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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
June 26, 2007 Filed Jun 26, 2007 19:13 UTC PurchaseCommon Stock 50,000 $26.45 $1,322,500.00
Disclosure

SEC source: 0000875320-07-000070 · edgar.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,000

Read SEC document
June 18, 2007 Filed Jun 19, 2007 17:28 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionCommon Stock 7,626 $13.11 $99,976.86
Disclosure

SEC source: 0000875320-07-000069 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,095,842

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 08, 2007 Filed Jun 11, 2007 17:51 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionStock Option · Derivative 3,657 $0.00 Strike: $13.67 $0.00
Disclosure

SEC source: 0000875320-07-000068 · edgar.xml · derivative · entry 6

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,657 shares

Expires 2007-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

Read SEC document
June 08, 2007 Filed Jun 11, 2007 17:51 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionStock Option · Derivative 9,822 $0.00 Strike: $10.19 $0.00
Disclosure

SEC source: 0000875320-07-000068 · edgar.xml · derivative · entry 5

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 9,822 shares

Expires 2008-09-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

Read SEC document
June 08, 2007 Filed Jun 11, 2007 17:51 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionCommon Stock 3,657 $13.67 $49,991.19
Disclosure

SEC source: 0000875320-07-000068 · edgar.xml · nonDerivative · entry 2

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,088,216

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 08, 2007 Filed Jun 11, 2007 17:51 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionCommon Stock 9,822 $10.19 $100,086.18
Disclosure

SEC source: 0000875320-07-000068 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,084,559

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 08, 2007 Filed Jun 19, 2007 17:28 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionStock Option · Derivative 7,626 $0.00 Strike: $13.11 $0.00
Disclosure

SEC source: 0000875320-07-000069 · edgar.xml · derivative · entry 4

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,626 shares

Expires 2009-12-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

Read SEC document
June 04, 2007 Filed Jun 5, 2007 16:06 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
Exercise / conversionStock Option · Derivative 3,000 $0.00 Strike: $11.40 $0.00
Disclosure

SEC source: 0000875320-07-000067 · edgar.xml · derivative · entry 4

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,000

Underlying: Common Stock · 3,000 shares

Expires 2015-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/15/2005.

Read SEC document
June 04, 2007 Filed Jun 5, 2007 16:06 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
SaleCommon Stock 3,000 $29.51 $88,530.00
Disclosure

SEC source: 0000875320-07-000067 · edgar.xml · nonDerivative · entry 2

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,273

F1 · kind: Transaction made pursuant to Dr. Hartmann's company approved trading plan established under Rule 10b5-1.

Read SEC document
June 04, 2007 Filed Jun 5, 2007 16:06 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
Exercise / conversionCommon Stock 3,000 $11.40 $34,200.00
Disclosure

SEC source: 0000875320-07-000067 · edgar.xml · nonDerivative · entry 1

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:39 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000058 · edgar.xml · derivative · entry 2

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:42 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000059 · edgar.xml · derivative · entry 1

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:46 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000061 · edgar.xml · derivative · entry 1

CORDES EUGENE · CIK 0001192609 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:44 UTC
BRANDT ERICDirector
GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000060 · edgar.xml · derivative · entry 1

BRANDT ERIC · CIK 0001190639 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:48 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000062 · edgar.xml · derivative · entry 1

BRIMBLECOMBE ROGER W · CIK 0001197034 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:50 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000063 · edgar.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:52 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000064 · edgar.xml · derivative · entry 1

COLLINSON STUART J · CIK 0001197037 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:54 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000065 · edgar.xml · derivative · entry 1

Slater Eve Elizabeth · CIK 0001289739 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
June 01, 2007 Filed Jun 4, 2007 16:57 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000066 · edgar.xml · derivative · entry 1

Emmens Matthew · CIK 0001298332 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
May 31, 2007 Filed Jun 4, 2007 16:39 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $29.84 $0.00
Disclosure

SEC source: 0000875320-07-000058 · edgar.xml · derivative · entry 1

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2017-05-30

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
May 29, 2007 Filed May 30, 2007 16:33 UTC Exercise / conversionStock Option · Derivative 10,000 $0.00 Strike: $13.32 $0.00
Disclosure

SEC source: 0000875320-07-000056 · edgar.xml · derivative · entry 3

Slater Eve Elizabeth · CIK 0001289739 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2015-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan. Fully vested.

Read SEC document
May 29, 2007 Filed May 30, 2007 16:33 UTC SaleCommon Stock 10,000 $30.42 $304,200.00
Disclosure

SEC source: 0000875320-07-000056 · edgar.xml · nonDerivative · entry 2

Slater Eve Elizabeth · CIK 0001289739 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,105

F1 · balance_after: Dr. Slater disclaims beneficial ownership of 1,105 shares, which are held jointly with her adult son.

Read SEC document
May 29, 2007 Filed May 30, 2007 16:33 UTC Exercise / conversionCommon Stock 10,000 $13.32 $133,200.00
Disclosure

SEC source: 0000875320-07-000056 · edgar.xml · nonDerivative · entry 1

Slater Eve Elizabeth · CIK 0001289739 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,105

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Dr. Slater disclaims beneficial ownership of 1,105 shares, which are held jointly with her adult son.

Read SEC document
May 29, 2007 Filed May 30, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $11.27 $0.00
Disclosure

SEC source: 0000875320-07-000057 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 837

Underlying: Common Stock · 125 shares

Expires 2014-10-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan vesting in 16 equal quarterly installments from 10/7/2004.

