEC source: 0000899243-22-013705 · doc4.xml · nonDerivative · entry 1

Sanna Bastiano · CIK 0001829069 · EVP, Cell & Genetic Therapies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,068

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:06 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 223 $266.68 $59,469.64
Disclosure

SEC source: 0000899243-22-013708 · doc4.xml · nonDerivative · entry 5

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,620

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Wagner undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F7 · price: Open market sales reported on this line occurred at a weighted average price of $266.68 (range $266.55 to $266.83).

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:06 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 536 $265.95 $142,549.20
Disclosure

SEC source: 0000899243-22-013708 · doc4.xml · nonDerivative · entry 4

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,843

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Wagner undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $265.95 (range $265.55 to $266.47).

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:06 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 1,142 $265.06 $302,698.52
Disclosure

SEC source: 0000899243-22-013708 · doc4.xml · nonDerivative · entry 3

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,379

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Wagner undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $265.06 (range $264.53 to $265.48).

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:06 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 381 $263.67 $100,458.27
Disclosure

SEC source: 0000899243-22-013708 · doc4.xml · nonDerivative · entry 2

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,521

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Wagner undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $263.67 (range $263.45 to $264.42).

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:06 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 300 $261.42 $78,426.00
Disclosure

SEC source: 0000899243-22-013708 · doc4.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,902

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

F2 · price: Mr. Wagner undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $261.42 (range $261.04 to $261.80).

Read SEC document
April 01, 2022 Filed Apr 5, 2022 20:06 UTC
Ambrose KristenSVP & Chief Accounting Officer
Tax withholdingCommon Stock 137 $263.09 $36,043.33
Disclosure

SEC source: 0000899243-22-013713 · doc4.xml · nonDerivative · entry 1

Ambrose Kristen · CIK 0001856587 · SVP & Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,823

Read SEC document
March 31, 2022 Filed Apr 4, 2022 20:05 UTC Exercise / conversionCommon Stock (right to buy) · Derivative 5,000 $127.54 Strike: $127.54 $637,700.00
Disclosure

SEC source: 0000899243-22-013305 · doc4.xml · derivative · entry 5

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 5,000 shares

Expires 2025-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Fully vested

Read SEC document
March 31, 2022 Filed Apr 4, 2022 20:05 UTC SaleCommon Stock 1,011 $262.97 $265,862.67
Disclosure

SEC source: 0000899243-22-013305 · doc4.xml · nonDerivative · entry 4

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,099

F1 · kind: Transaction made pursuant to Ms. McGlynn's company approved trading plan under Rule 10b5-1.

F3 · price: Ms. McGlynn undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $262.97 (range $262.80 to $263.34).

Read SEC document
March 31, 2022 Filed Apr 4, 2022 20:05 UTC SaleCommon Stock 2,970 $262.37 $779,238.90
Disclosure

SEC source: 0000899243-22-013305 · doc4.xml · nonDerivative · entry 3

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,110

F1 · kind: Transaction made pursuant to Ms. McGlynn's company approved trading plan under Rule 10b5-1.

F3 · price: Ms. McGlynn undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $262.37 (range $261.79 to $262.78).

Read SEC document
March 31, 2022 Filed Apr 4, 2022 20:05 UTC SaleCommon Stock 1,019 $261.28 $266,244.32
Disclosure

SEC source: 0000899243-22-013305 · doc4.xml · nonDerivative · entry 2

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,080

F1 · kind: Transaction made pursuant to Ms. McGlynn's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $261.28 (range $260.78 to $261.73).

F3 · price: Ms. McGlynn undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
March 31, 2022 Filed Apr 4, 2022 20:05 UTC Exercise / conversionCommon Stock 5,000 $127.54 $637,700.00
Disclosure

SEC source: 0000899243-22-013305 · doc4.xml · nonDerivative · entry 1

MCGLYNN MARGARET G · CIK 0001215126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,099

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
March 17, 2022 Filed Mar 21, 2022 20:10 UTC
Sanna BastianoEVP, Cell & Genetic Therapies
SaleCommon Stock 2,122 $250.06 $530,627.32
Disclosure

SEC source: 0000899243-22-011701 · doc4.xml · nonDerivative · entry 1

Sanna Bastiano · CIK 0001829069 · EVP, Cell & Genetic Therapies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,412

F1 · kind: Transaction made pursuant to Mr. Sanna's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $250.06 (range $250.00 to $250.48).