Read SEC document
May 29, 2007 Filed May 30, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $30.49 $3,811.25
Disclosure

SEC source: 0000875320-07-000057 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,564

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 29, 2007 Filed May 30, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $11.27 $1,408.75
Disclosure

SEC source: 0000875320-07-000057 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 21, 2007 Filed May 22, 2007 18:34 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $11.27 $0.00
Disclosure

SEC source: 0000875320-07-000055 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 962

Underlying: Common Stock · 125 shares

Expires 2014-10-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan vesting in 16 equal quarterly installments from 10/7/2004.

Read SEC document
May 21, 2007 Filed May 22, 2007 18:34 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $31.56 $3,945.00
Disclosure

SEC source: 0000875320-07-000055 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,564

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 21, 2007 Filed May 22, 2007 18:34 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $11.27 $1,408.75
Disclosure

SEC source: 0000875320-07-000055 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 17, 2007 Filed May 21, 2007 19:18 UTC
GARRISON RICHARD CSVP, Catalyst
SaleCommon Stock 632 $31.95 $20,192.40
Disclosure

SEC source: 0000875320-07-000050 · edgar.xml · nonDerivative · entry 1

GARRISON RICHARD C · CIK 0001256466 · SVP, Catalyst

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,374

F1 · kind: Transaction made pursuant to Mr. Garrison's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 17, 2007 Filed May 21, 2007 19:21 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 794 $31.95 $25,368.30
Disclosure

SEC source: 0000875320-07-000051 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,324

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 17, 2007 Filed May 21, 2007 19:24 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 220 $31.95 $7,029.00
Disclosure

SEC source: 0000875320-07-000052 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,564

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under rule 10b5-1.

Read SEC document
May 17, 2007 Filed May 21, 2007 19:26 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
SaleCommon Stock 824 $31.95 $26,326.80
Disclosure

SEC source: 0000875320-07-000053 · edgar.xml · nonDerivative · entry 1

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,273

F1 · kind: Transaction made pursuant to Dr. Hartmann's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 17, 2007 Filed May 21, 2007 19:29 UTC
SMITH IAN FEVP & CFO
SaleCommon Stock 823 $31.95 $26,294.85
Disclosure

SEC source: 0000875320-07-000054 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,114

F1 · kind: Transaction made pursuant to Mr. Smith's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 14, 2007 Filed May 15, 2007 15:55 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $11.27 $0.00
Disclosure

SEC source: 0000875320-07-000049 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,087

Underlying: Common Stock · 125 shares

Expires 2014-10-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan vesting in 16 equal quarterly installments from 10/7/2004.

Read SEC document
May 14, 2007 Filed May 15, 2007 15:55 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $30.05 $3,756.25
Disclosure

SEC source: 0000875320-07-000049 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,564

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
May 14, 2007 Filed May 15, 2007 15:55 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $11.27 $1,408.75
Disclosure

SEC source: 0000875320-07-000049 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 07, 2007 Filed May 8, 2007 18:49 UTC Exercise / conversionStock Option · Derivative 10,000 $0.00 Strike: $19.78 $0.00
Disclosure

SEC source: 0000875320-07-000043 · edgar.xml · derivative · entry 3

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2007-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan. Fully vested.

Read SEC document
May 07, 2007 Filed May 8, 2007 18:49 UTC SaleCommon Stock 10,000 $30.53 $305,300.00
Disclosure

SEC source: 0000875320-07-000043 · edgar.xml · nonDerivative · entry 2

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,383

Read SEC document
May 07, 2007 Filed May 8, 2007 18:49 UTC Exercise / conversionCommon Stock 10,000 $19.78 $197,800.00
Disclosure

SEC source: 0000875320-07-000043 · edgar.xml · nonDerivative · entry 1

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,383

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 7,626 $0.00 Strike: $13.11 $0.00
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · derivative · entry 8

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,626 shares

Expires 2009-12-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan. Fully Vested

Read SEC document
May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 3,188 $0.00 Strike: $13.63 $0.00
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,188 shares

Expires 2008-12-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan. Fully Vested

Read SEC document
May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 5,550 $0.00 Strike: $10.19 $0.00
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,550 shares

Expires 2008-09-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan. Fully Vested

Read SEC document
May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 7,626 $13.11 $99,976.86
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,324

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 3,188 $13.63 $43,452.44
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,698

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 5,550 $10.19 $56,554.50
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,510

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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May 07, 2007 Filed May 8, 2007 18:52 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 32,500 $30.59 $994,175.00
Disclosure

SEC source: 0000875320-07-000044 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,960

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

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May 07, 2007 Filed May 8, 2007 18:55 UTC
BOGER KENNETH SSVP & General Counsel
SaleCommon Stock 12,684 $30.60 $388,130.40
Disclosure

SEC source: 0000875320-07-000045 · edgar.xml · nonDerivative · entry 1

BOGER KENNETH S · CIK 0001046336 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,677

F1 · kind: Transaction made pursuant to Mr. Boger's company approved trading plan established under rule 10b5-1.

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May 07, 2007 Filed May 8, 2007 18:59 UTC
SMITH IAN FEVP & CFO
SaleCommon Stock 32,500 $30.61 $994,825.00
Disclosure

SEC source: 0000875320-07-000046 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,114

F1 · kind: Transaction made pursuant to Mr. Smith's company approved trading plan established under Rule 10b5-1.

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May 07, 2007 Filed May 8, 2007 19:01 UTC
MUELLER PETERCSO&EVP Drug Innov&Realization
SaleCommon Stock 11,401 $30.59 $348,756.59
Disclosure

SEC source: 0000875320-07-000047 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · CSO&EVP Drug Innov&Realization

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,430

F1 · kind: Transaction made pursuant to Dr. Mueller's company approved trading plan established under Rule 10b5-1.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.