F3 · price: Mr. Sanna undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
March 17, 2022 Filed Mar 21, 2022 20:12 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 61 $251.05 $15,314.05
Disclosure

SEC source: 0000899243-22-011703 · doc4.xml · nonDerivative · entry 2

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,202

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

Read SEC document
March 17, 2022 Filed Mar 21, 2022 20:12 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
SaleCommon Stock 3,110 $250.13 $777,904.30
Disclosure

SEC source: 0000899243-22-011703 · doc4.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,263

F1 · kind: Transaction made pursuant to Mr. Wagner's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $250.13 (range $250.00 to $250.61).

F3 · price: Mr. Wagner undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
March 17, 2022 Filed Mar 21, 2022 20:15 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 34 $251.24 $8,542.16
Disclosure

SEC source: 0000899243-22-011705 · doc4.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,356

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

Read SEC document
March 17, 2022 Filed Mar 21, 2022 20:15 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 2,799 $250.10 $700,029.90
Disclosure

SEC source: 0000899243-22-011705 · doc4.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,390

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $250.10 (range $250.00 to $250.55).

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 560 $232.68 $130,300.80
Disclosure

SEC source: 0000899243-22-008109 · doc4.xml · nonDerivative · entry 5

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,077

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $232.68 (range $232.43 to $232.87).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 2,784 $231.64 $644,885.76
Disclosure

SEC source: 0000899243-22-008109 · doc4.xml · nonDerivative · entry 4

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,637

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $231.64 (range $231.08 to $232.07).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 3,188 $230.62 $735,216.56
Disclosure

SEC source: 0000899243-22-008109 · doc4.xml · nonDerivative · entry 3

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,421

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $230.62 (range $230.07 to $231.05).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 1,040 $229.41 $238,586.40
Disclosure

SEC source: 0000899243-22-008109 · doc4.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,609

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $229.41 (range $228.91 to $229.81).

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:27 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 18 $232.80 $4,190.40
Disclosure

SEC source: 0000899243-22-008123 · doc4.xml · nonDerivative · entry 6

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,189

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F7 · price: Open market sales reported on this line occurred at a weighted average price of $232.80 (range $232.59 to $232.92).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:27 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 87 $231.81 $20,167.47
Disclosure

SEC source: 0000899243-22-008123 · doc4.xml · nonDerivative · entry 5

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,207

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $231.81 (range $231.52 to $232.31).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:27 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 115 $230.97 $26,561.55
Disclosure

SEC source: 0000899243-22-008123 · doc4.xml · nonDerivative · entry 4

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,294

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $230.97 (range $230.50 to $231.47).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:27 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 77 $230.26 $17,730.02
Disclosure

SEC source: 0000899243-22-008123 · doc4.xml · nonDerivative · entry 3

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,409

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $230.26 (range $229.50 to $230.48).

Read SEC document
February 25, 2022 Filed Feb 28, 2022 22:27 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 28 $228.88 $6,408.64
Disclosure

SEC source: 0000899243-22-008123 · doc4.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,486

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $228.88 (range $228.39 to $229.36).

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
February 24, 2022 Filed Feb 28, 2022 22:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Tax withholdingCommon Stock 6,038 $227.86 $1,375,818.68
Disclosure

SEC source: 0000899243-22-008109 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,649

Read SEC document
February 24, 2022 Filed Feb 28, 2022 22:19 UTC Tax withholdingCommon Stock 7,246 $227.86 $1,651,073.56
Disclosure

SEC source: 0000899243-22-008111 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP, COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,066

Read SEC document
February 24, 2022 Filed Feb 28, 2022 22:20 UTC
Bozic CarmenEVP and CMO
Tax withholdingCommon Stock 1,242 $227.86 $283,002.12
Disclosure

SEC source: 0000899243-22-008112 · doc4.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,823

Read SEC document
February 24, 2022 Filed Feb 28, 2022 22:21 UTC
Kewalramani ReshmaDirector · CEO & President
Tax withholdingCommon Stock 7,246 $227.86 $1,651,073.56
Disclosure

SEC source: 0000899243-22-008116 · doc4.xml · nonDerivative · entry 1

Kewalramani Reshma · CIK 0001735944 · Director · CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 122,842

Read SEC document
February 24, 2022 Filed Feb 28, 2022 22:23 UTC
LEIDEN JEFFREY MDirector · Executive Chairman
Tax withholdingCommon Stock 12,141 $227.86 $2,766,448.26
Disclosure

SEC source: 0000899243-22-008119 · doc4.xml · nonDerivative · entry 1

LEIDEN JEFFREY M · CIK 0001242825 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,949

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February 24, 2022 Filed Feb 28, 2022 22:24 UTC
Liu JoySVP, General Counsel
Tax withholdingCommon Stock 1,554 $227.86 $354,094.44
Disclosure

SEC source: 0000899243-22-008120 · doc4.xml · nonDerivative · entry 1

Liu Joy · CIK 0001847529 · SVP, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,454

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February 24, 2022 Filed Feb 28, 2022 22:25 UTC
Sachdev AmitEVP, Chief Patient Officer
Tax withholdingCommon Stock 7,368 $227.86 $1,678,872.48
Disclosure

SEC source: 0000899243-22-008121 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, Chief Patient Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,210

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February 24, 2022 Filed Feb 28, 2022 22:27 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
Tax withholdingCommon Stock 2,590 $227.86 $590,157.40
Disclosure

SEC source: 0000899243-22-008123 · doc4.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,514

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February 24, 2022 Filed Feb 28, 2022 22:29 UTC
WAGNER CHARLES F JREVP & Chief Financial Officer
Tax withholdingCommon Stock 2,189 $227.86 $498,785.54
Disclosure

SEC source: 0000899243-22-008128 · doc4.xml · nonDerivative · entry 1

WAGNER CHARLES F JR · CIK 0001223348 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,373

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February 18, 2022 Filed Feb 22, 2022 21:51 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 1,038 $233.27 $242,134.26
Disclosure

SEC source: 0000899243-22-007203 · doc4.xml · nonDerivative · entry 6

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,687

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F7 · price: Open market sales reported on this line occurred at a weighted average price of $233.27 (range $232.91 to $233.50).

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February 18, 2022 Filed Feb 22, 2022 21:51 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 600 $231.85 $139,110.00
Disclosure

SEC source: 0000899243-22-007203 · doc4.xml · nonDerivative · entry 5

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,725

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $231.85 (range $231.67 to $232.01).

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February 18, 2022 Filed Feb 22, 2022 21:51 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 385 $231.01 $88,938.85
Disclosure

SEC source: 0000899243-22-007203 · doc4.xml · nonDerivative · entry 4

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,325

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $231.01 (range $230.66 to $231.43).

Read SEC document
February 18, 2022 Filed Feb 22, 2022 21:51 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 1,303 $230.05 $299,755.15
Disclosure

SEC source: 0000899243-22-007203 · doc4.xml · nonDerivative · entry 3

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,710

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $230.05 (range $229.65 to $230.59).

Read SEC document
February 18, 2022 Filed Feb 22, 2022 21:51 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 986 $229.22 $226,010.92
Disclosure

SEC source: 0000899243-22-007203 · doc4.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,013

F1 · kind: Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $229.22 (range $228.65 to $229.60).

F3 · price: Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
February 18, 2022 Filed Feb 22, 2022 22:03 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 120 $233.48 $28,017.60
Disclosure

SEC source: 0000899243-22-007216 · doc4.xml · nonDerivative · entry 5

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,104

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $233.48 (range $233.18 to $233.73).

Read SEC document
February 18, 2022 Filed Feb 22, 2022 22:03 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 80 $232.04 $18,563.20
Disclosure

SEC source: 0000899243-22-007216 · doc4.xml · nonDerivative · entry 4

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,224

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $232.04 (range $231.89 to $232.13).

Read SEC document
February 18, 2022 Filed Feb 22, 2022 22:03 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 101 $230.42 $23,272.42
Disclosure

SEC source: 0000899243-22-007216 · doc4.xml · nonDerivative · entry 3

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,304

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $230.42 (range $230.05 to $230.75).

Read SEC document
February 18, 2022 Filed Feb 22, 2022 22:03 UTC
Tatsis OuraniaEVP, Chief Reg. & Quality Off.
SaleCommon Stock 218 $229.52 $50,035.36
Disclosure

SEC source: 0000899243-22-007216 · doc4.xml · nonDerivative · entry 2

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,405

F1 · kind: Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $229.52 (range $229.05 to $229.97).

F3 · price: Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.